Abstract: The invention is a method and apparatus for removing veneer coating shards from granular, medicinal formulations which are being reworked. The formulation is ground up, sifted to remove the smaller pieces which do not contain veneer shards, and then placed into an air suspension under an inverted funnel-like separator cone. The separator cone has air outlets for the air suspension apparatus, as well as a vacuum inlet, adjacent its upper end. The light veneer shards ride up the sloped walls of the separator cone, and they are sucked into the vacuum inlet, thereby removing them from the granulation.

Abstract: An adjustable slide tray made of a base and a sliding tray which fits within the base is described. The slide tray unit may be used for holding such objects as medicines in a pharmacist's refrigerator. The slide tray unit also includes interlock means for holding trays together.

Abstract: The strontium-rubidium infusion system includes means for generating a solution containing rubidium-82, measuring the radioactivity in the solution, and infusing it into a patient in order to perform various studies on the patient's heart. The system includes a wash syringe which can be used by a physician to manually inject a bolus containing a large amount of radioactivity directly into a patient in order to perform first pass ventriculography studies.

Abstract: This invention is directed to phosphinylmethylaminocarbonyl imino acid compounds of the formula ##STR1## wherein X represents various unsubstituted or substituted imino acids or esters.

Abstract: 7-Oxabicycloheptane substituted thio prostaglandin analogs are provided having the structural formula ##STR1## wherein p is 0 to 4; A is CH.dbd.CH, (CH.sub.2).sub.2, or a single bond; m is 0 to 8; R is H, lower alkyl, alkali metal or tris(hydroxymethyl)aminomethane; n is 1 to 4; n' is 0, 1 or 2; q is 1 to 12; X is ##STR2## wherein R.sup.2 and R.sup.3 may be the same or different and are H or lower alkyl; t is 0 to 5; and R.sup.1 is H, lower alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl, and including all stereoisomers thereof.The compounds are cardiovascular agents and antiinflammatory agents useful, for example, in the treatment of thrombolytic disease, inflammation and pain.

Abstract: Compounds of the formula ##STR1## wherein A is a cycloalkyl ring, a substituted cycloalkyl ring, a phenyl ring, or a substituted phenyl ring and ##STR2## are various dipeptide groups are disclosed. The compounds possess angiotensin converting enzyme inhibition activity and depending upon the terminal amino acid may also possess enkephalinase inhibition activity.

Abstract: Compounds of the structure ##STR1## are provided which are inhibitors of angiotensin converting enzyme and are useful in the treatment of hypertension.

Abstract: Antibacterial activity is exhibited by 2-azetidinones having a 3-acylamino substituent and a 1-substituent of the formula ##STR1## (or a salt or ester thereof), wherein Z.sub.1 and Z.sub.2 are each independently oxygen or sulfur.

Abstract: Intermediates of the formula ##STR1## are disclosed. These compounds are useful in the preparation of amino thiol dipeptides possessing angiotensin converting enzyme inhibition activity and enkephalinase inhibition activity.

Abstract: 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

Abstract: Phosphorus containing compounds of the formula ##STR1## wherein X is a substituted or unsubstituted imino or amino acid and A is ##STR2## These compounds possess angiotensin converting enzyme activity and are thus useful as hypertensive agents.

Abstract: Angiotensin converted enzyme inhibitor activity if exhibited by compounds having the formula ##STR1## and salts thereof wherein R.sub.1 is hydrogen, aryl, or heteroaryl; R.sub.2 is hydrogen, amino, alkanoylamino, arylcarbonylamino, or heteroarylcarbonylamino;R.sub.3 is hydrogen, alkyl, or aminoalkyl;R.sub.4 and R.sub.5 are the same or different and each is hydrogen, alkyl, halogen, aryl, arylalkyl, hydroxy, alkoxy, alkylthio, aryloxy, arylthio, or cycloalkyl, or R.sub.4 and R.sub.5 taken together are oxo, ethylenedithio or propylenedithio;one of R.sub.6 and R.sub.7 is ##STR2## and the other is hydrogen, alkyl or arylalkyl; R.sub.8 is hydrogen, alkl or aryl;R.sub.9 is hydrogen or alkyl;n is 0 or an integer of 1 to 8;m is 0 or 1; andA is --(CH.sub.2).sub.p --wherein p is 0 or 1, --NH--, or --O--.

Abstract: 7-Oxabicycloheptane substituted thio prostaglandin analogs are provided having the structural formula ##STR1## wherein R is hydrogen, lower alkyl or alkali metal, R.sup.1 is lower alkyl, arylalkyl, aryl, cycloalkyl or cycloalkylalkyl, X is O, S or NH, A is --CH.dbd.CH-- or --(CH.sub.2).sub.2, p is 0 to 4, n is 1 to 4, n' is 0 to 2, q is 1 to 4 and m is 0 to 8, and including all stereoisomers thereof.The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease; and are antiinflammatory agents useful, for example, in the treatment of rheumatoid arthritis.

Abstract: 2-Pyridylcarboxamides are provided having the structure ##STR1## wherein n is 1 to 10; R is hydrogen, lower alkyl, alkali metal or an amine salt; andR.sup.1 is C.sub.6 -C.sub.20 alkyl, C.sub.6 -C.sub.20 alkenyl, C.sub.6 to C.sub.20 alkoxy or phenyl. These compounds are useful as inhibitors of arachidonic acid release and as such are useful as antiallergy agents.

Abstract: A method is provided for enhancing penicillin acylase production wherein a Bacillus subtilis plasmid containing an insert of a chromosomal DNA fragment of Bacillus megaterium which includes the appropriate gene for enhancing penicillin acylase production is cloned into Bacillus megaterium and the Bacillus megaterium containing the above plasmid is employed in the production of penicillin acylase.A plasmid method for forming same and host plasmid combination which are useful in the above method are also provided.

Abstract: A pouch having a bottom wall secured to an adhesive layer that can be cut to fit around a wound or surgical opening, gusseted side walls, and a top wall provided with one or more access openings. An irrigation port and a catheter access port can be secured to these top wall openings. The bottom wall extends beyond the adhesive layer and is provided with a large exit port oriented so that gravity will drain wound exudate from the pouch. This exit port is also large enough to accommodate a hand to aid in locating the pouch on the body and permit access to the wound site without removing the pouch from the body.

Abstract: An enkephalin-degrading aminopeptidase enzyme is inhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salt thereof, wherein R.sub.1 and R.sub.2 are each independently hydrogen, alkyl, carboxyalkyl, halo substituted alkyl, hydroxyalkyl, aminoalkyl, mercaptoalkyl, alkylthioalkyl, (cycloalkyl)alkyl, (heteroaryl)alkyl, arylalkyl, carbamoylalkyl, guanidinylalkyl, or heteroaryl;R.sub.3 is hydroxy, alkoxy, (substituted alkyl)oxy, arylalkoxy, (heteroaryl)alkoxy or --NY.sub.1 Y.sub.2, wherein Y.sub.1 and Y.sub.2 are each independently hydrogen, alkyl, aryl, or arylalkyl or Y.sub.1 is hydrogen and Y.sub.2 is substituted alkyl or (heteroaryl)alkyl;A.sub.1 is glycyl, alanyl, leucyl, phenylalanyl, arginyl, sarcosyl, seryl, asparagyl, lysyl, glutamyl, histidyl, tryptophyl, cysteinyl, methionyl, threonyl, tyrosyl, leucyl, valyl, aspartyl, prolyl, norleucyl, norvalyl, or ##STR2## wherein n.sub.6 is an integer of 2 to 15; A.sub.2, A.sub.3, A.sub.4 and A.sub.

Abstract: Antibacterial activity is exhibited by (3-acylamino)-2-azetidinones having in the 1-position a group of the formula ##STR1## or a salt or ester thereof wherein R.sub.5 and R.sub.6 are the same or different and each is hydrogen or alkyl.

Abstract: Antibiotic activity is exhibited by .beta.-lactams having an ##STR1## substituent in the 1-position and an acylamino substituent in the 3-position.

Abstract: Medical grade pressure sensitive adhesive compositions comprising a homogeneous mixture of one or more polyisobutylenes or blends of one or more polyisobutylenes and butyl rubber, one or more styrene radial or block type copolymers, mineral oil, one or more water soluble hydrocolloid gums, and a tackifier. One or more water swellable cohesive strengthening agents, an antioxidant, and various other optional ingredients may be included within the adhesive composition.