Abstract: The present invention concerns complexing agents of formula (I) in which a, b, c, chrom1, chrom2, chrom3, R3, R4 and R5 are as defined in the description. The invention also concerns lanthanide complexes comprising said complexing agents, as well as a method for synthesizing said agents.

Abstract: A method for depositing a photocatalytic coating on a support, the method having the steps: a) providing an aqueous and/or alcoholic suspension of nanoparticles of a semiconducting material, b) providing a sol in an aqueous and/or alcoholic solution of a hydrolyzed organosilane, c) mixing the suspension and the sol and proceeding with deposition of the obtained mixture on the support to be covered, d) performing a drying operation, e) and optionally producing an illumination of the obtained coating after drying at one wavelength at least causing activation of the semiconducting material, so as to remove at least 3% of the organic groups initially present in the coating and bound to the silicon atoms through a Si—C bond; as well as coatings with photocatalytic properties, materials, notably textiles, covered with such a coating and the use of such coatings and materials for photocatalysis.

Abstract: The invention relates to a system for determining surroundings in a wireless network, the system including first and second nodes, each node being programmed to periodically detect the nodes located in the surroundings thereof every time period ?, characterized in that: the first node comprises a transmitter (1) and control means (3) for activating the transmitter (1) for a transmission time ? less than the time period ?, the transmitter transmitting an identification signal during the transmission time ?; the second node comprises a receiver (2) and control means (3) for activating the receiver (2) for a reception time ? less than the time period ?, the receiver (2) listening for the signals from the adjacent nodes during the reception time a, the control means (3) of the second node activating the receiver once per time period ?.

Abstract: The invention relates to contrast agents for magnetic resonance imaging comprising a chelating ligand and a transition metal ion, said ligand carrying a substituent capable of reacting chemically or biochemically with a target substance while bringing about a change in the spin state.

Abstract: The present invention concerns complexing agents of formula (I) in which a, b, c, chrom1, chrom2, chrom3, R3, R4 and R5 are as defined in the description. The invention also concerns lanthanide complexes comprising said complexing agents, as well as a method for synthesizing said agents.

Abstract: The subject matter of the present disclosure relates to an in vitro method for the screening of anti-cancer compounds based on the capacity for these compounds to interact with neurotrophin 3 (NT-3 or NT3), to the extracellular domain or TrkC receptor and/or to inhibit the dimerization of the intracellular domain of the TrkC receptor expressed in tumor cells, particularly in neuroblastoma. The disclosure also relates to a method for predicting the presence of metastatic cancer or a bad prognosis cancer, or for determining the efficiency of an anti-cancer treatment based on the measuring of the expression level of neurotrophin 3. The disclosure further comprises kits and compounds as a medicament for the treatment of neuroblastoma or cancer overexpressing neurotrophin 3 by the tumor cells.

Abstract: This method comprises bringing drops to be separated into contact with an interface (40) suitable for allowing an osmotic equilibrium between the content of each drop to be separated. The method comprises an osmotic flow between the drops (20A) of the first group of drops through the interface (40) in order to modify the density of each drop (20A) of the first group of drops and the separation of the drops (20A, 20B) according to the density thereof or a combination of the density and the volume in order to isolate the drops (20A) of the first group of drops from the drops (20B) of a second group of drops.

Abstract: The present invention relates to a high-resolution scanning surface-plasmon microscope including a source (LG) of coherent light and a medium for coupling and confining a surface plasmon including an objective (O, OM) with a large numerical aperture, immersion oil (Hi), and a glass cover slip (GS). A metal layer (MS) covers a surface of the glass cover slip (GS). The microscope also includes a heterodyne-mode Twyman-Green interferometer placed between the light source and means (PL1, PL2, EC) for scanning the metal layer using a light beam and means (PD) for detecting the beam from the interferometer connected to processing means (S, F, DTec, COMP) for forming an image from that beam. According to the invention, at least one polarization converter (CP) for converting the light beams (L) emitted by the light source (LG) from linear polarization to radial polarization is disposed between the light source and the interferometer.

Abstract: This velocimeter for measuring the speed of flow of an electrically conducting fluid comprises: —two sensors (16, 19) disposed in such a way that, in the absence of flow of the electrically conducting fluid (4), the difference between the current strengths measured by the two sensors (16, 19) is non zero, —a processing unit (18) is able to calculate the speed of flow of the fluid in a direction parallel to the first measurement direction (7) on the basis of the difference between the current strengths measured by the two sensors (16, 19).

Abstract: A tool for aiding management of a communicating physical device includes: a device controller operating the physical device using operating parameters; a data storage interlinking an identifier from the physical device and dated values of attributes and a list of control functions capable of modifying some of the operating parameters; an interpreter adapted for receiving a device identifier datum and a time horizon parameter at the same time and for responding thereto by establishing a series of respective events using the information from the data storage, related to the time horizon, each event interlinking a date, one or more identifiers of control functions, and parameters for these functions, established in accordance with a dated attribute value; and a sequencer arranged to call the interpreter and carry out chronologically the calls of the functions of each event of the series as returned by the interpreter.

Abstract: The present invention relates to heptamethine hemicyanine chromophores of formula (I): where R1, R2, R3, R4, R?4, R5, R?5, R6, R?6, R7, X, Y1 and Y2 are as defined in claim 1, to the method for preparing same as well as to the use of such chromophores for the second-order nonlinear optical property thereof.

Abstract: The present invention relates to peptides and polypeptides having the sequence SAVTFAVCAL or variants thereof, capable of binding to Calcineurin and/or to NS5A-TP2 and to their use in therapy, as well as to nucleic acid sequences and vectors encoding these peptides and polypeptides, and to cells comprising said polypeptides, nucleic acid sequences or vectors. The invention further relates to the use of the peptides, polypeptides or their derivatives to bring about phenotypic changes in mammalian cells, particularly to up-regulate calcineurin activity. The invention finally relates to a method for intracellular identification of substances which bind to calcineurin and which modulate the physiological effects of calcineurin.

Abstract: The present invention relates to a method of toxicological evaluation of a candidate substance on at least one tissue or organ, characterized in that it comprises the steps of: (a) obtaining a bioartificial tissue or organ by simulation or modelling of the metabolic activity of said tissue or organ by at least one bioreactor; (b) exposure of said bioartificial tissue or organ to said substance; (c) observation of the metabolic response of the bioartificial tissue or organ and acquisition without a priori of an associated multidimensional data set; (d) identification by means of a method of multivariate statistical analysis of the components of the multidimensional data set which are quantitatively correlated with predetermined variables; (e) generation of a predictive model on the basis of the components of the data set that are actually retained; (f) testing of the predictive nature of said model by at least one statistical method of estimating reliability; (g) identification of the metabolic response of the

Abstract: The invention relates to a passive optical limiter having a nonlinear material capable of switching in a predetermined optical band from a transparent state to an opaque state as a function of the power of an incident laser beam. The nonlinear material is an organic dye which comprises molecules derived from 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene into which a nitrogen atom is inserted at the meso position, referred to as aza-bodipy molecules, and which have conjugated ? chains functionalized so as to exhibit absorption for two photons around an incident beam wavelength lying between 1.45 ?m and 1.6 ?m.

Abstract: The present invention relates to peptides and polypeptides having the sequence SAVTFAVCAL or variants thereof, capable of binding to Calcineurin and/or to NS5A-TP2 and to their use in therapy, as well as to nucleic acid sequences and vectors encoding these peptides and polypeptides, and to cells comprising said polypeptides, nucleic acid sequences or vectors. The invention further relates to the use of the peptides, polypeptides or their derivatives to bring about phenotypic changes in mammalian cells, particularly to up-regulate calcineurin activity. The invention finally relates to a method for intracellular identification of substances which bind to calcineurin and which modulate the physiological effects of calcineurin.

Abstract: The present invention relates to a high-resolution surface plasmon microscope including a heterodyne interferometer (6) for splitting an excitation light beam into at least one reference beam and at least one measurement beam directed toward a coupling medium (7) to generate a surface plasmon, said heterodyne interferometer consists essentially of guide optical fibers (12, 13, 14, 15) optically connected at a first of their ends to an optical coupler (16) and each also optically connected at their second end to a light source (1), an optical coupling medium (7), an element (17) for reflecting the reference beam, and means (28) for detecting an interferometer beam, respectively.

Abstract: The subject matter of the present disclosure relates to an in vitro method for the screening of anti-cancer compounds based on the capacity for these compounds to interact with neurotrophin 3 (NT-3 or NT3), to the extracellular domain, or TrkC receptor and/or to inhibit the dimerization of the intracellular domain of the TrkC receptor expressed in tumor cells, particularly in neuroblastoma. The disclosure also relates to a method for predicting the presence of metastatic cancer or a bad prognosis cancer, or for determining the efficiency of an anti-cancer treatment based on the measuring of the expression level of neurotrophin 3. The disclosure further comprises kits and compounds as a medicament for the treatment of neuroblastoma or cancer overexpressing neurotrophin 3 by the tumor cells.

Abstract: The invention relates to a mixer that includes:—at least one instrumented particle (24) included in a mixture of products, each instrumented particle being: a. capable of moving freely and independently within the mixture under the action of products stirred by an agitator (14), and b. equipped with at least one sensor capable of measuring a characteristic of the mixture;—and a processing unit (30) capable of monitoring or controlling the mixer on the basis of the measures made by each instrumented particle.

Abstract: Polynucleotides with insulating properties allowing protection of the expression of a transgene from adjacent cis elements in higher eukaryotic cells. In particular, these polynucleotides can be used for transgenesis, gene therapy and the production of recombinant proteins.

Abstract: The invention relates to a passive optical limiter having a nonlinear material capable of switching in a predetermined optical band from a transparent state to an opaque state as a function of the power of an incident laser beam. The nonlinear material is an organic dye which comprises molecules derived from 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene into which a nitrogen atom is inserted at the meso position, referred to as aza-bodipy molecules, and which have conjugated ? chains functionalized so as to exhibit absorption for two photons around an incident beam wavelength lying between 1.45 ?m and 1.6 ?m.