Abstract: The present invention concerns complexing agents of formula (I) in which a, b, c, chrom1, chrom2, chrom3, R3, R4 and R5 are as defined in the description. The invention also concerns lanthanide complexes comprising said complexing agents, as well as a method for synthesizing said agents.

Abstract: The subject matter of the present disclosure relates to an in vitro method for the screening of anti-cancer compounds based on the capacity for these compounds to interact with neurotrophin 3 (NT-3 or NT3), to the extracellular domain or TrkC receptor and/or to inhibit the dimerization of the intracellular domain of the TrkC receptor expressed in tumor cells, particularly in neuroblastoma. The disclosure also relates to a method for predicting the presence of metastatic cancer or a bad prognosis cancer, or for determining the efficiency of an anti-cancer treatment based on the measuring of the expression level of neurotrophin 3. The disclosure further comprises kits and compounds as a medicament for the treatment of neuroblastoma or cancer overexpressing neurotrophin 3 by the tumor cells.

Abstract: A method and a system is provided for configuring a device for correcting the effect of a medium on a light signal having propagated through the medium, the device including at least one optical element whose phase profiles are individually adjustable. The configuring system and method include propagating a reference signal and a disordered signal obtained at the output of the medium through the correcting device. An interference parameter is measured and optimized by modifying the phase profile of each of the optical elements of the correcting device. A method and a system is also provided for correcting the effect of a medium on a light signal having propagated through the medium.

Abstract: The invention relates to a microfluidic system for controlling a card for the concentration of molecules capable of stimulating a target, for example formed by an assembly of living cells, characterized in that the system comprises a microfluidic device (1) comprising: n?1 microfluidic channel(s) (4, 40), the or each channel being provided with at least one inlet orifice for at least one fluid and with at least one outlet orifice for this fluid; n?2 openings (47, 470) formed in the microfluidic channel or distributed in the various microfluidic channels, said openings being arranged in one and the same plane so that they form a network having at least one dimension in this plane, the numbers n of microfluidic channel(s) and n of openings being linked by the relationship (I) with 1?i?n and n the number of openings for the channel c; at least one microporous membrane (5) covering the network of openings, the target being intended to be positioned on the side of the membrane which is opposite the microfluidic ch

Abstract: The present disclosure relates to a method for producing an insulated electrode comprising a conductive material coated with an electrically insulating material. The method includes at least the following steps of: forming a mold in an electrically insulating material, the mold including at least one channel, the mold being adapted to confine a conductive material, introducing the conductive material in a liquid state into the channel of the mold, the conductive material having a melting point that is lower than the melting point of the electrically insulating material.

Abstract: A method for the recognition of objects in at least one digital image includes: a) simulating from the digital image a plurality of digital rotations and at least two digital tilts different from 1 in order to develop a simulated image for each rotation-tilt pair; and b) applying an algorithm generating values that are invariant in translation, rotation and zoom onto the simulated images in order to determine so-called SIF (scale invariant features) local characteristics used for recognizing objects. The SIFT method can be used in step b.

Abstract: The invention relates to a microfluidic system for controlling a concentration profile of molecules capable of stimulating a target, for example formed by an assembly of living cells, this system comprising: -a microfluidic device (1) comprising at least one microfluidic channel (4) equipped with at least one inlet orifice (21) and with at least one outlet orifice (22) for at least one fluid; -at least one means for supplying the microfluidic channel (4) with at least one fluid comprising molecules capable of stimulating the target; -at least one chamber (8) or another microfluidic channel comprising a base (6) intended to receive the target; and -at least one microporous membrane (5) separating the chamber (8) or the other microfluidic channel from the microfluidic channel (4), said microporous membrane (5) being positioned away from the base (6) so that when the supply means provides the microfludic channel (4) with said at least one fluid flowing in laminar flow in contact with the microporous membrane (5)

Abstract: This method comprises bringing drops to be separated into contact with an interface (40) suitable for allowing an osmotic equilibrium between the content of each drop to be separated. The method comprises an osmotic flow between the drops (20A) of the first group of drops through the interface (40) in order to modify the density of each drop (20A) of the first group of drops and the separation of the drops (20A, 20B) according to the density thereof or a combination of the density and the volume in order to isolate the drops (20A) of the first group of drops from the drops (20B) of a second group of drops.

Abstract: In a control system comprising control device adapted for, on the one hand, receiving signal indicating a first biometric datum (W), and, on the other hand, obtaining a second biometric datum captured (w?), at the level of the control device, the first and second biometric date are compared. Next, it is decided whether the first and second biometric data correspond on the basis of the comparison. Thereafter, at least a secret cryptographic key part (H(w)) is generated by applying cryptographic function to the first biometric datum.

Abstract: The present invention relates to a high-resolution scanning surface-plasmon microscope including a source (LG) of coherent light and a medium for coupling and confining a surface plasmon including an objective (O, OM) with a large numerical aperture, immersion oil (Hi), and a glass cover slip (GS). A metal layer (MS) covers a surface of the glass cover slip (GS). The microscope also includes a heterodyne-mode Twyman-Green interferometer placed between the light source and means (PL1, PL2, EC) for scanning the metal layer using a light beam and means (PD) for detecting the beam from the interferometer connected to processing means (S, F, DTec, COMP) for forming an image from that beam. According to the invention, at least one polarization converter (CP) for converting the light beams (L) emitted by the light source (LG) from linear polarization to radial polarization is disposed between the light source and the interferometer.

Abstract: This velocimeter for measuring the speed of flow of an electrically conducting fluid comprises: —two sensors (16, 19) disposed in such a way that, in the absence of flow of the electrically conducting fluid (4), the difference between the current strengths measured by the two sensors (16, 19) is non zero, —a processing unit (18) is able to calculate the speed of flow of the fluid in a direction parallel to the first measurement direction (7) on the basis of the difference between the current strengths measured by the two sensors (16, 19).

Abstract: The present inventor relates to an electrochemical device for measuring the redox state of the skin, comprising at least one working electrode, such as a microelectrode, a counter electrode, and a reference electrode, said electrodes all being fixed into a single support intended to allow each of said electrodes to be simultaneously brought into contact with the surface of the skin to be tested, the electrodes being connected, on the one hand, to a means for imposing a defined voltage between the working electrode and the reference electrode, such as a potentiostat, and, or the other hand, to a device for measuring the intensity of the current generated at the working electrode by the detection of redox species. The invention also related to a method of measuring the redox state of the skin.

Abstract: Described herein is a method for determining a nucleic acid sequence, said method comprising: a) denaturing a double-stranded nucleic acid molecule corresponding to the said nucleic acid sequence; b) hybridizing a single-stranded nucleic acid molecule, the primer, with the said denatured double-stranded nucleic acid molecule; c) applying a tension to the hybridized primer/double-stranded nucleic acid molecule obtained in b); d) incubating the hybridized primer/double-stranded nucleic acid molecule obtained in b) with a polymerase in conditions which will lead to at least one pause in replication; and e) determining a position of the said pause in replication with respect to one end of the double-stranded nucleic acid.

Abstract: Described herein is a method for determining a nucleic acid sequence, said method comprising: a) denaturing a double-stranded nucleic acid molecule corresponding to the said nucleic acid sequence by applying a physical force to the said molecule; b) providing a single-stranded nucleic acid molecule; c) renaturing the said double stranded nucleic acid molecule in the presence of the said single-stranded nucleic acid molecule; and d) detecting a blockage of the renaturation of the double-stranded nucleic acid.

Abstract: A tool for aiding management of a communicating physical device includes: a device controller operating the physical device using operating parameters; a data storage interlinking an identifier from the physical device and dated values of attributes and a list of control functions capable of modifying some of the operating parameters; an interpreter adapted for receiving a device identifier datum and a time horizon parameter at the same time and for responding thereto by establishing a series of respective events using the information from the data storage, related to the time horizon, each event interlinking a date, one or more identifiers of control functions, and parameters for these functions, established in accordance with a dated attribute value; and a sequencer arranged to call the interpreter and carry out chronologically the calls of the functions of each event of the series as returned by the interpreter.

Abstract: The present invention relates to heptamethine hemicyanine chromophores of formula (I): where R1, R2, R3, R4, R?4, R5, R?5, R6, R?6, R7, X, Y1 and Y2 are as defined in claim 1, to the method for preparing same as well as to the use of such chromophores for the second-order nonlinear optical property thereof.

Abstract: The present invention relates to peptides and polypeptides having the sequence SAVTFAVCAL or variants thereof, capable of binding to Calcineurin and/or to NS5A-TP2 and to their use in therapy, as well as to nucleic acid sequences and vectors encoding these peptides and polypeptides, and to cells comprising said polypeptides, nucleic acid sequences or vectors. The invention further relates to the use of the peptides, polypeptides or their derivatives to bring about phenotypic changes in mammalian cells, particularly to up-regulate calcineurin activity. The invention finally relates to a method for intracellular identification of substances which bind to calcineurin and which modulate the physiological effects of calcineurin.

Abstract: The invention relates to a method for manufacturing an aluminum/metal assembly including the steps involving: thermally processing an aluminum sheet by heating said sheet to a temperature of between 80% and 100% of the melting temperature of the material of which it consists for a sufficiently long duration to create and stabilize by allotropic conversion an alpha alumina layer at the surface of said aluminum sheet, and then cooling same; providing a metal layer having a ductility less than or equal to the ductility of the aluminum sheet after cooling, said layer having surface irregularities having a depth greater than or equal to the thickness of the alpha alumina layer; and roll bonding the aluminum layer and the metal layer to produce the metal assembly.

Abstract: The present invention relates to a method of toxicological evaluation of a candidate substance on at least one tissue or organ, characterized in that it comprises the steps of: (a) obtaining a bioartificial tissue or organ by simulation or modelling of the metabolic activity of said tissue or organ by at least one bioreactor; (b) exposure of said bioartificial tissue or organ to said substance; (c) observation of the metabolic response of the bioartificial tissue or organ and acquisition without a priori of an associated multidimensional data set; (d) identification by means of a method of multivariate statistical analysis of the components of the multidimensional data set which are quantitatively correlated with predetermined variables; (e) generation of a predictive model on the basis of the components of the data set that are actually retained; (f) testing of the predictive nature of said model by at least one statistical method of estimating reliability; (g) identification of the metabolic response of the

Abstract: A method for manufacturing a metal assembly including an aluminum sheet and at least one metal sheet. An aluminum sheet is treated by heating to a temperature of between 80% and 100% of the melting temperature of the material of which it is comprised for a sufficiently long duration to create and stabilize an alpha alumina layer at the surface of the aluminum sheet. The sheet is then cooled. A metal sheet having a ductility less than or equal to the ductility of the alumimum sheet after cooling is provided, which has surface irregularities having a depth greater than or equal to the thickness of the alpha alumina layer. The aluminum sheet and the metal sheet are roll bonded in a rolling mill to produce the metal assembly, wherein the rolling mill includes at least one cylinder, the outer rolling surface of which is provided with raised portions.