Abstract: Disclosed are methods of purifying (20R) and (20S) analogs of 2-methylene-19-nor-22-dimethyl-1?,25-dihydroxyvitamin D3 to obtain the (20R) and (20S) analogs in crystalline form. The method includes the steps of preparing a solvent of either diethyl ether or a mixture of 2-propanol and hexane, dissolving a product containing the (20R) and (20S) analog to be purified in the solvent, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of crystals, and recovering the crystals.

Abstract: Disclosed are methods of purifying the compound (20R)-2-methylene-19-nor-24-difluoro-1?,25-dihydroxyvitamin D3 to obtain the compound in crystalline form. The methods typically include the steps of dissolving a product containing the compound in a solvent comprising hexane and 2-propanol, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of crystals, and recovering the crystals.

Abstract: The invention provides amphiphilic compounds and methods for manipulating membrane proteins. Compounds of the invention, for example, the compounds of Formulas I-XIX, can be prepared from readily available starting materials. The amphiphilic compounds can manipulate membrane protein at relatively low concentrations compared to many known detergents. The compounds can be used to aid the isolation of membrane proteins, for example, to aid their solubilization and/or purification. The compounds can also be used to aid the functional and structural determination of membrane proteins, including their stabilization and crystallization.

Abstract: A heart pump and a catheter assembly therefor are provided that include a flexible catheter body having a proximal end and a distal end, the catheter body having a plurality of lumens therethrough. The catheter body can be sufficiently flexible to extend from a peripheral access to a patient's heart. The catheter assembly can also include an impeller assembly having an impeller and a housing. The impeller assembly can be coupled with the flexible catheter body such that a tensile force applied to opposite ends of the catheter assembly enhances the security of the connection between the catheter body and the impeller assembly.

Abstract: Provided is a method and apparatus for measuring efficiency of an optical device. In the method, a power of emission light from the optical device is calculated by irradiating an excitation stimulus on the optical device. A power of a reference excitation stimulus at which a variation of recombination coefficients in a quantum well of the optical device with respect to a variation of carrier concentration in the quantum well of the optical device becomes minimum is extracted. An internal quantum efficiency of the optical device at the power of the reference excitation stimulus is calculated. An internal quantum efficiency of the optical device at powers of various excitation stimuli is calculated from the internal quantum efficiency of the optical device at the power of the reference excitation stimulus.

Abstract: A tunable super-lens (TSL) for nanoscale optical sensing and imaging of bio-molecules and nano-manufacturing utilizes negative-index materials (NIMs) that operate in the visible or near infrared light. The NIMs can create a lens that will perform sub-wavelength imaging, enhanced resolution imaging, or flat lens imaging. This new TSL covers two different operation scales. For short distances between the object and its image, a near-field super-lens (NFSL) can create or enhance images of objects located at distances much less than the wavelength of light. For the far-zone, negative values are necessary for both the permittivity ? a permeability ?. While well-structured periodic meta-materials, which require delicate design and precise fabrication, can be used, metal-dielectric composites are also candidates for NIMs in the optical range. The negative-refraction in the composite films can be made by using frequency-selective photomodification.

Abstract: The present invention provides a system and a method monitoring the health of structural joints by monitoring the strain developed near the joint due to perturbation applied away from that joint and comparing the monitored ratio between near field and far field strain to strain ratio which develops in a healthy joint due to comparable perturbation. The system for monitoring joints comprises: at least one near field strain measuring device installed near a monitored joint for monitoring the induced strain; at least one far field strain measuring device installed away from monitored joint indicating, measuring or producing the perturbation; and a data processor connected to said near field strain measuring device and to said near field strain measuring device for analyzing the response of the structure to the perturbation and determining the integrity of said joint.

Abstract: At least two biometric measurements of a person are collected, then a statistical measure based on the measurements is computed. The statistical measure is abounded estimate of the discriminative power of a test based on the measurements. While the discriminative power is less than a target value, additional biometric measurements are collected. When enough measurements have been collected, a biometric template is constructed from the measurements and stored for use in future identifications. Systems and software to implement similar methods are also described and claimed.

Abstract: A method is provided for producing, with a magnetic resonance (MR) system, a nuclear magnetic resonance spectrum that has been corrected for errors arising from phase offsets and time shifts in the acquired spectroscopic data. A spectroscopic data set includes temporal information indicative of the underlying phase offsets and time shifts. In general, this temporal information is utilized to correct for errors in the acquired data. As a result, a plurality of acquired spectroscopic data sets are more accurately combined by first individually correcting each spectroscopic data set for such errors. Exemplary sources of the phase offsets and time shifts include the physical separation between a volume of interest and the detectors in the MRI system. Using the temporal information, T2 decay in the produced spectrum is also corrected.

Abstract: Attenuated, neuraminidase deficient influenza virus, and compositions and methods to prepare that virus, are provided.

Abstract: An apparatus and method for correcting for the polarization mode distortion of an optical signal is described. The optical data signal to be transmitted is processed by a switch configured to place the signal into a plurality of polarization states on a periodic basis. At the receiving end of the system, a portion to the signal is coupled to a polarimeter and the wavelength-dependent state of polarization (SOP) of the received signal determined for the plurality of polarization states imposed on the transmitted signal. The data for two of the transmitted polarization states is selected to be used as the basis for correcting the SOP so as to compensate for the wavelength dependence thereof. The corrections may be applied in an optical pulse shaper.

Abstract: Provided is a control method of a control apparatus for a multi-cell communication system including a plurality of cells, the method including determining a cell edge terminal or an inner cell terminal from each of terminals included in each of the cells, and selecting, from base stations included in the plurality of cells, a first base station and a second base station. The first base station may serve all of a corresponding cell edge terminal and a corresponding inner cell terminal, and the second base station may serve only the corresponding inner cell terminal between the corresponding cell edge terminal and the corresponding inner cell terminal.

Abstract: A method of detecting a compromised machine on a network. The method receives an email message from a machine on the network and classifies it as either spam or non-spam. A probability ratio is then updated, according to whether the message was spam or non-spam, by applying a sequential probability ratio test. If the probability ratio is greater than or equal to a first threshold, then the machine is compromised. If the probability ratio is less than or equal to a second threshold, then the machine is normal. The operations of receiving a message, classifying the message, updating the probability ratio, and indicating the machine is normal or compromised until the probability ratio is greater than or equal to the first threshold are repeated for a plurality of messages. Such repeated operations are performed on each of the messages one at a time, as each of the messages is received.

Abstract: There are disclosed a photovoltaic and fuel cell (PV-FC) hybrid generation system using a single converter and a single inverter, and a method of controlling the same. The PV-FC hybrid generation system includes a DC/DC converter unit converting an FC output voltage from a fuel cell, converting chemical energy into electrical energy, into a preset voltage, a DC link unit commonly connecting an output terminal of a photovoltaic cell, converting the sunlight into electrical energy, and an output terminal of the DC/DC converter unit, and linking the converted FC output voltage from the DC/DC converter unit with a PV output voltage from the photovoltaic cell to thereby generate a DC voltage, and a DC/AC inverter unit converting the DC voltage from the DC link unit into a preset AC voltage. Furthermore, a method of controlling the PV-FC hybrid generation system is proposed.

Abstract: The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligation detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the amplified ligation product, and identifying the target nucleotide sequence. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence difference.

Abstract: The present invention relates to a multiferroic material capable of freely controlling magnetic field size at room temperature, and to a method of manufacturing the same. Said multiferroic material includes hexaferrites containing magnetic iron ions partially substituted by non-magnetic ions. Said non-magnetic ions act to change the magnetic anisotropy of said hexaferrites.

Abstract: In a method of communicating in a radio frequency identification (RFID) system including a RFID reader and a plurality of RFID tags, a plurality of spread spectrum data are stored in the plurality of RFID tags. The plurality of spread spectrum data are transmitted from the plurality of RFID tags to the RFID reader. A plurality of original data respectively corresponding to the plurality of RFID tags are simultaneously extracted from the plurality of spread spectrum data at the RFID reader.

Abstract: A system and method for automatically generating sample points from a series of medical images and identifying a significant region are presented. An image acquisition system acquires the medical images of a region of interest (ROI) and an automated mask generator reviews the images to generate a parenchyma mask. Using the parenchyma mask, an automated sample point generator then detects portions of the medical images indicative of a material expected to be in a ROI and designates sample points therefrom. A target-tissue identification system uses the sample points to create a mathematical description of a target tissue and an enhanced target-tissue. A target-tissue change detection system then detects changes in the mathematical descriptions from those created using prior images. Finally, a significant region detector, which includes a training process to generate a quantitative definition of significance, automatically identifies a significant object in the series of medical images.

Abstract: A method of detecting a compromised machine on a network. The method receives an email message from a machine on the network and classifies it as either spam or non-spam. A probability ratio is then updated, according to whether the message was spam or non-spam, by applying a sequential probability ratio test. If the probability ratio is greater than or equal to a first threshold, then the machine is compromised. If the probability ratio is less than or equal to a second threshold, then the machine is normal. The operations of receiving a message, classifying the message, updating the probability ratio, and indicating the machine is normal or compromised until the probability ratio is greater than or equal to the first threshold are repeated for a plurality of messages. Such repeated operations are performed on each of the messages one at a time, as each of the messages is received.

Abstract: A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of retinoic acid, wherein the cells express Hoxb4, but not Otx2 or Bf1.