Abstract: The present invention provides methods of treating various disorders associated with mitochondrial dysfunction, including but not limited to metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, and diseases of aging.

Abstract: An ocular drainage system is provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the system includes an implantable device and an external control unit, the implantable device includes a non-invasively adjustable valve featuring at least one deformable tube and a disk rotatably mounted within a housing, such that rotation of the disk using the external control unit causes the disk to apply a selected amount of compression to the deformable tube, thereby adjusting the fluidic resistance of the deformable tube and regulating the intraocular pressure.

Abstract: A thermal water purification system and a related method including distilling units consecutively flowed through by raw feed liquid, each having a boiling liquid section and a vapor section, and including a heat exchanger cavity adapted to transfer thermal energy to the raw feed liquid before entering the boiling liquid section of a first distilling unit. Heat exchanger tubes in fluidic communication with the heat exchanger cavity extend through the boiling liquid section of the first distilling unit to transfer thermal energy from a medium in the tubes to cause the raw feed liquid to boil. Preheating tubes extend through the vapor section of each distilling unit to heat the raw feed liquid before entering the boiling sections using thermal energy from vapor condensing against external surfaces of the preheating tubes, which produces the distillate liquid that flows through a discharge port and a conduit supplying a storage tank.

Abstract: The method for drawing a fiber with a textured surface comprises the following steps: —forming of a preform from which the fiber is to be drawn with a textured surface; —addition of an outer layer to the textured preform to preserve the shape of the texture of the preform surface during the drawing operation; —drawing of a fiber from the preform, whereby the fiber keeps the formed texture of the preform surface and —removing the additional outer layer to leave the original surface textured fiber exposed. The obtained fiber can be used as a mold to form a textured hollow channel in another material, as a surface coating and as a pressure detector.

Abstract: Described herein are microelectrode array devices, and methods of fabrication, assembly and use of the same, to provide highly localized neural recording and/or neural stimulation to a neurological target. The device includes multiple microelectrode elements arranged protruding shafts. The protruding shafts are enclosed within an elongated probe shaft, and can be expanded from their enclosure. The microelectrode elements, and elongated probe shafts, are dimensioned in order to target small volumes of neurons located within the nervous system, such as in the deep brain region. Beneficially, the probe can be used to quickly identify the location of a neurological target, and remain implanted for long-term monitoring and/or stimulation.

Abstract: A method produces a device adapted to be implanted into the human body for purposes such as neural stimulation, sensing or the like. The method includes: providing a stretchable layer or membrane of an insulating material; forming on the layer or membrane at least one stretchable conductive path; depositing at least one small bolus of a soft and conductive paste or material onto pre-defined areas or portions of the at least one conductive path, and inserting a first end portion of a conductive element 71 into the at least one bolus of soft conductive paste or material. A second end portion of the conductive element opposite to the first end portion is not inserted into the at least one bolus.

Abstract: A semiconductor sensor includes a source element; a drain element; and a semiconductor channel element between the source element and the drain element, forming an electrically conductive channel. An insulator is positioned between the semiconductor channel element and a solution to be sensed. A reference contacts the solution and sets an electric potential of the solution. A bias voltage source generates an external sensor bias voltage for electrically biasing the reference electrode. A sensing surface interacts with the solution comprising analytes for generating a surface potential change at the sensing surface dependent on the concentration of analytes. The sensor further includes a ferroelectric capacitance element between the insulator and the bias voltage source for generating a negative capacitance for a differential gain between the external sensor bias voltage and an internal sensor bias voltage sensed at a surface of the channel element facing the insulator or ferroelectric capacitance element.

Abstract: The present invention relates to a compound of formula (I) based on carbazole substituted by diphenylamine and used as organic hole conductors or hole transporting material in an optoelectronic or photoelectrochemical device, with (I), D being selected from formula (1) or (2):

Abstract: The present invention concerns a luminescent particle comprising a nanoparticle of formula A1?xLnxVO4(1?y)(PO4)y ??(I) in which A is selected from yttrium (Y), gadolinium (Gd), lanthanum (La), and mixtures thereof; Ln is selected from europium (Eu), dysprosium (Dy), samarium (Sm), neodymium (Nd), erbium (Er), ytterbium (Yb), and mixtures thereof; 0<x<1; and 0<y<1; characterized in that the nanoparticle on its surface has tetraalkylammonium cations in an amount such that said nanoparticle has a zeta potential, ?, of less than or equal to ?28 mV in an aqueous medium with a pH?5, more particularly with a pH?5.5, and with an ionic conductivity >100 ?S.cm?1. It also concerns a method for preparing such luminescent particles, a colloidal suspension of these particles, and the use thereof as a diagnostic agent, and also a diagnostic kit comprising such luminescent particles.

Abstract: Methods and systems are provided for triggering electrical stimulation of a spinal cord during execution of a motor event. In one example, a method comprises monitoring motor cortex activity while execution of a desired motor movement is attempted during a first mode where one or more nerve fibers are not stimulated, and during a second mode where the one or more nerve fibers are stimulated. Delivery timing of electrical stimulation may be closed-loop controlled based on current motor cortex activity and the motor cortex activity recorded previously during both the first and second modes.

Abstract: The present invention relates to a method for producing a solid solar cells, including the steps of providing a hole collector layer, applying a conductive layer onto the hole collector layer, applying an electron blocking layer onto the conductive layer, applying a sensitizer layer onto the electron blocking layer, applying a hole blocking layer onto the sensitizer layer, and providing a current collector and/or a metal layer or a conductor. The sensitizer layer including an organic-inorganic perovskite is applied by co-deposition of one or more sublimated divalent or trivalent salts and of one or more sublimated organic ammonium salts to obtain the organic-inorganic perovskite. The invention also relates to solid state solar cells, wherein the charge flow is inverted compared to the charge flow in a solar cell of conventional architecture and/or obtained by the above method.

Abstract: The present invention concerns a geosynthetic element for a geotechnical engineering application. The geosynthetic element comprises: bacteria carriers for carrying bacteria arranged to be propagated from the geosynthetic element to a surrounding geomaterial; and a flow network comprising openings on its surface to allow a reactant to escape the flow network to the surrounding geomaterial along the flow network to produce solid calcium carbonate when in contact with the bacteria. The reactant flow network further comprises a set of inlets for feeding the reactant into the flow network, and a set of outlets for recovering at least a part of the reactant from the reactant flow network.

Abstract: Apparatus for salt separation (2) under supercritical water conditions, comprising a heat exchanger (4) and a fluidized bed reactor (6). The fluidized bed reactor comprising a supercritical water pressure containing wall (8) defining therein a fluidized bed chamber (10) connected to an inlet system (16) at one end thereof and an outlet system (18) configured to separate solids from supercritical fluid at another end thereof. The fluidized bed chamber receives a fluidized bed (12) therein and is configured to receive through the inlet system (16) a liquefied aqueous substance (14) for treatment in the fluidized bed chamber. The inlet system (16) comprises an inlet chamber (20) and a fluidization plate (22) positioned between the inlet chamber (20) and the fluidized bed chamber (10).

Abstract: The present invention concerns a method for encoding a given 3D shape into a target 2D linkage. The method comprises: (a) providing an initial 2D surface; and (b) defining on the initial 2D surface an auxetic pattern of geometric elements planarly linked between them to obtain the target 2D linkage, the pattern allowing the target 2D linkage to be virtually stretched. The target 2D linkage has a spatially varying scale factor thereby spatially varying the stretching capability of the 2D linkage.

Abstract: A signal processing apparatus, being configured for transmitting and receiving coherent parallel optical signals, comprises a transmitter apparatus including a first single soliton micro-resonator device and a modulator device, wherein the first single soliton micro-resonator device is adapted for creating a single soliton providing a first frequency comb, wherein the first frequency comb provides a plurality of equidistant optical carriers with a frequency spacing corresponding to a free spectral range of the first single soliton micro-resonator device, and the modulator device is adapted for modulating the optical carriers according to data to be transmitted, and a receiver apparatus including a coherent receiver device with a plurality of coherent receivers and a local oscillator device providing a plurality of reference optical signals, wherein the coherent receiver device and the local oscillator device are arranged for coherently detecting the transmitted modulated optical carriers, wherein the signal p

Abstract: Molecular sensing system including: a sensing device (5) comprising at least one support layer (10), and an active layer (6) mounted on said support layer and having at least one nano-pore (12) configured for translocation of a molecular analyte (18) therethrough; an electrically conducting liquid (4) in contact with the active layer in a region around said nano-pore; and a signal processing circuit (7) comprising an ionic current circuit (8) configured to generate and measure an ionic current (Ii) in the electrically conducting liquid influenced by the translocation of the molecular analyte through the nano-pore. The molecular sensing device of the invention allows for single-nucleotide discrimination and detection of the specific sequence within ssDNA.

Abstract: The application provides fluorescent dyes, which are cyanine dyes that incorporate additional aza moieties in the indolenium heterocycles and/or in the methine chains connecting them. Symmetrical and unsymmetrical chemically reactive azacyanine dyes are described for conjugation, as well as their bioconjugates for in-vitro and in-vivo assays and fluorescence imaging.

Abstract: The invention relates to the selective targeting of specific ?2 adrenergic receptor subtypes for facilitating and also restoring standing and walking in a subject affected by spinal cord disorders, in particular spinal cord injury. In particular, the improvement of locomotion by targeting specific receptor subtypes can be achieved by stimulation of the ?2c receptor subtype using an ?2c specific agonist or by blocking the ?2a receptor subtype using ?2a antagonists. A combination of an ?2c agonist and an ?2a antagonist is also provided for a synergistic effect. Alternatively, a large ?2 agonist can be used in combination with an ?2a antagonist to achieve specific stimulation of the ?2c receptor. Pharmaceutical compositions, kit-of-parts and therapeutic systems comprising said agonists/antagonists as active agents are objects of the present invention.

Abstract: An oscillator arrangement for time-to-digital converters for a 3D image sensor device includes a plurality of oscillators arranged as an array each oscillator being associated to one time-to-digital converter, and at least one coupling unit respectively arranged between at least two of the oscillators, so that oscillation in the at least two oscillators at a fundamental frequency is synchronized between the at least two coupled oscillators.

Abstract: The present invention concerns a method for generating technical design solutions satisfying a given performance target for a building. The method comprises: selecting a design model for the building; selecting a first set of design parameters from a first database; qualifying and/or quantifying the design parameters in the first set; generating a first set of design parameter combinations from the first set of design parameters; attributing the first set of design parameter combinations to the design model to obtain a first set of design alternatives; accessing a second database to determine the impact of the first set of design alternatives on a performance of the building; and ranking the first set of design parameters according to their contribution to the performance of the building.