Patents Assigned to Emory University
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Patent number: 12290439Abstract: The disclosure relates to a device that is configured to be implanted on the native leaflet of a heart valve to increase its length and/or thickness and thereby to improve the valve function and reduce regurgitation. The device may include a leaflet section. The leaflet section may include a central member. The central member may include a first portion, a second portion that opposes the first portion, and a base portion disposed between the first portion and the second portion. The first section may extend from the first portion and the second section may extend from the second portion. The device may include one or more engaging members extending from the central member at an angle with respect to the first section and the second section. The second section may be larger than the first section. The leaflet section may define a three-dimensional region or a bulge.Type: GrantFiled: March 22, 2024Date of Patent: May 6, 2025Assignee: Emory UniversityInventors: Sai Muralidhar Padala, Eric Leo Sarin
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Publication number: 20250136706Abstract: The present invention relates to methods, treatment regimens, uses, kits and therapies for prevention of graft rejection in solid organ transplantation, particularly solid organ xenotransplantation, by administering an anti-CD40 antibody or a combination of an anti-CD40 antibody and an anti-C5 antibody.Type: ApplicationFiled: October 2, 2024Publication date: May 1, 2025Applicants: Novartis AG, Emory University, The UAB Research FoundationInventors: Guido JUNGE, James RUSH, Andrew B. ADAMS, Alfred Joseph TECTOR, III
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Publication number: 20250135041Abstract: It is disclosed herein that ssAAV and scAAV vectors of the same serotype administered by injection into the cerebrospinal fluid (CSF) via the intracerebroventricular (ICV) or intrathecal (cisternal or lumbar) route exhibit different cellular tropisms in the central nervous system. Thus, a subject can be treated by injection into the CSF of ssAAV or scAAV vector encoding a therapeutic protein, such as an ssAAV9 or scAAV9 vector. The therapeutic protein can be targeted to specific cells using these vectors. In some embodiments, scAAV9 is utilized to achieve superior transduction in the hippocampus, cerebellum and cerebral cortex where both neurons, particularly Purkinje neurons, and glial cells (such as astrocytes) are transduced. In other embodiments, ssAAV9 is utilized to minimize transduction of astrocytes. In further embodiments, an immunosuppressive agent is also administered to the subject.Type: ApplicationFiled: July 12, 2024Publication date: May 1, 2025Applicants: Emory University, REGENXBIO Inc.Inventors: Anthony Donsante, Karen Kozarsky, Nicholas Matthew Boulis, Jonathan Patrick Riley
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Patent number: 12286434Abstract: This disclosure relates to compounds according to Formula (I), salts, prodrugs and pharmaceutical formulation comprising the compound are provided herein for the treatment of CXCR4 and CCR5 related conditions. The conditions may include viral infections, abnormal cellular proliferation, retinal degeneration and inflammatory diseases, or the compounds may be used as immunostimulants or immunosuppressants. Furthermore, the compounds may be used in combination with another active ingredient selected from an antiviral agent or chemotherapeutic agent.Type: GrantFiled: April 10, 2023Date of Patent: April 29, 2025Assignee: Emory UniversityInventors: Dennis Liotta, Edgars Jecs, Yesim Altas Tahirovic, Lawrence Wilson, Stephen Pelly
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Patent number: 12280238Abstract: The devices and systems can allow for safe and cost-effective administration intravenous medication, for example, in psychiatric settings by mitigating ligature, disassembly, and weaponization risks associated with intravenous administration. The system may include a fluid connection device. The fluid connection device may include an internal conduit configured to deliver a medical fluid and a housing disposed in which the internal conduit is disposed. The housing may include a first rigid segment and a second rigid segment spaced from the first rigid segment. The housing may also include a first joint segment disposed between the first rigid segment and the second rigid segment and configured to bend to the predetermined bending angle with respect to the first rigid segment.Type: GrantFiled: November 20, 2020Date of Patent: April 22, 2025Assignee: Emory UniversityInventors: Nathan J. Skoller, Rush Austin Leigh, Tamera Tyra Mason, Rachael Elizabeth Price, Ian Smith
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Patent number: 12279856Abstract: In some embodiments, the systems and methods of the disclosure can efficiently and accurately classify neurodegenerative disorder(s) and/or movement disorder(s) of a subject (e.g., a patient) using at least quantitative features associated with one or more regions of interest determined from one or more sets of image data of the subject's brain. The method may include processing one or more sets of MRI image data of the subject's brain to extract one or more quantitative features for one or more regions. The one or more quantitative features may include a first quantitative and a second quantitative feature. The method may further include classifying at least the one or more quantitative features into one or more classes associated with neurodegenerative dementia disorder, neurodegenerative movement disorder, non-neurodegenerative movement disorder and/or heathy control. The method may include generating a report including a classification of at least the one or more quantitative features.Type: GrantFiled: February 21, 2024Date of Patent: April 22, 2025Assignee: Emory UniversityInventors: Daniel Huddleston, Babak Mahmoudi
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Patent number: 12268498Abstract: A smartphone-based hemoglobin (Hgb) assessment application quantitatively analyzes pallor in patient-sourced photos using image analysis algorithms to enable a noninvasive, accurate quantitative smartphone app for detecting anemia. A user takes a photo of his/her fingernail beds using the app and receives an accurate displayed Hgb level. Since fingernails do not contain melanocytes, the primary source of color of these anatomical features is blood Hgb. At the same time, quality control software minimizes the impact of common fingernail irregularities (e.g. leukonychia and camera flash reflection) on Hgb level measurement. Metadata recorded upon capturing the image is leveraged for determining a users' Hgb level thereby eliminating the need for external equipment. A personalized calibration of image data with measured Hgb levels improves the accuracy of the application.Type: GrantFiled: November 5, 2019Date of Patent: April 8, 2025Assignees: EMORY UNIVERSITY, CHILDREN'S HEALTHCARE OF ATLANTA, INC., GEORGIA TECH RESEARCH CORPORATION, INC., Sanguina, Inc.Inventors: Robert Mannino, Wilbur Lam, Gari Clifford, Erika Tyburski
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Patent number: 12268723Abstract: Compounds, compositions and methods for preventing, treating or curing a coronavirus, picornavirus, and/or hepeviridae virus infection in human subjects or other animal hosts. Specific viruses that can be treated include enteroviruses. In one embodiment, the compounds can be used to treat an infection with a severe acute respiratory syndrome virus, such as human coronavirus 229E, SARS, MERS, SARS-CoV-1 (OC43), and SARS-CoV-2. In another embodiment, the methods are used to treat a patient co-infected with two or more of these viruses, or a combination of one or more of these viruses and norovirus.Type: GrantFiled: December 7, 2021Date of Patent: April 8, 2025Assignee: Emory UniversityInventors: Raymond F. Schinazi, Keivan Zandi, Franck Amblard
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Patent number: 12269864Abstract: This disclosure relates to collagen-like polypeptides and materials containing the same and uses in biomedical applications. In certain embodiments, this disclosure contemplates that collagen-like polypeptides and materials containing the same are functionalized with proteins or small molecules to create useful scaffolds for drug delivery or testing. In certain embodiments, collagen-like polypeptides and materials containing the same are used in cardiac patches, cosmetic surgery, bone grafts, tissue regeneration, and wound healing.Type: GrantFiled: January 4, 2021Date of Patent: April 8, 2025Assignee: Emory UniversityInventors: Vincent Conticello, Andrea Merg, Gavin Touponse
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Publication number: 20250108064Abstract: Phosphate prodrugs of cannabinoids are disclosed herein as are pharmaceutical compositions comprising one or more of the same. Such compounds and compositions are useful for the treatment of diseases, disorders, and/or conditions, including neurological disorders and neuropathic pain.Type: ApplicationFiled: July 29, 2022Publication date: April 3, 2025Applicant: Emory UniversityInventors: Luke E. Hodson, Nicole Pribut, Stephen F. Traynelis, Dennis C. Liotta
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Patent number: 12262956Abstract: An exemplary embodiment of the present disclosure provides an MRI-compatible robot comprising one or more fiducial markers, a first planar stage comprising a first joint configured to receive a surgical tool and a first mechanism configured to move the surgical tool, a second planar stage comprising a second joint configured to receive the surgical tool and a second mechanism configured to move the surgical tool, and wherein the second planar stage is generally parallel with the first planar stage.Type: GrantFiled: August 17, 2021Date of Patent: April 1, 2025Assignees: Georgia Tech Research Corporation, Emory UniversityInventors: Waiman Meinhold, Ai-Ping Hu, John N. Oshinski, Jun Ueda, Daniel E. Martinez
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Patent number: 12257296Abstract: This disclosure relates to chimeric respiratory syncytial virus (RSV), live attenuated vaccine and immunogenic compositions, and methods of use. In certain embodiments, the chimeric respiratory syncytial virus has a mutated gene pattern encoding an RSV F protein having M at position 79, R at position 191, K at position 357, and/or Y at position 371.Type: GrantFiled: January 14, 2022Date of Patent: March 25, 2025Assignee: Emory UniversityInventors: Martin L. Moore, Christina Rostad
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Patent number: 12257225Abstract: The disclosure relates polyoxometalate complexes and uses in the management, treatment, or prevention of cancer. In certain embodiments, the polyoxometalate complexes comprise polydentate oxygen bridging ligands such as those of the following formula: [POM{(OCH2)3CX}2], [M6O13{(OCH2)3CX}2], [V6O13{(OCH2)3CX}2], salts, or derivatives thereof wherein POM is a polyoxometalate, M is a metal, and X is defined herein. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising polyoxometalate complexes disclosed herein.Type: GrantFiled: May 13, 2022Date of Patent: March 25, 2025Assignee: Emory UniversityInventors: Jie Song, Shuming Nie, Craig Hill
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Publication number: 20250073228Abstract: The present disclosure provides novel cell compositions engineered to express at least a chimeric antigen receptor and a survival factor. Methods of using such cell compositions are also described.Type: ApplicationFiled: May 3, 2024Publication date: March 6, 2025Applicants: The UAB Research Foundation, Emory University, Children's Healthcare of Atlanta, Inc.Inventors: Lawrence S. Lamb, H. Trent Spencer, G. Yancey Gillespie
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Patent number: 12240829Abstract: The disclosure relates to Prostnglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing conditions and diseases in which EP2 receptor activation has a physiological role, such as but not limited to, brain injury, inflammatory diseases, epilepsy, neuroinflammation after a seizure, pain, endometriosis, cancer, rheumatoid arthritis, skin inflammation, vascular inflammation, colitis, and neurological disorders by administering a pharmaceutical composition comprising a compound disclosed herein to a subject in need thereof.Type: GrantFiled: March 19, 2020Date of Patent: March 4, 2025Assignee: Emory UniversityInventors: Thota Ganesh, Raymond J. Dingledine, Radhika Amaradahi, Shabber Mohammed
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Patent number: 12239655Abstract: Nucleoside compounds, which in some embodiments include an alkynyl substituent at the 4?-position, compositions and methods for treating or preventing HIV and other viral infections, particularly where the virus is present in macrophages, microglia, and primary myeloid cells, and eliminating and/or treating infection in patients infected by these viruses, are disclosed.Type: GrantFiled: December 27, 2018Date of Patent: March 4, 2025Assignee: Emory UniversityInventors: Raymond F. Schinazi, Franck Amblard, Christina Gavegnano, Bryan Cox, Seema Mengshetti
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Patent number: 12233087Abstract: This disclosure relates to palladium hyaluronic acid particles such as dibenzylideneacetone palladium hyaluronic acid particles. In certain embodiments, this disclosure relates to methods of managing cancer or angiogenic conditions using particles disclosed herein and pharmaceutical compositions comprising the same. In certain embodiments, an objective of this disclosure is hyaluronic acid targeting of CD44, a tumor stem cell marker. In certain embodiments, this disclosure relates to treatment with hyaluronic acid palladium particles disclosed herein for depleting CD44 cells.Type: GrantFiled: May 16, 2019Date of Patent: February 25, 2025Assignees: Emory University, The United States Government represented byt The United States Department of Veterans AffairsInventors: Jack Arbiser, Lily Yang
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Patent number: 12224068Abstract: An electronic processing system agent accesses population health literacy data from at least 100 individuals pertaining to assessed health literacy of members of the population, and demographic data from the population corresponding to age, race, and education level. The agent collects skills data from the patient corresponding to a set of questions relating to skills needed for understanding therapeutic instructions, and personal data relating to the patient's age, race, and education level. The agent carries out a polytomous logistic regression using the collected population health literacy data, demographic data, skills data, and personal data to assign a health literacy level to the patient corresponding to one of a plurality of groups, and communicates a strategy for the patient corresponding to the patient's assigned health literacy level, in real time, to enable the patient to have a communication of therapeutic instructions when the patient has responded to the set of questions.Type: GrantFiled: January 11, 2019Date of Patent: February 11, 2025Assignees: Nova Southeastern University, Emory UniversityInventors: Raymond L. Ownby, Amarilis Acevedo, Drenna Waldrop-Valverde
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Patent number: 12213962Abstract: The present disclosure is generally related to methods for combining chemotherapy and immunotherapy for the treatment of a cancer.Type: GrantFiled: December 9, 2019Date of Patent: February 4, 2025Assignees: Emory University, The UAB Research Foundation, Children's Healthcare of Atlanta, Inc.Inventors: Harold Trent Spencer, Anindya Dasgupta, Lawrence S. Lamb
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Patent number: D1071175Type: GrantFiled: June 27, 2023Date of Patent: April 15, 2025Assignee: Emory UniversityInventors: Cynthia Glenn Timms, Ronald Lloyd Bracken, George Louis Cavagnaro, Jr.