Patents Assigned to E.R. Squibb
  • Non-peptidic angiotensin-II-receptor-antagonists
    Patent number: 5378704
    Abstract: Novel compounds having the formula ##STR1## wherein R.sub.1, R.sub.2, X and Y are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: April 15, 1992
    Date of Patent: January 3, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Harold N. Weller, III
  • Aryl and heteroaryl(phosphinylmethyl)phosphonate squalene synthetase inhibitors and method
    Patent number: 5374628
    Abstract: Phosphonic acid squalene synthetase inhibitors are provided which are effective in lowering serum cholesterol and have the formula ##STR1## wherein m is 0 to 3, n is 1 to 5, Y.sup.1 and Y.sup.2 are H or halogen, R.sup.2, R.sup.3 and R.sup.4 are H, metal ion, C.sub.1 to C.sub.8 alkyl, C.sub.3 to C.sub.12 alkenyl, or prodrug ester, and R.sup.1 is a substituted or unsubstituted heteroaryl group or a substituted phenyl group.
    Type: Grant
    Filed: October 18, 1993
    Date of Patent: December 20, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Scott A. Biller
  • Aryl urea (thiourea) and cyanoguanidine derivatives
    Patent number: 5374643
    Abstract: Novel compounds useful, for example, in the treatment of ischemic conditions and arrhythmia having the formula I ##STR1## wherein X is oxygen, sulfur or --NCN and the R groups are as defined herein.
    Type: Grant
    Filed: August 12, 1993
    Date of Patent: December 20, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Karnail S. Atwal, George C. Rovnyak
  • Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives
    Patent number: 5374615
    Abstract: Novel compounds are disclosed having the formula ##STR1## wherein X, R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are substituents. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: February 7, 1992
    Date of Patent: December 20, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • Ostomy pouch
    Patent number: 5370638
    Abstract: The ostomy pouch is formed of a flexible plastic material with a waste inlet opening and a gas outlet opening proximate the waste inlet opening. The gas outlet opening is of a configuration and size that resists entry of outside water into the pouch through the gas outlet opening. A filter aligned with the gas outlet opening is bonded at a peripheral zone surrounding the gas outlet opening, leaving an unbonded area that communicates with the gas outlet opening. A free face of the filter is gas impermeable. Gases within the pouch pass through an exposed, gas permeable peripheral edge of the filter toward the center and exit into the unbonded section for evacuation through the gas outlet opening.
    Type: Grant
    Filed: December 22, 1992
    Date of Patent: December 6, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Denis E. Keyes
  • Hydroxymethyl cyclobutyl purines
    Patent number: 5369098
    Abstract: Antiviral activity is exhibited by compounds having the formula ##STR1## and their pharmaceutically acceptable salts. R.sub.1 is ##STR2## R.sub.2 is hydrogen, --PO.sub.3 H.sub.2, ##STR3## wherein R.sub.3 is hydrogen, alkyl, substituted alkyl, or aryl, and R.sub.4 is alkyl.
    Type: Grant
    Filed: June 16, 1989
    Date of Patent: November 29, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: William A. Slusarchyk
  • Nitrogen-substituted mevinic acid derivatives useful as HMG-CoA reductase inhibitors
    Patent number: 5369123
    Abstract: Novel nitrogen-substituted mevinic acid derivatives which inhibit the activity of HMG-CoA reductase. Pharmaceutical compositions, and methods of use for the treatment or prevention of hypercholesterolemia, atherosclerosis, hyperlipoproteinaemia and hyperlipidemia are provided, as are novel methods for preparation and intermediate compounds.
    Type: Grant
    Filed: October 9, 1992
    Date of Patent: November 29, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Dinos P. Santafianos, Kathleen M. Poss, Eric M. Gordon, Peggy J. McCann
  • Method for inhibiting myocardial cell necrosis and preserving heart function during myocardial ischemia and/or reperfusion
    Patent number: 5354764
    Abstract: A method is provided for inhibiting myocardial cell necrosis and improving myocardial function during myocardial ischemia and/or reperfusion by locally administering to the heart a potent potassium channel activator such as pinacidil or cromakalim.
    Type: Grant
    Filed: November 2, 1992
    Date of Patent: October 11, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Gary J. Grover, Karnail Atwal
  • Membrane, e.g. for use in an ileostomy bag
    Patent number: 5352316
    Abstract: A method of making a gas-permeable liquid-impermeable membrane includes the steps of perforating a film of linear low density polyethylene (or other suitable polyolefin) in such a way as to yield an array of holes each having an average diameter of approximately 350, microns and then solution coating the needled film with a porous polyurethane material having pores of a pore size of 1 to 10 microns.Such a film is advantageously embodied in an ileostomy bag, and is fixed to a bag wall thereof in a location to prevent faecal material contacting the bag filter, by a heat or RF welding operation by which the polyolefin is welded to the bag wall which carries the filter. In use, the polyurethane is exposed to the bag contents, and permits gases to pass but prevents any liquid reaching the filter.
    Type: Grant
    Filed: August 19, 1991
    Date of Patent: October 4, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Graham E. Steer
  • Monoclonal antibodies which bind (E)-5- (2-bromovinyl)-arabinofuranosyluracil and diagnostic methods based thereon
    Patent number: 5352584
    Abstract: Monoclonal antibodies which bind (E)-5-(2-bromovinyl)-arabinofuranosyluracil and/or immunologically related compounds, hybrid cell lines which produce these monoclonal antibodies, and immunoassay methods for detecting (E)-5-(2-bromovinyl)-arabinofuranosyluracil and/or immunologically related compounds using these monoclonal antibodies.
    Type: Grant
    Filed: January 22, 1990
    Date of Patent: October 4, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Edward M. Croze, Jan-I Tu, Marc D. Ogan
  • Dihydropyrimidine derivatives
    Patent number: 5350752
    Abstract: Novel A-II receptor antagonists have the formula ##STR1## or its isomer ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6, are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: December 16, 1991
    Date of Patent: September 27, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Michael A. Poss, John Lloyd, Karnail S. Atwal
  • Nucleic acid encoding human mevalonate kinase
    Patent number: 5349058
    Abstract: Nucleic acid sequences, particularly DNA sequences, coding for all or a portion of human mevalonate kinase, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods for detecting the DNA sequences or the corresponding RNA sequences. The invention also concerns polypeptide molecules comprising all or a portion of human mevalonate kinase.
    Type: Grant
    Filed: February 6, 1990
    Date of Patent: September 20, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Richard D. Tanaka, Beverly S. Ricci, Stephen T. Mosley
  • Process for the preparation of 4-phosphinyl-3-keto-carboxylate and 4-phosphonyl-3-keto-carboxylate intermediates useful in the preparation of phosphorus containing HMG-COA reductase inhibitors
    Patent number: 5349069
    Abstract: A process for the preparation of compounds of formula ##STR1## or salt thereof where R.sub.1 is --X--Z and X is --C.tbd.C--,R.sub.2 and R.sub.2 ' are independently hydrogen, alkyl or trialkylsilyl;R.sub.3 is hydrogen or alkyl; andZ is a hydrophobic anchor;which includes reacting a compound of formula ##STR2## where R.sub.4 is alkyl, cycloalkyl or aryl; and R.sub.5 is trialkylsilyl or triarylsilyl with a compound of formula ##STR3## where Y is a halogen, to form a compound of formula ##STR4## and hydrolyzing the compound of formula IV to obtain the compounds of formula I. Compounds of formula I or salt thereof where R.sub.1 is --OR.sub.2 ' may be prepared by reacting a compound of formula III with a compound of formulaP(OR.sub.2).sub.3.
    Type: Grant
    Filed: December 21, 1993
    Date of Patent: September 20, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: John K. Thottathil, Wen S. Li
  • DNA encoding TRKC protein
    Patent number: 5348856
    Abstract: Nucleic acid sequences, particularly DNA sequences, coding for all or part of a trkC protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of a trkC protein and methods for producing these polypeptide molecules.
    Type: Grant
    Filed: July 7, 1992
    Date of Patent: September 20, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Mariano Barbacid, Fabienne Lamballe
  • Mouse vav proto-oncogene DNA and protein sequences
    Patent number: 5348864
    Abstract: Nucleic acid sequences, particularly DNA sequences, coding for all or part of a vav mouse proto-oncogene protein or for a modified vav mouse proto-oncogene protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of a vav mouse proto-oncogene protein or a modified vav mouse proto-oncogene protein, and methods for producing these polypeptide molecules.
    Type: Grant
    Filed: January 25, 1991
    Date of Patent: September 20, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Mariano Barbacid
  • Method of preparing 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
    Patent number: 5347007
    Abstract: A method is provided for preparing 7-oxabicycloheptyl substituted heterocyclic aide prostaglandin analogs which are thromboxane A.sub.2 (TXA.sub.2) receptor antagonists or combined thromboxane A.sub.2 receptor antagonists/thromboxane synthetase inhibitors useful, for example, in the treatment of thrombotic and/or vasospastic disease, wherein a vinyl bromide of the formula, for example, ##STR1## wherein m, n, R.sup.1 and R.sup.2 are as defined herein is treated with a cyclizing agent to forth the corresponding oxazole.
    Type: Grant
    Filed: October 4, 1993
    Date of Patent: September 13, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jagabandhu Das, David Kronenthal
  • Intermediates in the synthesis of an optically active cyclobutane nucleoside
    Patent number: 5344962
    Abstract: Cyclobutane intermediates wherein the absolute stereochemistry is (1S,2R) of the formula ##STR1## are disclosed. These intermediates are useful in the preparation of compounds having anti-viral activity.
    Type: Grant
    Filed: May 10, 1993
    Date of Patent: September 6, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Saleem Ahmad
  • Hydroxymethyl(methylenecyclopentyl) purines and pyrimidines
    Patent number: 5340816
    Abstract: Antiviral activity is exhibited by compounds having the formula ##STR1## and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: January 15, 1993
    Date of Patent: August 23, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Robert Zahler, William A. Slusarchyk
  • Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
    Patent number: 5324662
    Abstract: Microorganisms or reductases derived therefrom reduce a diketo ester ##STR1## to form the associated 3-hydroxy, 5-hydroxy, or 3,5-dihydroxy esters.
    Type: Grant
    Filed: May 15, 1992
    Date of Patent: June 28, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ramesh N. Patel, Clyde G. McNamee, Amit Banerjee, Laszlo J. Szarka
  • 10'desmethoxystreptonigrin production by Streptomyces albus
    Patent number: 5320955
    Abstract: 10'-Desmethoxystreptonigrin, obtainable by cultivation of a strain of Streptomyces albus, A.T.C.C. No. 55161, and salts, esters and amides thereof. The novel compounds have antitumor and antibiotic activity.
    Type: Grant
    Filed: July 30, 1992
    Date of Patent: June 14, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Edward Meyers, Terrence W. Doyle, Veeraswamy Manne, Wen-Chih Liu