Patents Assigned to Euroimmun Medizinische Labordiagnostika AG
-
Publication number: 20240118209Abstract: A method is proposed for detecting at least one fluorescence pattern on an immunofluorescence image of a biological cell substrate, comprising the following steps: incubating the cell substrate with a liquid patient sample, which potentially includes primary antibodies, and furthermore with secondary antibodies, which are marked using a fluorescence stain, irradiating the cell substrate using excitation radiation and capturing the immunofluorescence image, determining segmentation information comprising at least one first and one second segmentation area, wherein the segmentation areas each represent a respective cell substrate area, via segmentation of the immunofluorescence image using a first neural network, determining a boundary area, which represents a transition from the first cell substrate area towards the second cell substrate area in the fluorescence image, on the basis of the segmentation information, selecting multiple partial images from the immunofluorescence image along the boundary area, deteType: ApplicationFiled: September 29, 2023Publication date: April 11, 2024Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Jens Hocke, Jens Krauth, Stefan Gerlach, Christopher Krause, Melanie Hahn, Jörn Voigt, Enno SCHMIDT, Nina VAN BEEK
-
Publication number: 20240119589Abstract: A method is proposed for detecting a presence of a fluorescence pattern on an immunofluorescence image of a biological cell substrate, comprising the following steps: incubating the cell substrate with a liquid patient sample, which potentially comprises primary antibodies, and furthermore with secondary antibodies, which are marked using a fluorescence stain, irradiating the cell substrate using excitation radiation and capturing the immunofluorescence image, determining respective items of location information, which indicate respective locations of respective relevant subsections of the cell substrate in the fluorescence image, and determining respective first partial confidence measures of respective presences of the fluorescence pattern on the respective subsections by means of a first neural network on the basis of the overall fluorescence image, extracting respective image subsections, which correspond to the respective subsections of the cell substrate, from the fluorescence image on the basis of theType: ApplicationFiled: September 22, 2023Publication date: April 11, 2024Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Jens KRAUTH, Jens HOCKE, Stefan GERLACH, Christopher KRAUSE, Melanie HAHN, Jörn VOIGT
-
Patent number: 11867579Abstract: A method for detecting an error state when aspirating a liquid to identify whether a pre-determined volume of liquid was aspirated. The method including: immersing a tip of an aspiration needle in the liquid, aspirating a predetermined partial volume of the liquid in the aspiration needle, continuously acquiring a sensor signal curve, which indicates a pressure in the aspiration needle, during an overall time period, detecting the error state in the case that the sensor signal falls below a first threshold value during the predetermined time period, characterized by providing a reference signal curve, determining a deviation measure, which indicates a deviation of the sensor signal curve from the reference signal curve during the further time period, providing a predetermined second threshold value, detecting the error state as a function of the deviation measure and the second threshold value.Type: GrantFiled: June 18, 2022Date of Patent: January 9, 2024Assignee: EUROIMMUN Medizinische Labordiagnostika AGInventors: Danny Farell, Anna Katharina Laarmann
-
Patent number: 11854191Abstract: An image processing method is provided for displaying cells from a plurality of pathology images or overall images. A respective overall image represents a respective patient tissue sample or a respective patient cell sample.Type: GrantFiled: March 2, 2021Date of Patent: December 26, 2023Assignee: EUROIMMUN Medizinische Labordiagnostika AGInventors: Christian Marzahl, Stefan Gerlach, Joern Voigt, Christine Kroeger
-
Patent number: 11835519Abstract: A method for diagnosing a disease can include detecting, in a sample from a patient, an autoantibody binding to Septin-7. A polypeptide comprising Septin-7 or a variant thereof can be used for the diagnosis of a disease. Preferably, the polypeptide is used to detect an autoantibody binding to Septin-7 in a sample. A kit is useful for the diagnosis of a disease. The kit may include a polypeptide that includes Septin-7 or a variant thereof or a medical device that includes a polypeptide that includes Septin-7 or a variant thereof and an autoantibody to Septin-7.Type: GrantFiled: December 8, 2020Date of Patent: December 5, 2023Assignees: EUROIMMUN Medizinische Labordiagnostika AG, Mayo Foundation for Medical Education and ResearchInventors: Ramona Miske, Madeleine Scharf, Lars Komorowski, Yvonne Denno, Stefanie Hahn, Christiane Radzimski, Mandy Unger, Andrew McKeon, Sean Pittock, Thomas Kryzer, Vanda Lennon, Josephe Honorat
-
Patent number: 11828758Abstract: A recombinant polypeptide can be used in the diagnosis of the presence of a Zika virus in a patient. The recombinant polypeptide includes SEQ ID NO: 1 or a variant thereof. The recombinant peptide may be a monomer, a dimer, or a hexamer.Type: GrantFiled: October 1, 2020Date of Patent: November 28, 2023Assignee: EUROIMMUN Medizinische Labordiagnostika AGInventors: Katja Steinhagen, Andrea Deerberg, Erik Lattwein, Christiane Radzimski, Jana Böthfür
-
Patent number: 11814196Abstract: A pressure-tight storage vessel contains a liquid, has an elongated main body rotationally symmetrical with respect to an axis of symmetry, and forms, at least partially, a rotationally symmetrical hollow space in which the liquid is substantially received, wherein the main body is terminated at its bottom side by a base. Furthermore, at its top side, the storage vessel has an opening which is closed off in a pressure-tight manner by a closure, has a plurality of reinforcement elements, which bears against the main body at the outside, which extends parallel to the axis of symmetry of the main body, and arranged rotationally symmetrically about the axis of symmetry of the main body. In each case between adjacent reinforcement elements, respective externally exposed wall sections of the main body are formed, and the composition of the exposed wall sections permits a pressure-tight insertion by at least two hollow needles.Type: GrantFiled: December 18, 2019Date of Patent: November 14, 2023Assignee: EUROIMMUN Medizinische Labordiagnostika AGInventors: Bianca Huth, Alexander Kowtun, Lars Koschinat, Frank Mollenhauer, Winfried Stoecker
-
Publication number: 20230213534Abstract: Provide are a diagnostically useful carrier coated with a recombinant polypeptide comprising SEQ ID NO: 1, an isolated autoantibody binding specifically to a polypeptide having SEQ ID NO: 1, a kit comprising the carrier, a method for the diagnosis of a membranous nephropathy (MN) that includes detecting the presence or absence of an autoantibody binding specifically to a polypeptide having SEQ ID NO: 1 in a liquid sample comprising antibodies from a subject, a use of an autoantibody binding specifically to a polypeptide having SEQ ID NO: 1 or a polypeptide comprising SEQ ID NO: 1, and a aqueous solution comprising an autoantibody binding specifically to a polypeptide having SEQ ID NO: 1.Type: ApplicationFiled: December 2, 2021Publication date: July 6, 2023Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Inga-Madeleine DETTMANN, Swantje MINDORF, Christian PROBST
-
Publication number: 20230202052Abstract: A method according to the invention is proposed for filtering a sensor signal, said method comprising various steps. A time-discrete sensor signal is provided as an input signal, and an output signal is generated via a continuous filtering of the input signal using a time-discrete filter in the time domain, which performs the following filter steps for each value of the input signal: comparing a specified signal value of a specified time index of the input signal with two further signal values of the input signal, wherein a first signal value of the two further signal values is temporally prior to the specified signal value and wherein a second signal value of the further signal values is temporally after the specified signal value, and replacing the specified signal value in the output signal by a new value in dependence on a value interval spanned by the two further signal values.Type: ApplicationFiled: December 20, 2022Publication date: June 29, 2023Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Felix AHLBORG, Arne VON DRATHEN, Siegfried WESSEL
-
Publication number: 20230166260Abstract: An apparatus is provided for holding down membrane elements in respective wells of a multiwell plate, which has, at its top side, respective openings of the respective wells. The apparatus has, at its upper region, a support structure having respective openings, and respective corresponding retention elements which extend downwards from the respective openings of the support structure, so that respective retention elements protrude into respective wells when the support structure has been placed onto the top side of the multiwell plate. A retention element has multiple webs which extend downwards from the support structure and the ends of which are connected to one another at a bottom side of the apparatus by means of a connection element.Type: ApplicationFiled: March 10, 2022Publication date: June 1, 2023Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Bianca Huth, Patrick Auer, Philip Rosenstock
-
Patent number: 11644463Abstract: A diagnostically useful carrier includes a peptide including the amino acid sequence set forth in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4 or a variant thereof. A kit, a composition, a detection method, use for detecting a neurological disease, a human autoantibody specifically binding to Drebrin and a therapeutic compound or combination for use in the treatment of a neurological use are also useful.Type: GrantFiled: August 11, 2020Date of Patent: May 9, 2023Assignee: Euroimmun Medizinische Labordiagnostika AGInventors: Susanne Schoch McGovern, Albert Becker
-
Publication number: 20230133318Abstract: Netrin G1 is disclosed as a biomarker of membranous glomerulonephritis (MGN). Netrin G1 antigen-comprising polypeptides and Netrin G1 antibodies can be used in in vitro methods and kits for diagnosis, prognosis and monitoring of MGN of patients with circulating Netrin G1 autoantibodies.Type: ApplicationFiled: October 13, 2022Publication date: May 4, 2023Applicant: Euroimmun Medizinische Labordiagnostika AGInventors: Rolf STAHL, Elion Hoxha, Linda Reinhard
-
Publication number: 20230071078Abstract: There is proposed a method for detecting a presence of a fluorescence pattern type on an organ segment via immunofluorescence microscopy and digital image processing. The steps comprise: provision of the organ segment, incubation of the organ segment with a liquid patient sample, incubation of the organ segment with secondary antibodies which have been labelled with a fluorescent dye, acquisition of a fluorescence image of the organ segment in a colour channel corresponding to the fluorescent dye, and provision of the fluorescence image to a neural network. What takes place by means of the neural network is simultaneous determination of segmentation information through segmentation of the fluorescence image and, furthermore, of a measure of confidence indicating an actual presence of the fluorescence pattern type.Type: ApplicationFiled: August 25, 2022Publication date: March 9, 2023Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Stefan GERLACH, Jens KRAUTH, Christian MARZAHL, Christopher KRAUSE, Jens HOCKE, Maick DANCKWARDT, Melanie HAHN, Jörn VOIGT
-
Patent number: 11598772Abstract: A diagnostically useful carrier includes a means for specifically capturing an antibody to a polypeptide from the group including squid MLC1 or squid MLC2 or a variant thereof in a sample from a subject. A method includes the step detecting in a sample from a subject the presence or absence of an antibody to squid MLC1 or squid MLC2. The polypeptide or the carrier or a polypeptide binding specifically to an IgE antibody from the sample of a patient to squid MLC1 or squid MLC2 are useful for the manufacture of a diagnostic kit, preferably for the diagnosis of allergy.Type: GrantFiled: June 17, 2020Date of Patent: March 7, 2023Assignees: EUROIMMUN Medizinische Labordiagnostika AG, Hospital Clinic de Barcelona, Institut D'Investigacions Biomédiques August Pi i SunyerInventors: Waltraud Suer, Marco Klinge, Alf Weimann, Stefanie Rohwer, Henning Seismann, Mariona Pascal Capdevila
-
Publication number: 20230022761Abstract: A method is used for the qualitative evaluation of real-time PCR data, where a time/PCR amplification plot of an associated sample is classified as a negative plot or as a positive plot. The method involves providing a real-time PCR amplification plot to be classified, plotting at least 20 successive amplitude values of corresponding successive PCR cycle indices of the sample. Next, a quality metric is determined, on the basis of the at least one amplitude value. A first criterion is determined by a comparison of the quality metric with a first standard value. A sequence of values is then determined, which indicates a gradient of the PCR amplification plot to be classified, and a second criterion is determined as to whether the sequence of values exceeds a second standard value. Finally, the real-time PCR amplification plot is classified as a positive plot if all the criteria given above are satisfied.Type: ApplicationFiled: December 18, 2020Publication date: January 26, 2023Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Christodoulos Filippis, Ulf Steller, Fiona Schilling
-
Patent number: 11549889Abstract: A method and a device are useful for detecting a binding of autoantibodies from a patient sample to double-stranded deoxyribonucleic acid (DNA) using Crithidia luciliae cells by fluorescence microscopy and by digital image processing.Type: GrantFiled: March 17, 2020Date of Patent: January 10, 2023Assignee: EUROIMMUN Medizinische Labordiagnostika AGInventors: Stefan Gerlach, Christian Marzahl, Maick Danckwardt, Joern Voigt
-
Publication number: 20220404226Abstract: A method is proposed for detecting an error state when aspirating a liquid, including: immersing a tip of an aspiration needle in the liquid, generating a negative pressure in the aspiration needle for a predefined time period to aspirate a predetermined partial volume of the liquid in the aspiration needle, continuously acquiring a sensor signal curve by means of continuous measurement of a sensor signal, which indicates a pressure in the aspiration needle, during an overall time period, which comprises the predetermined time period and furthermore a further time period following the predetermined time period, detecting the error state in the case that the sensor signal falls below a first threshold value during the predetermined time period, characterized by providing a reference signal curve, determining a deviation measure, which indicates a deviation of the sensor signal curve from the reference signal curve during the further time period, providing a predetermined second threshold value, detecting the eType: ApplicationFiled: June 18, 2022Publication date: December 22, 2022Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Danny FARELL, Anna Katharina LAARMANN
-
Publication number: 20220405940Abstract: An apparatus is proposed for identifying respective cover slip regions of respective cover slips having respective tissue sections on a specimen slide, which has multiple optical identifiers. The apparatus includes a planar light source, an image acquisition unit, a holding unit for positioning the specimen slide between the planar light source and the image acquisition unit, a slit diaphragm, which has multiple opening slits, reversibly positionable between the planar light source and the specimen slide, and an illumination unit, which is designed to illuminate that surface of the specimen slide which faces toward the image acquisition unit. Furthermore, the apparatus includes a monitoring unit which is designed, on the basis of a completely illuminated transmitted light image, an incident light image, and a partially darkened transmitted light image, to assign respective tissue sections to respective optical identifiers.Type: ApplicationFiled: December 17, 2020Publication date: December 22, 2022Applicant: EUROIMMUN MEDIZINISCHE LABORDIAGNOSTIKA AGInventors: Christian FEIRER, Erik Bernitt-Ringering, Martin RATEIKE, Simon SCHWAB, Winfried STÖCKER
-
Publication number: 20220404283Abstract: A method for detecting at least one potential presence of at least one fluorescence pattern type on an organ section by means of immunofluorescence microscopy and by means of digital image processing is disclosed. An organ section is provided on a slide and the section is incubated with a liquid patient sample which potentially includes primary antibodies and with secondary antibodies which have been labelled with a fluorescent dye. A fluorescence image of the organ section is acquired. A determination is made, by segmentation of the fluorescence image by means of a first neural network, of a sub-area of the fluorescence image that is relevant to formation of the fluorescence pattern type. A determination is made, on the basis of the fluorescence image by means of a second neural network, of the measure of confidence that indicates an actual presence of the fluorescence pattern type.Type: ApplicationFiled: December 21, 2021Publication date: December 22, 2022Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Jens Krauth, Stefan Gerlach, Christian Marzahl, Christopher Krause, Jens Hocke, Melanie Hahn, Joern Voigt
-
Patent number: D979787Type: GrantFiled: August 18, 2020Date of Patent: February 28, 2023Assignee: EUROIMMUN Medizinische Labordiagnostika AGInventors: Torsten Gruen, Frank Mollenhauer