Abstract: Provided is a method for quantifying A? in plasma by treating the plasma with MPP and/or TCEP, and a method for diagnosing, using the quantifying method, whether or not clinical cognitive deterioration and pathological A? accumulation occur. Through cut-off values of measured values measured by the method for quantifying A? according to the present subject matter, it is possible to identify normal, MCI and AD subjects and determine whether or not accumulation of A? in the brain occurs, and it is possible to predict progression to AD.

Abstract: This document provides devices and methods for interventional treatment of heart conditions. For example, this document provides devices and methods that enhance intra-cardiac echocardiography visualization of interventional devices such as trans-septal puncturing needles.

Abstract: An electrode sheet including a multi-walled carbon nanotube including plural graphene layers, each of which has a trioxotriangulene derivative of formula (1) dispersed therein, where X's are hydrogen, a halogen, or a monovalent organic group, and may be the same as or different from each other.

Abstract: There is provided a composition including a 3-bromo-4,5-dihydroxybenzaldehyde (BDB) for protecting human skin keratinocyte from ultraviolet, in which the BDB has a photo-protective effect against cell damage caused by ultraviolet in human HaCaT skin keratinocyte, activity of removing a free radical, and ultraviolet absorption activity, and inhibits formations of lipid peroxidation and protein carbonyl, inhibits DNA damage, protects a cell, and thereby exhibits cell protective activity. Thus, the BDB decreases apoptosis induced by ultraviolet, and then protect a cell to recover cell viability.

Abstract: In a method of forming an electrode structure for a photovoltaic cell, a transparent conductive layer is formed on a semiconductor layer of amorphous silicon material doped with dopants of a first conductive type. Then, a first metal pattern is formed on the transparent conductive layer by performing an ink jet process using metal nano ink. After forming a metal paste layer using a conductive paste through a screen printing process to cover the first metal pattern, the metal paste layer is fired to transform the metal paste layer into a second metal pattern such that the first and the second metal patterns are formed on the transparent metal layer to define a metal electrode.

Abstract: The subject invention concerns a compound and compositions having activity as an inhibitor of Stat3 protein and methods of using the compound and compositions. In one embodiment, a compound of the invention has the structure shown in formula I, formula II, or formula III. The subject invention also concerns methods of using the compounds and compositions of the invention.

Abstract: An aqueous composition including: a conductive metal nanoparticle having an organic compound disposed on a surface of the conductive metal nanoparticle; a conductive metal nanowire; and a solvent including water and optionally an alcohol.

Abstract: A needle electrode is provided incorporating a protective flap and optionally a retraction chamber. By providing an impenetrable barrier covering the area of skin over the needle's tip, the protective flap protects against needle sticks that can occur when the tip of a needle electrode is pushed back out through the skin. An adhesive layer on the skin-side of the protective flap secures the needle in place without the use of a separate piece of adhesive tape. Other types of needles can incorporate flaps for protection or for securing the needle to the patient.

Abstract: This document provides a transgenic mouse for studying the role of senescent cells in an age-related phenotype. A recombinant polypeptide is expressed in senescent cells under control of a p16INK4a promoter. The polypeptide can be triggered to directly induce cell death in senescent cells. As a result, progression of one or more age-related phenotypes is delayed in the mouse. An example is the INK-ATTAC mouse which also expresses a marker polypeptide in senescent cells.

Abstract: The present disclosure is directed to providing: a new cell-penetrating peptide; and a composition for delivering a biologically active substance, a composition for gene therapy, a method for delivering a biologically active substance and a method for gene therapy using the same. The cell-penetrating peptide of the present disclosure can effectively deliver a protein into human cells and tissues, can deliver a protein with higher efficiency in comparison with a TAT peptide that is commercially used as a cell-penetrating peptide, and can also be usefully used in delivering a biologically active substance such as a protein, a genetic material, a chemical compound, etc. which may be used for a therapeutic purpose into cells.

Abstract: The present invention provides, among other things, therapeutic compositions and methods that can effectively treat, slow or prevent a neurological disease (e.g., a neurodegenerative disease, e.g., mild cognitive impairment (MCI) or Alzheimer's disease (AD)), in particular, based on therapeutically effective amount of nifedipine, oxidized or nitroso nifedipine derivatives, lactam (e.g., a compound of formula (Ic) or (Ic-i), e.g., NFD-L1), thyroxine (T4), triiodothyronine (T3) and combinations thereof.

Abstract: An internet-connected server comprising a first module for authorizing a user to access the server for: setting up, on the server, a given configuration for conducting a computer-executable experiment, wherein the given configuration comprises at least an executable instruction and a parameter or input data; executing, on the server, the computer-executable experiment with the given configuration so to produce a numerical result; certifying, on the server, the numerical result so to produce a certified result; and generating, on the server, a certification identifier of the certified result. The internet-connected server further comprises a second module for authorizing a reviewer for: providing the server with the certification identifier; and requesting and/or accessing, on the server, the certified numerical result on the basis of the provided certification identifier.

Abstract: An apparatus and a method for stabilizing output of a light source are disclosed. The stabilization device located outside of a light source comprises a stabilization element, and a stabilization controller configured to control a light output from the light source so that a part of the light output and other part of the light cross propagate in the stabilization element.

Abstract: A high flux and low pressure drop microfiltration (MF) membrane and a method for making the MF membrane. The microfiltration membranes are formed by a method that includes: preparing a nanofibrous structure; and modifying the surface of the nanofibrous structure with a surface modifier. The nanofibrous structure includes an electrospun nanofibrous scaffold or a polysaccharide nanofiber infused nanoscaffold or mixtures thereof. The electrospun nanofibrous scaffold can include polyacrylonitrile (PAN) or polyethersulfone (PES))/polyethylene terephthalate (PET) or mixtures thereof. The surface modifier includes polyethylenimine (PEI) and polyvinyl amine (Lupamin) cross-linked by ethylene glycol diglycidyl ether (EGdGE)/glycidyltrimethylammonium chloride (GTMACl) or poly(1-(1-vinylimidazolium)ethyl-3-vinylimdazolium dibromide (VEVIMIBr).

Abstract: Disclosed herein is a surgical operation by wire (SOBW) type surgical operation apparatus including an end effector configured so as to remove or minimize configurations of a mechanical cable. The SOBW type surgical operation apparatus includes: a body part; an extension part having one end connected to the body part; and an end effector formed at the other end of the extension part, and receiving electrical energy transferred through the body part and the extension part and converting the electrical energy into mechanical energy.

Abstract: An adaptive hydraulic pressure generator is provided for systems in which the mechanical force producing energy varies significantly, especially for wave energy systems. The pressure generator includes at least two fluid chambers with a piston surface/displacement surface arranged to reciprocate with the fluid chamber, whereby the piston surface/displacement surface acts on the fluid in the chamber by means of the said mutual reciprocating movement. The pressure generator is equipped with a control system which is arranged to connect the chambers to each other and/or to different pressure ducts in such a way that the effective area of the piston/displacement surfaces changes in accordance with the changes in the driving force exerted on the piston/displacement surfaces and/or the body forming the fluid chamber in such a way that the pressure produced by the pressure generator in the fluid supplied to the application exceeds the threshold pressure.

Abstract: A wearable electronic device for proximity-based social and professional networking which features electronics and software for the passive automated local wireless exchange of personal and/or business information with other electronic devices is disclosed. In some embodiments, an electronic device includes a controller having an operations unit; a communication unit configured to receive and/or transmit data from a first external source; and a memory unit configured to communicate with the controller and receive and/or transmit data from the controller. The operations unit may be configured to determine if received data from the first external source meets a set threshold and wherein the operations unit may be configured to instruct communication unit to accept data that meets or exceeds said threshold. The communication unit may receive and transmit data from the first external source provided the external source is within a predetermined proximity.

Abstract: Disclosed are a multi-axial force sensor capable of measuring multi-axial force and a grasper for sensing multi-axial force using the same. The multi-axial force sensor includes: a first operating section which includes a first member, and a first protrusion module formed protruding from one side of the first member; an elastic section which is formed at one end of the first member; a second operating section which includes a second member formed with one end to face one end of the first member with the elastic section therebetween, and a second protrusion module formed protruding from one side of the second member to face the first protrusion module; and an electrode section which is formed in the first protrusion module. With this, there is provided a force sensor capable of precisely measuring force through a simple structure.

Abstract: Disclosed herein are isotopically labeled calcofluor derivatives and uses of such to detect fungi, such as filamentous fungi, including Aspergillus species, such as by positron emission tomography (PET) scanning.