Abstract: A compound having the formula ##STR1## can be prepared by heating an anion having the formula ##STR2## with a cation having the formula ##STR3## or a cation having the formula ##STR4##

Abstract: Antibacterial activity is exhibited by .beta.-lactams having a ##STR1## substituent in the 1-position and an acylamino substituent in the 3-position wherein Z is oxygen or sulfur, and R is alkyl, alkenyl, alkynyl, substituted alkyl, phenyl, substituted phenyl, a 5,6 or 7-membered heterocycle (R.sub.c), phenylalkyl, (substituted phenyl)alkyl, R.sub.c -alkyl or --NR.sub.a R.sub.b wherein R.sub.a and R.sub.b are the same or different and each is hydrogen, alkyl, substituted alkyl, phenyl, substituted phenyl, phenylalkyl, or (substituted phenyl)alkyl or one of R.sub.a and R.sub.b is hydrogen, alkyl, phenyl, substituted phenyl, phenylalkyl or (substituted phenyl)alkyl and the other is amino, alkanoylamino, arylcarbonylamino, alkoxycarbonylamino, alkylsulfonylamino, alkylamino, dialkylamino, phenylamino, (substituted phenyl)amino, hydroxy, cyano, alkoxy, phenyloxy, (substituted phenyl)oxy, phenylalkoxy, (substituted phenyl)alkoxy, R.sub.c, R.sub.c -alkyl, R.sub.

Abstract: The dosimetry system used with a strontium-rubidium infusion system is a very high speed circuit capable of measuring the radioactive dosage infused into a patient in real time. The dosimetry system is capable of receiving very short duration input pulses generated by a photomultiplier tube in response to the presence of radioactivity.

Abstract: The dosimetry system used with a strontium-rubidium infusion system is a very high speed circuit capable of measuring the radioactive dosage infused into a patient in real time. The dosimetry system is capable of receiving very short duration input pulses generated by a photomultiplier tube in response to the presence of radioactivity.

Abstract: A catheter support comprising an anchoring pad and a flexible strap, a portion of which is attached thereto, is disclosed. One side of the anchoring pad carries an adhesive compatible for use with human skin. One side of the strap carries a fastener material. With the pad in place, a catheter is laid against the pad, and the free end of the strap is folded across the catheter. The fastener material of the free end is pressed against the fastener material attached to the pad to hold the catheter in place. Alternatively, the side of the pad opposite the side with the adhesive carries fastener material, and the flexible strap is separate therefrom. A channel is present through the fastener material on either the pad, flexible strap or both to receive the catheter.

Abstract: Vasodilating activity is exhibited by compounds having the formula ##STR1## n is 2 or 3; X is oxygen or sulfur;R.sub.1 and R.sub.2 are each independently hydrogen alkyl, cycloalkyl, or allyl, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached are pyrrolidinyl, piperidinyl, or morpholinyl;R.sub.3 is alkyl, alkoxy, halogen, trifluoromethyl, or nitro;R.sub.4 is hydrogen, halogen, trifluoromethyl, or nitro; andR.sub.5 and R.sub.6 are each independently alkyl or cycloalkyl or R.sub.5 and R.sub.6 together with the nitrogen atom to which they are attached are pyrrolidinyl, piperidinyl, or morpholinyl.

Abstract: 7-Oxabicycloheptane substituted oxo prostaglandin analogs are provided having the structural formula ##STR1## wherein R is hydrogen, lower alkyl, alkali metal or trihydroxymethylaminomethane, R.sup.1 is lower alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl, R.sup.2 is hydrogen or lower alkyl, A is --CH.dbd.CH-- or --(CH.sub.2).sub.2 --, n is 1 to 4, and m is 1 to 8, and including all stereoisomers thereof.The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

Abstract: Processes for preparing the useful intermediates having the formula ##STR1## are disclosed herein, utilizing novel chemical compounds having the formula ##STR2##

Abstract: A tube coupling having a male body, a female body for receiving at least a portion of the male body and at least one peripheral member made from a relatively compressible plastic material molded into a groove within either the relatively rigid male or female body. The peripheral member is disposed to become compresed against a surface of the mating body to form a liquid seal. At least two peripheral members disposed in grooves in a tubular shaped end portion of the male body are made of a compressible plastic and serve as liquid sealing and locking means. The female body comprises a receiving end portion with a tapered interior adapted to receive the male tubular end portion. As the tubular end portion is inserted into the receiving end portion, one of the peripheral members engages the tapered interior surface and becomes compressed there against as the tubular end portion is further inserted.

Abstract: Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids are useful for the treatment of hypertension.

Abstract: Antibacterial activity is exhibited by 2-azetidinones having a 3-acylamino substituent and a 1-substituent of the formula ##STR1## (or a salt or ester thereof).

Abstract: A drug delivery system is provided which is in the form of hydrogel beads employed in a new interpenetrating polymer network which is formed by swelling hydrogel beads with an acrylic swelling agent and reacting the swelling agent with a cross-linking agent. The drug delivery system has superior drug loading capacity and controlled release characteristics.

Abstract: Apparatus is provided for use in detecting defects, such as pin holes, cracks and/or uneven gelatin distribution, in capsule shells. The apparatus is comprised of a light box which includes one or a plurality of light bulbs disposed within the box, one or more opaque panels which are disposed in front of each light bulb, and a plurality of openings disposed in the panels, each opening being adapted to receive a capsule body or cap which fits snugly therein and protrudes outwardly away from the light bulbs. Light shining through the capsule shells disposed in the openings indicates defects such as pin holes, cracks and/or uneven distribution of gelatin in the capsules.

Abstract: 7-Oxabicycloheptane substituted prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

Abstract: Antibacterial activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein, R.sub.1 is an acyl group derived from a carboxylic acid;R.sub.2 is hydrogen, methoxy, or formamido ##STR2## and one of R.sub.3 and R'.sub.3 is hydrogen and the other is ##STR3## and R.sub.4 is hydrogen alkyl, substituted alkyl, phenyl, substituted phenyl, phenylalkyl or (substituted phenyl)alkyl.

Abstract: Compounds of the formula ##STR1## wherein X is various imino or amino acids or esters are disclosed. These compounds possess angiotensin converting enzyme inhibition activity and depending upon the definition of X also possess enkephalinase inhibition activity.

Abstract: 3,6-Dihydroxyphenazine-1-carboxylic acid, a hypotensive agent, and its production by culturing aerobically Streptomyces species A.T.C.C. No. 39460 are disclosed herein.

Abstract: Phosphonamide substituted lactams of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents.

Abstract: Compounds of the formula ##STR1## wherein X is an amino acid or ester are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.

Abstract: New X-ray contrast agents are provided which are esters of diatrizoic acid having the structure ##STR1## wherein R is an alkyl group of 10 to 22 carbons or a group of the structure ##STR2## wherein R.sup.1 is an alkyl group of 2 to 15 carbons. X-ray contrast medium containing the above X-ray contrast agent and a carrier therefor such as a liposome carrier, and a method for the X-ray visualization of body cavities and organs are also provided.