Patents Assigned to Emory University
  • Patent number: 11844802
    Abstract: The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed herein, such as 2,4-diamino-1,3,5-triazine derivatives or salts thereof, for use in bone growth processes. In a typical embodiment, a bone graft composition is implanted in a subject at a site of desired bone growth or enhancement.
    Type: Grant
    Filed: September 28, 2022
    Date of Patent: December 19, 2023
    Assignees: Emory University, The US Govt as represented by the Dept of VA
    Inventors: Scott D. Boden, Sreedhara Sangadala
  • Patent number: 11844785
    Abstract: This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases such as cystic fibrosis, chronic obstructive pulmonary disease, chronic pancreatitis, chronic bronchitis, asthma, mucus formation, comprising administering an effective amount of a 3-(phenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide compound, salt, or derivative thereof to a subject in need thereof. In certain embodiments, the 2-amino-N?-benzylidene-acetohydrazide compound is 3-(3,5-dibromo-4-hydroxyphenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide.
    Type: Grant
    Filed: May 5, 2021
    Date of Patent: December 19, 2023
    Assignees: Emory University, Children's Healthcare of Atlanta, Inc.
    Inventors: Nael McCarty, Guiying Cui
  • Patent number: 11826336
    Abstract: This disclosure relates to nutritional formulas and uses for treating or preventing a gastrointestinal condition and/or motor-planning speech and/or coordinator difficulties. In certain embodiments, this disclosure relates to a nutritional formula comprising medium chain fatty acids, or esters thereof (such as and tri-, di-, mono-glycerides, or alkyl esters), unsaturated fatty acids, and a vitamin E and optionally other nutrients. In certain embodiments, any of the compounds or nutrients may be in alternative salt forms.
    Type: Grant
    Filed: June 1, 2021
    Date of Patent: November 28, 2023
    Assignees: Emory University, Children's Healthcare of Atlanta, Inc.
    Inventor: Claudia R. Morris
  • Patent number: 11826503
    Abstract: Systems relate to a reusable console system that can be used with a plurality of different types of disposable cassettes. The cassettes may be structured for different therapies, different fluid volumes, among others, or a combination thereof. The disposable cassette may include a plurality of fluid circuits. Each circuit may include a pump chamber disposed along the path. The disposable cassette and the panel of a console may be configured to mate so that each of the one or more actuators of the console align with a pump chamber of the disposable cassette. The console may be configured to control a flow of the fluid in the path in the cassette when the disposable cassette is mated on the panel. Because the console can be mated with different cassettes, the system can efficiently and accurately deliver different medical fluid therapies and/or different patient populations (e.g., pediatric and adult).
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: November 28, 2023
    Assignees: Children's Healthcare of Atlanta, Inc., Emory University
    Inventors: Matthew Paden, Sivakkumar Arjunon, Ajit Yoganathan, Brian Walsh
  • Patent number: 11813104
    Abstract: The systems and methods can accurately and efficiently determine boundary conditions for an arterial segment and thereby efficiently determine hemodynamic information for that segment. The method may include receiving medical image data of a patient. The method may further include generating a geometrical representation of the one or more arterial segments from the medical image data. The method may further include determining boundaries and geometry data for each arterial segment. The method may further include determining boundary conditions for the inflow boundary and each outflow boundary. The boundary conditions for each outflow boundary may be determined using an outflow distribution parameter. The outflow distribution parameter may be determined using the geometry data for one or more of the one or more outflow boundaries, stored hemodynamic data, or a combination thereof. The method may further include determining flow field for each arterial segment and determining hemodynamic information.
    Type: Grant
    Filed: October 8, 2018
    Date of Patent: November 14, 2023
    Assignee: Emory University
    Inventors: Habib Samady, Alessandro Veneziani, Don Giddens, David Molony, Adrien Lefieux, Alexander Fuller Viguerie
  • Patent number: 11801255
    Abstract: This disclosure relates to lipid disulfide prodrugs and in particular to lipid disulfide phosphodiester nucleosides and derivatives thereof, pharmaceutical compositions, and uses related thereto. According to one embodiment of the disclosure there is provided a compound of Formula I, or pharmaceutically acceptable salts or derivatives thereof, wherein substitutents are disclosed herein.
    Type: Grant
    Filed: July 7, 2021
    Date of Patent: October 31, 2023
    Assignee: Emory University
    Inventors: Dennis Liotta, Kyle Giesler
  • Patent number: 11786580
    Abstract: In certain embodiments, this disclosure relates to VIP and VIP agonists, optionally conjugated to nanoparticles, for use in methods of treating inflammatory T cell-mediated diseases or conditions, e.g., treating or preventing GvHD. In certain embodiments, this disclosure relates to methods of pulmonary administration of VIP and VIP agonists, optionally conjugated to nanoparticles. In certain embodiments, this disclosure contemplates nanoparticles disclosed herein.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: October 17, 2023
    Assignee: Emory University
    Inventors: Giacomo Waller, Yiwen Li, Edmund Waller
  • Publication number: 20230299945
    Abstract: Aspects of the subject disclosure may include, for example, a non-transitory, machine-readable medium, comprising executable instructions that, when executed by a processing system including a processor, facilitate performance of operations including receiving a call; selecting a next carrier to handoff the call; generating a call data record (CDR) for the handoff to the next carrier; encrypting the CDR using a call encryption key, thereby creating an encrypted CDR; encrypting the encrypted CDR using a committee encryption key, thereby creating a double encrypted CDR; recording the double encrypted CDR to a blockchain; and sending the call encryption key to the next carrier. Other embodiments are disclosed.
    Type: Application
    Filed: May 24, 2023
    Publication date: September 21, 2023
    Applicants: Emory University, AT&T Intellectual property I, L.P.
    Inventors: Divesh Srivastava, Yaron Kanza, Tamraparni Dasu, Teddy Chu, Shuaicheng Ma, Li Xiong
  • Patent number: 11760965
    Abstract: Mesofluidic devices for culturing cell aggregates and methods of using the same are disclosed. An exemplary mesofluidic device comprises at least one fluid inlet, at least one fluid outlet, a plurality of fluid channels, and a plurality of culture chambers. Each culture chamber can comprise at least one chamber inlet and at least one chamber outlet. The at least one chamber inlet can be in fluid communication with the at least one fluid inlet via at least one of the plurality of fluid channels. The at least one chamber outlet can be in fluid communication with the at least one fluid outlet via at least one of the plurality of fluid channels. The mesofluidic device can be configured to contain a cell aggregate in each of the plurality of culture chambers.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: September 19, 2023
    Assignees: Georgia Tech Research Corporation, Emory University
    Inventors: Emily Jackson-Holmes, Hang Lu, Zhexing Wen
  • Patent number: 11744831
    Abstract: Compounds, compositions, and methods of treatment and prevention of Hepacivirus, Pestivirus, Flavivirus or Alphavirus infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidine JAK inhibitors. Combinations of these JAK inhibitors and additional antiretroviral compounds, such as NRTI, NNRTI, integrase inhibitors, entry inhibitors, protease inhibitors, and the like, are also disclosed. In one embodiment, the combinations include a combination of adenine, cytosine, thymidine, and guanine nucleoside antiviral agents, optionally in further combination with at least one additional antiviral agent that works via a different mechanism than a nucleoside analog. This combination has the potential to eliminate the presence of Hepacivirus, Pestivirus, Flavivirus or Alphavirus in an infected patient.
    Type: Grant
    Filed: June 29, 2021
    Date of Patent: September 5, 2023
    Assignees: Emory University, The United States Government as Represented by the Department of Veterans Affairs
    Inventors: Christina Gavegnano, Raymond F Schinazi
  • Patent number: 11738095
    Abstract: This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer cell imaging, cancer cell growth inhibition, and detecting cancer cells, for example. Compounds of the invention are preferentially taken up by cancer cells as compared to normal cells. This allows many uses in the cancer treatment, diagnosis, tracking and imaging fields.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: August 29, 2023
    Assignee: Emory University
    Inventors: Leland W. K. Chung, Lucjan Strekowski, Chunmeng Shi, Maged Henary, Gabor Patonay, James J. Krutak, Xiaojian Yang, Guodong Zhu, Ruoxiang Wang, Haiyen E. Zhau
  • Patent number: 11738008
    Abstract: A series of subunit selective allosteric modulators of NMDA receptor function according to Formula (I) is provided herein. Also provided is a method of treating neurological disorders such as Alzheimer's disease Parkinson's disease, schizophrenia, depression, stroke, psychosis and the like using compounds of Formula (I), optionally in combination with one or more further active agent. Pharmaceutical compositions containing a compound of Formula (I) and optionally one or more active agent for treating such disorders may be provided in the form of a tablet, capsule, pill, gel, granules, aerosol, aqueous buffer or a nanoparticle formulation, emulsion, liposome, etc.
    Type: Grant
    Filed: February 9, 2019
    Date of Patent: August 29, 2023
    Assignee: Emory University
    Inventors: Dennis Liotta, Stephen F. Traynelis, David Menaldino, Matthew Epplin
  • Patent number: 11739138
    Abstract: The present disclosure relates to constructs useful in expressing biotinylated monomers and tetramers produced from these monomers. The present disclosure also relates to methods for production and use of these tetramers in identifying and isolating antigen specific B cells and cloning antibodies thereto.
    Type: Grant
    Filed: December 21, 2021
    Date of Patent: August 29, 2023
    Assignees: Emory University, Rutgers, the State University of New Jersey
    Inventors: Arash Grakoui, Joseph Marcotrigiano
  • Patent number: 11730701
    Abstract: This disclosure relates to microcapsule particles for targeted delivery of drugs. In certain embodiments, the particles comprise polyelectrolyte polymers, e.g., layers of anionic polymers and cationic polymers. In certain embodiments, the particles have a fibrinogen coating. In certain embodiments, the particles contain a polysaccharide core and/or a polysaccharide coating encapsulating drugs, proteins, clotting agents, coagulation factors, or anticoagulants. In certain embodiments, this disclosure contemplates methods of using particles disclosed herein to prevent or reduce onset of or duration of bleeding. In certain embodiments, this disclosure contemplates methods of using particles disclosed herein to prevent or reduce onset of blood clotting.
    Type: Grant
    Filed: September 23, 2022
    Date of Patent: August 22, 2023
    Assignees: Emory University, Georgia Tech Research Corporation, Chapman University, Children's Healthcare of Atlanta, Inc.
    Inventors: Wilbur A. Lam, Caroline Hansen, Yumiko Sakurai, Andrew Lyon
  • Patent number: 11725025
    Abstract: This disclosure relates to progesterone phophate derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation such as those resulting from traumatic brain injury or stroke.
    Type: Grant
    Filed: June 28, 2021
    Date of Patent: August 15, 2023
    Assignee: Emory University
    Inventors: David Brian Guthrie, Mark Andrew Lockwood, Michael G. Natchus, Dennis C. Liotta, Donald G. Stein, Iqbal Sayeed
  • Patent number: 11727570
    Abstract: The systems and methods can accurately and efficiently determine a myocardial risk from a lesion disposed along a coronary segment using hemodynamic characteristic(s) associated with one or more sections of the corresponding lesion site. The method may include segmenting one or more lesion sites disposed along at least one arterial segment of the one or more arterial segments of the coronary model into one or more sections. Each lesion site includes a lesion. The method may include determining one or more characteristics for at least one section using at least the one or more characteristics associated with the at least one arterial segment. The one or more characteristics for the at least one section including hemodynamic force characteristic(s) (e.g., wall shear stress (WSS)). The method may include determining one or more risk indices for each lesion site using at least the hemodynamic force characteristic(s) for the at least one section.
    Type: Grant
    Filed: May 20, 2022
    Date of Patent: August 15, 2023
    Assignee: Emory University
    Inventors: Habib Samady, Alessandro Veneziani, Don Giddens, David Molony, Adrien Lefieux, Arnav Kumar
  • Patent number: 11712564
    Abstract: The systems and methods can automatically determine a patient-specific set of stimulation parameters using optimization for exploring and/or programming a neurostimulation device, e.g., deep brain stimulation (DBS). In one implementation, the method may include receiving patient data and set of stimulation parameters associated stimulation delivered to a patient by a neurostimulation device. The method may include determining one or more objective metrics using the patient data for each set of stimulation parameters. The one or more objective metrics may be a quantitative value that represents a rating or score of tremor severity and/or side effect severity. The method may further include generating a patient specific response model using the one or more objective metrics and the associated set of stimulation parameters. The method may also include applying an optimization algorithm to the generated response model to determine a candidate set of one or more stimulation parameters.
    Type: Grant
    Filed: May 7, 2021
    Date of Patent: August 1, 2023
    Assignee: Emory University
    Inventors: Svjetlana Miocinovic, Babak Mahmoudi, Parisa Sarikhani
  • Patent number: 11713349
    Abstract: This disclosure relates to antibodies and antigen binding fragments that specifically bind Ebola virus particles. In certain embodiments, the antibodies and fragments are capable of treating or preventing an Ebola viral infection. In certain embodiments, the antibodies and antigen binding fragments are also contemplated for diagnostic methods and compositions related thereto.
    Type: Grant
    Filed: March 9, 2021
    Date of Patent: August 1, 2023
    Assignees: Emory University, The Scripps Research Institute
    Inventors: Rafi Ahmed, Carl Davis, Erica Ollmann Saphire
  • Patent number: 11712540
    Abstract: Delivery devices, systems, and methods may be configured to define a barrier region at a treatment site to deliver one or more therapeutic materials. A device for delivering one or more therapeutic materials to a treatment site may include a body; one or more members that are movable with respect to the body and that are configured to define a barrier region at the treatment site; and one or more delivery lumens configured to deliver one or more therapeutic materials to the barrier region.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: August 1, 2023
    Assignee: Emory University
    Inventors: Rebecca Levit, Peter Campbell
  • Patent number: 11701389
    Abstract: This disclosure relates to methods of preserving mesenchymal stromal/stem cells (MSCs) for use in clinical applications. In certain embodiments, this disclosure relates to methods of preserving MSCs comprising mixing MSCs with interferon-gamma prior to cryopreserving, freezing, or cooling the MSCs to a temperature below zero degrees Celsius.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: July 18, 2023
    Assignees: Emory University, Children's Healthcare of Atlanta, Inc.
    Inventors: Jacques Galipeau, Raghavan Chinnadurai