Patents Assigned to Evolva SA
  • Production of steviol glycosides in recombinant hosts
    Patent number: 10837041
    Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: November 17, 2020
    Assignee: EVOLVA SA
    Inventors: Veronique Douchin, Michael Dalgaard Mikkelsen, Iben Møller-Hansen
  • Production of steviol glycosides in recombinant hosts
    Patent number: 10815514
    Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides, glycosides of steviol precursors, and steviol glycoside precursors.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: October 27, 2020
    Assignee: Evolva SA
    Inventors: Kim Olsson, Joseph Michael Sheridan, Laura Tatjer Recorda, Christian Nyffengger, Veronique Douchin
  • Biosynthesis of phenylpropanoids and phenylpropanoid derivatives
    Patent number: 10760062
    Abstract: Provided herein are methods and compositions for producing phenylpropanoid derivatives, such as chalcones and stilbenes, and dihydrophenylpropanoid derivatives, such as dihydrochalcones and dihydrostilbenes, in microorganisms. In particular, the disclosure provides recombinant microorganisms and methods of use thereof for producing phenylpropanoid derivative compounds and dihydrophenylpropanoid derivative compounds.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: September 1, 2020
    Assignee: EVOLVA SA
    Inventors: Michael Naesby, Ernesto Simón Vecilla, Michael Eichenberger, Beata Joanna Lehka, Walden Emil Bjørn-Yoshimoto, Niels Bjerg Jensen
  • Methods and materials for enzymatic synthesis of mogroside compounds
    Patent number: 10738340
    Abstract: Methods and materials for enzymatic synthesis of mogroside compounds described.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: August 11, 2020
    Assignee: EVOLVA SA
    Inventors: Yaoquan Liu, Jung Yeop Lee, Monika Khare
  • Vanillin synthase
    Patent number: 10689672
    Abstract: The invention relates to methods for producing vanillin and related compounds. The methods involve use of a vanillin synthase capable of catalyzing side chain cleavage of ferulic acid to form vanillin. The invention also relates to host organisms expressing such vanillin synthases useful in the methods.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: June 23, 2020
    Assignees: EVOLVA SA, UNIVERSITY OF COPENHAGEN
    Inventors: Birger Lindberg Møller, Esben Halkjaer Hansen, Jørgen Hansen, Nethaji Janeshawari Gallage
  • Methods and materials for biosynthesis of mogroside compounds
    Patent number: 10662458
    Abstract: The invention relates to methods for producing mogrosides with the aid of enzymes. In particular the invention proposes various biosynthetic pathways useful for mogroside production and enzymes useful for mogroside production are provided. Furthermore, the invention provides recombinant hosts useful in performing the methods of the invention.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: May 26, 2020
    Assignee: EVOLVA SA
    Inventors: Yaoquan Liu, Jorgen Hansen, Jens Houghton-Larsen, Muthuswamy Panchapagesa Murali, Sathish Kumar, Nina Nicoline Rasmussen
  • Methods and materials for biosynthesis of mogroside compounds
    Patent number: 10633685
    Abstract: Methods for recombinant and enzymatic production of mogroside compounds and compositions containing mogroside compounds are provided by this invention.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: April 28, 2020
    Assignee: EVOLVA SA
    Inventors: Jens Houghton-Larsen, Katarzyna Krzystanek, Angelika Semmler, Iver Klavs Riishede Hansen, Soren Damkiaer, Yaoquan Liu, Jorgen Hansen, Sathish Kumar, Muthuswamy Panchapagesa Murali, Nina Nicoline Rasmussen
  • Methods for improved production of rebaudioside D and rebaudioside M
    Patent number: 10612066
    Abstract: Methods for recombinant production of steviol glycoside and compositions containing steviol glycosides are provided by this invention.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: April 7, 2020
    Assignee: Evolva SA
    Inventors: Michael Dalgaard Mikkelsen, Jorgen Hansen, Ernesto Simon, Federico Brianza, Angelika Semmler, Kim Olsson, Simon Carlsen, Louis Düring, Alexei Ouspenski, Paula Hicks
  • Production of steviol glycosides in recombinant hosts
    Patent number: 10612064
    Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: April 7, 2020
    Assignee: Evolva SA
    Inventors: Helene Lunde Robertson, Iben Nordmark Andersen, Adam Matthew Takos, Swee Chuang Lim Hallwyl, Francesca Ambri, Manuel Quiros Asensio, Michael Dalgaard Mikkelsen, Jens Houghton-Larsen, Veronique Douchin, Jane Dannow Dyekjaer, Simon Carlsen, Nina Nicoline Rasmussen, Esben Halkjaer Hansen
  • Methods and materials for biosynthesis of mogroside compounds
    Patent number: 10465222
    Abstract: The invention relates to methods for producing mogrosides with the aid of enzymes. In particular the invention proposes various biosynthetic pathways useful for mogroside production and enzymes useful for mogroside production are provided. Furthermore, the invention provides recombinant hosts useful in performing the methods of the invention.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: November 5, 2019
    Assignee: EVOLVA SA
    Inventors: Yaoquan Liu, Jorgen Hansen, Jens Houghton-Larsen, Muthuswamy Panchapagesa Murali, Sathish Kumar, Nina Nicoline Rasmussen
  • Recombinant production of steviol glycosides
    Patent number: 10435730
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: October 8, 2019
    Assignee: EVOLVA SA
    Inventors: Jens Houghton-Larsen, Paula Hicks, Michael Naesby, Thomas Tange Ostergaard, Jorgen Hansen, Michael Mikkelsen Dalgaard, Esben Hansen Halkjaer, Ernesto Simon, Sabina De Andrade Periera Tavares
  • Production of steviol glycosides in recombinant hosts
    Patent number: 10421983
    Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: September 24, 2019
    Assignee: EVOLVA SA
    Inventors: Veronique Douchin, Michael Dalgaard Mikkelsen, Iben Møller-Hansen
  • Production of steviol glycosides in microorganisms
    Patent number: 10392644
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express novel recombinant genes encoding steviol biosynthetic enzymes and UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol or steviol glycosides, e.g., rubusoside or Rebaudioside A, which can be used as natural sweeteners in food products and dietary supplements.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: August 27, 2019
    Assignee: EVOLVA SA
    Inventors: Ganesh M. Kishore, Jorgen Hansen, Jens Houghton-Larsen, Esben Halkjaer Hansen, Michael Dalgaard Mikkelsen, Sabina Tavares, Charlotte Blom
  • Production of steviol glycoside in recombinant hosts
    Patent number: 10364450
    Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides, glycosylated ent-kaurenol, and glycosylated ent-kaurenoic acid.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: July 30, 2019
    Assignee: EVOLVA SA
    Inventors: Kim Olsson, Ernesto Simon, Michael Dalgaard Mikkelsen, Simon Carlsen, Veronique Douchin, Swee Chuang Lim, Louis During
  • PRODUCTION OF STEVIOL GLYCOSIDES IN RECOMBINANT HOSTS
    Publication number: 20190153495
    Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides, glycosides of steviol precursors, and steviol glycoside precursors.
    Type: Application
    Filed: May 16, 2017
    Publication date: May 23, 2019
    Applicant: EVOLVA SA
    Inventors: Kim Olsson, Joseph Michael Sheridan, Laura Tatjer Recorda, Christian Nyffengger, Veronique Douchin
  • Biosynthesis of phenylpropanoids and phenylpropanoid derivatives
    Patent number: 10294499
    Abstract: Provided herein are recombinant hosts and methods for producing phenylpropanoid and phenylpropanoid derivative compounds. It was found that tyrosine ammonia lyase from Aeromonas salmonicida A449 provides improved coumaric acid production.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: May 21, 2019
    Assignee: EVOLVA SA
    Inventors: Ernesto Simon Vecilla, Beata Joanna Lehka, Carlos Casado Vazquez
  • Biosynthesis of forskolin and related compounds
    Patent number: 10240173
    Abstract: The invention described materials and methods for producing oxidized 13R-MO, such as forskolin. In particular, the invention describes P450s involved in oxidation of 13R-MO including CYP76AH8, CYP76AH11, CYP76AH15, CYP76AH17, CYP71D381 and CYP76AH9. Host organisms expressing one or more of these P450s are useful in the production of oxidized 13R-MO.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: March 26, 2019
    Assignees: University of Copenhagen, Danmarks Tekniske Universitet, Evolva SA
    Inventors: Björn Hamberger, Birger Lindberg Møller, Eirini Pateraki, Johan Andersen-Ranberg, Niels Bjerg Jensen
  • Methods and materials for biosynthesis of manoyl oxide
    Patent number: 10208326
    Abstract: The invention relates to recombinant microorganisms and methods for producing manoyl oxide.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: February 19, 2019
    Assignee: EVOLVA SA
    Inventor: Niels Bjerg Jensen
  • Compositions and methods for the biosynthesis of vanillan or vanillin beta-D-glucoside
    Patent number: 10208293
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express a mutant AROM polypeptide and/or mutant catechol-O-methyltransferase polypeptide alone or in combination with one or more vanillin biosynthetic enzymes or UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce vanillin or vanillin beta-D-glucoside.
    Type: Grant
    Filed: August 7, 2012
    Date of Patent: February 19, 2019
    Assignees: International Flavors & Fragrances Inc., Evolva SA
    Inventors: Joergen Hansen, Esben Halkjaer Hansen, Honey Polur, Joseph M. Sheridan, Jonathan R. Heal, William D. O. Hamilton
  • Increased production of terpenes and terpenoids
    Patent number: 10190140
    Abstract: This invention provides recombinant cells and methods for producing terpenes and terpenoids by increasing production or accumulation or both of isoprenoid precursors thereof.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: January 29, 2019
    Assignee: EVOLVA SA
    Inventors: Thomas Oestergaard Tange, Michael Naesby, Christophe Folly, Fanny Delegrange, Jens Houghton-Larsen, Simon Carlsen