Abstract: Methods and compositions for inhibiting tumorigenicity both in vitro and in vivo in a subject in need thereof, comprising administering an effective amount of an anti-miR-494 nucleic acid construct sufficient to target one or more tumor suppressor genes (TSGs) are described. Activation of the ERK1/2 pathway is a major determinant of diverse cellular processes and cancer development and is responsible for the transcription of several important miRNAs. Described herein is a link between the ERK1/2 pathway and BIM expression through miR-494. This ERK1/2 pathway regulates apoptosis and cell proliferation through miR-494 and mechanisms responsible for TRAIL resistance. Materials and methods related to the study and treatment of cancer are described.

Abstract: Provided is a microbial fuel cell (MFC). The MFC includes a microfluidic element having an inlet portion and an outlet portion for intake and discharge of a culture fluid containing cells and a microchannel portion for capturing the cells and interconnecting the inlet portion and the outlet portion, a microprobe-array element having microprobes as anodes for extracting electrons produced during a metabolic process of the cells, and delivering the extracted electrons to an external circuit outside the cells, and a cathode for delivering the electrons used in the external circuit to an electron acceptor outside the cells. The microprobes penetrate the microfluidic element and are inserted into a plurality of single cells captured by the microchannel portion when the microfluidic element and the microprobe-array element are coupled together. The microprobes are separated from the single cells when the microfluidic element and the microprobe-array element are separated from each other.

Abstract: A drum brake is provided that improves the direction of the actuating forces to reduce stress, improve efficiency and permit thicker brake linings. First and second brake shoes each have a first end pivotally coupled to a brake spider. First and second cam followers are disposed at corresponding second ends of the brake shoes. A cam engages the cam followers with movement of the cam causing the brake shoes to move between positions of engagement and disengagement with a braking surface. The cam followers are offset such that a center of the first cam follower is disposed at a first distance from a center axis of the brake and a center of the second cam follower is disposed at a second distance from the center axis with the first distance different from the second distance so as to improve the direction of the cam force vector.

Abstract: The invention provides novel compounds of formula I: that are opioid receptor ligands. The invention also provides pharmaceutical compositions comprising such compounds as well as methods for treating diseases associated with opioid receptor function by administering such compounds to a mammal in need of treatment. Compounds of the invention are useful to modulate (e.g. agonize or antagonize) opioid receptor function.

Abstract: This document provides methods and materials for treating diabetes and/or liver steatosis. For example, methods for using compositions containing a potato polysaccharide preparation to reduce one or more symptoms of diabetes or liver steatosis are provided. In some cases, a composition containing a potato polysaccharide preparation provided herein can be used to treat fatty liver disease.

Abstract: Disclosed is a method of capturing carbon dioxide using a hydrazine derivative.

Abstract: This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding synthetic peptidoglycan where the collagen-binding synthetic peptidoglycan can be aberrant or can have amino acid homology with a portion of the amino acid sequence of a protein or a proteoglycan that regulates collagen fibrillogenesis. The invention also relates to kits, compounds, compositions, and engineered graft constructs comprising such collagen-binding synthetic peptidoglycans or engineered collagen matrices and methods for their preparation and use.

Abstract: In some aspects, methods are provided for the treatment of mantle cell lymphoma (MCL) in a patient comprising administering a therapeutically relevant or effective amount of avicin D to the patient.

Abstract: Organic dyes that are covalently bonded multimers or higher order symmetrical structures where one or more dye units may optionally contain deuterium substitutions are disclosed. The disclosed dyes are particularly useful for optical coatings, new optical nanomaterials, high density storage devices. The structural and optical characteristics of the disclosed dyes provide avenues for increased information-content through surface-enhanced Raman resonance spectroscopy.

Abstract: An injection locked frequency divider is disclosed. The injection-locked frequency divider includes a sub-harmonic injection-locked oscillator, a reference clock divider, a counter, and a variable load resistor control unit. The sub-harmonic injection-locked oscillator has variable load resistors that are adjusted in response to a resistance adjustment signal, and, when oscillation frequency determined based on the magnitudes of the variable load resistors is a sub-harmonic of an injection signal, outputs signals having the oscillation frequency as divided output signals. The reference clock divider generates a count-enable signal from a reference clock signal according to a reference division ratio. The counter generates divided output count signals based on the divided output signals in response to the count-enable signal.

Abstract: Various methods and systems are provided for adaptive background estimation. In one embodiment, among others, a signal processing device includes at least one processing unit and a memory storing a background estimation system executable in the at least one processing unit. The background estimation system, when executed, causes the signal processing device to separate foreground objects from at least one image frame in a sequence of image frames based at least in part upon a correntropy cost function. In another embodiment, a method includes obtaining an image frame from a sequence of image frames; performing correntropy filtering on the image frame to separate foreground objects from the image frame; and providing the foreground objects for rendering. The correntropy filtering may adapt to compensate for diffusion effects in the image frame.

Abstract: A substituted phenol compound represented by Formula I: or a pharmaceutically acceptable salt or prodrug thereof. At least one of X and Y is CH, and the other one of X and Y is N or CH. R1 is C1-C4 alkyl or C1-C4 haloalkyl. R2 is C1-C4 alkyl, or halogen. R3 is H, C1-C4 alkyl, aryl, or —(CH2)n-aryl, in which n is 1, 2, or 3. The compound is useful as anticonvulsant.

Abstract: In one embodiment, a therapy apparatus includes a support, a body harness mounted to the body support, a gearbox positioned below the harness, the gearbox comprising at least one gear and supporting a crankshaft, crankarms mounted to the crankshaft, and pedals mounted to the crankarms, a driveshaft coupled to the at least one gear such that rotation of the driveshaft results in rotation of the crankshaft, crankarms, and pedals, and a motor that drives the driveshaft, wherein the apparatus is adapted to support part of the weight of an subject with the harness and part of the weight of the subject with the pedals and wherein rotation of the pedals due to operation of the motor provides therapy to the subject.

Abstract: An apparatus and a method for feeding a channel back in a wireless communication system using multiple input multiple output antennas (MIMO) are provided. The method includes receiving a signal from a transmitter and configuring a channel matrix for the received signal, configuring a basis transformed sparse channel using a sparsifying basis function with respect to the channel matrix, selecting a channel part to be fed back to the transmitter from the transformed sparse channel, and creating a codebook by quantizing the selected channel part, and feeding a codebook index corresponding to the created codebook back to the transmitter.

Abstract: The invention provides novel substituted pyridopyrimidines represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of the phosphoinositide 3? OH kinase family (PI3K) for the treatment of inflammatory diseases, cancer, cardiovascular diseases, allergy, asthma and autoimmune disorders.

Abstract: Air-stable coated particles, which include an oxidizable core having a coating substantially encompassing the oxidizable core, where the coating comprises a first organic ligand and/or a second organic ligand, are disclosed and described. The coated particles can also be substantially free of an oxide layer, especially oxide layers around the oxidizable core. As such, the coating of organic ligand(s) acts as a protective or passivating coating. The air-stable coated particles can be formed via a particle size-reduction process. An oxidizable particulate can be crushed and contacted with a first organic ligand and subsequently with a second organic ligand. The process conditions are maintained such that an oxide layer is preempted from forming on the oxidizable core. Such materials can be effective as high energy density additives for various fuels, pyrotechnic, ionic liquids, and rocket propellant applications and for biomedical applications.

Abstract: A system and methods for controlling superconducting quantum circuits are provided. The system includes at least one superconducting quantum circuit described by multiple quantum states, and at least one single flux quantum (“SFQ”) control circuit configured to generate a voltage pulse sequence that includes a plurality of voltage pulses temporally separated by a pulse-to-pulse spacing timed to a resonance period. The system also includes at least one coupling between the at least one superconducting quantum circuit and the at least one SFQ control circuit configured to transmit the voltage pulse sequence generated using the SFQ control circuit to the at least one superconducting quantum circuit. In some aspects, the system further includes a controller system configured to optimize the pulse-to-pulse spacing to minimize a gate infidelity due to at least one of a timing error, a timing jitter and a weak qubit anharmonicity.

Abstract: Light-emitting devices having a multiple quantum well (MQW) pin diode structure and methods of making and using the devices are provided. The devices are composed of multilayered semiconductor heterostructures. The devices include one or more interfacial layers of a material that allows current tunneling through lattice mismatched heterogeneous junctions at the interfaces between the intrinsic active region and the p-type and/or n-type doped charge injection layers.

Abstract: High density films of semiconducting single-walled carbon nanotubes having a high degree of nanotube alignment are provided. Also provided are methods of making the films and field effect transistors (FETs) that incorporate the films as conducting channel materials. The single-walled carbon nanotubes are deposited from a thin layer of organic solvent containing solubilized single-walled carbon nanotubes that is continuously supplied to the surface of an aqueous medium, inducing evaporative self-assembly upon contacting a solid substrate.

Abstract: A combination capacitor and inductor employ a common volume for energy-storing electrical and magnetic fields thereby reducing the bulk of these components with respect to separate components of comparable value.