Patents Assigned to E.R. Squibb
  • Pseudomonas fluorescens lipase
    Patent number: 5534427
    Abstract: Nucleic acid sequences, particularly DNA sequences, coding for all or part of a lipase of Pseudomonas fluorescens, wherein said lipase has the amino acid sequence encoded by the nucleotide sequence of the BamHI/HindIII insert of the plasmid pRJ-Ltac1 from Escherichia coli BL21/pRJ-Ltac1 deposited with the American Type Culture Collection, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of a lipase of Pseudomonas fluorescens, wherein said lipase has the amino acid sequence encoded by the nucleotide sequence of the plasmid pRJ-Ltac1 from Escherichia coli BL21/pRJ-Ltac1 BamHI/HindIII insert of deposited with the American Type Culture Collection, and methods for producing these polypeptides.
    Type: Grant
    Filed: July 31, 1992
    Date of Patent: July 9, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Robert M. Johnston, Steven L. Goldberg, Paul M. Cino
  • Male incontinence device
    Patent number: 5531725
    Abstract: An improved male incontinence comprises a condom located within a hollow tubular applicator open at both ends, in which a strip of tape having a medical grade adhesive on one surface and a release layer strip on the other surface is arranged in a helically wound configuration within the condom with the adhesive engaging the inner surface of the condom and the release layer strip located radially inwardly of the adhesive, there being a pull-cord or equivalent attached to a free end of the release layer strip so that upon removal thereof, the adhesive is exposed and can be brought into contact with the penis of the wearer in order to securely attach the device.
    Type: Grant
    Filed: February 2, 1995
    Date of Patent: July 2, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Graham E. Steer
  • Callus cell induction from partially submerged explant tissue in liquid medium for preparation of taxanes
    Patent number: 5527702
    Abstract: A method for the induction of callus cells capable of producing taxanes from explant tissue by partially submerging the explant tissue in a liquid culture medium on a membrane raft, resulting in callus formation. The induction of callus cells by this method provides direct transfer of the cells formed to a liquid medium for a suspension cell culture preparation of taxanes. Thus, there is no need of a separate growth or proliferation step in the method of this invention. Furthermore, callus cells can be produced by the method; and also disclosed is a method for the use of the callus cells so produced in a suspension cell culture preparation for taxanes.
    Type: Grant
    Filed: February 23, 1994
    Date of Patent: June 18, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Paul M. Cino, Steven R. Schwarz, Dana L. Cazzulino
  • Process for the preparation of an antiviral agent
    Patent number: 5525726
    Abstract: Racemic Feist's acid is treated with (R)-(+) -.alpha.-methylbenzylamine to yield (1R-trans)-3-methylene -cyclopropane-1,2-dicarboxylic acid, (R)-.alpha.-methylbenzyl-amine (1:1) salt. This salt can then be converted to (1R-trans)-3-methylene-1,2-cyclopropanedicarboxylic acid, dimethyl ester which is an intermediate in the preparation of the antiviral agent [1R-(1.alpha.,2.beta.,3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobut yl]-1,9-dihydro-6H-purin-6-one. The improved process also enables the recovery of racemic Feist's acid from the resolution.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: June 11, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jollie D. Godfrey, Jr., Richard H. Mueller, Thomas P. Kissick, Janak Singh
  • Dispensing device for dispensing at least two fluids
    Patent number: 5520658
    Abstract: A dispensing device for dispensing at least two fluids comprises a housing (12,22) of a pistol-like configuration having an integral handle (50), in which a spring-biased trigger (60) is received. Within the housing (12,22) of the dispensing device (10), two syringes (80,81) are received and fixated, which syringes contain respective fluids to be accurately dispensed. Provided a cover (22) of the housing is closed, the motion of the trigger (60) relative to the handle (50) is transmitted to a toothed rack which cooperates with a propeller body (70) in a ratchet-like manner. The ratchet-like cooperation allows a uni-directional motion of the propeller body (70) and prevents a motion of the propeller body (70) in the opposite direction.
    Type: Grant
    Filed: December 12, 1994
    Date of Patent: May 28, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Niels E. Holm
  • Self-aligning ostomy device
    Patent number: 5520670
    Abstract: The ostomy device includes a waste collection pouch and an adhesive faceplate adapted to mount the pouch to the body, adjacent the stoma. To attach the pouch to the faceplate, coupling rings, mounted respectively on each part, are aligned and snapped together. A hook member provided on the vertical centerline of the faceplate has a planar top surface which cooperates with a laterally extending elongated element located on the vertical centerline of the pouch to allow the pouch to swing to a position where the couplng rings are aligned to facilitate coupling of the rings. The hook may also have a mechanism to lock the pouch element, acting as an auxilary connection.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: May 28, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: John L. Blum
  • Process for preparing [IR-(1.alpha.,2.beta.-3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclob utyl]-1,9-dihydro-6H-purin-6-one
    Patent number: 5516903
    Abstract: The protected cyclobutanone of the formula ##STR1## is treated with a dialkylaluminum chloride, an alkylaluminum dichloride, a trialkylaluminum compound, hydrogen in the presence of the catalysts ruthenium black or ruthenium on alumina, diphenyl-silane in the presence of tris(triphenylphosphine) rhodium (I) chloride, or iridium tetrachloride to yield the corresponding diprotected cyclobutanol. This compound is useful as an intermediate in the preparation of antiviral agents.
    Type: Grant
    Filed: November 4, 1994
    Date of Patent: May 14, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Janak Singh, Gregory S. Bisacchi, Richard H. Mueller
  • Aminocarbonyl (thiocarbonyl) and cyanoguanidine derivatives of quinoline and indoline
    Patent number: 5514690
    Abstract: Novel compounds having potassium channel activating activity and useful, for example, as antiischemic agents are disclosed. These compounds have the general formula ##STR1## wherein A is ##STR2## or a single bond to complete an indoline nucleus; X is --O--, --S-- or --NCN; and the R groups are as defined herein.
    Type: Grant
    Filed: August 24, 1993
    Date of Patent: May 7, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Karnail S. Atwal, Francis N. Ferrara
  • Pyridine anchors for HMG-CoA reductase inhibitors
    Patent number: 5506219
    Abstract: Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have a quinoline or a pyridine anchor attached by means of a linker to a binding domain sidechain, which compounds inhibit the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
    Type: Grant
    Filed: March 7, 1995
    Date of Patent: April 9, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Jeffrey A. Robl
  • Hydrocolloid wound gel
    Patent number: 5503847
    Abstract: A hydrocolloid wound gel composition useful for cleansing an debriding wounds and having some capacity for absorbing wound exudate and a method of treating wounds comprising applying the hydrocolloid wound gel to a wound.The composition includes sodium carboxymethylcellulose, pectin, propylene glycol and water.
    Type: Grant
    Filed: April 15, 1993
    Date of Patent: April 2, 1996
    Assignee: E. R. Squibb and Sons, Inc.
    Inventors: Douglas Queen, Lesley A. Chambers, Simon M. Adams, Hugh Delargy
  • Kit for administering radiologic material to an ostomate and method of use
    Patent number: 5503625
    Abstract: A radiology kit for use with a catheter includes a first connection member 20 for attachment to the skin of the patient around the stomal orifice and a second connection member 30 (a cap) constructed for releasable attachment to a first connection means, i.e. a rib 23, on the first connection member. The cap has an end wall 33 with a hole 39 therein through which a catheter 40 can be threaded. A third connection member 50 of the kit is attached to a drainage sleeve 52 and constructed for releasable attachment to a second connection means, i.e. a rib 25 on the first connection member 20.
    Type: Grant
    Filed: October 31, 1994
    Date of Patent: April 2, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Ronald A. Plass
  • Inhibitors of neutral endopeptidase
    Patent number: 5496805
    Abstract: Diuresis, natriuresis, and the lowering of blood pressure are produced in a host by administering one or more neutral endopeptidase inhibitors. An additional blood pressure lowering agent such as an angiotensin converting enzyme inhibitor can be administered along with the neutral endopeptidase inhibitor.
    Type: Grant
    Filed: July 12, 1990
    Date of Patent: March 5, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Norma G. Delaney, Eric M. Gordon, Jack M. DeForrest, David W. Cushman
  • Male incontinence device
    Patent number: 5495858
    Abstract: A male incontinence device has one coupling part 200 attachable to a silicone pad 500 and a second coupling part 300 attached to a condom-like drainage member 400. A stretchable ring or wall 312 can be shifted ("snapped") by manual pressure between a locking position wherein the two coupling parts are locked together and an unlocking position wherein the two coupling parts can be separated to permit removal of the condom-like drainage member from the silicone pad.
    Type: Grant
    Filed: October 26, 1994
    Date of Patent: March 5, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter L. Steer, Graham D. Bannister, Howard Barrett
  • Combined two stage method for cleaning and decontaminating surgical instruments
    Patent number: 5489531
    Abstract: A two stage method using the same container for both cleaning and microbiologically decontaminating grossly soiled surgical instruments is described. A presoak in an enzyme solution is followed by direct addition of a compatible disinfectant and a continued soak to decontaminate surgical instruments and other paraphernalia used in healthcare facilities.
    Type: Grant
    Filed: July 24, 1992
    Date of Patent: February 6, 1996
    Assignee: E. R. Squibb and Sons, Inc.
    Inventor: Leslee M. Benson
  • Dihydropyrimidine derivatives
    Patent number: 5470975
    Abstract: Novel A-II receptor antagonists have the formula ##STR1## and its isomer ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are as defined herein.
    Type: Grant
    Filed: January 11, 1994
    Date of Patent: November 28, 1995
    Assignee: E.R. Squibb & Sons, Inc.
    Inventor: Karnail Atwal
  • N-substituted imidazole and benzimidazole derivatives useful as angiotenson II antagonists
    Patent number: 5466704
    Abstract: Compounds are disclosed having the formula ##STR1## These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: June 22, 1994
    Date of Patent: November 14, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
    Patent number: 5466817
    Abstract: A new method for the treatment of ischemia conditions and arrhythmia is disclosed. The method uses compounds of the formula ##STR1## wherein A can be --CH.sub.2 --, --O--, --NR.sub.9 --, --S--, --SO--, --SO.sub.2 --; X can be oxygen or sulfur; Y can be --NR.sub.8, --O--, --S--, --CH.sub.2 -- and the R groups are as defined herein. Novel compounds within the definition of formula I are also disclosed.
    Type: Grant
    Filed: October 13, 1993
    Date of Patent: November 14, 1995
    Assignee: E.R. Squibb & Sons, Inc.
    Inventor: Karnail Atwal
  • Process for the preparation of intermediates useful in the preparation of pyranyl cyanoguanidine derivatives
    Patent number: 5463059
    Abstract: A process for preparing compounds of the formula ##STR1## where a, b, c, R.sub.1, R.sub.2, and R.sub.3 are as defined herein including the step of alkylating a phenol of formula ##STR2## with an acetylene of formula ##STR3## where X is chlorine; bromine; --OC(O)--R.sub.5, where R.sub.5 is alkyl, aryl or substituted aryl; or --OCO.sub.2 R.sub.6, where R.sub.6 is alkyl or ##STR4## in the presence of a catalytic amount of a cuprous or cupric salt. The compounds of formula I are intermediates useful in the preparation of pyranyl cyanoguanidine derivatives.
    Type: Grant
    Filed: October 1, 1993
    Date of Patent: October 31, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jollie D. Godfrey, Jr., Richard H. Mueller, Thomas C. Sedergran, Nachimuthu Soundararajan
  • Method for treating hypertension employing a cholesterol lowering drug
    Patent number: 5461039
    Abstract: A method is provided for treating hypertension in normotensive patients having insulin resistance by administering a cholesterol lowering drug, such as pravastatin, alone or in combination with an ACE inhibitor, especially one containing a mercapto moiety, such as captopril or zofenopril.
    Type: Grant
    Filed: November 1, 1993
    Date of Patent: October 24, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Werner Tschollar, Cary S. Yonce, James L. Bergey, James C. Kawano
  • Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-CoA reductase inhibitors
    Patent number: 5457227
    Abstract: A novel, overall process for the preparation of a compound of the formula I: ##STR1## where R.sup.1 and R.sup.2 are each independently hydrogen, an alkyl group, a cycloalkyl group, an aryl group or, taken together with the carbon atom to which they are attached, form a cycloalkyl group; andR.sup.3 is hydrogen, an alkyl group, or an aryl group, or salts thereof, useful as intermediates in the preparation of HMG-CoA reductase inhibitors; novel methods within the overall process; and novel intermediates produced by those methods.
    Type: Grant
    Filed: October 8, 1993
    Date of Patent: October 10, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: John K. Thottathil, Yadagiri Pendri, Wen-Sen Li, David R. Kronenthal