Patents Assigned to Emory University
  • Patent number: 12268498
    Abstract: A smartphone-based hemoglobin (Hgb) assessment application quantitatively analyzes pallor in patient-sourced photos using image analysis algorithms to enable a noninvasive, accurate quantitative smartphone app for detecting anemia. A user takes a photo of his/her fingernail beds using the app and receives an accurate displayed Hgb level. Since fingernails do not contain melanocytes, the primary source of color of these anatomical features is blood Hgb. At the same time, quality control software minimizes the impact of common fingernail irregularities (e.g. leukonychia and camera flash reflection) on Hgb level measurement. Metadata recorded upon capturing the image is leveraged for determining a users' Hgb level thereby eliminating the need for external equipment. A personalized calibration of image data with measured Hgb levels improves the accuracy of the application.
    Type: Grant
    Filed: November 5, 2019
    Date of Patent: April 8, 2025
    Assignees: EMORY UNIVERSITY, CHILDREN'S HEALTHCARE OF ATLANTA, INC., GEORGIA TECH RESEARCH CORPORATION, INC., Sanguina, Inc.
    Inventors: Robert Mannino, Wilbur Lam, Gari Clifford, Erika Tyburski
  • Patent number: 12268723
    Abstract: Compounds, compositions and methods for preventing, treating or curing a coronavirus, picornavirus, and/or hepeviridae virus infection in human subjects or other animal hosts. Specific viruses that can be treated include enteroviruses. In one embodiment, the compounds can be used to treat an infection with a severe acute respiratory syndrome virus, such as human coronavirus 229E, SARS, MERS, SARS-CoV-1 (OC43), and SARS-CoV-2. In another embodiment, the methods are used to treat a patient co-infected with two or more of these viruses, or a combination of one or more of these viruses and norovirus.
    Type: Grant
    Filed: December 7, 2021
    Date of Patent: April 8, 2025
    Assignee: Emory University
    Inventors: Raymond F. Schinazi, Keivan Zandi, Franck Amblard
  • Patent number: 12269864
    Abstract: This disclosure relates to collagen-like polypeptides and materials containing the same and uses in biomedical applications. In certain embodiments, this disclosure contemplates that collagen-like polypeptides and materials containing the same are functionalized with proteins or small molecules to create useful scaffolds for drug delivery or testing. In certain embodiments, collagen-like polypeptides and materials containing the same are used in cardiac patches, cosmetic surgery, bone grafts, tissue regeneration, and wound healing.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: April 8, 2025
    Assignee: Emory University
    Inventors: Vincent Conticello, Andrea Merg, Gavin Touponse
  • Publication number: 20250108064
    Abstract: Phosphate prodrugs of cannabinoids are disclosed herein as are pharmaceutical compositions comprising one or more of the same. Such compounds and compositions are useful for the treatment of diseases, disorders, and/or conditions, including neurological disorders and neuropathic pain.
    Type: Application
    Filed: July 29, 2022
    Publication date: April 3, 2025
    Applicant: Emory University
    Inventors: Luke E. Hodson, Nicole Pribut, Stephen F. Traynelis, Dennis C. Liotta
  • Patent number: 12262956
    Abstract: An exemplary embodiment of the present disclosure provides an MRI-compatible robot comprising one or more fiducial markers, a first planar stage comprising a first joint configured to receive a surgical tool and a first mechanism configured to move the surgical tool, a second planar stage comprising a second joint configured to receive the surgical tool and a second mechanism configured to move the surgical tool, and wherein the second planar stage is generally parallel with the first planar stage.
    Type: Grant
    Filed: August 17, 2021
    Date of Patent: April 1, 2025
    Assignees: Georgia Tech Research Corporation, Emory University
    Inventors: Waiman Meinhold, Ai-Ping Hu, John N. Oshinski, Jun Ueda, Daniel E. Martinez
  • Patent number: 12257225
    Abstract: The disclosure relates polyoxometalate complexes and uses in the management, treatment, or prevention of cancer. In certain embodiments, the polyoxometalate complexes comprise polydentate oxygen bridging ligands such as those of the following formula: [POM{(OCH2)3CX}2], [M6O13{(OCH2)3CX}2], [V6O13{(OCH2)3CX}2], salts, or derivatives thereof wherein POM is a polyoxometalate, M is a metal, and X is defined herein. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising polyoxometalate complexes disclosed herein.
    Type: Grant
    Filed: May 13, 2022
    Date of Patent: March 25, 2025
    Assignee: Emory University
    Inventors: Jie Song, Shuming Nie, Craig Hill
  • Patent number: 12257296
    Abstract: This disclosure relates to chimeric respiratory syncytial virus (RSV), live attenuated vaccine and immunogenic compositions, and methods of use. In certain embodiments, the chimeric respiratory syncytial virus has a mutated gene pattern encoding an RSV F protein having M at position 79, R at position 191, K at position 357, and/or Y at position 371.
    Type: Grant
    Filed: January 14, 2022
    Date of Patent: March 25, 2025
    Assignee: Emory University
    Inventors: Martin L. Moore, Christina Rostad
  • Publication number: 20250073228
    Abstract: The present disclosure provides novel cell compositions engineered to express at least a chimeric antigen receptor and a survival factor. Methods of using such cell compositions are also described.
    Type: Application
    Filed: May 3, 2024
    Publication date: March 6, 2025
    Applicants: The UAB Research Foundation, Emory University, Children's Healthcare of Atlanta, Inc.
    Inventors: Lawrence S. Lamb, H. Trent Spencer, G. Yancey Gillespie
  • Patent number: 12240829
    Abstract: The disclosure relates to Prostnglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing conditions and diseases in which EP2 receptor activation has a physiological role, such as but not limited to, brain injury, inflammatory diseases, epilepsy, neuroinflammation after a seizure, pain, endometriosis, cancer, rheumatoid arthritis, skin inflammation, vascular inflammation, colitis, and neurological disorders by administering a pharmaceutical composition comprising a compound disclosed herein to a subject in need thereof.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: March 4, 2025
    Assignee: Emory University
    Inventors: Thota Ganesh, Raymond J. Dingledine, Radhika Amaradahi, Shabber Mohammed
  • Patent number: 12239655
    Abstract: Nucleoside compounds, which in some embodiments include an alkynyl substituent at the 4?-position, compositions and methods for treating or preventing HIV and other viral infections, particularly where the virus is present in macrophages, microglia, and primary myeloid cells, and eliminating and/or treating infection in patients infected by these viruses, are disclosed.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: March 4, 2025
    Assignee: Emory University
    Inventors: Raymond F. Schinazi, Franck Amblard, Christina Gavegnano, Bryan Cox, Seema Mengshetti
  • Patent number: 12233087
    Abstract: This disclosure relates to palladium hyaluronic acid particles such as dibenzylideneacetone palladium hyaluronic acid particles. In certain embodiments, this disclosure relates to methods of managing cancer or angiogenic conditions using particles disclosed herein and pharmaceutical compositions comprising the same. In certain embodiments, an objective of this disclosure is hyaluronic acid targeting of CD44, a tumor stem cell marker. In certain embodiments, this disclosure relates to treatment with hyaluronic acid palladium particles disclosed herein for depleting CD44 cells.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: February 25, 2025
    Assignees: Emory University, The United States Government represented byt The United States Department of Veterans Affairs
    Inventors: Jack Arbiser, Lily Yang
  • Patent number: 12213962
    Abstract: The present disclosure is generally related to methods for combining chemotherapy and immunotherapy for the treatment of a cancer.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: February 4, 2025
    Assignees: Emory University, The UAB Research Foundation, Children's Healthcare of Atlanta, Inc.
    Inventors: Harold Trent Spencer, Anindya Dasgupta, Lawrence S. Lamb
  • Publication number: 20250034184
    Abstract: This disclosure relates to quaternary phosphonium compounds having lipophilic groups. In certain embodiments, this disclosure relates to quaternary phosphonium compounds having chemical formula as reported herein. In certain embodiments, this disclosure relates to compositions and devices comprising or coated with quaternary phosphonium compounds disclosed herein. In certain embodiments, this disclosure relates to preventing or treating a microbial infection or cancer using quaternary phosphonium compounds disclosed herein.
    Type: Application
    Filed: August 17, 2022
    Publication date: January 30, 2025
    Applicants: Emory University, Villanova University
    Inventors: William Wuest, Kevin Minbiole
  • Patent number: 12205713
    Abstract: The systems and methods of the disclosure can rapidly and automatically determine and monitor tracking events by generating event codes using messages from multiple source systems within the healthcare ecosystem. The method may include detecting one or more healthcare data messages of a plurality of types of healthcare data messages associated with healthcare of a patient. The method may include extracting text of each message of the first type and processing the extracted text of each message to determine one or more units of text. The method may include determining one or more tracking events by applying one or more trained models to each unit of text of each message. The method may include storing one or more event codes corresponding to the one or more tracking events and its associated deadline in a record for the patient of the tracking event database.
    Type: Grant
    Filed: January 11, 2022
    Date of Patent: January 21, 2025
    Assignees: Emory University, Children's Healthcare of Atlanta, Inc.
    Inventors: Valeria Makeeva, Peter Harri, Nabile Safdar, Kyle Jackson
  • Patent number: 12201692
    Abstract: This disclosure relates to targeted protease compositions and uses related thereto. In certain embodiments, the disclosure relates to nanoparticles wherein a targeting molecule is linked to the nanoparticle and wherein a catalytic domain of a protease is linked to the nanoparticle. In certain embodiments, the targeting molecule and the catalytic domain are within a single polypeptide sequence. In certain embodiments, the targeting molecule binds a molecule more highly expressed on cancer cells then non-cancerous cells, and the nanoparticles disclosed herein are used for the treatment of cancer by further attaching an anti-cancer agent to the nanoparticle or incorporating an anticancer agent within the nanoparticle.
    Type: Grant
    Filed: March 22, 2023
    Date of Patent: January 21, 2025
    Assignee: Emory University
    Inventors: Lily Yang, Xiangxue Guo
  • Patent number: 12194088
    Abstract: This disclosure relates to methods of promoting immune responses against HIV and compositions related thereto. In certain embodiments, this disclosure relates to methods of vaccinating for HIV comprising administering to the subject a priming composition followed by a boosting composition. In certain embodiments, the priming composition comprises a recombinant virus such as recombinant MVA that encodes an Env protein of HIV or segment thereof. In certain embodiments, the boosting composition comprises a trimeric cyclically permuted gp120 chimeric protein reported herein or DNA encoding the same.
    Type: Grant
    Filed: January 24, 2023
    Date of Patent: January 14, 2025
    Assignees: Emory University, Indian Institute of Science
    Inventors: Rama Rao Amara, Andrew Jones, Raghavan Varadarajan
  • Patent number: 12186386
    Abstract: In certain embodiments, the disclosure relates to the polynucleotide sequences of respiratory syncytial virus (RSV). In certain embodiments, the disclosure relates to isolated or recombinant nucleic acids and polypeptides comprising desirable nucleic acid sequences and mutations disclosed herein. In certain embodiments, isolated or recombinant RSV comprising the nucleic acids and polypeptides disclosed herein (e.g., attenuated recombinant RSV) are also provided, as are immunogenic compositions including such nucleic acids, polypeptides, and RSV genomes that are suitable for use as vaccines. Attenuated or killed RSV containing these nucleic acids and mutation in the form of copied nucleic acids (e.g., cDNAs) are also contemplated.
    Type: Grant
    Filed: October 14, 2022
    Date of Patent: January 7, 2025
    Assignee: Emory University and Children's Healthcare of Atlanta, Inc.
    Inventors: Martin L. Moore, Jia Meng, Anne Hotard, Elizabeth Littauer, Christopher Stobart
  • Patent number: 12188038
    Abstract: The systems and methods are directed to leveraging the channel geometry and configuration to overcome diffusion limitations of current transduction systems. The methods may include a method of transducing target cells using a device. The device may include at least one continuous channel. The method may include delivering target cells and viral vectors into a transduction region of the channel. After transducing for some incubation time, a flushing solution may be delivered. The method may include collecting transduced cells after the transducing incubation time and the delivering of the flushing solution.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: January 7, 2025
    Assignees: Emory University, Children's Healthcare of Atlanta, Inc., Georgia Tech Research Corporation
    Inventors: Reginald Tran, Wilbur Lam, David Myers, Christopher Doering, Harold Spencer
  • Patent number: 12186104
    Abstract: The devices, systems, and methods can improve magnetic resonance imaging (MRI), MR spectroscopy (MRS), MR spectroscopic imaging (MRSI) measurement(s), thereby providing more reliable quantification. The method may include a method for correcting MR image(s)/spectrum. The method may include providing an inhomogeneity field/response map of a region of interest; and providing MR image(s)/spectrum of the region of interest. The method may include determining an intravoxel/voxel inhomogeneity correction coefficient for each voxel of at least one subregion of the region of the interest using the inhomogeneity field/response map. The method may include correcting each voxel of the MR image(s)/spectrum of the region of interest using the intravoxel/voxel inhomogeneity correction coefficient.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: January 7, 2025
    Assignee: Emory University
    Inventor: Phillip Zhe Sun
  • Patent number: 12180350
    Abstract: This disclosure relates to non-naturally occurring light reflecting or color changing materials comprising a segmented array of flexible polymers, wherein the segmented array of flexible polymers comprise photonic crystal lattices embedded therein, wherein the segmented array of flexible polymers are themselves embedded within an elastic supporting polymer that maintains a near constant size during chromatic shifting of the photonic crystal lattices.
    Type: Grant
    Filed: August 9, 2021
    Date of Patent: December 31, 2024
    Assignee: Emory University
    Inventors: Khalid Salaita, Yixiao Dong