Abstract: A system for delivering electrical pulse stimulation to a subject includes a remote control device configured to at least intermittently transmit temporal pulse pattern programming and a stimulation device comprising a control interface, at least one electrode in electrical communication with the control interface, and an input device in at least intermittent communication with the remote control device to receive the temporal pulse pattern programming. The stimulation device is configured to deliver electrical pulse stimulation to a subject via the at least one electrode according to the temporal pulse pattern programming.
Abstract: The present disclosure provides compositions and methods for the treatment of pathogen-induced and/or chemical-induced lung injury, for regenerating lung epithelial cells following lung injury, for treating cancer, and for sensitizing a subject suffering from cancer to a chemotherapeutic agent.
Abstract: A transducer array includes at least one annular shear wave generation transducer that defines an interior area, the at least one annular shear wave generation transducer being configured to generate a shear wave excitation to a region of interest such that the shear wave excitation excites at least a part of a corresponding cylindrical portion of the region of interest and shear waves propagating from the cylindrical portion of the region of interest constructively interfere in an interior region of the cylindrical portion of the region of interest; and at least one tracking transducer positioned in the interior area of the at least one annular shear wave generation transducer, the at least one tracking transducer being configured to detect a shear wave in the interior region of the region of interest.
Abstract: In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelope selections from individual CH505, and methods for swarm immunizations using combinations of HIV-1 envelopes.
Type:
Grant
Filed:
March 11, 2021
Date of Patent:
January 30, 2024
Assignees:
DUKE UNIVERSITY, TRIAD NATIONAL SECURITY, LLC
Inventors:
Barton F. Haynes, Mattia Bonsignori, Hua-Xin Liao, Bette T. Korber, Peter T. Hraber, Kevin O. Saunders
Abstract: Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.
Abstract: Provided herein are compositions and methods for detection of N6-methyladenosine (m6A) in ribonucleic acid (RNA). The provided compositions include fusion proteins that can be used to edit RNA and detect m6A residues. Also provided are nucleic acids, vectors, constructs, host cells, and transgenic animals that encode or express such fusions proteins.
Abstract: Disclosed herein are compositions and methods for treating uterine fibroids in vivo, and methods of reducing symptoms associated with uterine fibroids, including pain, bleeding and infertility. The disclosed compositions comprise collagenase in an amount effective to cause shrinkage and/or reduce stiffness of uterine fibroids.
Type:
Grant
Filed:
October 14, 2020
Date of Patent:
January 16, 2024
Assignees:
The Johns Hopkins University, Duke University, BioSpecifics Technologies LLC
Inventors:
James H. Segars, Phyllis Carolyn Leppert, Thomas L. Wegman, Jean-Marie Soma
Abstract: A method of using at least one implantable mesh extension for repairing a tissue defect or reconstructing tissue, wherein the mesh extension is comprised of a mesh having a width and a length extending between a first end and a second end, includes passing the first end of the mesh extension through tissue adjacent to the tissue defect or tissue to be reconstructed at least once and then passing the first end of the mesh extension through a portion of the mesh. The mesh extension is then pulled to create a first self-locking stitch to anchor the mesh extension to the adjacent tissue so as to immediately resist high tension.
Abstract: The present disclosure provides methods and compositions for the treatment of cancer. In some aspects, the present disclosure provides splice-switching oligonucleotides that downregulate AR expression and methods of using these splice-switching oligonucleotides to treat cancer, specifically castrate resistant prostate cancer.
Type:
Grant
Filed:
March 22, 2019
Date of Patent:
January 9, 2024
Assignee:
Duke University
Inventors:
Jennifer Freedman, Steven Patierno, Daniel George, Bruce Sullenger, Bonnie LaCroix, Brendon Patierno
Abstract: The disclosure is directed to a G-protein coupled receptor complex. The complex includes (i) a chimeric G protein-coupled receptor (GPCR) comprising a non-native amino acid sequence located within the C-terminus of the GPCR and a synthetic phosphopeptide ligated to the non-native amino acid sequence; and (ii) a ?-arrestin (?arr) protein bound to the C-terminus of the GPCR. The disclosure also provides an in vitro method for producing the aforementioned complex, as well as methods for identifying compounds or ligands which bind to and modulate the activity of the complex. Positive allosteric modulators of the ?2 adrenergic receptor identified by screening a DNA-encoded library potentiate the activity of ?2 agonists and have application in the treatment of obstructive airway disease, bronchospasm, or pre-term labor.
Type:
Grant
Filed:
February 7, 2019
Date of Patent:
January 9, 2024
Assignee:
Duke University
Inventors:
Robert J. Lefkowitz, Seungkirl Ahn, Biswaranjan Pani, Alem W. Kahsai, Laura Wingler, Dean Staus
Abstract: A system and method for imaging or treating a disease in a human or animal body. The system provides to the human or animal body a pharmaceutical carrier including one or more phosphors which are capable of emitting ultraviolet or visible light into the body and which provide x-ray contrast. The system includes one or more devices which infuse a diseased site with a photoactivatable drug and the pharmaceutical carrier, an initiation energy source comprising an x-ray or high energy source which irradiates the diseased site with at least one of x-rays, gamma rays, or electrons to thereby initiate emission of said ultraviolet or visible light into the body, and a processor programmed to at least one of 1) produce images of the diseased site or 2) control a dose of said x-rays, gamma rays, or electrons to the diseased site for production of said ultraviolet or visible light at the diseased site to activate the photoactivatable drug.
Type:
Grant
Filed:
December 27, 2019
Date of Patent:
January 9, 2024
Assignees:
IMMUNOLIGHT, LLC., DUKE UNIVERSITY
Inventors:
Harold Walder, Frederic A. Bourke, Jr., Zakaryae Fathi, Wayne F. Beyer, Jr., Mark Dewhirst, Mark Oldham, Justus Adamson, Michael Nolan
Abstract: Compositions and methods for treating uterine fibroids are described, wherein a uterine fibroid treatment agent comprising collagenase in an amount effective to cause shrinkage of uterine fibroids is injected or inserted into the uterine fibroid.
Type:
Grant
Filed:
April 5, 2021
Date of Patent:
January 2, 2024
Assignees:
BioSpecifics Technologies LLC, Duke University
Inventors:
Phyllis Carolyn Leppert, Thomas L. Wegman
Abstract: The present subject matter provides biosensors for bicarbonate and calcium as well as compositions, devices, and methods comprising such biosensors.
Abstract: An apparatus for guiding the migration of cancer and other cells includes a reservoir device, a cover, a tube, a nanofiber structure, and a lock device. The reservoir device defines a reservoir having an open top. The cover is configured for removable installation over the open top of the reservoir. The tube has a proximal end portion reaching into the reservoir. The nanofiber structure communicates an inlet port in the tube with the reservoir. The lock device interlocks the tube with the reservoir device, and also interlocks the nanofiber structure with the reservoir device.
Type:
Grant
Filed:
December 3, 2019
Date of Patent:
December 26, 2023
Assignee:
DUKE UNIVERSITY
Inventors:
Nassir Mokarram-Dorri, Ravi Bellamkonda, Barun Brahma, James Leo Pokorney, Jack Cabell Griffis, III, Donald Kenneth Griffin, II
Abstract: A MIMO communication system is provided. The system may include a first antenna comprising a first cavity, a first plurality of RF ports for generating a feed wave within the first cavity, and a first plurality of sub-wavelength artificially structured material elements as arranged on a surface of the first cavity as RF radiators. The first antenna is configured to generate a plurality of radiation patterns respectively corresponding to the first plurality of ports. The system may also include a second antenna comprising a second cavity and a second plurality of sub-wavelength artificially structured material elements arranged on a surface of the second cavity.
Type:
Grant
Filed:
November 14, 2022
Date of Patent:
December 26, 2023
Assignee:
Duke University
Inventors:
Insang Yoo, Seyedmohammadreza Faghih Imani, Timothy Sleasman, David R. Smith
Abstract: A thermoacoustic measurement probe includes an open-ended hollow radio-frequency (RF) waveguide; at least two RF feeds positioned within the open-ended hollow RF waveguide, wherein each RF feed is configured to provide RF energy; and a thermoacoustic transducer, wherein the open-ended hollow RF waveguide, in the form of a sleeve, surrounds and is mechanically joined to the thermoacoustic transducer.
Type:
Grant
Filed:
April 3, 2023
Date of Patent:
December 19, 2023
Assignees:
ENDRA Life Sciences Inc., Duke University
Inventors:
Christopher Nelson Davis, Paolo Maccarini, Idan Steinberg, Michael M. Thornton
Abstract: Example methods and systems for photon energy synthesis and introducing energy modulation into radiation treatment planning process and delivery process are provided. Example methods comprise obtaining, via a linear accelerator, a first photon energy beam dosimetric data, a second photon energy beam dosimetric data, and an intermediate photon energy beam dosimetric data, and fitting the first photon energy beam dosimetric data and the second photon energy beam dosimetric data according to a preset fitting coefficient. A synthesized photon beam is then generated from dosimetric data from the fitted first photon energy beam dosimetric data and the fitted second photon energy beam dosimetric data. Further, continuously variable photon energies can be derived, where two or more existing photon energy beams are combined linearly and applied to both forward and inverse radiation planning modules for a radiation treatment plan.
Type:
Grant
Filed:
July 1, 2020
Date of Patent:
December 19, 2023
Assignee:
Duke University
Inventors:
Qiuwen Wu, Bo Liu, Fugen Zhou, Xile Zhang