Abstract: The present invention relates to a method of producing a heterologous protein or polypeptide having phytase activity in a yeast system. The invention also provides proteins having phytase activity which have increased thermostability. Yeast strains which produce a heterologous phytase and the vectors used to produce the phytase are also provided.

Abstract: A graphene sheet and a method of manufacturing the graphene sheet are provided. The method includes: growing a graphene sheet on a graphene growth support by applying carbon sources and heat to the graphene growth support, the graphene growth support including a carbonization catalyst; and forming at least one ripple on the graphene sheet by cooling at least one of the graphene growth support and the graphene sheet, wherein the graphene growth support and the graphene sheet have different thermal expansion coefficients.

Abstract: A process for quenching, separating and collecting targeted components of a hot pyrolysis product stream from the pyrolysis of biomass is provided. The process utilizes sequential steps of rapid quenching and electrostatic precipitation comprising injecting a coolant comprising at least one of nitrogen, a noble gas and mixtures thereof into a hot pyrolysis vapor to selectively condense a first fraction of components from the hot pyrolysis vapor at a first predetermined temperature which is then collected by electrostatic precipitation in a first electrostatic precipitator at about the first predetermined temperature, where a wall temperature of the first electrostatic precipitator is maintained slightly higher than the first predetermined temperature. The sequential steps of coolant injection and collection are repeated at progressively cooler temperatures in order to selectively collect one or more fractions of the hot mixture.

Abstract: A system (100) and method for creating three dimensional images using probe molecules is disclosed and described. A sample is mounted on a stage (160). The sample has a plurality of probe molecules. The sample is illuminated with light, causing the probe molecules to luminesce. The probe luminescence can be split into at least four paths corresponding to at least four detection planes corresponding to object planes in the sample. The at least four detection planes are detected via a camera (155). Object planes in corresponding recorded regions of interest are recorded in the camera (155). A signal from the regions of interest is combined into a three dimensional image.

Abstract: A device, a computer readable medium and a method that may include performing a shortened read attempt of multiple data memory cells that store data to provide an estimate of the data; wherein the shortened read attempt has a duration that is shorter than a duration of a full read attempt; performing a shortened read attempt of redundant memory cells that store redundant information to provide an estimate of the redundant information; wherein the estimate of the redundant information is indicative of an expected number of data memory cells that store a certain logic value; determining, based on the estimate of the data, an estimated number of data memory cells that store the certain logic value; comparing the expected number to the estimated number; and providing the estimate of the data as a read result if the expected number and the estimated number equal each other.

Abstract: Methods of using portions of the N-terminal domain of prion protein for binding hemin are disclosed. In a particular embodiment, a method comprises administering at least one isolated amino acid sequence comprising a peptide from the octarepeat region of PrPC to a solution containing hemin, wherein the isolated amino acid sequence is effective for forming one or more chemical bonds with hemin.

Abstract: A medical garment formed of a central body region and two side regions with a pair of belts and a pair of fasteners for securing the garment around a patient's body is provided. The central body region may be worn on the back or front and may have a v-neck form. A waistband extends across the central body region and across one side region with a first belt secured at the junction of the central region and the second side region and extending to the outer edge of the first side region. The second belt extends from the secured end of the first belt through the waistband across the central body region, the second belt exiting the waistband at the junction of the second side region and central body region. A first fixed tie is positioned at the outer edge of the second side region along the position of the waistband. A second fixed tie is secured to the inside of the waistband between the central body region and first side region.

Abstract: Methods of isolating weakly interacting molecules in a fluidic sample using an immiscible phase filtration technique are disclosed. A complex is formed between a solid phase substrate, a molecule immobilized on the solid phase substrate, and at least one target molecule present in the fluidic sample. The complex is transferred into an immiscible phase by applying an external force to the solid phase substrate. The methods eliminate the need for complex and time consuming washing steps.

Abstract: A method to evaluate, determine and optimize production parameters for a coating application of a UV cationic polymerizable coating system to a substrate is provided. The method is based on a simulation model which includes both shadow and dark cure processes. Both of an active center generation process and the active center diffusion process are mathematically described. In the model, the two processes are considered separately since they are driven by different fundamental phenomena and occur on different timescales. Evaluation or prediction of the effect of process variables on the curing of a cationic coating of a complex substrate according to the described method allows characterization and understanding of process variables which may save set-up costs and improve production efficiency.

Abstract: There are provided a gamma ray detecting apparatus, including: a secondary electron emitter causing a Compton scattering reaction with an incident gamma ray to emit secondary electrons in a progress direction of the gamma ray; a first radiation detector provided to be opposed to the secondary electron emitter with respect to an emission progress direction of the secondary electrons and detecting the position and transfer energy of the secondary electron; a second radiation detector provided to be opposed to the first radiation detector with respect to the emission progress direction of the secondary electron and detecting the position and the transfer energy of the secondary electron passing through the first radiation detector; a third radiation detector provided to be opposed to the second radiation detector with respect to the emission progress direction of the secondary electron and detecting residual energy of the secondary electron by absorbing the secondary electron passing through the second radiation

Abstract: The electrode array is a device for making electrical contacts with cellular tissue or organs. The electrode array includes an assembly of electrically conductive electrodes arising from a substrate where the electrodes are hermetically bonded to the substrate. A method of manufacture of an electrode array and associated circuitry is disclosed where the braze preform tab disappears during the braze bonding process and is completely drawn into the substrate feedthrough holes such that the braze perform tab is completely involved in the braze joint and is no longer connecting the adjacent electrodes.

Abstract: A system capable of providing directional cues to a user of the vehicle comprises a vehicle component, configured to be installed within a vehicle that is adapted to be controlled by a user. A tactile display system is operably coupled to the vehicle component. The tactile display system includes: a contact pad, operable to engage a target area of a user's skin; a restraining system, operable to restrain a portion of the user's skin distal from the target area of the skin; and an actuation system, operably coupled to one of: i) the contact pad and the ii) restraining system. The actuation system is capable of moving the contact pad and the restraining system relative to one another to apply a tangential displacement or shear force across the target area of the user's skin to thereby provide tactile information to the user.

Abstract: An apparatus for processing an audio signal and method thereof are disclosed. The present invention includes receiving, by an audio processing apparatus, an audio signal including a first data of a first block encoded with rectangular coding scheme and a second data of a second block encoded with non-rectangular coding scheme; receiving a compensation signal corresponding to the second block; estimating a prediction of an aliasing part using the first data; and, obtaining a reconstructed signal for the second block based on the second data, the compensation signal and the prediction of aliasing part.

Abstract: Relational clustering has attracted more and more attention due to its phenomenal impact in various important applications which involve multi-type interrelated data objects, such as Web mining, search marketing, bioinformatics, citation analysis, and epidemiology. A probabilistic model is presented for relational clustering, which also provides a principal framework to unify various important clustering tasks including traditional attributes-based clustering, semi-supervised clustering, co-clustering and graph clustering. The model seeks to identify cluster structures for each type of data objects and interaction patterns between different types of objects. Under this model, parametric hard and soft relational clustering algorithms are provided under a large number of exponential family distributions.

Abstract: The present invention relates to animal food products and methods of producing thereof. The methods of the present invention comprise mixing a binding agent with feed meal at a temperature of between about 10° C. and about 70° C. to produce a mash, passing the mash through an extruder to form an animal feed product, and drying the animal feed product. In certain embodiments, the temperature of the meal, mash and final product is kept at 70° C. or below.

Abstract: An achievable sum data rate with respect to each of available candidate transmission/reception modes may be calculated to select a transmission/reception mode of transmission/reception pairs repeatedly using radio resources. A transmission/reception mode to be applied may be selected from the candidate transmission/reception modes based on the calculated sum data rate. Information associated with the selected transmission/reception mode may be shared by the transmission/reception pairs.

Abstract: A system for automatic segmentation of tumor tissue, useful for motion correction during radiotherapy using real-time imaging, identifies multiple regions based on the values of data and then identifies the tumors within the regions based on a priori knowledge about tumor size and/or location. The regions may be refined with robust and fast morphological operations, providing segmentation at speeds commensurate with the motion to be corrected.

Abstract: An apparatus for providing a reference indication to a patient tissue includes a primary locating block having a patient-specific primary mating surface contoured for mating contact with a portion of the patient tissue in a predetermined primary mating orientation custom-configured responsive to preoperative imaging of the patient tissue. At least one mounting feature is provided to the primary locating block. At least one secondary item is configured for selective engagement with the primary locating block. The secondary item is at least one of a noncustomized secondary item and a patient-specific secondary item. The secondary item provides a reference indication to at least a portion of the patient tissue. The mounting feature of the primary locating block is configured for engagement with at least one secondary item in a predetermined secondary mounting relationship. The secondary mounting relationship is custom-configured for the patient tissue responsive to preoperative imaging of the patient tissue.

Abstract: The invention relates generally to effective treatment leukemia. In particular, the present invention provides compositions and methods to inhibit the interaction of menin with MLL and MLL-fusion oncoproteins, and well as systems and methods to screen for such compositions.