Abstract: The present invention concerns a process to carry out an ester hydrolysis wherein the ester compound (c) is made from at least an alcohol (a) and a carboxylic acid (b), and wherein said alcohol (a) and said carboxylic acid (b) are forming a biphasic liquid system when mixed together; comprising at least a step of producing an ester compound (c)/water emulsion by using as stabilizing species amphiphilic solid particles of nanometric dimension and optionally a catalyst X.

Abstract: Described herein is a method for determining a nucleic acid sequence, said method comprising: a) denaturing a double-stranded nucleic acid molecule corresponding to the said nucleic acid sequence by applying a physical force to the said molecule; b) providing a single-stranded nucleic acid molecule; c) renaturing the said double stranded nucleic acid molecule in the presence of the said single-stranded nucleic acid molecule; and d) detecting a blockage of the renaturation of the double-stranded nucleic acid.

Abstract: Described herein is a method for determining a nucleic acid sequence, said method comprising: a) denaturing a double-stranded nucleic acid molecule corresponding to the said nucleic acid sequence; b) hybridizing a single-stranded nucleic acid molecule, the primer, with the said denatured double-stranded nucleic acid molecule; c) applying a tension to the hybridized primer/double-stranded nucleic acid molecule obtained in b); d) incubating the hybridized primer/double-stranded nucleic acid molecule obtained in b) with a polymerase in conditions which will lead to at least one pause in replication; and e) determining a position of the said pause in replication with respect to one end of the double-stranded nucleic acid.

Abstract: The present invention relates to a method of toxicological evaluation of a candidate substance on at least one tissue or organ, characterized in that it comprises the steps of: (a) obtaining a bioartificial tissue or organ by simulation or modelling of the metabolic activity of said tissue or organ by at least one bioreactor; (b) exposure of said bioartificial tissue or organ to said substance; (c) observation of the metabolic response of the bioartificial tissue or organ and acquisition without a priori of an associated multidimensional data set; (d) identification by means of a method of multivariate statistical analysis of the components of the multidimensional data set which are quantitatively correlated with predetermined variables; (e) generation of a predictive model on the basis of the components of the data set that are actually retained; (f) testing of the predictive nature of said model by at least one statistical method of estimating reliability; (g) identification of the metabolic response of the

Abstract: A method of determining the non-propagation threshold of fatigue cracks at high frequency, wherein cyclic loading is exerted on at least one testpiece having an elliptical hole in a testpiece zone, the elliptical hole having a notch at one end and the testpiece being held between two rigid masses with two rigid pre-stress plates being arranged on either side of the at least one testpiece and each fastened at its two ends to the two rigid masses, which cyclic loading is at a frequency that is selected as being equal to the resonant frequency of the assembly including the testpiece, the masses, and the stress plates, so as to generate a fatigue crack from the notch, and then once it has been observed that the crack has stopped propagating, the final length of the crack is measured and a chart is used to determine the non-propagation threshold.

Abstract: The invention relates to a microfluidic system for controlling a concentration profile of molecules capable of stimulating a target, for example formed by an assembly of living cells, this system comprising: —a microfluidic device (1) comprising at least one microfluidic channel (4) equipped with at least one inlet orifice (21) and with at least one outlet orifice (22) for at least one fluid; —at least one means for supplying the microfluidic channel (4) with at least one fluid comprising molecules capable of stimulating the target; —at least one chamber (8) or another microfluidic channel comprising a base (6) intended to receive the target; and —at least one microporous membrane (5) separating the chamber (8) or the other microfluidic channel from the microfluidic channel (4), said microporous membrane (5) being positioned away from the base (6) so that when the supply means provides the microfludic channel (4) with said at least one fluid flowing in laminar flow in contact with the microporous membrane (5)

Abstract: Non aqueous solvents or mixtures for DNP NMR spectroscopy, method to prepare said solvents or mixtures and use of said solvents or mixtures The present invention concerns a method to determine the efficiency of a solvent to impregnate a sample material for use in a dynamic nuclear polarization (DNP) nuclear magnetic resonance (NMR) experiments, characterized in that the method comprising: —selecting a non-aqueous solvent, —providing a polarizing agent that is soluble in the non-aqueous solvent, —dissolving the polarizing agent in the non-aqueous solvent, —impregnating or dissolving the sample material with the non-aqueous solvent containing the polarizing agent, —performing a solid state DNP NMR experiment on the impregnated sample material, —determining a DNP enhancement factor of the DNP NMR experiment.

Abstract: The invention relates to a method for manufacturing an aluminum/metal assembly including the steps involving: thermally processing an aluminum sheet by heating said sheet to a temperature of between 80% and 100% of the melting temperature of the material of which it consists for a sufficiently long duration to create and stabilize by allotropic conversion an alpha alumina layer at the surface of said aluminum sheet, and then cooling same; providing a metal layer having a ductility less than or equal to the ductility of the aluminum sheet after cooling, said layer having surface irregularities having a depth greater than or equal to the thickness of the alpha alumina layer; and roll bonding the aluminum layer and the metal layer to produce the metal assembly.

Abstract: The invention relates to a method for manufacturing an aluminum/metal assembly consisting of a metal layer made of a first metal on the surface of a metal object made of a second metal, the first or second metal being aluminum, wherein said method includes the following steps: placing a metal foam having an open porosity on a surface of the metal object, and applying mechanical stress to the metal foam in such a manner that said foam becomes embedded in the surface of the object.

Abstract: This method comprises bringing drops to be separated into contact with an interface (40) suitable for allowing an osmotic equilibrium between the content of each drop to be separated. The method comprises an osmotic flow between the drops (20A) of the first group of drops through the interface (40) in order to modify the density of each drop (20A) of the first group of drops and the separation of the drops (20A, 20B) according to the density thereof or a combination of the density and the volume in order to isolate the drops (20A) of the first group of drops from the drops (20B) of a second group of drops.

Abstract: The present invention concerns complexing agents of formula (I) in which a, b, c, chrom1, chrom2, chrom3, R3, R4 and R5 are as defined in the description. The invention also concerns lanthanide complexes comprising said complexing agents, as well as a method for synthesizing said agents.

Abstract: A method for depositing a photocatalytic coating on a support, the method having the steps: a) providing an aqueous and/or alcoholic suspension of nanoparticles of a semiconducting material, b) providing a sol in an aqueous and/or alcoholic solution of a hydrolyzed organosilane, c) mixing the suspension and the sol and proceeding with deposition of the obtained mixture on the support to be covered, d) performing a drying operation, e) and optionally producing an illumination of the obtained coating after drying at one wavelength at least causing activation of the semiconducting material, so as to remove at least 3% of the organic groups initially present in the coating and bound to the silicon atoms through a Si—C bond; as well as coatings with photocatalytic properties, materials, notably textiles, covered with such a coating and the use of such coatings and materials for photocatalysis.

Abstract: A method and a system is provided for configuring a device for correcting the effect of a medium on a light signal having propagated through the medium, the device including at least one optical element whose phase profiles are individually adjustable. The configuring system and method include propagating a reference signal and a disordered signal obtained at the output of the medium through the correcting device. An interference parameter is measured and optimized by modifying the phase profile of each of the optical elements of the correcting device. A method and a system is also provided for correcting the effect of a medium on a light signal having propagated through the medium.

Abstract: A new dual biomarker of neurodegeneration and of neuroregeneration

Abstract: The present invention is related to a decision-support system and method for providing with a score an object represented by a target item from a multidimensional space, said score being representative of the probability that the object satisfies a given binary property. The method and/or decision support-system may be performed in a computer environment comprising processing means connected to memory means.

Abstract: The invention relates to a microfluidic system for controlling a card for the concentration of molecules capable of stimulating a target, for example formed by an assembly of living cells, characterized in that the system comprises a microfluidic device (1) comprising: n?1 microfluidic channel(s) (4, 40), the or each channel being provided with at least one inlet orifice for at least one fluid and with at least one outlet orifice for this fluid; n?2 openings (47, 470) formed in the microfluidic channel or distributed in the various microfluidic channels, said openings being arranged in one and the same plane so that they form a network having at least one dimension in this plane, the numbers n of microfluidic channel(s) and n of openings being linked by the relationship (I) with 1?i?n and n the number of openings for the channel c; at least one microporous membrane (5) covering the network of openings, the target being intended to be positioned on the side of the membrane which is opposite the microfluidic ch

Abstract: A process for calculating an indice of arterial stiffness, including the step of extracting pulse wave analysis data from a recorded pressure of an artery, the recorded pressure is recorded as a function of time, the indice being calculated as a function of the extracted data, and the extracted pulse wave analysis data including at least one time interval.

Abstract: A method of determining the non-propagation threshold of fatigue cracks at high frequency, wherein cyclic loading is exerted on at least one testpiece having an elliptical hole in a testpiece zone, the elliptical hole having a notch at one end and the testpiece being held between two rigid masses with two rigid pre-stress plates being arranged on either side of the at least one testpiece and each fastened at its two ends to the two rigid masses, which cyclic loading is at a frequency that is selected as being equal to the resonant frequency of the assembly including the testpiece, the masses, and the stress plates, so as to generate a fatigue crack from the notch, and then once it has been observed that the crack has stopped propagating, the final length of the crack is measured and a chart is used to determine the non-propagation threshold.

Abstract: The invention relates to a system for determining surroundings in a wireless network, the system including first and second nodes, each node being programmed to periodically detect the nodes located in the surroundings thereof every time period ?, characterized in that: the first node comprises a transmitter (1) and control means (3) for activating the transmitter (1) for a transmission time ? less than the time period ?, the transmitter transmitting an identification signal during the transmission time ?; the second node comprises a receiver (2) and control means (3) for activating the receiver (2) for a reception time ? less than the time period ?, the receiver (2) listening for the signals from the adjacent nodes during the reception time a, the control means (3) of the second node activating the receiver once per time period ?.

Abstract: The invention relates to contrast agents for magnetic resonance imaging comprising a chelating ligand and a transition metal ion, said ligand carrying a substituent capable of reacting chemically or biochemically with a target substance while bringing about a change in the spin state.