Abstract: The invention relates to a method for manufacturing an aluminum/metal assembly consisting of a metal layer made of a first metal on the surface of a metal object made of a second metal, the first or second metal being aluminum, wherein said method includes the following steps: placing a metal foam having an open porosity on a surface of the metal object, and applying mechanical sress to the metal foam in such a manner that said foam becomes embedded in the surface of the object.

Abstract: The invention concerns image data processing, through noise reduction comprising the following steps: associating a learning zone (ZA) with a reference point (Pref) of the image (IM); for each variable point (PC, PC?) of the learning zone, evaluating a distance (d,d?,) between: values of points in a first window (f1) of the image, centered on the reference point, and values of points in a second window (f2, f2,), of similar format as the format of the first window and centered on the variable point; repeating said distance calculation for all the points of the learning zone as successive variable points and estimating an average value to assign to the reference point, said average being weighted on the basis of the distances evaluated for each variable point.

Abstract: A method of stabilizing the distance (L) between two mirrors (3, 4) of an optical cavity (2). The method includes the steps of injecting into the cavity an incident light beam in the form of a comb of frequencies; observing the spectrum of the light emitted or reflected by the cavity by using a photodiode having at least two sensitive zones that are arranged relative to the emitted or reflected light in such a manner that when the spectrum is centered, the two sensitive zones of the photodiode are illuminated equally; and modifying the distance between the mirrors of the cavity so as to cancel any offset of the spectrum relative to a situation in which the spectrum is centered.

Abstract: The invention concerns image data processing, through noise reduction comprising the following steps: associating a learning zone (ZA) with a reference point (Pref) of the image (IM); for each variable point (PC, PC?,) of the learning zone, evaluating a distance (d, d?,) between: values of points in a first window (f1) of the image, centered on the reference point, and values of points in a second window (f2, f?2,), of similar format as the format of the first window and centered on the variable point; repeating said distance calculation for all the points of the learning zone as successive variable points and estimating an average value to assign to the reference point, said average being weighted on the basis of the distances evaluated for each variable point.

Abstract: The present invention relates to a method for treating proliferative mastocytosis comprising administering a Bruton tyrosine kinase (BTK) inhibitor, a BTK antisense to a mammal in need of such treatment. The invention is more particularly suited for treating category II, III and IV mastocytosis.

Abstract: The invention relates to a passive optical limiter having a nonlinear material capable of switching in a predetermined optical band from a transparent state to an opaque state as a function of the power of an incident laser beam. The nonlinear material is an organic dye which comprises molecules derived from 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene into which a nitrogen atom is inserted at the meso position, referred to as aza-bodipy molecules, and which have conjugated ? chains functionalized so as to exhibit absorption for two photons around an incident beam wavelength lying between 1.45 ?m and 1.6 ?m.

Abstract: The present invention relates to peptides and polypeptides having the sequence SAVTFAVCAL or variants thereof, capable of binding to Calcineurin and/or to NS5A-TP2 and to their use in therapy, as well as to nucleic acid sequences and vectors encoding these peptides and polypeptides, and to cells comprising said polypeptides, nucleic acid sequences or vectors. The invention further relates to the use of the peptides, polypeptides or their derivatives to bring about phenotypic changes in mammalian cells, particularly to up-regulate calcineurin activity. The invention finally relates to a method for intracellular identification of substances which bind to calcineurin and which modulate the physiological effects of calcineurin.

Abstract: The present invention relates to a high-resolution surface plasmon microscope including a heterodyne interferometer (6) for splitting an excitation light beam into at least one reference beam and at least one measurement beam directed toward a coupling medium (7) to generate a surface plasmon, said heterodyne interferometer consists essentially of guide optical fibers (12, 13, 14, 15) optically connected at a first of their ends to an optical coupler (16) and each also optically connected at their second end to a light source (1), an optical coupling medium (7), an element (17) for reflecting the reference beam, and means (28) for detecting an interferometer beam, respectively.

Abstract: The invention relates to a durable hydrophilic non-porous surface-modified polymer composition, to aqueous fluid channels based on said composition, to a microfluidic system comprising said channels, to a method for the production thereof and to a microfluidic chip or cells incorporating said composition.

Abstract: The subject matter of the present disclosure relates to an in vitro method for the screening of anti-cancer compounds based on the capacity for these compounds to interact with neurotrophin 3 (NT-3 or NT3), to the extracellular domain, or TrkC receptor and/or to inhibit the dimerization of the intracellular domain of the TrkC receptor expressed in tumor cells, particularly in neuroblastoma. The disclosure also relates to a method for predicting the presence of metastatic cancer or a bad prognosis cancer, or for determining the efficiency of an anti-cancer treatment based on the measuring of the expression level of neurotrophin 3. The disclosure further comprises kits and compounds as a medicament for the treatment of neuroblastoma or cancer overexpressing neurotrophin 3 by the tumor cells.

Abstract: A method for the recognition of objects in at least one digital image includes: a) simulating from the digital image a plurality of digital rotations and at least two digital tilts different from 1 in order to develop a simulated image for each rotation-tilt pair; and b) applying an algorithm generating values that are invariant in translation, rotation and zoom onto the simulated images in order to determine so-called SIF (scale invariant features) local characteristics used for recognising objects. The SIFT method can be used in step b.

Abstract: The invention relates to a mixer that includes:—at least one instrumented particle (24) included in a mixture of products, each instrumented particle being: a. capable of moving freely and independently within the mixture under the action of products stirred by an agitator (14), and b. equipped with at least one sensor capable of measuring a characteristic of the mixture;—and a processing unit (30) capable of monitoring or controlling the mixer on the basis of the measures made by each instrumented particle.

Abstract: Polynucleotides with insulating properties allowing protection of the expression of a transgene from adjacent cis elements in higher eukaryotic cells. In particular, these polynucleotides can be used for transgenesis, gene therapy and the production of recombinant proteins.

Abstract: In a control system comprising control device adapted for, on the one hand, receiving signal indicating a first biometric datum (W), and, on the other hand, obtaining a second biometric datum captured (w?), at the level of the control device, the first and second biometric date are compared. Next, it is decided whether the first and second biometric data correspond on the basis of the comparison. Thereafter, at least a secret cryptographic key part (H(w)) is generated by applying cryptographic function to the first biometric datum.

Abstract: The invention relates to a passive optical limiter having a nonlinear material capable of switching in a predetermined optical band from a transparent state to an opaque state as a function of the power of an incident laser beam. The nonlinear material is an organic dye which comprises molecules derived from 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene into which a nitrogen atom is inserted at the meso position, referred to as aza-bodipy molecules, and which have conjugated ? chains functionalized so as to exhibit absorption for two photons around an incident beam wavelength lying between 1.45 ?m and 1.6 ?m.

Abstract: The invention concerns image data processing, through noise reduction comprising the following steps: associating a learning zone (ZA) with a reference point (Pref) of the image (IM); for each variable point (PC, PC?,) of the learning zone, evaluating a distance (d, d?,) between: values of points in a first window (f1) of the image, centered on the reference point, and values of points in a second window (f7, f?2,), of similar format as the format of the first window and centered on the variable point; repeating said distance calculation for all the points of the learning zone as successive variable points and estimating an average value to assign to the reference point, said average being weighted on the basis of the distances evaluated for each variable point.

Abstract: The invention relates to an interacting polypeptide consisting of or comprising a heptapeptide pattern of sequence X1X2X3X4X5X6X7 and a transduction domain, characterized in that it is a chimera polypeptide, the amino acid X7 is located between 5 and 35 amino acids of the C-terminal end of said polypeptide, and that the domain (b) is situated in C-terminal relative to pattern (a). The invention also relates to screening methods for identifying interacting polypeptides capable of modifying the phenotype of a cell and to uses of interacting polypeptides as mentioned in phenotypic screens or for therapeutic purposes. Lastly, the invention concerns interacting polypeptides capable of modifying the function of the HIV-1 Rev viral protein.

Abstract: The invention relates to a device useful for non-invasive detection of the properties of a medium by means of interferometry. The device comprises an optical source which is used for illuminating a zone of the medium that is to be probed with a light beam, and an interferometer for splitting the light beam into a reference beam and a probe beam. The interferometer has a cutoff frequency for the automatic control of respective path lengths of the reference beam and of the probe beam. The device also comprises scanning means which, together with the probe beam, are used to scan the zone to be probed at an image acquisition frequency greater than the cutoff frequency.

Abstract: A pharmaceutical composition for the treatment, prevention or diagnosis of a tumoral pathology comprising an active agent which stabilizes an actin network of a cellular cytoskeleton.

Abstract: The invention concerns modified avian ES cells, specifically expressing an exogenous gene when they have a pluripotent character. The invention also concerns a nucleic acid and a polypeptide specifically expressed in pluripotent avian cells, and methods for detecting the pluripotent character of cells using said nucleic acid and polypeptide.