Patents Assigned to E. R. Squibb & Sons
  • S-Acylation products of mercaptoacyl amino acids and carboxyl group containing diuretics
    Patent number: 4482725
    Abstract: The S-acylation of a mercaptoacyl amino acid having ACE inhibitory action with a diuretic containing a carboxyl group yields a product having both ACE inhibitory action and diuretic activity in vivo.
    Type: Grant
    Filed: April 3, 1980
    Date of Patent: November 13, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Denis E. Ryono
  • Powdered wax, tablet coated therewith and method
    Patent number: 4482387
    Abstract: A novel powdered wax is provided which is especially adapted for use as a polishing agent for tablets and as a substrate for print carried by such tablets. A method for forming such powdered wax is also provided which includes the steps of milling pieces of wax with dry ice and then allowing the dry ice to evaporate while maintaining the milled wax at cool temperatures to prevent clumping.
    Type: Grant
    Filed: December 2, 1983
    Date of Patent: November 13, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Thomas G. Wood, Steven M. Oblack
  • 17-Substituted thia-17-alkyl(or alkenyl or alkynyl)androstenes
    Patent number: 4481144
    Abstract: Antiinflammatory activity is exhibited by steroids having the formula ##STR1## and the 1,2-dehydro derivatives thereof, wherein R is hydrogen, alkyl, or aryl;R.sub.1 is hydrogen, alkyl, ##STR2## alkylthio, alkoxy, fluoro, hydroxyalkyl, cyanoalkyl, alkoxycarbonyl-(CH.sub.2).sub.p -, mono-, di- or trifluoromethyl, or ##STR3## wherein p is 0, 1, 2, 3 or 4, Y.sub.1 is alkyl or aryl, and Y.sub.2 and Y.sub.3 are the same or different and each is hydrogen or alkyl;R.sub.2 is alkyl, alkenyl or alkynyl;R.sub.3 is carbonyl or .beta.-hydroxymethylene;R.sub.4 is hydrogen or halogen;R.sub.5 is hydrogen, methyl or fluorine; andn is 0, 1 or 2.
    Type: Grant
    Filed: February 3, 1984
    Date of Patent: November 6, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Ravi K. Varma
  • Cationic technetium (I) complexes
    Patent number: 4481184
    Abstract: Myocardial perfusion can be measured and ischemia and infarction can be diagnosed using compounds having the formula[.sup.99m Tc(L).sub.n ].sup..sym. A.sup..crclbar.whereinA is an anion;n is 1, 2, 3 or 6;if n is 1, L is a hexadentate ligand, if n is 2, L is a tridentate ligand, if n is 3, L is a monodentate ligand.
    Type: Grant
    Filed: February 14, 1983
    Date of Patent: November 6, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: James F. Kronauge, Kenneth A. Glavan
  • 2-Oxo-1-(substituted phosphorous)azetidines
    Patent number: 4478749
    Abstract: Antibacterial activity is exhibited by .beta.-lactams having a phosphinic or phosphonic substituent in the 1-position and an acylamino substituent in the 3-position.
    Type: Grant
    Filed: March 15, 1982
    Date of Patent: October 23, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William H. Koster, Christopher M. Cimarusti
  • 7-Oxabicycloheptane substituted thio prostaglandin analogs useful in treating platelet aggregation and bronchoconstriction
    Patent number: 4474803
    Abstract: 7-Oxabicycloheptane substituted thio prostaglandin analogs are provided having the structural formula ##STR1## wherein R is hydrogen, lower alkyl or alkali metal, R.sup.1 is lower alkyl, arylalkyl, aryl, cycloalkyl or cycloalkylalkyl. A is --CH.dbd.CH or --(CH.sub.2).sub.2, n is 1 to 4, n' is 0 to 2 and m is 1 to 8, and including all stereoisomers thereof.The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
    Type: Grant
    Filed: March 14, 1983
    Date of Patent: October 2, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Steven E. Hall, Martin F. Haslanger
  • Lactam containing compounds, their pharmaceutical compositions and method of use
    Patent number: 4474778
    Abstract: Compounds of the formula ##STR1## are disclosed wherein R is ##STR2## The compounds possess hypotensive activity.
    Type: Grant
    Filed: November 9, 1983
    Date of Patent: October 2, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Donald S. Karanewsky
  • Enkephalinase inhibitors
    Patent number: 4474799
    Abstract: The degradation of enkephalins in a mammalian host is inhibited by administration of an enkephalinase enzyme inhibitor of the formula ##STR1##
    Type: Grant
    Filed: May 27, 1983
    Date of Patent: October 2, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Roland Greenberg, David W. Cushman, B. Richard Vogt, Frank L. Weisenborn, Michael J. Antonaccio
  • 7-Oxabicycloheptane prostaglandin intermediates and method for preparing same
    Patent number: 4474972
    Abstract: Optically active 7-oxabicycloheptane prostaglandin intermediates are provided having the general structure ##STR1## wherein one of R.sup.1 and R.sup.2 is --COOH, ##STR2## or --CH.sub.2 OH and the other is ##STR3## A method for preparing the above intermediates is also provided.
    Type: Grant
    Filed: March 14, 1983
    Date of Patent: October 2, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jagabandhu Das, Martin F. Haslanger
  • [16,17-a]Cyclopentano pregnenes
    Patent number: 4474702
    Abstract: Antiinflammatory activity is exhibited by pregnenes having the structural formula ##STR1## wherein R.sub.1 is hydrogen, hydroxy, halogen, or acyloxy;R.sub.2 and R.sub.3 are each hydrogen, R.sub.2 and R.sub.3 are each methyl, R.sub.2 and R.sub.3 are each alkylthio, R.sub.2 is hydrogen and R.sub.3 is alkyl, R.sub.2 is hydroxyl and R.sub.3 is alkyl, or R.sub.2 and R.sub.3 taken together are --(CH.sub.2).sub.2 --, methylene, or oxo; andR.sub.4 is hydrogen, fluorine, chlorine or bromine.
    Type: Grant
    Filed: January 20, 1984
    Date of Patent: October 2, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Donald S. Karanewsky, Christopher M. Cimarusti
  • Enkephalinase inhibitors
    Patent number: 4474795
    Abstract: The degradation of enkephalins in a mammalian host is inhibited by administration of an enkephalinase enzyme inhibitor of the formula ##STR1##
    Type: Grant
    Filed: May 27, 1983
    Date of Patent: October 2, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Roland Greenberg, David W. Cushman, B. Richard Vogt, Frank L. Weisenborn, Michael J. Antonaccio
  • 7-Oxabicyclo substituted prostaglandin phenyl carboxylic acid derivatives useful as cardiovascular agents
    Patent number: 4474804
    Abstract: 7-Oxabicyclo substituted prostaglandin phenyl carboxylic acid derivatives are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
    Type: Grant
    Filed: September 19, 1983
    Date of Patent: October 2, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jagabandhu Das, Martin F. Haslanger
  • ACE inhibitors produced from Nocardia orientalis
    Patent number: 4474693
    Abstract: N.sup.2 -[N-(N-acetylmuramoyl)-L-alanyl]-N-(5,6-diamino-1-carboxy-6-oxohexyl)-D-.a lpha.-glutamine, N.sup.2 -[N-(N-acetylmuramoyl)-L-alanyl]-N-[5,6-diamino-1-[[1-[(1-carboxyethyl)car bamoyl]ethyl]carbamoyl]-6-oxohexyl]-D-.alpha.-glutamine and EM5556C are obtained as a mixture by cultivating a strain of the microorganism Nocardia orientalis A.T.C.C. No. 39444.
    Type: Grant
    Filed: October 31, 1983
    Date of Patent: October 2, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Pushpa Singh, Karen Bush, Dorothy S. Slusarchyk
  • Substituted peptide compounds
    Patent number: 4470973
    Abstract: Substituted peptide compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: June 2, 1983
    Date of Patent: September 11, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sesha I. Natarajan, Eric M. Gordon
  • Nitrobenzofuran derivatives
    Patent number: 4469870
    Abstract: Nitrobenzofurazan derivatives having the formula ##STR1## are provided wherein R.sub.1 and R.sub.2 each is hydrogen, lower alkyl or phenyl-lower alkyl; R.sub.3 is hydrogen, hydroxy or lower alkyl; R.sub.4 is hydrogen or lower alkyl; m is 2 or 3; and n is 0, 1 or 2; these compounds are useful analytical tools.
    Type: Grant
    Filed: April 28, 1983
    Date of Patent: September 4, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Callixtus E. Ita, Anthony F. Heald, Peter Egli
  • Esters of phosphinylalkanoyl substituted prolines
    Patent number: 4468519
    Abstract: Hypotensive activity is exhibited by compounds having the formula ##STR1## and salts thereof wherein R.sub.1 is alkyl, aryl, arylalkyl, cycloalkyl, or cycloalkylalkyl;R.sub.2 is cycloalkyl, 3-cyclohexenyl or 2-alkyl-3-cyclohexenyl;R.sub.3 is alkyl, cycloalkyl, phenyl or alkoxy;R.sub.4 is hydrogen or alkyl;one of R.sub.5 and R.sub.6 is hydrogen and the other is alkyl-X-, phenyl-X-, alkoxy, phenyloxy, phenyl, cycloalkyl, alkyl, or phenylalkyl; or together R.sub.5 and R.sub.6 are --XCH.sub.2 CH.sub.2 X--;R.sub.7 is hydrogen or ##STR2## and n is 0 or 1.
    Type: Grant
    Filed: June 14, 1982
    Date of Patent: August 28, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: John Krapcho
  • 7-Oxabicycloheptane substituted carbamate prostaglandin analogs useful in treating platelet aggregation and bronchoconstriction
    Patent number: 4466979
    Abstract: 7-Oxabicycloheptane substituted carbamate prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
    Type: Grant
    Filed: January 21, 1983
    Date of Patent: August 21, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jagabandhu Das, Martin F. Haslanger
  • Closures for open ended ostomy pouch
    Patent number: 4465486
    Abstract: An open ended ostomy pouch having a folding bar attached to the bottom of the pouch. The folding bar extends on both sides beyond the width of the pouch at the bottom opening and includes interlocking closure components on opposite ends.
    Type: Grant
    Filed: September 30, 1982
    Date of Patent: August 14, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: John A. Hill
  • Carboxyalkyl amino acid derivatives of various substituted prolines
    Patent number: 4462943
    Abstract: Carboxyalkyl dipeptides of the formula ##STR1## wherein R.sub.4 is a 3-, 4-, 5-, or 4,4-substituted proline are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity.
    Type: Grant
    Filed: September 28, 1981
    Date of Patent: July 31, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Edward W. Petrillo, Jr., Eric M. Gordon, John Krapcho, Peter W. Sprague
  • Method for preparing a prostacyclin intermediate
    Patent number: 4463183
    Abstract: A method is provided for preparing compounds of the formulae ##STR1## wherein A may be --C.dbd.C-- or --C.tbd.C--, by reducing an epoxy lactone of the structure ##STR2## to form the corresponding epoxy hemiacetal, reacting the epoxy hemiacetal with a silyl compound to form an epoxy silyl acetal, reacting the epoxy silyl acetal with an acetylenic derivative to form a silyl acetal, removing the silyl protecting group to form a hemiacetal, reacting the hemiacetal compound with an appropriate Wittig reagent to form a protected difluoro PGF.sub.2.alpha. type compound, removing the protecting group, reacting the difluoro PGF.sub.2.alpha. with an iodine compound to form an iodoether and reacting the iodoether with a base to form the desired compounds.Novel intermediates produced in the above method are also provided.
    Type: Grant
    Filed: April 25, 1983
    Date of Patent: July 31, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Martin F. Haslanger