Abstract: 7-Oxabicycloheptane substituted ether prostaglandin analogs are provided having the structural formula ##STR1## wherein A is O or ##STR2## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

Abstract: Antibacterial activity is exhibited by 3-acylamino-2-azetidinones having in the 1-position a group of the formula ##STR1## or an ester of salt thereto, wherein R.sub.5 and R.sub.6 are the same or different and each is hydrogen, alkyl, phenyl or substituted phenyl.

Abstract: Antibacterial activity is exhibited by .beta.lactams having a 3-acylamino substituent and in the 1-position a group of the formula ##STR1## wherein R.sub.5 and R.sub.6 are the same or different and each is hydrogen, alkyl, alkenyl, alkynyl, phenyl, substituted phenyl, cycloalkyl or R.sub.c, or R.sub.5 and R.sub.6 together with the carbon atom to which they are attached are cycloalkyl or R.sub.c, or one of R.sub.5 and R.sub.6 is hydrogen and the other is azido, halomethyl, dihalomethyl, trihalomethyl, alkoxycarbonyl, alkenyl, alkynyl, 2-phenylethenyl, 2-phenylethynyl, carboxyl, --CH.sub.2 X.sub.1, --S--X.sub.2, --O--X.sub.2, or ##STR2## and R.sub.7 is alkyl, substituted alkyl, phenyl or substituted phenyl; andR.sub.c is 4,5,6 or 7-membered heterocycle.

Abstract: The indicator includes a transparent hollow cylindrical chamber with co-linearly aligned inlet and outlet ports located at spaced points along the cylindrical wall, on opposite sides thereof. An element is freely rotatably mounted within the chamber. The element includes an axle and a plurality of blade-like projections radially extending from the axle towards the cylindrical wall. End portions of the axle extend laterally beyond the plane of the projections and are received in recesses in the circular chamber walls which are aligned with each other and the axis of the chamber. The indicator is particularly useful in low flow rate situations such as in conjunction with stoma or wound irrigation devices.

Abstract: Tetrahydrothienyl substituted ethers are provided having the structural formula ##STR1## wherein A is (CH.sub.2).sub.2, CH.dbd.CH or a single bond, m is 1 to 5, B is a single bond or CH.dbd.CH, n is 1 to 4, X is O or ##STR2## wherein n' is 0, 1 or 2, R is H, lower alkyl or alkali metal and R.sup.1 is lower alkyl, arylalkyl, aryl, cycloalkyl, cycloalkylalkyl or lower alkenyl and including all stereoisomers thereof.The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease and as antiinflammatory agents and analgesics.

Abstract: Tetrahydrofuranyl substituted prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

Abstract: Antifungal suppositories are provided which preferably include nystatin as the antifungal agent, together with a hydrocolloid, such as sodium carboxymethylcellulose or hydroxypropylmethylcellulose and a low melting suppository base. The antifungal suppositories of the invention function by melting at body temperature to release the hydrocolloid and antifungal agent which adhere to the vaginal membrane so that a uniform distribution of antifungal agent is retained at the site of infection.

Abstract: Bicycloheptane substituted prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

Abstract: 7-Oxabicycloheptane substituted prostaglandin alcohols are provided having the structural formula ##STR1## wherein A is --CH.dbd.CH--(CH.sub.2).sub.n -- or (CH.sub.2).sub.q ; B is a single bond or --CH.dbd.CH--; n is 1 to 5; q is 1 to 6; Q is --CH.dbd.CH-- or (CH.sub.2).sub.2 ; and R is lower alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl or lower alkenyl, with the proviso that when B is --CH.dbd.CH--, n is 1 to 3 or q is 1 to 4 and when B is a single bond, n is 1 to 5 or q is 1 to 6, and including all stereoisomers thereof.The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

Abstract: 7-Oxabicycloheptane substituted oxo prostaglandin analogs are provided having the structural formula ##STR1## wherein R is hydrogen, lower alkyl, alkali metal or tris(hydroxymethyl)aminomethane, R.sup.1 is hydrogen, lower alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl, A is --CH.dbd.CH-- or --(CH.sub.2).sub.2 --, y is 0 to 4, m is 0 to 8, and n is 1 to 4, p is 1 to 12 and q is 0 to 5, and including all stereoisomers thereof.The compounds are antiinflammatory agents useful, for example, in the treatment of inflammatory diseases and analgesic agents as well as cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

Abstract: A device for testing the torque required to break the seal of a medicine vial is comprised of a torque gauge mounted on a base. The torque gauge has an armature which is adapted to hold the bottom of a medicine vial. A torque arm is attached to a cylindrical unit made up of a housing and a concentric handle connected together by a coil spring such that the coil spring can be opened by turning the housing relative to the handle so that the spring fits over the cap of a vial and holds it securely when turned in a direction which tends to tighten the coils of the spring.

Abstract: This invention is directed to an occlusive dressing useful for treating skin lesions and a granular material capable of interacting with wound exudate. Wounds emitting a large amount of fluid can be treated by first packing with the granular material and then covering the wound with the occlusive dressing.

Abstract: An enkephalin-degrading aminopeptidase enzyme is inhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salt thereof, wherein R.sub.1 and R.sub.2 are each independently hydrogen, alkyl, carboxyalkyl, halo substituted alkyl, hydroxyalkyl, aminoalkyl, mercaptoalkyl, alkylthioalkyl, (cycloalkyl)alkyl, (heteroaryl)alkyl, arylalkyl, carbamoylalkyl, guanidinylalkyl, or heteroaryl;R.sub.3 is hydroxy, alkoxy, (substituted alkyl)oxy, arylalkoxy, (heteroaryl)alkoxy or --NY.sub.1 Y.sub.2, wherein Y.sub.1 and Y.sub.2 are independently hydrogen, alkyl, aryl, or arylalkyl or Y.sub.1 is hydrogen and Y.sub.2 is substituted alkyl or (heteroaryl)alkyl;A.sub.1 is glycyl, alanyl, leucyl, phenylalanyl, arginyl, sarcosyl, seryl, asparagyl, lysyl, glutamyl, histidyl, tryptophyl, cysteinyl, methionyl, threonyl, tyrosyl, leucyl, valyl, aspartyl, prolyl, norleucyl, norvalyl, or ##STR2## wherein n.sub.6 is an integer of 2 to 15; A.sub.2, A.sub.3, A.sub.4 and A.sub.

Abstract: Plastatin, an inhibitor of the enzyme phospholipase A.sub.2, can be prepared by cultivating Penicillium chermesinum under submerged aerobic conditions.

Abstract: 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

Abstract: 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

Abstract: 7-Oxabicycloheptane substituted prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

Abstract: Compounds of the formula ##STR1## are disclosed. They possess angiotensin converting enzyme inhibition activity and diuretic activity and are therefore useful as antihypertensive agents.

Abstract: 7-Oxabicycloheptane substituted interphenylene prostaglandin ethers are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

Abstract: Antibacterial activity and .beta.-lactamase inhibitory activity is exhibited by .beta.-lactams having a 3-acylamino substituent and in the 1-position a group having the formula ##STR1## wherein R.sub.5 is hydrogen, methyl or ethyl.