Abstract: Various examples are provided for tube nozzle electrospinning. In one example, among others, is a system including a nozzle tube with an array of nozzles configured to produce a plurality of electrospun nanofibers and a positioning stage configured to control deposition of the plurality of electrospun nanofibers on a substrate to form a layer of nanofibers. Another example is a method including generating a plurality of electrospun nanofibers from an array of nozzles positioned over a substrate and controlling movement of the substrate to form a layer of electrospun nanofibers.

Abstract: A system and optimization algorithm for determining the preferred operational wavelengths of a device configured for measurement of molecular analytes in a sample. Operational wavelengths are determined by solving a system of equations linking empirically defined functions representative of these analytes, spectrally dependent coefficients corresponding to these analytes, path lengths traversed by waves probing the analytes at wavelengths corresponding to the absorption level described by the functions representative of these analytes, and, optionally, a cost-function taking into account at least one of spectral separation between the operational wavelengths, manufacturability of wave source(s) producing wave(s) at operational wavelength(s), and the noise factor associated with the operation of such wave source(s).

Abstract: Methods, compositions, and systems for detecting gamma radiation is disclosed and described. A compound for detecting gamma radiation can comprise a conjugated imidazole having the following structure: [Formula I] where at least one of R1, R2, and R3 are conjugated organic groups. Additionally, the conjugated imidazole can be capable of reacting with a radical or ion formed by the reaction of gamma radiation with a radical generating component such as a halogen solvent to decrease a molar extinction coefficient of the conjugated imidazole in the visible light region or to quench fluorescence of the conjugated imidazole. As a sensor (100), a radiation detection indicator (108) can indicate the change in molar extinction coefficient or fluorescence of the conjugated imidazole material (120) upon exposure to gamma radiation.

Abstract: Lipid nanoparticle formulations, methods of making, and methods of using same are disclosed.

Abstract: Disclosed is a composition immunologically targeted to Alzheimer's disease (AD), the composition containing amine functionalized nanoparticles of Cerium oxide coated with polyethylene glycol and bearing an antibody specific for an amyloid-beta antigen associated with AD. The invention also includes a medication manufactured with the targeted nanoceria particles and methods of treatment by administering the targeted nanoceria particles to patients in need thereof.

Abstract: The present invention relates to a method of preventing or treating a disease caused by bacterial infection by administering an effective amount of a modulator of bacterial adenylyl cyclase. The invention also provides pharmaceutical compositions useful for preventing or treating a disease, with the compositions containing a therapeutically effective amount of a modulator of bacterial adenylyl cyclase. The invention also provides screening methods for identifying selective modulators of bacterial adenylyl cyclase that do not substantially modulate adenylyl cyclase of the subject. The invention also provides methods for culturing bacterial pathogens and methods for inducing the pathogenic state in vitro.

Abstract: A method for nucleic acid analysis including injecting a slight amount of nucleic acid sample for analysis, characterized in that most of a nucleic acid sample which is not used, excluding the slight amount of the nucleic acid sample which is used for analysis, can be obtained as a pure product which is not contaminated with a fluorescent material, and a microchip for analyzing nucleic acid which enables such method for nucleic acid analysis, are provided. The method for nucleic acid analysis may analyze at least two different nucleic acid samples in a continuous manner by sequentially injecting the at least two different nucleic acid samples.

Abstract: Disclosed is a software-defined radio terminal device of the present invention.

Abstract: A system and method for quantitative determination of density of vasa vasorum in an arterial wall that utilizes a detection of temporal and/or spatial displacement of blood-flow with the use of intravascular ultrasound system. Locations of extrema in the spatial distribution can be identified to detect vascular defects. The system and method support a clinically-useful application for early detection of indicators of diseases, such as coronary atherosclerosis.

Abstract: A method of manufacturing a thermal interface material, comprising providing a sheet comprising nano-scale fibers, the sheet having at least one exposed surface; and stabilizing the fibers with a stabilizing material disposed in at least a portion of a void space between the fibers in the sheet. The fibers may be CNT's or metallic nano-wires. Stabilizing may include infiltrating the fibers with a polymerizable material. The polymerizable material may be mixed with nano- or micro-particles. The composite system may include two films, with the fibers in between, to create a sandwich. Each capping film may include two sub films: a palladium film closer to the stabilizing material to improve adhesion; and a nano-particle film for contact with a device to be cooled or a heat sink.

Abstract: A method for reconstructing an image of an object that includes a plurality of image elements. The method includes accessing image data associated with a plurality of image elements, and reconstructing an image of the object by optimizing an objective function, where the objective function is optimized by iteratively solving a nested sequence of approximate optimization problems. The algorithm is composed of nested iterative loops, in which an inner loop iteratively optimizes an objective function approximating the outer loop objective function, and an outer loop that utilizes the solution of the inner loop to optimize the original objective function.

Abstract: This document discusses, among other things, systems and methods for determining volume of activation for deep brain stimulation (“DBS”) using a finite element model (FEM) circuit to determine a FEM of an implanted electrode and a tissue medium in which the electrode is implanted, a Fourier FEM solver circuit to calculate a potential distribution in the tissue medium using information from the FEM circuit and a capacitive component of at least one of the implanted electrode and the tissue medium, and a volume of activation (VOA) circuit to predict a VOA using the potential distribution and a neuron model.

Abstract: Provided are serum-free culture media which comprise basic fibroblast growth factor (bFGF), transforming growth factor beta-3, ascorbic acid, xeno-free serum replacement and a lipid mixture. The media may also comprise an IL6R/IL6 chimera, or leukemia inhibitory factor (LIF); wherein the culture medium is capable of maintaining pluripotent stem cells in an undifferentiated state in the absence of feeder cell support. Also provided are cell cultures comprising pluripotent stem cells such as human embryonic stem cells and induced pluripotent stem (iPS) cells, and methods of using the same for expanding pluripotent stem cells in an undifferentiated state using two-dimensional or three-dimensional culture systems. Methods of expanding iPS cells in a suspension culture devoid of substrate adherence and cell encapsulation are also provided.

Abstract: In a method of detecting a specific object using a multi-dimensional image including the specific object, with respect to each window slide of the image subjected to window sliding by applying a previously generated 3D cube filter, data of an area corresponding to the window sliding is normalized in a previously defined specific form. After the corresponding part of the normalized data is assigned to each cell in the 3D cube filter, a volume of the cell is then calculated, thereby expressing the volumes of the cells as one volumetric feature vector having a volumetric feature. The volumetric feature vector is applied to a classifier so as to decide whether or not the data of the area corresponding to the window slide corresponds to the specific object.

Abstract: A mobile terminal capable of localization, a localization server, and a method for localizing the mobile terminal using the localization server are disclosed. The disclosed localization server includes a control unit configured to control transmissions of visible-light signals from a multiple number of visible-light transmitting devices; and a position computing unit configured to compute a position of a mobile terminal based on time information regarding when the visible-light signals transmitted respectively from the plurality of visible-light transmitting devices were received at the mobile terminal, where the control unit controls the transmissions such that each of the plurality of visible-light transmitting devices sequentially transmits the visible-light signal for a particular first time period with no overlapping of transmission times of the visible-light signals transmitted respectively from the plurality of visible-light transmitting devices.

Abstract: An acceleration-triggered or shock-triggered, smart, tunable MEMS switch that may function as both a classic accelerometer and an acceleration threshold detector. A parallel element MEMS device has a stationary and a movable element forming a capacitor. Varying acceleration moves the movable member with respect to the stationary member, thereby changing the capacitance of the device. The capacitance varying may be used, in cooperation with appropriate circuitry, to provide a signal representative of instantaneous acceleration. By applying a biasing voltage, the movable element may be positioned in a predetermined fashion such that acceleration of a predetermined magnitude causes the movable element to pull in (snap down). The movable and stationary elements may function as a switch such that when the predetermined acceleration or shock level occurs, electrodes close, a current flows between the elements so that an external device such as an air bag may be activated.

Abstract: Disclosed herein is an article that includes a first plurality of spaced features. The spaced features are arranged in a plurality of groupings; the groupings of features include repeat units; the spaced features within a grouping are spaced apart at an average distance of about 1 nanometer to about 500 micrometers; each feature having a surface that is substantially parallel to a surface on a neighboring feature; each feature being separated from its neighboring feature; the groupings of features being arranged with respect to one another so as to define a tortuous pathway. The plurality of spaced features provide the article with an engineered roughness index of about 5 to about 20.

Abstract: The present disclosure demonstrates for the first time that Th-17 cells are the product of a distinct CD4+ T cell lineage with unique developmental and functional characteristics. The developmental signals required for Th-17 commitment and development are also described. As a result, the teachings of the present disclosure provide a basis for understanding the developmental pathway of Th-17 cells and offer novel avenues to modulate (stimulate or inhibit) this developmental program and offer new methods for the treatment and prevention of disease states and conditions related to aberrant activity of Th-17 cells.

Abstract: The present invention relates to an anti-tenascin C peptide aptamer having a specific amino acid sequence and a diagnosis kit comprising it. The anti-tenascin C peptide aptamer of the instant invention shows a predominant clearance rate due to its small molecular weight as well as specific binding affinity to tenascin C, having excellent advantages in in vivo or ex vivo tumor imaging.

Abstract: A pecan tree distinguished by the following unique combination of characteristics: Consistent and acceptable fruit production, small fruit cluster, moderately early nut maturity, large nut producing mammoth kernels with good color and no observed speckling, and no observed scab fungus.