Abstract: An electrode lead includes an elongate lead body and a nerve cuff. The nerve cuff may include a cuff body, with a front layer and a rear layer, affixed to the distal end of the lead body and a plurality of electrically conductive members located between the front and rear layers. Each of the electrically conductive member defines a front side, a rear side and an outer perimeter and may include a plurality of holes that extend from the front side to the rear side and that are located around the outer perimeter. The cuff body front layer includes a plurality of windows that are respectively aligned with and located inwardly of the outer perimeters of the electrically conductive members, and a plurality of window frames that extend from the windows to the outer perimeters of the electrically conductive members. The cuff body also includes a plurality of anchors that respectively extend through the electrically conductive member holes and connect the window frames to the cuff body rear layer.

Abstract: An optical display system and an electronics apparatus are disclosed. The optical display system comprises: an image source, which generates image light; and an optical combiner, which includes two reflection-type polarization volume lenses working in a Bragg regime, wherein a first reflection-type polarization volume lens of the two reflection-type polarization volume lenses diffracts the image light of a first polarization to a first image and transmits the image light of a second polarization, and a second reflection-type polarization volume lens of the two reflection-type polarization volume lenses diffracts the image light of a third polarization to a second image and transmits the image light of a fourth polarization, the optical combiner outputs the first image and/or the second image as an combined image.

Abstract: Methods and systems capable of measuring gas temperatures utilizing plasma discharges. Such a method performs a measurement of a temperature of a gas by generating a probing nanosecond plasma pulse in the gas, and then using an optical emission spectroscopy technique to measure the temperature of the gas by processing a light emission signal excited by the probing nanosecond plasma pulse.

Abstract: Disclosed are universal influenza based on a truncated influenza hemagglutin (HA) protein lacking a head domain (hrHA). Also disclosed is a composition comprising a nanoparticle coated with a disclosed hrHA polypeptide. Also disclosed is a composition comprising a virus like particle (VLP) expressing on its surface a disclosed hrHA polypeptide.

Abstract: Various embodiments disclosed relate to contact lens including nanopores. A contact lens can include a nanoporous film including nanopores that are on an inner surface of the contact lens, and a backing lens on the nanoporous film. Various embodiments further include a biomarker-sensing region of the nanoporous film, a drug storage and delivery region of the nanoporous film, or a combination thereof.

Abstract: A computer-implemented method for determining the volume of activation of neural tissue. In one embodiment, the method uses one or more parametric equations that define a volume of activation, wherein the parameters for the one or more parametric equations are given as a function of an input vector that includes stimulation parameters. After receiving input data that includes values for the stimulation parameters and defining the input vector using the input data, the input vector is applied to the function to obtain the parameters for the one or more parametric equations. The parametric equation is solved to obtain a calculated volume of activation.

Abstract: In an embodiment, the invention is directed to prodrug compounds of L-BHDU according to the chemical structure I: Where R1 is a —(CH2)n—O—R1a group or a —(CH2)j—O—C(O)Ok—R2a group; R2 is H, a —(CH2)n—O—R1a group or a —(CH2)j—O—C(O)Ok—R2a group; R1a is independently a C6-C30 alkyl group, often a C12-C22 alkyl group, often a C14-C20 alkyl group or a C16-C18 alkyl group, often a C16 or C18 alkyl group; R2a is independently a C1-C12 alkyl group, often a C2-C6 alkyl group, a C3-C4 alkyl group, an isopropyl, t-butyl or sec-butyl group, or an isopropyl or t-butyl group; Each j is independently 1-6, 1-3, often 1 or 2; Each k is 0 or 1; Each n is independently 1-6, 1-4, 2-4 or 2 or 3; or A pharmaceutically acceptable salt, solute or polymorph thereof. Additional embodiments are directed to pharmaceutical compositions based upon the disclosed chemical compounds and methods of treating or reducing the likelihood of VZV, HSV-1 or HSV-2 infections.

Abstract: An earthquake event classification method using an attention-based neural network includes: preprocessing input earthquake data by centering; extracting a feature map by nonlinearly converting the preprocessed earthquake data through a plurality of convolution layers having three or more layers; measuring importance of a learned feature of the nonlinear-converted earthquake data based on an attention technique in which interdependence of channels of the feature map is modeled; correcting a feature value of the measured importance value through element-wise multiply with the learned feature map; performing down-sampling through max-pooling based on the feature value; and classifying an earthquake event by regularizing the down-sampled feature value. Accordingly, main core features inherent in many/complex data are extracted through attention-based deep learning to overcome the limitations of the existing micro earthquake detection technology, thereby enabling earthquake detection even in low SNR environments.

Abstract: Systems and methods for optimizing virtual world computations through an n-tier architecture including at least three tiers are provided. In a sample three-tier architecture, a first tier comprises a client software engine configured to receive input data, send the data to the second tier, and perform end-user processing. A second tier connects to the first tier and to a third tier through a network and comprises a client-dedicated module that is dynamically instantiated and which is configured to either prepare the received data for subsequent processing from the client software engine or send the received data to the third tier. The third tier comprises a virtual world processing module configured to receive and process data from the second tier, generating world state updates, and to dynamically instantiate the client-dedicated module to spawn client-dedicated instances. The world state updates are sent to corresponding client-dedicated module instances for further processing.

Abstract: Methods of minimizing dysregulation of Staufen1-associated RNA metabolism can include introducing an amount of a Staufen1-regulating agent to a target cell sufficient to minimize the dysregulation. Therapeutic compositions for treating a neurodegenerative condition associated with Staufen1-induced dysregulation of RNA metabolism can include a therapeutically effective amount of a Staufen1-regulating agent and a pharmaceutically acceptable carrier.

Abstract: The present disclosure is concerned with thioquinolinone compounds for the treatment of disorders associated with heme oxygenase-1 (HO-1) signaling dysfunction such as, for example, kidney diseases (e.g., chronic kidney disease, acute kidney injury). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present disclosure describes various embodiments of systems, apparatuses, and methods for implementing an array antenna having a combination of ferromagnetic and nonferromagnetic conductors in alternating multilayers. One such antenna device comprises an array of patch antennas on a substrate, wherein the patch antennas are formed of a combination of ferromagnetic and nonferromagnetic conductors in alternating multilayers; and a microstrip feeding line coupled to the array of patch antennas. Other systems, apparatuses, and methods are also presented.

Abstract: A method of sensing a current in a conductor includes controlling a digital to analog converter output to cancel residual offset voltage in a magnetic tunnel junction device prior to sensing the current with the magnetic tunnel junction device. The method includes switching input to the magnetic tunnel junction device between a fixed voltage and an output of a digital to analog converter while switching input to a band pass filter between a lower and an upper voltage output of the magnetic tunnel junction device. The output of the digital to analog converter is modified to provide a low-amplitude unsaturated sine-wave at an output of the band pass filter, at which point changes in the output of the band pass filter are associated with the amount of current in a sensed conductor.

Abstract: The general problem of pattern change discovery between high-dimensional data sets is addressed by considering the notion of the principal angles between the subspaces is introduced to measure the subspace difference between two high-dimensional data sets. Current methods either mainly focus on magnitude change detection of low-dimensional data sets or are under supervised frameworks. Principal angles bear a property to isolate subspace change from the magnitude change. To address the challenge of directly computing the principal angles, matrix factorization is used to serve as a statistical framework and develop the principle of the dominant subspace mapping to transfer the principal angle based detection to a matrix factorization problem. Matrix factorization can be naturally embedded into the likelihood ratio test based on the linear models. The method may be unsupervised and addresses the statistical significance of the pattern changes between high-dimensional data sets.

Abstract: This document provides materials and methods for identifying and quantifying AIM polypeptides in a sample using mass spectrometry techniques. For example, methods of using mass spectrometry to identify and quantify AIM polypeptides in a serum sample are provided. In some cases, quantification of AIM polypeptides can be used to diagnose and/or treat patients having a disease or disorder characterized by altered (e.g., increased or decreased) AIM polypeptide levels.

Abstract: A system for monitoring an analyte concentration in liquid is provided. The system includes a coupon comprising an absorbent body with a window through the absorbent body wherein the liquid is maintained in said window by capillary action and surface tension. A reactant is in the absorbent body wherein the reactant is capable of diffusing into the window to react with an analyte in the liquid, or the reactant is able to react with the analyte within the coupon itself, with color-indicating by-products of the reaction diffusing into the window, wherein the analyte is present in an analyte concentration, to form a reactant with a color wherein the color has an intensity which correlates to the analyte concentration. A light source is provided which is capable of passing light into the window wherein the light is attenuated by the color proportional to the analyte concentration to form attenuated light. A detector is provided which is capable measuring an intensity of the attenuated light.

Abstract: An object mapping system for determination of a point of interest (POI) in an environment, including: creating a map of the environment; performing object recognition to locate objects of interest based on characteristics of the environment; generating a map with tags of the objects and the characteristics; providing navigation to guide a device to an object of interest selected from the objects based on a distance from a current location to a destination location of the device; determining angles from an initial position of a laser pointer to the object; generating signals to rotate servomotors based on the angles; processing the signals to rotate the servomotors such that the pointer is rotated from the initial position in coordinate-based directional angles to the object; generating a laser beam that targets the object for determination of the POI associated with the object that is associated with destination location of the computing device.

Abstract: ‘UF22-146-3’ is a new Coleus plant, selected for having a combination of desirable traits that make it well-suited for use as an annual plant in the summer landscape. ‘UF22-146-3’ was selected for its consistent and novel bright reddish brown to dark red foliage color and for its consistent compact and mounding habit and vigorous growth rate in the greenhouse and landscape. ‘UF22-146-3’ has large, lance-shaped leaves that are twice as long as they are wide. ‘UF22-146-3’ maintains its foliage colors and leaf patterns in both sun and shade until the end of the garden season. ‘UF22-146-3’ has a highly branched and spreading form, growing wider than it does tall.

Abstract: A new and distinct cultivar of Coleus (Coleus scutellarioides) plant named ‘UF21-9-16’ having a combination of desirable traits that make it well-suited for use as a versatile annual plant in the summer landscape. ‘UF21-9-16’ has consistent foliage color patterning and a fast growth rate and vigor in the greenhouse and landscape. ‘UF21-9-16’ has lance-shaped and lobed foliage that is predominantly dark red with consistent yellowish green leaf margins and uniform yellowish green spots across the leaf surface. ‘UF21-9-16’ maintains these contrasting colors and patterns in both sun and shade. ‘UF21-9-16’ is upright in habit, but it is highly branched and spreading in form, growing wider than it does tall.

Abstract: A new and distinct cultivar of Coleus (Coleus scutellarioides) plant named ‘UF21-9-4’ having a combination of desirable traits that makes it well-suited for use as a colorful annual plant in the summer landscape. ‘UF21-9-4’ has consistent foliage color patterning and fast growth rate and vigor in the greenhouse and landscape. ‘UF21-9-4’ has lance-shaped foliage that is predominantly yellowish green with consistent reddish brown centers and light yellow green spots. ‘UF21-9-4’ is exceptional because it maintains these contrasting colors and patterns in both sun and shade. ‘UF21-9-4’ is compact and upright in growth habit, but it is highly branched and spreading in form, growing wider than it does tall.