Patents Assigned to Foundation
  • Microfabricated instruments and methods to treat recurrent corneal erosion
    Patent number: 8591481
    Abstract: In one embodiment, the present invention provides a device and method for treating recurrent corneal erosion. In one embodiment, the method includes the steps of contacting an epithelium layer of a cornea with an array of glass micro-rods including a plurality of sharp features having a length that penetrates a Bowman's layer of the eye, wherein the plurality of sharp features of the array of glass micro-rods produces a plurality of punctures in the Bowman's layer of the eye that are of micro-scale or less. In another embodiment, the present invention provides a method and device for drug delivery. In one embodiment, the device includes an array of glass micro-rods, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature opposite a base of the array of glass micro-rods, wherein the sharp feature includes a treated surface for delivering a chemical compound to the eye.
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: November 26, 2013
    Assignees: UT-Battelle, LLC, University of Tennessee Research Foundation
    Inventors: Charles L. Britton, Brian R. D'Urso, Edward Chaum, John T. Simpson, Justin S. Baba, M. Nance Ericson, Robert J. Warmack
  • Optics for forming a linear beam in optical coherence tomography
    Patent number: 8593640
    Abstract: This invention relates to an optical coherence tomography, in which a light source and an optical linear beam forming system are adopted to obtain two dimensional image of high quality resolution within short time without affection by any mechanical movements. For such purpose, the optical linear beam forming system (20) comprises semicy Under lens (21), convex lens (22) and slit (23) to implement the frequency domain optical coherence tomography. Parallel light beam from the light source is incident on the surface of the semicylinder lens (21), and focal line of the semicylinder lens (21) is located in front of the convex lens (22). The convex lens (22) has short focal point where the parallel light component converges and long focal point where the diverging light component converges. The slit (23) is located between the short focal point and the long focal point.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: November 26, 2013
    Assignees: Industrial-Academic Cooperation Foundation, Yonsei University, MTC Medical Co., Ltd.
    Inventors: Beop-Min Kim, Sang-Won Lee
  • Catalytic platinum-copper alloy nanoparticles
    Patent number: 8592339
    Abstract: High-quality bimetallic PtxCu100-x (x=54-80 at. %) nanocubes can be prepared from a hot organic solution. Synthetic conditions, such as the ratio of oleylamine/tetraoctylammonium bromide as well as the doses of 1-dodecanethiol and 1,2-tetradecanediol have been optimized to ensure a formation of Pt—Cu nanocubes. Electrochemical evaluation shows that the catalytic activity of Pt60Cu40 nanocubes for methanol oxidation is superior, in comparison with those of spherical Pt60Cu40 nanocubes and Pt nanocubes with similar sizes, implying that the {100}-terminated Pt60Cu40 nanocubes offer a higher activity for methanol oxidation reaction than those with mixed crystallographic facets do.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: November 26, 2013
    Assignee: The Research Foundation for the State University of New York
    Inventors: Jiye Fang, Dan Xu
  • Method of managing power of multi-core processor, recording medium storing program for performing the same, and multi-core processor system
    Patent number: 8595527
    Abstract: Provided are a method of managing power of a multi-core processor, a recording medium storing a program for performing the method, and a multi-core processor system. The method of managing power of a multi-core processor having at least one core includes determining a parallel-processing section on the basis of information included in a parallel-processing program, collecting information for determining a clock frequency of the core in the determined parallel-processing section according to each core, and then determining the clock frequency of the core on the basis of the collected information. Accordingly, it is possible to minimize power consumption while ensuring quality of service (QoS).
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: November 26, 2013
    Assignee: Postech Academy—Industry Foundation
    Inventors: Ki-Seok Chung, Young-Si Hwang
  • Antimicrobial peptides and uses thereof
    Patent number: 8592651
    Abstract: The subject invention pertains to methods and materials for enhancing microbial resistance in plants. Specifically exemplified herein are grapevines transformed with polynucleotides that express a peptide which confers antimicrobial activity.
    Type: Grant
    Filed: June 13, 2006
    Date of Patent: November 26, 2013
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Zhijian T. Li, Dennis J. Gray
  • Field electron emitter, field electron emission device including the same, and method of manufacturing the field electron emitter
    Patent number: 8593049
    Abstract: A field electron emitter including a metal electrode; and a plurality of carbon nanotubes, wherein a portion of the plurality of carbon nanotubes protrude from a surface of the metal electrode and a portion of the plurality of carbon nanotubes are in the metal electrode. Also disclosed is a field electron emission device including the field electron emitter and a method of manufacturing the field electron emitter.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: November 26, 2013
    Assignees: Samsung Electronics Co., Ltd., Korea University Research and Business Foundation
    Inventors: Yoon-chul Son, Yong-chul Kim, Jeong-na Heo, Woo-sung Cho, Byeong-kwon Ju
  • Ceramides and apoptosis-signaling ligand
    Patent number: 8592419
    Abstract: The invention provides the compounds of formula (): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, A, X, Y, a, b and n are as defined herein. Also disclosed are methods for making the compounds of formula (I) and their use in treating or preventing diseases associated with cell overproliferation and dysfunctional sphingolipid signal transduction. The invention also encompasses the use of the compounds in combination with an apoptosis-signaling ligand, such as Fas ligand. Preferably, the Fas ligand is administered in the form of a gene therapy agent.
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: November 26, 2013
    Assignee: MUSC Foundation for Research Development
    Inventors: Alicja Bielawska, Yusuf A. Hannun, James Norris, Zdzislaw M. Szulc, Jian-yun Dong, Jacek Bielawski, David A. Schwartz, David H. Holman, Ahmed M. El-Zawahry, John McKillop
  • CCR3 inhibition for ocular angiogenesis and macular degeneration
    Patent number: 8592482
    Abstract: Provided are methods and compositions for the treatment or prevention of ocular angiogenesis and neovascularization. Administration of inhibitors of the CCR3 receptor or its ligands eotaxin (CCL11), eotaxin-2 (CCL24) or eotaxin-3 (CCL26) inhibits ocular angiogenesis.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: November 26, 2013
    Assignee: University of Kentucky Research Foundation
    Inventor: Jayakrishna Ambati
  • Barricade for crowd control
    Patent number: 8591137
    Abstract: A barricade is provided for crowd control. The barricade includes a first frame support member having an upper end, a lower end, an upper opening adapted for receiving an end of a first upper beam therein and a lower opening. A second frame support member is positioned at an acute angle to the first support frame member and has an upper end, a lower end adjacent the lower end of the first frame support member, an upper opening adapted for receiving an end of a second upper beam therein and a lower opening. A lower beam has a first end receivable in the lower opening of the first frame support member and a second end receivable in the lower opening of the second frame support member to interconnect the first and second frame support members.
    Type: Grant
    Filed: August 31, 2010
    Date of Patent: November 26, 2013
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Bruce A. Thompson, Mark A. Hanson
  • Automation method for computerized tomography image analysis using automated calculation of evaluation index of degree of thoracic deformation based on automatic initialization, and record medium and apparatus
    Patent number: 8594409
    Abstract: An automation method for CT image analysis for quantitatively analyzing the degree of thoracic deformation, and a record medium and apparatus are disclosed.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: November 26, 2013
    Assignee: Dongguk University Industry-Academic Cooperation Foundation
    Inventors: Sung Min Kim, Ho Chul Kim
  • Labeling peptides with tertiary amines and other basic functional groups for improved mass spectrometric analysis
    Patent number: 8592216
    Abstract: The present invention provides methods for enhancing the fragmentation of peptides for mass spectrometry by modifying the peptides with a tagging reagent containing a functional group, such as a tertiary amine, having a greater gas-phase basicity than the amide backbone of the peptide. These high gas-phase basicity functional groups are attached to a peptide by reacting the tagging reagent to one or more available carboxylic acid groups of the peptide. Linking these high gas-phase functional groups to the peptides leads to higher charge state ions from electrospray ionization mass spectrometry (ESI-MS), which fragment more extensively during fragmentation techniques, particularly non-ergodic fragmentation techniques such as electron capture dissociation (ECD) and electron transfer dissociation (ETD).
    Type: Grant
    Filed: April 14, 2010
    Date of Patent: November 26, 2013
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Brian L. Frey, April L. Jue, Casey J. Krusemark, Lloyd M. Smith, Joshua J. Coon
  • Immunoreactive protein orthologs of
    Patent number: 8591906
    Abstract: The present invention concerns gp36 immunoreactive compositions for E. canis and gp 47 immunoreactive compositions for E. chaffeensis. In particular, epitopes for E. canis gp36 and E. chaffeensis gp 47 are disclosed. In certain embodiments, the immunoreactive compositions comprise tandem repeats having carbohydrate moieties.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: November 26, 2013
    Assignee: Research Development Foundation
    Inventors: Jere W. McBride, Christopher K. Doyle
  • Endosurgery suturing device
    Patent number: 8591526
    Abstract: A suturing device includes an elongated sheath and a suturing assembly. The elongated sheath has a working end for insertion through a working channel in an endoscope and has an inner passage. The suturing assembly includes an elongated flexible base member, a first suturing arm and a second suturing arm. The suturing arms each have a proximal end interconnected with the elongated base member and an opposite distal end. A needle receiver is disposed at the distal end of each suturing arm. The suturing arms are movable between an open position wherein the distal ends are spaced apart by a first distance and a closed position wherein the distal ends are spaced apart by a second distance less than the first distance.
    Type: Grant
    Filed: November 2, 2007
    Date of Patent: November 26, 2013
    Assignee: The Penn State Research Foundation
    Inventors: James Cronin, Mary Frecker, Abraham Mathew
  • Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof
    Patent number: 8592209
    Abstract: The invention provides compositions and methods for preparing and characterizing multipotential mesenchymal stem cell aggregates. The invention further provides methods for using stem cell aggregates of the invention.
    Type: Grant
    Filed: January 30, 2007
    Date of Patent: November 26, 2013
    Assignee: University of Virginia Patent Foundation
    Inventors: Moshe Khurgel, Adam J. Katz
  • Daily contents updating teller toy and method for operating the same
    Patent number: 8591282
    Abstract: Provided are an interactive toy whose contents are updated daily, and a method of operating the interactive toy, and more particularly, to an interactive toy in which a wired or wireless communication device and a memory are installed and various contents are downloaded via a web server so as to extract conversation contents from the various contents according to date and other interactive toys and output the extracted conversation contents, and thus allow a user of the interactive toy to engage in conversations with the other users without using an additional conversation contents determining unit, and a method of operating the interactive toy.
    Type: Grant
    Filed: November 28, 2008
    Date of Patent: November 26, 2013
    Assignee: Sungkyunkwan University Foundation for Corporate Collaboration
    Inventor: Soko Jang
  • Image sensors and image processing systems
    Patent number: 8593319
    Abstract: An image sensor includes a delta-sigma analog-to-digital converter (ADC) including a delta-sigma modulator (DSM) and a voltage adjusting circuit. The DSM is configured to perform delta-sigma modulation on an analog signal from a unit pixel. The delta-sigma ADC is configured to convert the analog signal to a digital signal. The voltage adjusting circuit includes a replica inverter having a same configuration as at least one inverter included in the DSM. The voltage adjusting circuit is configured to adjust a power supply voltage and an input voltage provided to the at least one inverter based on a current flowing in the replica inverter.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: November 26, 2013
    Assignees: Samsung Electronics Co., Ltd., Industry-Academic Cooperation Foundation, Yonsei University
    Inventors: Min-Ho Kwon, Seog-Heon Ham, Jeong-Jin Roh, Jae-Jin Yeo, Yong-Suk Choi, Gun-Hee Han
  • Antenna device for a portable terminal
    Patent number: 8593353
    Abstract: An antenna device for a portable terminal includes: a ground pattern provided on one surface of a circuit board; a first antenna pattern configured to resonate at a first frequency band and provided on an opposite surface of the circuit board; and a second antenna pattern configured to resonate at a second frequency band different from the first frequency band and arranged along a periphery of the ground pattern. The second antenna pattern is a zeroth order mode resonator including a plurality of capacitors and a plurality of inductors. The antenna device easily secures the operation characteristics of different operation frequency bands and contributes to miniaturization of the portable terminal. Thus, a user can conveniently carry and use the portable terminal.
    Type: Grant
    Filed: June 12, 2009
    Date of Patent: November 26, 2013
    Assignees: Samsung Electronics Co., Ltd., Korea University Industrial & Academic Collaboration Foundation
    Inventors: Joon-Ho Byun, Soon-Ho Hwang, Mun-Il Kim, Do-Won Kim, Hyun-Seok Park
  • Target particles-separating device and method using multi-orifice flow fractionation channel
    Patent number: 8590710
    Abstract: A device separating target particles in a fluid sample includes first through third multi-orifice flow fractionation (“MOFF”) channels, each including a multi-orifice segment with an inlet and an outlet at opposite ends, and an alternating series of contraction channels and expansion chambers interconnected in a lengthwise direction; a first separation unit including a first separation channel which is interconnected in fluid communication with a center region of the outlet of the first MOFF channel, and first branch channels which are interconnected in fluid communication with sidewall regions of the outlet of the first MOFF channel, and respectively with inlets of the second and third MOFF channels; and buffer inlets which are connected to the inlets of the second and third MOFF channels and through which a buffer flows into the second and third MOFF channels.
    Type: Grant
    Filed: June 9, 2011
    Date of Patent: November 26, 2013
    Assignees: Samsung Electronics Co., Ltd., Industry-Academic Cooperation Foundation, Yonsei University
    Inventors: Tae-seok Sim, Jeong-gun Lee, Hyo-il Jung, Ki-ho Kwon
  • High activity mutants of butyrylcholinesterase for cocaine hydrolysis
    Patent number: 8592193
    Abstract: Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (?)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (?)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: November 26, 2013
    Assignee: University of Kentucky Research Foundation
    Inventors: Chang-Guo Zhan, Fang Zheng, Wenchao Yang, Liu Xue, Shurong Hou
  • camera plant named ‘UF-T4’
    Patent number: PP24043
    Abstract: A new and distinct cultivar of Lantana camara plant named ‘UF-T4’, characterized by its moderate vigor, mounding growth habit, free flowering, bright yellow/magenta flower color, little fruiting, high level of female sterility, high level of male sterility, and not hybridizing with Lantana depressa, is disclosed.
    Type: Grant
    Filed: February 7, 2012
    Date of Patent: November 26, 2013
    Assignee: Florida Foundation Seed Producers, Inc.
    Inventors: Zhanao Deng, David M. Czarnecki, II