Abstract: Novel compounds useful, for example, for the treatment of ischemic conditions and arrhythmia are disclosed. The compounds have the formula ##STR1## wherein X is oxygen or sulfur and the R groups are as defined herein.

Abstract: A method is provided for treatment of neuronal insult, such as caused by lack of oxygen, which neurons are prone to Parkinsonian degeneration by administering an ATP-sensitive potassium channel blocker, such as a sulfonyl urea, for example, tolbutamide.

Abstract: The present invention claims and describes an environmentally sound percarbonate based cleaner for removing cosmetic and pharmaceutical soils from pharmaceutical or cosmetic manufacturing surfaces. The invention includes a combination of a percarbonate; an ethylene oxide/propylene oxide block copolymer surfactant; and a bicarbonate salt. The invention is useful for removing hard-to-remove soils from a pharmaceutical or cosmetic manufacturing surface.

Abstract: The wound dressing securement device has one or more flexible adhesive base member strips that are secured to the skin around or at opposite sides of a wound with sufficient clearance for a wound dressing. A plurality of sheet retention members joined to one or more of the base members project vertically from an exposed surface of the base member. A flexible, foldable, stretchable hold-down sheet member has a plurality of openings to engage with engagement heads provided on the sheet retention members. The hold-down sheet member is sized to form a cover for the underlying wound dressing and bears against the wound dressing to hold it in position on the wound. When the wound dressing is to be changed, the hold-down sheet member is disengaged from the sheet retention members to uncover the wound dressing, and make it accessible for removal and replacement. The adhesive base member(s) remain in place during repeated changes of the wound dressing.

Abstract: Hypotensive activity is exhibited by new phosphonate substituted amino or imino acids of the formula ##STR1## isomeric mixtures thereof and pharmaceutically acceptable salts thereof, wherein:X is an imino or amino acid of the formula ##STR2##

Abstract: A method is provided for inhibiting cholesterol biosynthesis by inhibiting de novo squalene production employing methylene phosphonoalkylphosphinate compounds.

Abstract: S-enantiomers of the formula ##STR1## result from the reaction of a racemic form of compound I with an alcohol in the presence of an enzyme capable of selectively esterifying the R-enantiomers of the racemic compound.

Abstract: An enzymatic reduction method, particularly a stereoselective enzymatic reduction method, for the preparation of compounds useful as intermediates in the preparation of taxanes.

Abstract: Antibacterial activity is exhibited by novel compounds having the formula ##STR1## where R.sub.1, R.sub.2, and M are as defined herein and X is --(CH.sub.2).sub.n -- wherein n is 0, 1, 2, 3 or 4 or CR.sub.3 R.sub.4 wherein R.sub.3 and R.sub.4 are the same or different and each is hydrogen, --CH.sub.3 or --C.sub.2 H.sub.5 or R.sub.3 and R.sub.4 taken together with the carbon atom to which they are attached form a 3, 4, 5, 6 or 7-membered cycloalkyl ring. Also described are various intermediates for the preparation of compounds of formula 1.

Abstract: The separation device includes a container having a dome-shaped base and a peripheral wall surrounding the base to define a chamber for receiving a random mixture of defective and nondefective articles. A spiral-shaped ramp on the peripheral wall which surrounds the chamber and overhangs the base, leads to an elevated outlet opening. A vibrating device vibrates the chamber to excite movement of the defective and nondefective articles along the base and onto and up the ramp toward the outlet opening. The container also includes trap openings in the base and ramp to eliminate defective articles from the chamber. Discriminating devices are provided on the ramp that cause defective material to fall from the ramp back onto the base of the chamber. Only the nondefective articles can move on the ramp past the trapping devices toward the outlet of the container for transfer to another processing station.

Abstract: Compounds of the formula ##STR1## wherein Z is ##STR2## proline, pipecolic acid, an indolecarboxylic acid or an isoquinolinecarboxylic acid. These compounds are useful as cardiovascular agents.

Abstract: An enantiomerically pure compound of the formula ##STR1## is prepared when the associated racemic mixture is reacted with an acrylating agent R.sup.3 --C(O)--O--R in the presence of a microorganism or enzyme derived therefrom capable of catalyzing transesterification of an alcohol. X.sup.1 and X.sup.2 are each independently halogen, R is alkyl, R.sup.1 and R.sup.2 are each independently alkyl, cycloalkyl, aralkyl or aryl and R.sup.3 is alkyl, cycloalkyl, aryl or aralkyl.

Abstract: Compounds of the formula ##STR1## wherein m is zero or 1; n is zero, 1 or 2; p is zero or 1 to 6 provided that m and p are not both zero; R.sub.3 is hydrogen, acyl, or benzyl; and R.sub.1 is hydrogen, alkyl, phenyl, substituted phenyl, phenyl-alkylene, heterocyclic-alkylene, etc. These compounds are useful as cardiovascular agents.

Abstract: The protected cyclobutanone of the formula ##STR1## is treated with a dialkylaluminum chloride, an alkylaluminum dichloride, a trialkylaluminum compound, diphenylsilane in the presence of tris(triphenylphosphine) rhodium (I) chloride, or iridium tetrachloride to yield the corresponding diprotected cyclobutanol. This compound is useful as an intermediate in the preparation of antiviral agents.

Abstract: A retractile penis device comprises an apertured plate carrying an inflatable toroid ring, the ring being substantially aligned with the aperture and acting in use when inflated to apply pressure to the base of the penis and the surrounding skin area of the wearer.

Abstract: Isolated nucleic acid molecules capable of hybridizing to sequences of Candida albicans along with methods utilizing such probes for the detection of Candida albicans in clinical and other biological samples.

Abstract: Novel indane and quinoline derivatives, useful, for example, as antiischemic agents, having the formula ##STR1## where A, X, R.sub.1 -R.sub.7 are as defined herein, are disclosed.

Abstract: A process is described for selectively preparing a compound of the formula ##STR1## wherein: R.sup.1 is halogen;R.sup.2 is halogen, alkyl, cycloalkyl, aryl or ##STR2## and R.sup.3 hydrogen, alkyl, cycloalkyl, aryl, ##STR3## wherein the process comprises treating the associated ketone with an oxido-reductase or a microorganism comprising an oxidoreductase. Compounds prepared by this process are useful antipsychotic agents or useful intermediates therefor.

Abstract: Angiotensin II inhibition is exhibited by ##STR1## wherein: X is --CH.sub.2 -- or O;R is hydrogen, alkyl, aryl, cycloalkyl, aralkyl, or cycloalkylalkyl;R.sup.1 and R.sup.2 are each independently O or absent;R.sup.3 is hydrogen, alkyl, alkenyl, alkoxy, cycloalkyl, aryl, aralkyl, cycloalkylalkyl, halo, haloalkyl, or haloalkoxy;R.sup.4 is hydrogen, alkyl, alkenyl, alkoxy, aryl, cycloalkyl, aralkyl, cycloalkylalkyl, --R.sup.8 --OH, or --R.sup.8 CO.sub.2 R.sup.9 ;and the remaining symbols are as defined in the specification.

Abstract: The ostomy pouch has a coupling member that can be removed from the pouch envelope to permit flush disposal of the envelope without the coupling member. Flushability of the pouch is further enhanced by forming the pouch with converging side walls. Thus when the pouch is deposited in a toilet bottom end first in a carrier sleeve, the pouch can flow in streamlined fashion through the passages of a toilet and any sewer pipe or septic line connected to the toilet. Depending upon the flush capacity of the toilet and the flow rate of water through the toilet and sewer line, the ostomy pouch can be deposited in the toilet without a carrier sleeve.