Patents Assigned to Foundation
  • Publication number: 20140005263
    Abstract: This invention provides methods for treatment and inhibition of a male subject having an Androgen Decline in Aging Male (ADAM)-associated condition, for example sexual dysfunction, decreased sexual libido, erectile dysfunction, hypogonadism, sarcopenia, osteopenia, osteoporosis, an alteration in cognition and mood, depression, anemia, hair loss, obesity, muscle loss, dry eye, memory loss, benign prostate hyperplasia and/or prostate cancer, by administering to the subject a selective androgen receptor modulator (SARM) compound and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, pro-drug, polymorph, crystal, or any combination thereof.
    Type: Application
    Filed: May 21, 2013
    Publication date: January 2, 2014
    Applicant: University of Tennessee Research Foundation
    Inventors: James T. Dalton, Duane D. Miller, Donghua Yin, Yali He
  • Publication number: 20140004039
    Abstract: Embodiments of the present disclosure provide for RGD mimetic ?-AApeptide compounds, ?-AApeptide compounds capable of binding an RGD binding site on integrin ?v?3, linear ?-AApeptide compounds, cyclic ?-AApeptide compounds and multimeric RGD mimetic ?-AApeptide compounds, methods of making each, and methods of using each, and the like. In embodiments, the RGD mimetic ?-AApeptide compounds can be used in imaging, diagnostics, and treatment of angiogenesis related conditions.
    Type: Application
    Filed: June 18, 2013
    Publication date: January 2, 2014
    Applicants: Wisconsin Alumni Research Foundation, University of South Florida (A Florida Non-Profit Corporation)
    Inventors: Jianfeng Cai, Youhong Niu, Weibo Cai, Hao Hong
  • Publication number: 20140007293
    Abstract: Disclosed are isolated nucleic acid molecules (inducible promoters) capable of directing expression in plant cell. In some embodiments, the promoters include a nucleic acid sequence set forth as SEQ ID NO: 1 or SEQ ID NO: 2, or a variant thereof. In some embodiments, the promoter is capable of gene expression in plants of an operably linked nucleic acid sequence. Disclosed are transgenic plants or parts thereof, that can include expression cassettes and/or expression vectors, which can be stably incorporated into the genome of the plant. Methods of regulating the expression of a polynucleotide of interest in a plant cell are also disclosed.
    Type: Application
    Filed: March 11, 2013
    Publication date: January 2, 2014
    Applicant: University of Tennessee Research Foundation
    Inventors: C. Neal Stewart, Wusheng Liu, Mitra Mazarei
  • Publication number: 20140005152
    Abstract: Disclosed are methods of administering 2-methylene-19-nor-(20S)-1?,25-dihydroxyvitamin D3 to treat and/or prevent secondary hyperparathyroidism and/or its accompanying symptoms in a subject having or at risk for developing secondary hyperparathyroidism.
    Type: Application
    Filed: March 14, 2013
    Publication date: January 2, 2014
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Lori A. Plum, Julia B. Zella, Wendy Bedale, Margaret Clagett-Dame
  • Publication number: 20140005071
    Abstract: The invention provides methods for diagnosing, treating, or evaluating inflammatory and autoimmune diseases by sampling peripheral blood, serum, plasma, tissue, cerebrospinal fluid, or other bodily fluids from a human subject having a suspected diagnosis. The sample is analyzed for the presence and amount of certain cytokines, which provides the diagnosis, prognosis or evaluation of therapeutic response.
    Type: Application
    Filed: September 3, 2013
    Publication date: January 2, 2014
    Applicants: Oklahoma Medical Research Foundation, The Board of Regents of the University of Oklahoma
    Inventors: Cherie M. Chappell, Michael B. Centola, Philip J. Alex, Kenneth Hensley
  • Publication number: 20140006313
    Abstract: A system and method of aggregating and predicting stock ranking stocks. The novel system and method uses a neighborhood model to aggregate a plurality of “neighboring” or related stocks having similar pricing trends. The system and method then uses a ranking optimization method to predict the ranking of each stock based on percentage change in price. The current invention facilitates investors trading by using a novel methodology to predict stock rankings and providing a neighborhood of related stocks, while having an easy-to-use interface.
    Type: Application
    Filed: September 3, 2013
    Publication date: January 2, 2014
    Applicant: The Florida State University Research Foundation, Inc.
    Inventors: Piyush Kumar, Rajat Raychaudhuri
  • Publication number: 20140003366
    Abstract: Provided are a method and an apparatus for transmitting a signal suitable for an indoor environment. The method for transmitting a signal according to an exemplary embodiment of the present invention includes: preprocessing a signal using a signal power to sidelobe power ratio (SSR) parameter defining a signal to sidelobe ratio to minimize an inter-symbol interference and prevent performance deterioration due to reduction in signal strength; and transmitting the preprocessed signal to a receiving apparatus through a predetermined channel.
    Type: Application
    Filed: May 7, 2013
    Publication date: January 2, 2014
    Applicant: Industry-Academic Cooperation Foundation, Yonsei University
    Inventor: Industry-Academic Cooperation Foundation, Yonsei University
  • Patent number: 8618611
    Abstract: Embodiments of the invention integrate carbon nanotubes on a CMOS substrate using localized heating. An embodiment can allow the CMOS substrate to be in a room-temperature environment during the carbon nanotube growth process. Specific embodiments utilize a maskless post-CMOS microelectromechanical systems (MEMS) process. The post-CMOS MEMS process according to an embodiment of the present invention provides a carbon nanotube growth process that is foundry CMOS compatible. The maskless process, according to an embodiment, eliminates the need for photomasks after the CMOS fabrication and can preserve whatever feature sizes are available in the foundry CMOS process. Embodiments integrate single-walled carbon nanotube devices into a CMOS platform.
    Type: Grant
    Filed: June 16, 2008
    Date of Patent: December 31, 2013
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Huikai Xie, Ant Ural
  • Patent number: 8618072
    Abstract: The present invention relates to a composition comprising a Ninjurin1 expression or activity inhibitor for the prevention and treatment of inflammatory disease. Ninjurin1 protein is specifically expressed in macrophages around blood vessels, increases cell-cell adhesion and cell-matrix adhesion, increases expressions of Wnt7b (Wingless-type MMTV integration site family, member 7B) and Ang2 (angiopoietin-2), but reduces expression of Ang1 to induce apoptosis of vascular endothelial cells. In addition, Ninjurin1 protein is up-regulated when inflammation is induced and induces iNOS expression as well as increased NO generation. Therefore, the Ninjurin1 protein expression or activation inhibitor can be effectively used as an active ingredient of a composition for the prevention and treatment of inflammatory disease.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: December 31, 2013
    Assignee: SNU R&DB Foundation
    Inventors: Kyu-Won Kim, Hyo-Jong Lee, Bum Ju Ahn
  • Patent number: 8617573
    Abstract: It is disclosed here that synaptotagmin I (syt I) and synaptotagmin II (syt II) are the cellular receptors for botulinum neurotoxin B (BoNT/B) that mediate the cellular entry and toxicity of BoNT/B. The BoNT/B binding domains of syt I and II are also disclosed. While syt I needs gangliosides for BoNT/B binding, syt II can bind to BoNT/B in the absence of gangliosides. Various nucleic acids and polypeptides that relate to the BoNT/B binding domain of syt I or II are disclosed. Further disclosed are methods of reducing BoNT/B toxicity, methods of identifying agents that can block the binding between BoNT/B and syt I or II, methods of identifying agents that can bind to the BoNT/B binding domain of syt I or II, methods of detecting BoNT/B or Clostridium botulinum and kits for use thereof.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: December 31, 2013
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Edwin Raymond Chapman, Min Dong
  • Patent number: 8618244
    Abstract: Disclosed herein are a method for preparing a benzoxazole-based polymer by thermal rearrangement, the benzoxazole-based polymer prepared by the method and a gas separation membrane comprising the polymer. More specifically, provided are a method for preparing a benzoxazole-based polymer by subjecting poly(hydroxyamide) as an intermediate to thermal treatment involving dehydration, the benzoxazole-based polymer obtained thereby and gas separation membrane comprising the polymer. The benzoxazole-based polymer of the present invention can be simply prepared by thermally rearrangement via thermal treatment at low temperatures, and thus exhibits superior mechanical and morphological properties and has well-connected microcavities. Due to showing excellent permeability and selectivity for various gases, the benzoxazole-based polymer is suited for application to gas separation membranes, in particular, gas separation membranes for small gases.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: December 31, 2013
    Assignee: Industry-University Cooperation Foundation, Hanyang University
    Inventors: Young Moo Lee, Keun-Young Kim, Chul-Ho Jung, Ho-Bum Park
  • Patent number: 8618271
    Abstract: The present invention relates to an isolated DNA molecule encoding a fagopyritol synthase. A method for producing a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin mediator homologue, or an insulin mediator inhibitor is also described. The method includes providing a fagopyritol synthase, providing a substrate comprising a galactosyl donor and a galactosyl acceptor, and combining the fagopyritol synthase with the substrate under conditions effective produce a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin mediator homologue, or an insulin mediator inhibitor.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: December 31, 2013
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Ralph L. Obendorf, Ueda Takashi
  • Patent number: 8617888
    Abstract: A modified P. aeruginosa type III secretion system has been developed that efficiently delivers selected proteins into a host cell. In one example, a functional nuclear Cre Recombinase is injected into embryonic stem (ES) cells and can be used to induce pluripotent stem (iPS) cells. This method of in vitro lineage directed differentiation prevents insertional mutagenesis and provides a route to selected stem cell renewal and cell-based therapies.
    Type: Grant
    Filed: July 23, 2010
    Date of Patent: December 31, 2013
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Shouguang Jin, Candace Bichsel
  • Patent number: 8620409
    Abstract: A system and method for confocal imaging of tissue in vivo and in situ, e.g., for minimally invasive diagnosis of patients. A catheter is provided that has a dye carrier coupled to the distal end of a fiber optics bundle, which allows for the introduction of at least one fluorescent dye therein the dye carrier into a portion of the tissue of interest of a subject or patient when the dye carrier is selectively brought into contact with the portion of the tissue of interest. The resulting confocal images permit the acquisition of diagnostic information on the progression of diseases at cellular/tissue level in patients. Furthermore, a system for ECG-triggered image acquisition is provided.
    Type: Grant
    Filed: August 4, 2009
    Date of Patent: December 31, 2013
    Assignee: University of Utah Research Foundation
    Inventors: Frank B. Sachse, John H. Bridge, Robert Hitchcock
  • Patent number: 8617307
    Abstract: The present invention relates to an alkali-activated binder which can be used as a binder for replacing cement, and more particularly, to an alkali-activated binder, and to mortar, concrete, concrete products, and wet loess paving material comprising the binder, in which inorganic sodium-free alkaline materials are contained to reduce the total amount of Na2O and K2O in concrete, thus improving the workability and the strength stability and inhibiting the alkali-aggregate reaction.
    Type: Grant
    Filed: January 29, 2010
    Date of Patent: December 31, 2013
    Assignee: Industry Foundation of Chonnam National University
    Inventors: Jin Kyu Song, Keun Hyeok Yang
  • Patent number: 8619766
    Abstract: A method and apparatus for classifying packets, e.g., at wire speed are disclosed. The method receives a packet and processes the packet through a hardware-based packet classifier having at least one evolving rule. The method then processes the packet through a software-based packet classifier if the hardware-based packet classifier is unable to classify the packet. In one embodiment, the at least one evolving rule is continuously modified in accordance with learned traffic characteristics of the received packets.
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: December 31, 2013
    Assignees: AT&T Intellectual Property II, L.P., Wisconsin Alumni Research Foundation
    Inventors: Jia Wang, Suman Banerjee, Qunfeng Dong
  • Patent number: 8618972
    Abstract: There are provided an analog-to-digital signal conversion method and apparatus therefor, and a digital phase locked loop circuit including the same. The analog-to-digital signal conversion method may include: generating a first digital output signal having N number of bits by comparing each of N number of delay signals detected from output terminals of N number of delay cells with a reference signal; generating a second digital output signal by comparing an auxiliary delay signal generated by an (N+1)th delay cell with the reference signal; and determining a change in a delay time of each of the N number of delay cells based on the first digital output signal and the second digital output signal.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: December 31, 2013
    Assignees: Samsung Electro-Mechanics Co., Ltd., Research & Business Foundation Sungkyunkwan University
    Inventors: Yoo Sam Na, Kang Yoon Lee, Young Gun Pu, Hyung Gu Park, Hong Jin Kim, Yoo Hwan Kim, Dong Su Lee
  • Patent number: 8621319
    Abstract: A multiple input multiple output (MIMO) iterative receiver detects a soft log likelihood ratio value from a signal outputted from a transmitter and decodes the detected soft log likelihood ratio value in order to extract a hard value and a soft value from the detected soft log likelihood ratio value. After whether or not a CRC of the hard value is acknowledged is determined, a CRC of a data burst is determined or iteration of signal demodulation of the MIMO iterative receiver is determined by feeding back the soft value or a CRC of data is performed assembling signals of the burst unit in accordance with the determination result.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: December 31, 2013
    Assignees: Electronics and Telecommunications Research Institute, Industry-Academic Cooperation Foundation, Yonsei University
    Inventors: Young Jin Moon, Dong Seung Kwon, Jee Hwan Noh, Chungyong Lee
  • Patent number: 8618510
    Abstract: Devices and methods for screening emissive properties of a cell, such as the resistance to photobleaching or other photophysical property. In one example, a device may include a microfluidic reservoir having at least an input channel for receiving the cell, a main channel fluidly coupled with the input channel, at least a first output channel and a second output channel, the first and second output channels fluidly coupled with the main channel; and a multibeam interrogation section generating a plurality of light beams impinging upon the main channel of the microfluidic reservoir. As a cell passes from the input channel through the main channel of the microfluidic reservoir, the cell is exposed to the plurality of light beams thereby generating emissions that are received by a signal processing section. A cell trapping section selectively diverts the cell to the second output channel if the cell contains desired emissive properties.
    Type: Grant
    Filed: January 28, 2012
    Date of Patent: December 31, 2013
    Assignees: The Regents of the University of Colorado, University of Tennessee Research Foundation, National Institute of Standards and Technology
    Inventors: Amy E. Palmer, Ralph Jimenez, Kevin Dean, Jennifer Lubbeck, Lloyd M. Davis
  • Patent number: 8617083
    Abstract: A method of creating a non-invasive predictor of both physiologic and imposed patient effort from airway pressure and flow sensors attached to the patient using an adaptive mathematical model. The patient effort is commonly measured via work of breathing, power of breathing, or pressure-time product of esophageal pressure and is important for properly adjusting ventilatory support for spontaneously breathing patients. The method of calculating this non-invasive predictor is based on linear or nonlinear calculations using multiple parameters derived from the above-mentioned sensors.
    Type: Grant
    Filed: July 8, 2009
    Date of Patent: December 31, 2013
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Neil R. Euliano, Victor L. Brennan, Paul B. Blanch, Michael J. Banner