Patents Assigned to E. R. Squibb & Sons
  • Aryl substituted 7-oxabicycloheptane compounds, useful in inhibiting platelet aggregation
    Patent number: 4463015
    Abstract: 7-Oxabicycloheptane and prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
    Type: Grant
    Filed: August 18, 1982
    Date of Patent: July 31, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Martin F. Haslanger, Masami Nakane
  • Iminothiazolyl ureido cephalosporins
    Patent number: 4461767
    Abstract: Cephalosporins of the formula ##STR1## wherein R is hydrogen, sodium, potassium or certain ester groups; R.sub.1 is in the .alpha.-configuration and is hydrogen or methoxy; R.sub.2 is hydrogen, ##STR2## R.sub.4 is hydrogen or lower alkyl; R.sub.5 is hydrogen, lower alkyl, ##STR3## or --(CH.sub.2).sub.n --N--(lower alkyl).sub.2 ; R.sub.6 is hydrogen, sodium, or potassium; n is an integer from 1 to 4; are disclosed. These compounds are useful as anti-bacterial agents.
    Type: Grant
    Filed: June 6, 1979
    Date of Patent: July 24, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, Uwe D. Treuner, Theodor Denzel
  • Thiazine and thiazepine containing compounds
    Patent number: 4460579
    Abstract: This invention is directed to compounds of the formula ##STR1## wherein X is a thiazine or thiazepine selected from ##STR2## These compounds possess angiotensin converting enzyme inhibition activity and are thus useful as hypotensive agents.
    Type: Grant
    Filed: February 28, 1983
    Date of Patent: July 17, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Donald S. Karanewsky
  • 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
    Patent number: 4456615
    Abstract: 7-Oxabicycloheptane substituted amino prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
    Type: Grant
    Filed: October 25, 1982
    Date of Patent: June 26, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Masami Nakane, David L. Snitman, Joyce Reid, Martin F. Haslanger
  • 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
    Patent number: 4456617
    Abstract: 7-Oxabicycloheptane substituted amino prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
    Type: Grant
    Filed: January 12, 1983
    Date of Patent: June 26, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Masami Nakane, Martin F. Haslanger
  • 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
    Patent number: 4456616
    Abstract: 7-Oxabicycloheptane substituted amino prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
    Type: Grant
    Filed: December 27, 1982
    Date of Patent: June 26, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Martin F. YHaslanger, Masami Nakane, Steven E. Hall
  • 4-Substituted dehydroprolines
    Patent number: 4456761
    Abstract: Compounds of the formula ##STR1## are useful as intermediates in the preparation of various hypotensive agents.
    Type: Grant
    Filed: July 29, 1982
    Date of Patent: June 26, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: John Krapcho
  • Powdered wax, tablet coated therewith and method
    Patent number: 4456629
    Abstract: A novel powdered wax is provided which is especially adapted for use as a polishing agent for tablets and as a substrate for print carried by such tablets. A method for forming such powdered wax is also provided which includes the steps of milling pieces of wax with dry ice and then allowing the dry ice to evaporate while maintaining the milled wax at cool temperatures to prevent clumping.
    Type: Grant
    Filed: July 12, 1982
    Date of Patent: June 26, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Thomas G. Wood, Steven M. Oblack
  • Carboxy and substituted carboxy aroly peptides
    Patent number: 4456595
    Abstract: Peptides of the formula ##STR1## wherein X is various amino or imino acids or esters are useful as hypotensive agents.
    Type: Grant
    Filed: December 6, 1982
    Date of Patent: June 26, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Eric M. Gordon
  • Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
    Patent number: 4452790
    Abstract: Phosphonyl hydroxyacyl amino acids of the formula ##STR1## wherein X is a substituted or unsubstituted imino or amino acid or ester. These compounds possess angiotensin converting enzyme activity and are thus useful as hypotensive agents.
    Type: Grant
    Filed: June 23, 1982
    Date of Patent: June 5, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Donald S. Karanewsky, Edward W. Petrillo, Jr.
  • Chromans including heterocyclic substituent
    Patent number: 4452801
    Abstract: The invention relates to chroman derivatives of the general formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, substituted phenyl, phenyl, phenyl-lower alkyl, substituted phenyl-lower alkyl or lower alkyl-amino-lower alkyl;R.sub.2 is ##STR2## R.sub.3, R.sub.4, R.sub.5 and R.sub.6 each is independently selected from hydrogen, hydroxy, amino, -o-acyl, -o-lower alkyl; ##STR3## halogen, lower alkyl, or halo substituted lower alkyl; and salts and hydrates thereof.These compounds are useful as anti-inflammatory agents; for inhibition of blood platelet aggregation, as antiallergy and as antihypertensive agents.
    Type: Grant
    Filed: September 13, 1982
    Date of Patent: June 5, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Joseph E. Sundeen
  • Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
    Patent number: 4452791
    Abstract: Compounds of the structure ##STR1## are provided which are inhibitors of angiotensin converting enzyme and are useful in the treatment of hypertension.
    Type: Grant
    Filed: March 15, 1982
    Date of Patent: June 5, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Denis E. Ryono, Edward W. Petrillo, Jr.
  • Ostomy bag with an adjustable vent
    Patent number: 4451258
    Abstract: An air vent for an ostomy bag has a variable flow rate so that the flow rate through a deodorizing filter housed in the vent can be varied to enhance the effectiveness of the filter. The vent also permits precise control over the degree of inflation of the bag.
    Type: Grant
    Filed: March 4, 1982
    Date of Patent: May 29, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Ole R. Jensen
  • Phosphinylmethylaminocarbonyl imino acid compounds useful for treating hypertension
    Patent number: 4448772
    Abstract: This invention is directed to phosphinylmethylaminocarbonyl imino acid compounds of the formula ##STR1## wherein X represents various unsubstituted or substituted imino acids or esters.
    Type: Grant
    Filed: April 22, 1982
    Date of Patent: May 15, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Donald S. Karanewsky
  • Androstene-17-dithioketals
    Patent number: 4447363
    Abstract: Antiinflammatory activity is exhibited by steroids having the formula ##STR1## and the 1,2-dehydro, 6,7-dehydro and 15,16-dehydro derivatives thereof, whereinone of R.sub.1 and R.sub.2 is alkyl, cycloalkyl, aryl, arylalkyl, or --CH.sub.2 X wherein X is alkylthio, alkoxy, aroyloxy, alkanoyloxy or alkoxycarbonyl, and the other is alkylthioalkyl, alkoxyalkyl, alkanoyloxyalkyl, aroyloxyalkyl, alkoxycarbonylalkyl, carboxyalkyl or arylalkyl;R.sub.3 is hydrogen, hydroxy, alkoxy, aryloxy, oxo, methylene, alkylthio, arylthio, alkanoyl, alkanoyloxy, or halogen;R.sub.4 is carbonyl or .beta.-hydroxymethylene;R.sub.5 is hydrogen or halogen; andR.sub.6 is hydrogen, methyl, hydroxy, alkanoyl or halogen.
    Type: Grant
    Filed: July 7, 1982
    Date of Patent: May 8, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Ravi K. Varma
  • Steroid monohydrates, formulations containing same and method
    Patent number: 4447426
    Abstract: A monohydrate of a steroid having the structure ##STR1## and the 1,2-dehydro derivatives thereof, is provided which monohydrate is in the form of a particulate material having a stable average particle size of less than about 20 microns. Cream and lotion formulations containing the steroid monohydrate and a method for forming the monohydrate are also provided.
    Type: Grant
    Filed: December 27, 1982
    Date of Patent: May 8, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Yu-Chang J. Wang, Friedrich Dursch, Richard L. O'Laughlin, Thaddeus Prusik
  • Intermediates useful in the preparation of 17,17-bis(substituted thio) androstenes
    Patent number: 4446071
    Abstract: Androstenes having the formula ##STR1## wherein R.sub.1 hydrogen and R.sub.2 is alkyl, cycloalkyl, aryl, arylalkyl, alkylthioalkyl, alkoxyalkyl, alkanoyloxyalkyl, aroyloxyalkyl, alkoxycarbonylalkyl, carboxyalkyl, or arylalkyl, or R.sub.1 is alkanoyl or aroyl and R.sub.2 is alkyl;R.sub.3 is hydrogen, hydroxy, alkoxy, aryloxy, oxo, methylene, alkylthio, arylthio, alkanoyl, alkanoyloxy, or halogen;R.sub.4 is carbonyl, .beta.-hydroxymethylene or .beta.-acetyloxymethylene;R.sub.5 is hydrogen or halogen; andR.sub.6 is hydrogen, methyl, hydroxy, alkanoyl or halogen are useful intermediates for the preparation of steroids having antiinflammatory activity.
    Type: Grant
    Filed: May 27, 1983
    Date of Patent: May 1, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Ravi K. Varna
  • Amino and substituted amino phosphinylalkanoyl compounds useful for treating hypertension
    Patent number: 4444765
    Abstract: Compounds of the formula ##STR1## wherein X is an amino acid or ester are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.
    Type: Grant
    Filed: July 14, 1982
    Date of Patent: April 24, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Donald S. Karanewsky, Edward W. Petrillo, Jr.
  • Method for the isolation and presumptive diagnosis of Bacillus cereus and tellurite medium therefor
    Patent number: 4444883
    Abstract: A method is provided for the isolation and presumptive diagnosis of Bacillus cereus which method is useful in the assay of antibiotic preparations, food products such as milk, drug products and cosmetics. A medium for use in such method is also provided which medium includes tellurite, glycine and polymyxin, and inhibits most organisms which grow and resemble Bacillus cereus on this medium. If an organism grows on the medium and has characteristic colonies, a presumptive diagnosis of Bacillus cereus can be assumed until further tests are made.
    Type: Grant
    Filed: August 9, 1982
    Date of Patent: April 24, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Robert L. Brown, Thomas B. Platt
  • Process for preparing (3S)-3-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]-acetyl]a mino]-2-oxo-1-azetidinesulfonic acid, and 4-substituted derivatives
    Patent number: 4443374
    Abstract: Disclosed herein is a process for preparing a compound having the formula ##STR1## which comprises coupling a compound having the formula ##STR2## or a salt thereof, with a compound having the formula ##STR3## to obtain a compound having the formula ##STR4## reacting that compound with 2-aminooxy-2-methylpropanoic acid, or a salt thereof, to obtain a compound having the formula ##STR5## and, if R is an amino protecting group, deprotecting that compound to yield the desired product; whereinR is hydrogen or an amino protecting group;R.sub.1 is hydrogen, methyl or ethyl;M.sup..sym. is an inorganic cation or a substituted ammonium ion; andM.sub.1.sup..sym. is hydrogen, an inorganic cation or a substituted ammonium ion.
    Type: Grant
    Filed: February 1, 1982
    Date of Patent: April 17, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Christopher M. Cimarusti, Rita T. Fox, Alan W. Fritz, William H. Koster, Jerome L. Moniot