Patents Assigned to Duke University
  • Benzoylglycine derivatives and methods of making and using same
    Patent number: 12103904
    Abstract: Disclosed are compounds of formulae: and pharmaceutically acceptable salts thereof, wherein the variables, R1, R2, R3, R4, R5, R6, R7, R11, R12, R13, R14, R15, R16, R17, n, and m are defined herein. These compounds are useful for treating Gram-negative bacteria infections. Also disclosed are methods of making these compounds.
    Type: Grant
    Filed: March 19, 2021
    Date of Patent: October 1, 2024
    Assignees: Duke University, The University of North Carolina at Chapel Hill
    Inventors: Pei Zhou, Eric J. Toone, Robert A. Nicholas, Ramesh Gopalaswamy, Xiaofei Liang, Frank Navas, III
  • VON WILLEBRAND FACTOR (VWF)-TARGETING AGENTS AND METHODS OF USING THE SAME
    Publication number: 20240318178
    Abstract: Provided herein are aptamers capable of inhibiting the activity of Von Willebrand Factor (VWF). Pharmaceutical compositions comprising these aptamers are also provided. Methods of preventing blood clot formation in a subject by administering the aptamers are provided and methods of treating a blood clot by administering a VWF-targeting agent are also provided.
    Type: Application
    Filed: March 29, 2024
    Publication date: September 26, 2024
    Applicants: Duke University, Ohio State Innovation Foundation
    Inventors: Shahid M. NIMJEE, Bruce SULLENGER, George A. PITOC, Juliana LAYZER
  • Compositions and methods for the treatment of cancer
    Patent number: 12098117
    Abstract: This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to Heat Shock Transcription Factor 1 (HSF1) activity and/or function. More particularly, this disclosure relates to methods of inhibiting HSF1 activity with these compounds and pharmaceutical compositions thereof, and methods of treating diseases associated with HSF1 activity and/or function, such as cancer.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: September 24, 2024
    Assignee: Duke University
    Inventors: Dennis J. Thiele, Bushu Dong, Alexander M. Jaeger, Philip F. Hughes, Timothy Haystead, Jiyong Hong
  • Systems and methods for multiplexing and alternating light of different wavelengths in an ophthalmoscope
    Patent number: 12089897
    Abstract: Systems and method for multiplexing and alternating light of different wavelengths in an ophthalmoscope are disclosed herein. According to an aspect, an imaging system includes an illumination system configured to generate and output light that alternates between at least two different wavelengths. The imaging system includes a multiplexer configured to receive the output light and to multiplex the light of different wavelengths onto a single optical channel. Further, the imaging system includes a scanning laser ophthalmoscope probe configured to operatively receive the multiplexed light, to apply the multiplexed light to a subject for imaging, and to receive light returning from the subject for generating an image of the subject.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: September 17, 2024
    Assignee: Duke University
    Inventors: Al-Hafeez Dhalla, Anthony Kuo, Joseph Izatt
  • Drainage or infusion catheter and method of use
    Patent number: 12090260
    Abstract: A drainage or infusion catheter and methods of use are disclosed. In one embodiment, the catheter includes a tube body having a proximal end and a distal end, and a plurality of ports arranged along the tube body from the distal end to the proximal end. The distal end of the tube body is configured to deform around itself into a substantially spiral shape so as to cover at least one of the plurality of ports located near the proximal end of the tube body. In another embodiment, a flap is configured to erupt from apertures arranged in the tube and extend outwardly around the tube body so as to cover at least one of the plurality of ports located near the proximal end of the tube body.
    Type: Grant
    Filed: April 4, 2022
    Date of Patent: September 17, 2024
    Assignee: Duke University
    Inventor: Muath Bishawi
  • Implementation of batch optimization for robust two-qubit gates for quantum computation
    Patent number: 12093788
    Abstract: The present disclosure describes techniques for optimizing two-qubit gates performance in a quantum circuit of a quantum computing system. A quantum computing system selects, from qubits in the quantum circuit, a pair of target qubits on which to perform a quantum gate operation. The quantum computing system selects, from the plurality of qubits, a second plurality of qubits on which to introduce an intentional noise. The intentional noise is applied to the second plurality of qubits via a numerical optimizer. An optimized frequency is determined based on the applied intentional noise. The quantum gate operation is performed by modifying the pair of target qubits frequency to the optimized frequency.
    Type: Grant
    Filed: April 14, 2022
    Date of Patent: September 17, 2024
    Assignee: Duke University
    Inventors: Kenneth Brown, Mingyu Kang, Qiyao Liang, Bichen Zhang
  • Gene signatures for monitoring acute rejection and methods of using same
    Patent number: 12084509
    Abstract: The present disclosure provides methods and compositions for detecting and treating acute transplant rejection.
    Type: Grant
    Filed: April 30, 2021
    Date of Patent: September 10, 2024
    Assignee: Duke University
    Inventors: Eileen Chambers, Qing Cheng, Allan Kirk
  • Vaccines against an oncogenic isoform of HER2 (ErbB2) and methods of using the same
    Patent number: 12083172
    Abstract: Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods include administering a vaccine comprising a polynucleotide encoding a polypeptide whose expression or activation is correlated with development of resistance of the cancer or precancer to the cancer therapeutic or prevention agent to a subject. The vaccine may include a polynucleotide encoding a HER2 polypeptide or a truncation, deletion or substitution mutant thereof. Methods of using the vaccine including the polynucleotide encoding the HER2 polypeptide to treat a cancer or precancer are also provided. The vaccines may be administered with a cancer therapeutic or prevention agent or a checkpoint inhibitor immunomodulatory agent.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: September 10, 2024
    Assignee: Duke University
    Inventors: Herbert K. Lyerly, Takuya Osada, Zachary C. Hartman
  • Unstructured non-repetitive polypeptides having lcst behavior
    Patent number: 12084480
    Abstract: Described herein are unstructured polypeptides lacking any discernible repeat motif. Also described herein are fusion proteins including at least one of the unstructured polypeptides and at least one binding polypeptide. Further described are methods for treating a disease in a subject in need thereof. The methods may include administering to the subject an effective amount of the fusion protein.
    Type: Grant
    Filed: September 16, 2021
    Date of Patent: September 10, 2024
    Assignee: Duke University
    Inventors: Ashutosh Chilkoti, Nicholas Tang, Garrett Kelly
  • Mobile brain computer interface
    Patent number: 12072686
    Abstract: A method includes receiving, by a mobile computing device from an electroencephalogram (EEG) monitoring headset, an incoming wireless communication signal including an EEG data stream. The method may further include processing, by an application running on the mobile computing device, the received EEG data stream to determine at least one actionable command for at least one peripheral device. The method may also include transmitting, by the mobile computing device to the at least one peripheral device, at least one outgoing wireless communication signal including the at least one determined actionable command.
    Type: Grant
    Filed: June 16, 2023
    Date of Patent: August 27, 2024
    Assignee: Duke University
    Inventors: Allen Song, Chris Petty
  • Methods for automated detection of cervical pre-cancers with a low-cost, point-of-care, pocket colposcope
    Patent number: 12073559
    Abstract: A method for automated detection of cervical pre-cancer includes: providing at least one cervigram; pre-processing the at least one cervigram; extracting features from the at least one pre-processed cervigram; and classifying the at least one cervigram as negative or positive for cervical pre-cancer based on the extracted features.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: August 27, 2024
    Assignee: Duke University
    Inventors: Mercy Asiedu, Nirmala Ramanujam, Guillermo Sapiro
  • Compositions, methods and kits for eliciting an immune response
    Patent number: 12070496
    Abstract: The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one CMV antigen expressed by a cancer cell, in particular for treating and preventing cancer. CMV determination methods, compositions, and kits also are provided.
    Type: Grant
    Filed: May 31, 2022
    Date of Patent: August 27, 2024
    Assignee: Duke University
    Inventors: John H. Sampson, Duane A. Mitchell
  • Gene expression signatures useful to predict or diagnose sepsis and methods of using the same
    Patent number: 12071668
    Abstract: The present disclosure provides methods for determining whether a subject has sepsis, or is at risk of developing sepsis, and methods of treating the subject based on the determination. Also provided are methods for determining an increased risk of mortality in a subject with sepsis or suspected of having sepsis, and methods of treating the subject based on the determination. Systems useful for the same are also provided.
    Type: Grant
    Filed: February 18, 2022
    Date of Patent: August 27, 2024
    Assignees: Duke University, United States Government as Represented by the Department of Veterans Affairs
    Inventors: Ephraim L. Tsalik, Geoffrey S. Ginsburg, Christopher W. Woods, Ricardo Henao Giraldo, Rachel A. Myers
  • Peptide compounds for suppressing inflammation
    Patent number: 12071469
    Abstract: Provided herein are peptides that exhibit ApoE biological activity, as well as compositions and pharmaceutical formulations that include the peptides. The peptides, compositions, and methods disclosed herein have broad applications as they can be used to treat a broad spectrum of injury, diseases, disorders, and clinical indications.
    Type: Grant
    Filed: September 1, 2021
    Date of Patent: August 27, 2024
    Assignee: Duke University
    Inventors: Daniel T. Laskowitz, Hana Dawson, Brad Kolls
  • Splice-switching oligonucleotides and methods of use
    Patent number: 12071626
    Abstract: The present disclosure provides methods and compositions for the treatment of cancer. In some aspects, the present disclosure provides splice-switching oligonucleotides that downregulate AR or EGFR expression and methods of using these splice-switching oligonucleotides to treat cancer.
    Type: Grant
    Filed: September 1, 2021
    Date of Patent: August 27, 2024
    Assignee: Duke University
    Inventors: Jennifer Freedman, Brendon Patierno, Bonnie LaCroix, Timothy Robinson, Bruce Sullenger, Daniel George, Steven Patierno
  • ANTIBIOTICS COMPRISING LPXH-TARGETING COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20240279174
    Abstract: Disclosed herein are novel antibiotic compositions and methods of making and using the same. The antibiotic compositions may comprise LPXH-targeting compounds.
    Type: Application
    Filed: April 3, 2024
    Publication date: August 22, 2024
    Applicant: Duke University
    Inventors: Pei Zhou, Jiyong Hong
  • Cultured thymus tissue transplantation promotes donor-specific tolerance to allogeneic solid organ transplants
    Patent number: 12064452
    Abstract: Methods and compositions for promoting donor-specific tolerance and immunocompetence to a recipient of a solid organ transplant, by implanting an allogeneic solid organ in a recipient in need of a solid organ transplant and further comprising surgical implantation of a tissue-engineered allogeneic cultured postnatal thymus tissue product in the recipient of a solid organ from a donor.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: August 20, 2024
    Assignee: Duke University
    Inventor: Mary Louise Markert
  • Synthetic hydrogel composite
    Patent number: 12064533
    Abstract: Cellulose-reinforced hydrogels may include a cellulose nanofiber network and an interstitial hydrogel portion within interstitial regions of the cellulose nanofiber network, the interstitial hydrogel portion comprising polyvinyl alcohol (PVA), wherein the hydrogel component has a crystallinity of 20% or greater.
    Type: Grant
    Filed: May 26, 2023
    Date of Patent: August 20, 2024
    Assignee: Duke University
    Inventors: Benjamin J. Wiley, Huayu Tong, Jiacheng Zhao
  • Compositions and Methods for Identifying and Modulating Metabolic Health
    Publication number: 20240264172
    Abstract: This invention provides reagents, methods and biochemical markers for identifying and providing therapeutic intervention for individuals with metabolic dysfunction, or individuals at risk for metabolic dysfunction.
    Type: Application
    Filed: January 16, 2024
    Publication date: August 8, 2024
    Applicant: Duke University
    Inventors: John F. Rawls, James E.N. Minchin
  • Inhibitors of intracellular invasion
    Patent number: 12053460
    Abstract: The disclosure provides compounds that inhibit the invasion of host cells by intracellular parasites. These find use, for example, in treating and preventing periodontitis or a periodontitis-related condition or symptom.
    Type: Grant
    Filed: August 16, 2021
    Date of Patent: August 6, 2024
    Assignees: Meharry Medical College, Duke University
    Inventors: Hua Xie, Chin-Ho Chen