Patents Assigned to Foundation
  • Patent number: 8623376
    Abstract: The invention relates to the development of chimeric OpsA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: January 7, 2014
    Assignees: Baxter International Inc., Baxter Healthcare S.A., Research Foundation for the State University of New York, Brookhaven Science Associates, LLC
    Inventors: Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger, John J. Dunn, Benjamin J. Luft
  • Patent number: 8622993
    Abstract: The present invention is directed to devices and methods for administering at least one effective dose of at least one therapeutic substance to at least one of the maxillary sinuses of a patient in need thereof. Alternate embodiments may comprise administration of the at least one effective dose of at least one therapeutic substance to both maxillary sinuses, where the administered therapeutic substance(s) are either the same or differ from sinus to sinus. Still further alternative embodiments may comprise more than an initial effective dose administered to a patient's maxillary sinus(es), so that the therapeutic substance may be delivered over time, thereby requiring a larger dose be deposited within at least one of the maxillary sinuses so that the maxillary sinus(es) serve as a therapeutic substance depot for long-term release to the target structure(s).
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: January 7, 2014
    Assignee: HealthPartners Research Foundation
    Inventors: William H. Frey, II, Neil J. Johnson
  • Patent number: 8624039
    Abstract: A method for preparing [18F]fallypride is disclosed, which comprises a first step for trapping a fluorine-18 to a polymer ion exchange cartridge; a second step for extraction of fluorine-18 by inputting low base concentrations: 5.0˜25 ?L of 40% TBAHCO3 or K2.2.2./K2CO3 (5˜25 mg/0.5˜3.0 mg) as a phase-transfer catalyst in a mixture of alcohol/water (1.0/0.2 (v/v)) or alcohol as a solvent into the polymer ion exchange cartridge trapped by the fluorine-18; a third step for preparing a [18F]fallypride product by removing the solvent from the trapped fluorine-18, by inputting tosylate precursor in CH3CN as a solvent into a reactor and by reacting the same for 5˜35 minutes at 50˜120° C.; and a fourth step for preparing a pure [18F]fallypride by purifying the prepared [18F]fallypride product.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: January 7, 2014
    Assignee: SNU R&DB Foundation
    Inventors: Sang Eun Kim, Byung Chul Lee, Byung Seok Moon, Yu Kyeong Kim
  • Patent number: 8623403
    Abstract: The present invention provides a method for preparing chitosan and xylan composite thereto-gelling solutions to allow regulating the conditions in which the chitosan and xylan solution will gel. The present invention also provides methods for using chitosan/xylan solutions as compositions and for using chitosan/xylan solutions in vitro and in vivo. A thermally-responsive composite hydrogel has been developed and synthesized from the natural polymers chitosan and xylan. The new material is a viscous liquid at room temperature, but turns to a solid gel at physiological temperature (37 C). Rate of gelation is controlled with addition of a salt solution. Applications are for tissue engineering and local delivery of therapeutic agents, including proteins and drugs, as wells as cells.
    Type: Grant
    Filed: November 30, 2010
    Date of Patent: January 7, 2014
    Assignee: University of Virginia Patent Foundation
    Inventor: Joshua R. Bush
  • Patent number: 8624043
    Abstract: Described is a method to make liquid chemicals. The method includes deconstructing cellulose to yield a product mixture comprising levulinic acid and formic acid, converting the levulinic acid to ?-valerolactone, and converting the ?-valerolactone to pentanoic acid. Alternatively, the ?-valerolactone can be converted to a mixture of n-butenes. The pentanoic acid can be decarboxylated yield 1-butene or ketonized to yield 5-nonanone. The 5-nonanone can be hydrodeoxygenated to yield nonane, or 5-nonanone can be reduced to yield 5-nonanol. The 5-nonanol can be dehydrated to yield nonene, which can be dimerized to yield a mixture of C9 and C18 olefins, which can be hydrogenated to yield a mixture of alkanes.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: January 7, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: James A. Dumesic, Juan Carlos Serrano Ruiz, Ryan M. West
  • Patent number: 8622910
    Abstract: A system and method is provided for substantially synchronizing the acquisition of blood-vessel data to an identifiable portion of heartbeat data. Specifically, a data-gathering device is adapted to acquire heartbeat data and blood-vessel data from a heart-monitoring device and a data-gathering probe, respectively. In a preferred embodiment of the present invention, the blood-vessel data is acquired during a cyclical portion of the heartbeat data. By identifying a cyclical (or commonly reoccurring) portion of the heartbeat data and acquiring blood-vessel data during this cyclical portion (or during an interval that substantially corresponds thereto), the blood vessel can be analyzed as if it were standing still—i.e., not expanding and relaxing. In one embodiment of the present invention, the heart-monitoring device includes an EKG device, the data-gathering device includes an intra-vascular ultrasound (IVUS) device and a computing device, and the data-gathering probe includes at least one transducer.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: January 7, 2014
    Assignee: The Cleveland Clinic Foundation
    Inventors: Barry D. Kuban, Jon D. Klingensmith, D. Geoffrey Vince, Anuja Nair
  • Patent number: 8621868
    Abstract: A method for storing heat from a solar collector CSTC in Concentrating Solar Power plants and delivering the heat to the power plant PP when needed. The method uses a compressed gas such as carbon dioxide or air as a heat transfer medium in the collectors CSTC and transferring the heat by depositing it on a bed of heat-resistant solids and later, recovering the heat by a second circuit of the same compressed gas. The storage system HSS is designed to allow the heat to be recovered at a high efficiency with practically no reduction in temperature. Unlike liquid heat transfer media, our storage method itself can operate at very high temperatures, up to 3000° F., a capability which can lead to greater efficiency.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: January 7, 2014
    Assignee: Research Foundation of the City University of New York
    Inventor: Reuel Shinnar
  • Patent number: 8621797
    Abstract: A steel structure including pre-stressing brackets for improving load-carrying capacity and serviceability comprises: a steel girder; a plurality of connecting brackets connected to the bottom surface of the steel girder spaced and apart from one; and a cover plate connected to the bottom surfaces of the connecting brackets. Since the cover plate is installed regardless of the connecting portion of the steel girder, pre-stressing section can be consecutively formed therefore pre-stress effect is improved. Moreover, since the connecting brackets space the cover plate a constant distance from the steel girder, the moment of inertia is increased so the span of a bridge might be increased.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: January 7, 2014
    Assignees: Yooho Development & Construction Co. Ltd., Industry-Academic Cooperation Foundation, Yonsei University
    Inventors: Sang Hyo Kim, Jin Hee Ahn, Jung Ho Yoo, Seung Soo Han, Chang Keon Cho, Kyu Tae Choi
  • Patent number: 8623493
    Abstract: Methods of fabricating complex three-dimensional structures on patterned substrates and related compositions are provided. The methods involve depositing on the substrate a block copolymer material that is “mismatched” to the substrate pattern, and then ordering the material to form a complex three-dimensional structure. According to various embodiments, the copolymer material mismatches the substrate pattern in that the symmetry and/or length scale of its bulk morphology differs from that of the pattern. When ordered, a balance between the physics that determines the bulk block copolymer morphology and the physics that determines the substrate surface interfacial interactions results in a thermodynamically stable complex three-dimensional film that varies in a direction perpendicular to the substrate and has a morphology that differs from its bulk morphology.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: January 7, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Paul Franklin Nealey, Mark Petar Stoykovich, Konstantinos C. Daoulas, Marcus Muller, Juan J. De Pablo, SangMin Park
  • Patent number: 8623662
    Abstract: Methods, processes and compositions are provided for a visual or chemochromic hydrogen-detector with variable or tunable reversible color change. The working temperature range for the hydrogen detector is from minus 100° C. to plus 500° C. A hydrogen-sensitive pigment, including, but not limited to, oxides, hydroxides and polyoxo-compounds of tungsten, molybdenum, vanadium, chromium and combinations thereof, is combined with nano-sized metal activator particles and preferably, coated on a porous or woven substrate. In the presence of hydrogen, the composition rapidly changes its color from white or light-gray or light-tan to dark gray, navy-blue or black depending on the exposure time and hydrogen concentration in the medium. After hydrogen exposure ceases, the original color of the hydrogen-sensitive pigment is restored, and the visual hydrogen detector can be used repeatedly.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: January 7, 2014
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventor: Nazim Z. Muradov
  • Patent number: 8623611
    Abstract: The invention relates to glycoproteins having a cancer-specific glycoform. Cancer-specific glycoforms are useful in diagnostics and therapeutics.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: January 7, 2014
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: James Michael Pierce, Karen L. Abbott
  • Patent number: 8623854
    Abstract: A method of treating cancer in a subject comprising the step of administering to the subject in need thereof an effective amount of a combination of a compound that binds a nuclear export signal (NES inhibitor) on topoisomerase II? and a topoisomerase inhibitor. Twenty small molecule inhibitors (SMI) that bind to the two nuclear export sequences (NES) topo II? have been identified from the NCI database using computer-generated molecular modeling. These SMI will improve the effectiveness of topo II directed therapeutics, particularly in the treatment of diseases such as multiple myeloma (MM). In vitro apoptosis assays indicate that these drugs may be effective as single agents or in combination with currently used cancer drugs that target topo II.
    Type: Grant
    Filed: June 13, 2011
    Date of Patent: January 7, 2014
    Assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc., University of Florida Research Foundation, Inc.
    Inventors: Daniel M. Sullivan, Joel G. Turner, Thomas C. Rowe, David A. Ostrov
  • Patent number: 8625476
    Abstract: The present invention relates to a mobility management system and method for distributed mobility management network providing initial connection and handoff processes of mobile nodes to support IP multicast, and a method of selecting agents and networks to receive multicast data by anchor agents in the distributed mobility management network, comprising: a mobile node receiving network access services by conducting wireless communications in the distributed mobility management network through the wireless transmitter-receiver as a device consists of a wireless transmitter-receiver, an antenna and a control unit; a mobility management anchor agent supporting the mobility of the above mobile node, and taking the role of anchor each time the mobile node moves; a mobility management information server receiving information on agent or network transmitting multicast channel and data currently received from the above mobility management anchor agent, and then registering and updating the information.
    Type: Grant
    Filed: November 25, 2011
    Date of Patent: January 7, 2014
    Assignee: Soongsil University Foundation of University-Industry Cooperation
    Inventors: Young-Han Kim, Se-il Jeon
  • Patent number: 8625661
    Abstract: Systems and methods for the pulse edge modulation of digital carrier signals for communications systems. A digital carrier signal is generated and the carrier is pulse edge modulated with digital data. A pulse edge modulated signal is generated by either retarding or advancing each pulse edge of a carrier to be modulated relative to its original position in time, depending on the state of the digital bit to be modulated on that edge.
    Type: Grant
    Filed: May 12, 2009
    Date of Patent: January 7, 2014
    Assignee: Alfred E. Mann Foundation for Scientific Research
    Inventors: Edward K. F. Lee, Eusebiu Matei
  • Patent number: 8623496
    Abstract: A method of forming extremely small pores in a substrate that is used, for example, in patch clamp applications is provided that employs an energy absorbing material beyond a back side of the substrate to allow a laser to be focused adjacent the exit side of the substrate so as to generate a pore through the substrate and can also form a crater in the back side of the substrate and in which the pore may propagate from the crater in a drilling direction that can oppose a laser transmission direction.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: January 7, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Robert H. Blick, Minrui Yu
  • Patent number: 8624222
    Abstract: An electrical device comprising (A) a substrate having a surface and (B) a nanohole superlattice superimposed on a portion of the surface is provided. The nanohole superlattice comprises a plurality of sheets having an array of holes defined therein. The array of holes is characterized by a band gap or band gap range. The plurality of sheets forms a first edge and a second edge. A first lead comprising a first electrically conductive material forms a first junction with the first edge. A second lead comprising a second electrically conductive material forms a second junction with the second edge. The first junction is a Schottky barrier with respect to a carrier. In some instances a metal protective coating covers all or a portion of a surface of the first lead. In some instances, the first lead comprises titanium, the second lead comprises palladium, and the metal protective coating comprises gold.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: January 7, 2014
    Assignee: University of Utah Research Foundation
    Inventors: Feng Liu, Ye Zhang, Rujie Sun
  • Patent number: 8627401
    Abstract: Embodiments of a white space identifier are provided. According to one embodiment, the active channel information of a cable TV can be obtained through receiving and decoding a channel changing operation command from a remote control. The active channel information can then be transmitted to white space devices located within an interference range using a wireless transmitter. The wireless transmitter can be set to utilize a narrow fixed bandwidth.
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: January 7, 2014
    Assignee: University of Florida Research Foundation, Incorporated
    Inventor: Liuqing Yang
  • Patent number: 8625107
    Abstract: A target for use in a motion tracking system includes an optically transparent substrate with front and rear artwork. A robust landmark is comprised of portions of the front and rear artwork, and includes alternating spokes and interstitial spaces. The front and rear artwork also define orientation dependent radiation regions that occupy a portion of the interstitial spaces. The artwork also provides target identification markings and markings for providing in-plane rotation information. The surface area of the robust landmark maximized with respect to the total surface area of the target size.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: January 7, 2014
    Assignee: UWM Research Foundation, Inc.
    Inventors: Todd P. Kusik, Brian S. R. Armstrong, Robert T. Barrows, Ethan V. Munson
  • Patent number: 8623435
    Abstract: The present invention provides compositions and methods for preparing cheese with low fat content and with improved texture, color and baking properties. The compositions and methods of the invention include acidification of the cheese base and the addition of glycerides to manufacture processed or heated curd cheese with improved properties such as texture, stickiness, color and baking properties.
    Type: Grant
    Filed: April 16, 2008
    Date of Patent: January 7, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: John A. Lucey, Ciara A. Brickley, Selvarani Govindasamy-Lucey, Mark E. Johnson, John A. Jaeggi, Eileen Merlini Salim
  • Patent number: PP24142
    Abstract: A new and distinct cultivar of the muscadine grape plant, Vitis rotundifolia Michx., named ‘Ga. 5-1-45’, which has: early ripening berries, typically beginning in the first week in August in Georgia; black berries; self-fertile flowers; berries with flesh that adheres to the skin (non-slip skin); berries that are firm in texture and with a high soluble solids content; and berries that are large for a self-fertile cultivar.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: January 7, 2014
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: Patrick J. Conner