Abstract: The NSAID, sulindac and/or its metabolites and derivatives, in combination with hydrogen peroxide or another oxidizing agent, such as arsenic trioxide that generates reactive oxygen species (ROS), significantly enhances the killing of cancer cells. This effect occurs at concentrations of each compound that individually have little or no activity directed against cancer cells. A skin cream has been developed and used to treat skin cancer and precancerous skin growths that effectively removes the lesions with no effect on surrounding normal skin.

Abstract: The present invention relates to systems and methods for processing acoustic signals, such as music and speech. The method involves nonlinear frequency analysis of an incoming acoustic signal. In one aspect, a network of nonlinear oscillators, each with a distinct frequency, is applied to process the signal. The frequency, amplitude, and phase of each signal component are identified. In addition, nonlinearities in the network recover components that are not present or not fully resolvable in the input signal. In another aspect, a modification of the nonlinear oscillator network is used to track changing frequency components of an input signal.

Abstract: An enzyme having diterpene cyclase activity has been purified from P. elisabethae using a series of chromatography steps. The purified enzyme has an apparent molecular weight of about 47 kilodaltons and an isoelectric point of about 5.1. The purifed enzyme catalyzed the cyclization of geranyl geranyl diphosphate to elisabethatriene.

Abstract: A composition and method for the preparation of micro-particles of chitin (a naturally occurring polymer of N-acetyl-D-glucosamine), the characterization of chitin micro-particles as an immune adjuvant and the use of chitin micro-particles to enhance protective immunity against intracellular infectious agents and diseases as well as to inhibit allergic responses and diseases.

Abstract: A system for authenticating access to a data processing device or database is provided. The system includes a comparison module for comparing an attempt identifier with an account identifier, and a state-determining module for determining a state variable associated with at least one of the attempt identifier and the account identifier. The state-determining module determines the state variable by incrementing the state variable if the attempt identifier does not match the account identifier and if the state variable is less than a predetermined upper bound threshold, decrementing the state variable if the attempt identifier does match the account identifier and if the state variable is greater than a predetermined lower bound threshold, and authenticating the attempt identifier if the attempt identifier does match the account identifier and if the state variable equals the predetermined lower bound threshold.

Abstract: A method for producing electronic video signals representative of color images of a scene, includes the following steps: providing a sensor having a color filter thereover; providing a motion picture film camera type of lens system that focuses light from the image onto the color filter and sensor; and producing electronic video signals from the output of the sensor; the sensor including a sensor array having alternate lines offset by half a pixel spacing, and diagonally coupled pixels on successive lines, and the color filter having repeating R, G, and B patterns offset on successive lines so that R pixels are arranged diagonally, G pixels are arranged diagonally, and B pixels are arranged diagonally.

Abstract: A method is disclosed for producing progressive scan signals representative of an image of a scene, including the following steps: providing an image sensor onto which the image is projected, the image sensor having a diagonal pixel pattern; producing frame pairs as follows: during one frame of a frame pair, outputting pixel values alternately from successive adjacent line pairs of the sensor, starting at an odd numbered line, and, during the other frame of a frame pair, outputting pixel values alternately from successive adjacent line pairs of the sensor, starting at an even numbered line.

Abstract: The invention provides small molecules that act as catalytic antioxidants and methods of use thereof. The compounds can repeatedly bind and destroy reactive oxygen species by serving as substates for enzymes of the methionine sulfoxide reductase (Msr) class. Some embodiments of the catalytic antioxidant compounds are derived from drugs with anti-inflammatory activity due to inhibition of cyclooxygenase enzymes.

Abstract: A method for producing electronic video signals representative of a focused moveable image includs the following steps: providing a charge coupled device, masking substantially less than half of the lines of the device to form a masked storage area and a substantially larger unmasked sensing area; disposing the sensing area in the path of the image; providing a shutter for periodically blocking the image from the sensing area; and providing clocking signals to the device to shift sensed lines of the image from the sensing area to the storage area and to clock image representative electronic video signals out of the device.

Abstract: The invention provides small molecules that act as catalytic antioxidants and methods of use thereof. The compounds can repeatedly bind and destroy reactive oxygen species by serving as substates for enzymes of the methionine sulfoxide reductase (Msr) class. Some embodiments of the catalytic antioxidant compounds are derived from drugs with anti-inflammatory activity due to inhibition of cyclooxygenase enzymes.

Abstract: The NSAID, sulindac and/or its metabolites and derivatives, in combination with hydrogen peroxide or another oxidizing agent, such as arsenic trioxide that generates reactive oxygen species (ROS), significantly enhances the killing of cancer cells. This effect occurs at concentrations of each compound that individually have little or no activity directed against cancer cells. A skin cream has been developed and used to treat skin cancer and precancerous skin growths that effectively removes the lesions with no effect on surrounding normal skin.

Abstract: A method for producing electronic signals representative of images on a source film includes the following steps: illuminating the film with a light source to obtain an illuminated frame; providing an electronic image sensor; providing a lens array for projecting the illuminated frame on the electronic image sensor, and providing an aperture in conjunction with the lens array for high spatial frequency cutoff in the image; and reading out image representative electronic signals from the electronic image sensor.

Abstract: A system for transcoding a video file is provided. The system includes a video file decoder for generating an uncompressed file segment based upon a received compressed video file compressed according to a first data compression standard. The system additionally includes one or more macroblock (MB) determining modules for determining an MB mode based upon coefficients generated by the decoding of the compressed video file. The system further includes a video file encoder for compressing the uncompressed file segment according to a second data compression standard based on the determined MB mode.

Abstract: A technique for producing electronic video signals representative of color images of a scene includes use of a regular CCD for the color channel and a back-thinned CCD for a luminance channel; a technique for deriving blue and reconstructing full resolution R, G, B from full resolution white and a red and green checkerboard pattern; and a technique for deriving an automatic gain control signal using an unshielded white area on the CCD to obtain a white reference.

Abstract: A high speed scalable multiplier. The high speed scalable multiplier can include a folding multiplier configured to fold multiplicands and multipliers where individual ones of the multiplicands and multipliers exceed a folding threshold. The folding multiplier also can compute a product of the multiplicands and multipliers based on less than all bits forming the multiplicands and multipliers. The high speed scalable multiplier also can include a conventional multiplier and at least one additional folding multiplier, each of the multipliers being individually, selectably activatable.

Abstract: Methods for treating, preventing, or inhibiting diseases and disorders associated with inflammation, cell-proliferation, and pain comprising the administration of a compound having the structural formula wherein R1 is a hydrogen, alkyl, aryl, hydroxyalkyl, cycloalkyl, cycloalkenyl, carboxylic acid, alkylamino or amide group having from 2 to 20 carbon atoms, R2, R3, and R4 are each independently hydrogen or an acyl residue having from 1 to 6 carbon atoms, R5 is hydrogen, CH3, or CH2OH, and R6 is an organo group such as a hydrocarbon having from 1 to 10 carbon atoms are disclosed. Other seco-pseudopterosins and compounds related to pseudopterosins are disclosed.

Abstract: A photovoltaic powering system is provided that includes a movable platform connected to a self-propelled vehicle. An array of one or more photovoltaic cells is carried by the movable platform. A platform movement mechanism carried by the vehicle moves the movable platform. A platform alignment module carried by the vehicle and connected to the platform movement mechanism causes the photovoltaic cells to be aligned relative to ambient sunlight. The one or more photovoltaic cells converts ambient sunlight to energy that is supplied to a battery carried by the vehicle to thereby recharge the battery if a charge associated with the battery is less than a predetermined threshold.

Abstract: Methods and systems are disclosed for displaying images represented by image-representative video signals. In one embodiment, an apparatus is provided for displaying images represented by image-representative input signals, including: rows of micro light sources, such as microlasers or LEDs for producing sheets of light; a diffractive panel, in the path of the sheets of light, which receives the input signals and diffracts the sheets of light to obtain diffracted light imparted with image-representative information; and a Schleiren optical system for processing the diffracted light to produce images represented by the image-representative input signals.

Abstract: Isolation, synthesis and therapeutic use of compounds and related compositions based on a new class of conopeptides comprising the modified amino acid ?-hydroxyvaline (Hyv=V*). These isolated peptides are the first known example of a naturally occurring polypeptide chain containing Hyv. The active peptides, termed ?-Hydroxyconophans are heavily hydroxylated small peptides. These peptides contain a definitive structural motif which is a double modification of the polypeptide chain (?-OH-Hyv-D-Trp).

Abstract: An epinephrine auto-injector that is constructed and arranged to reduce the likelihood of accidental discharge of the injector The epinephrine injector may also be constructed and arranged to be safer to use and/or dispose of after use. As such, the present invention provides a epinephrine injector that may include a locking mechanism, an actuation mechanism, or both, to help prevent the accidental discharge of the injector. In addition, the epinephrine injector may include a two-part housing and may include means for covering the needle after the epinephrine injector has been used to help dispose of the epinephrine injector after use.