Abstract: A dosage form contains a biologically active ingredient for treating or preventing a disease in the animal or human body, where the treatment or prevention requires release of 50% or more of the biologically active ingredient in the small intestine within the pH range from 3 to 5.5. The dosage form contains: a) a core, containing the biologically active ingredient; b) an intermediate coating layer (ICL) onto or above the core, containing an alkaline agent; and c) an enteric coating layer (ECL) onto or above the intermediate coating layer, containing an enteric polymer. The relation of the alkaline agent to the enteric polymer is 5 to 95% when calculated by the formula: quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? I ? C ? L × 100 ( quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? I ? C ? L + quantity ? of ? enteric ? polymer ? in ? grams ? in ? the ? E ? C ? L ) .
Abstract: A trichlorogermanide of formula (I): [R4N]/[R4P]Cl[GeCl3] (I), where R is Me, Et, iPr, nBu, or Ph, tris(trichlorosilyl)germanide of formula (II): [R4N]/[R4P][Ge(SiCl3)3] (II), where R is Me, Et, iPr, nBu, or Ph, a tris(trichlorosilyl)germanide adduct of GaCl3 of formula (III): [Ph4P][Ge(SiCl3)3*GaCl3], and a tris(trichlorosilyl)germanide adduct of BBr3 of formula (IV): [Ph4P][Ge(SiCl3)3*BBr3]. Also, methods for preparing the trichlorogermanides of formula (I), the tris(trichlorosilyl)germanide of formula (II), the tris(trichlorosilyl)germanide adduct of BBr3 of formula (IV).
Abstract: An emulsion contains A) an alkyl ester quat of formula I wherein R1 is an acyl radical of a fatty acid with a chain length of from 6 to 24 carbon atoms, with the proviso that a mass fraction of saturated, linear fatty acids with a chain length of from 12 to 24 carbon atoms, is more than 50% by weight, based on all acyl radicals R1, wherein R2 is an alkyl radical having 1 to 6 carbon atoms, wherein a=1-3 and b=1-3, with the proviso that a+b=4, B) at least one consistency regulator, and C) at least one cosmetic oil.
Type:
Grant
Filed:
July 5, 2016
Date of Patent:
January 10, 2023
Assignee:
Evonik Operations GmbH
Inventors:
Juergen Meyer, Anna M. Howe, Maria L. Spohrer, Hans-Juergen Koehle, Brajesh Kumar Jha
Abstract: Spherical silica and/or silicate particles having a d50 median particle size from 1 to 5 ?m, a d95 particle size less than 8 ?m, an oil absorption from 40 to 100 cc/100 g, a pack density from 20 to 60 lb/ft3, and a sphericity factor (S80) of at least 0.9, are disclosed, as well as methods for making these spherical particles, and dentifrice compositions containing the spherical particles.
Type:
Grant
Filed:
August 24, 2018
Date of Patent:
January 10, 2023
Assignee:
Evonik Operations GmbH
Inventors:
John M. Cornelius, William J. Hagar, Karl W. Gallis, Terry W. Nassivera
Abstract: The invention relates to a method for producing a metal-foam body, comprising the steps of (a) providing a metal-foam body A, which consists of nickel, cobalt, copper, or alloys or combinations thereof, (b) applying an aluminum-containing material MP to metal-foam body A so as to obtain metal-foam body AX, (c) thermally treating of metal-foam body AX, with the exclusion of oxygen, to achieve the formation of an alloy between the metallic components of metal-foam body A and the aluminum-containing material MP so as to obtain metal-foam body B, wherein the duration of the thermal treatment is chosen in dependence on the temperature of the thermal treatment and the temperature of the thermal treatment is chosen in dependence on the thickness of the metal-foam body AX. The invention also relates to the metal-foam bodies obtainable by the methods according to the invention and to the use thereof as catalysts for chemical transformations.
Type:
Application
Filed:
September 25, 2020
Publication date:
January 5, 2023
Applicant:
EVONIK OPERATION GMBH
Inventors:
René Poss, Monika BERWEILER, Meike ROOS
Abstract: Silica-based hydrophobic granular material with an increased polarity Silica-based granular material, comprising silica and at least one IR-opacifier, hydrophobized with a surface treatment agent comprising a silicon atom, wherein the granular material has: a) a cumulative pore volume of pores>4 nm of more than 2.5 cm3/g, as determined by the mercury intrusion method according to DIN ISO 15901-1; b) a tamped density of 140 g/L to 290 g/L; c) a number of silanol groups relative to BET surface area dSiOH of at least 0.5 SiOH/nm2, as determined by reaction with lithium aluminium hydride. d) a number of silicon atoms in the surface treatment agent relative to BET surface area d[Si] of at least 1.0 [Si atoms]/nm2.
Type:
Application
Filed:
January 6, 2021
Publication date:
January 5, 2023
Applicant:
EVONIK OPERATIONS GMBH
Inventors:
Björn LAZAR, Alexander LYGIN, Ulrich BOES, Bettina GERHARZ-KALTE, Remi BRIAND, Maria NARGIELLO
Abstract: The present invention relates to a blend containing at least two different polyolefins which is characterized in that it contains as a further constituent an amorphous poly-alpha-olefin which is based on the monomers ethene, propene and 1-butene and has a viscosity at 190° C. of 200 mPa*s to 200,000 mPa*s, wherein it contains polyethylene and polypropylene as at least two different polyolefins and wherein the polyethylene has a melt flow index [MFI 2.16 kg@190° C.] determined according to the method ISO 1133 reported in the description of less than 10 g/10 min, preferably of 0.01 to 2 g/10 min, and the polypropylene has a melt flow index [MFI 2.16 kg@230° C.] determined according to the method reported in the description of less than 50 g/10 min, preferably of 0.01 to 25 g/10 min, to a process for producing such blends and to the use thereof.
Type:
Application
Filed:
October 13, 2020
Publication date:
January 5, 2023
Applicant:
Evonik Operations GmbH
Inventors:
Sebastian Babik, Steffen Cepa, Sebastian Heßner, Stefan Kirschbaum
Abstract: A dosage form contains a) a core, containing a biologically active ingredient, which is stable to a degree of at least 95% at a pH of 3 for 2 hours at 22° C.; b) an intermediate coating layer (ICL) onto or above the core, containing an alkaline agent; and c) an enteric coating layer (ECL) onto or above the intermediate coating layer, containing an enteric polymer. The relation in percent of the alkaline agent in the ICL to the enteric polymer in the ECL is 5 to 95% when calculated by the formula: quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? ICL × 100 ( quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? ICL + quantity ? of ? enteric ? polymer ? in ? grams ? in ? the ? ? ECL ) .
Abstract: The invention relates to silane mixtures comprising a silane of the formula I (R1)y(R2)3-ySi—R3—(S—R4)n—Sx—R5??(I) and a silane of the formula II (R1)y(R2)3-ySi—R3—Si(R1)y(R2)3-y??(II) where the molar ratio of silane of the formula I to silane of the formula II is 15:85-90:10. The silane mixture according to the invention can be prepared by mixing the silanes of the formula I and silanes of the formula II.
Type:
Grant
Filed:
November 16, 2018
Date of Patent:
January 3, 2023
Assignee:
Evonik Operations GmbH
Inventors:
Alexander Koepfer, Caren Roeben, Andre Hasse, Frank Forster
Abstract: The current invention relates to a method of isolating polyunsaturated fatty acids containing lipids from a lipids containing biomass. The method involves providing a suspension of cells with a PUFAs-containing lipid; optionally lysing the cells; concentrating the suspension; adding base equivalents to the suspension based on the total dry matter present; feeding a continuous reactor with the suspension; and separating the lipids-containing light phase from the water and cell debris-containing heavy phase.
Type:
Grant
Filed:
December 18, 2018
Date of Patent:
January 3, 2023
Assignees:
EVONIK OPERATIONS GMBH, DSM IP ASSETS B.V.
Inventors:
Martin Heining, Michael Benjamin Johnson, Jochen Lebert, Holger Pfeifer
Abstract: The invention relates to silane mixtures comprising a silane of the formula I ((R1)y(R2)3-ySi—R3—SH??(I) and a silane of the formula II (R1)y(R2)3-ySi—R3—(S—R4)z—Si(R1)y(R2)3-y??(II) where the molar ratio of silane of the formula I to silane of the formula II is 20:80-85:15. The silane mixture according to the invention can be prepared by mixing the silanes of the formula I and silanes of the formula II.
Type:
Grant
Filed:
November 16, 2018
Date of Patent:
January 3, 2023
Assignee:
Evonik Operations GmbH
Inventors:
Alexander Koepfer, Caren Roeben, Andre Hasse, Frank Forster
Abstract: A plasticizer composition contains a compound according to the following formula (I) wherein the radicals R1, R2 and R3 are each independently selected from n-pentyl, 2-methylbutyl and 3-methylbutyl. The plasticizer composition can be used as plasticizer for polymers and a corresponding plastic composition contains the plasticizer composition.
Type:
Application
Filed:
June 14, 2022
Publication date:
December 29, 2022
Applicant:
Evonik Operations GmbH
Inventors:
Michael Grass, Florian Boeck, Benjamin Woldt
Abstract: The present invention is directed to compositions containing polymer matrix, fiber and/or additives which are suitable for load bearing applications for medical devices. The matrix can be formed from a group of polymers which resorb inside the body after implantation. These compositions contain reinforcing fibers that are incorporated into a resorbable polymer matrix to improve properties such as mechanical. The reinforcing fibers can be resorbable, non-resorbable, natural, or metallic. Additives can be incorporated into the matrix material or the fibers or both to provide a secondary effect. These additives can be bioceramics to provide an osteoconductive effect; antimicrobial particles such as silver; coloring agents, and radiopaque additives to make the implants visible under fluoroscopy. The additives may also contribute to improve mechanical properties.
Type:
Application
Filed:
November 9, 2020
Publication date:
December 29, 2022
Applicant:
Evonik Operations GmbH
Inventors:
Jose Santiago-Anadon, Mahrokh Dadsetan, Balaji Prabhu, Ryan Lawson
Abstract: The invention relates to a process for producing polyurethanes using a component A comprising a polyhydrazide, a polysemicarbazide, a polysulfonyl hydrazide and/or carbodihydrazide, in particular a polyhydrazide, wherein the component A is employed in the form of a mixture C which further comprises a component B comprising a dispersion medium.
Type:
Application
Filed:
July 13, 2020
Publication date:
December 29, 2022
Applicant:
Evonik Operations GmbH
Inventors:
Eva Emmrich-Smolczyk, Mladen Vidakovic, Stephan Wendel, Juan Jesus Burdeniuc
Abstract: An extractive distillation column system contains a combination column and a side rectification column. A process can be used for separation of butenes from C4-hydrocarbon streams using the extractive distillation column system.
Type:
Application
Filed:
June 22, 2022
Publication date:
December 29, 2022
Applicant:
Evonik Operations GmbH
Inventors:
Philip Lutze, Stephan Peitz, Armin Matthias Rix, Tanita Valèrie Six, Moritz Schröder, Niklas Paul
Abstract: What is described is a composition for production of rigid polyurethane foam, comprising at least one isocyanate component, a polyol component, optionally a foam stabilizer, optionally blowing agent, wherein the composition contains at least one catalyst that catalyses the formation of a urethane or isocyanurate bond, wherein the catalyst comprises salts of amino acid derivatives.
Type:
Application
Filed:
September 8, 2020
Publication date:
December 22, 2022
Applicant:
Evonik Operations GmbH
Inventors:
Martin Glos, Jobst Grimminger, Torsten Panitzsch, Olga Fiedel
Abstract: A silicate-based lanthanide ion doped material converts electromagnetic radiation energy of a longer wavelength of below 530 nm to electromagnetic radiation energy of shorter wavelengths in the range of 220 to 425 nm. The silicate-based material is a crystalline silicate material doped with lanthanide ions selected from praseodymium, gadolinium, erbium, and neodymium. For co-doping, at least two of the lanthanide ions are used. The silicate-based material is obtainable from a blend comprising salts and an organic solvent, followed by specific calcination processes and tribological impacts to adjust particle size and to increase the crystallinity of the particles. The silicate-based material can be used to inactivate microorganisms or cells covering a surface containing the silicate-based material under exposure of electromagnetic radiation energy of a longer wavelength of below 500 nm.
Type:
Application
Filed:
October 5, 2020
Publication date:
December 22, 2022
Applicant:
Evonik Operations GmbH
Inventors:
Stefan Fischer, David Böhnisch, Thomas Jüstel, Simone Schulte, Markus Hallack
Abstract: The present invention is directed to moulding compounds comprising polyarylene ether ketones and glass particles, with the glass particles being broken, irregularly shaped particles.
Type:
Application
Filed:
November 18, 2020
Publication date:
December 22, 2022
Applicant:
Evonik Operations GmbH
Inventors:
Thomas Perl, Jonas Scherble, Frank Claus, Marc Knebel, Ingrid Velthoen
Abstract: The present invention relates to an additive manufacturing process using a composition comprising the reaction product of a polyester polyol and a compound comprising at least one functional group that can react with a hydroxyl-group of the polyester polyol and at least one further functional group, selected from acrylate- or methacrylate-group, wherein the polyester polyol is based on at least one organic acid comprising at least two carboxyl groups or its anhydride and at least one polyol comprising at least two hydroxy-groups, wherein the reaction product has a glass transition temperature Tg of below 23° C., wherein the composition optionally further comprises a photoinitiator, as a photopolymerisable material in.
Type:
Application
Filed:
December 4, 2020
Publication date:
December 22, 2022
Applicant:
Evonik Operations GmbH
Inventors:
David Bléger, Peter Altenbuchner, Emmanouil Spyrou, Thomas Pastor, Marie-Theres Wilkes, Odo Wunnicke, Benjamin Willy, Maik Dimmerling, Kim Bühning, Christiane Zatocil, Elke Gollan