Abstract: Embodiments of the present invention may provide a PET-MRI hybrid system capable of arranging a PET apparatus and an MRI apparatus in a line. An MRI room containing the MRI apparatus and a PET room containing the PET apparatus are provided at either side of a central waiting room as opposed to each other about the waiting room. A rail portion linearly extends from the PET room to the waiting room on their bottoms. Another rail portion linearly extends on the bottom of the MRI room. A transfer unit, which supports a subject lying thereon, travels along the rail portions of the waiting room, the MRI room and the PET room. A bridge unit is provided between the rail portion of the waiting room and the rail portion of the MRI room. The bridge unit provides a space for opening and closing a shield door of the MRI room and allows the transfer unit to be reciprocated between the waiting room and the MRI room by selectively connecting the rail portion of the waiting room and the rail portion of the MRI room.
Type:
Grant
Filed:
August 17, 2007
Date of Patent:
October 26, 2010
Assignee:
Gachon University Of Medicine & Science Industry-Academic Cooperation Foundation
Inventors:
Zang Hee Cho, Cheol Ok Lee, Young Bo Kim, Ja Weon Yun, Hyung Jin Ahn, Dong Sung Kim, Hong Shim
Abstract: We disclose a cell having double mutations of the hERG gene that lead to charge reversal amino acid substitutions at residues 466 and 534 of the wild type Kv11.1 channel protein. These double charge reversal mutations result in cells having constitutively open Kv11.1 channels. Such cells could be used in a method of testing development-stage drugs and other compounds for Kv11.1 channel block activity.
Type:
Grant
Filed:
February 29, 2008
Date of Patent:
October 26, 2010
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Craig T. January, Christine Anne Klemens, Brian Patrick Delisle, Blake D. Anson
Abstract: A nucleoside analogue compound is provided which has a six-membered aromatic ring system, the aromatic ring system being substituted in the para position with an unbranched unsubstituted alkyl or alkoxy moiety, wherein the alkyl or alkoxy moiety, in total, has from 3 to 8 carbon atoms. This compound shows anti-vira1 activity, for example with respect to varicella zoster virus and can thus be used in therapeutic methods for the prophylaxis and treatment of viral infections such as varicella zoster virus.
Type:
Grant
Filed:
April 12, 2001
Date of Patent:
October 26, 2010
Assignees:
Rega Foundation, University College Cardiff Consultants Limited
Abstract: A scrub typhus diagnostic method and vaccine using a composition comprising truncated r47 protein and truncated r56 protein is disclosed. Vaccines composed of r56 protein variants are also disclosed. Methods of reducing HIV viral loads using r47 and r56 proteins and antibodies raised against r47 and r56 are also disclosed.
Type:
Grant
Filed:
October 23, 2007
Date of Patent:
October 26, 2010
Assignees:
The United States of America as represented by the Secretary of the Navy, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Inventors:
Wei Mei Ching, Hong Ge, Chien-Chung Chao
Abstract: Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as are sulfotransferase allozymes. Methods for determining the sulfonator status of a subject also are described. In addition, methods for predicting the therapeutic efficacy of a compound in a subject are described, as are methods for estimating the dose of a compound to be administered to a subject.
Type:
Grant
Filed:
September 25, 2007
Date of Patent:
October 26, 2010
Assignee:
Mayo Foundation for Medical Education and Research
Inventors:
Bianca A. Thomae, Eric D. Wieben, Richard M. Weinshilboum
Abstract: A method for processing CoPt alloys with improved magnetic properties. The method includes sealing a sample of a CoPt alloy in an evacuated quartz tube, and heating the alloy to a temperature of approximately 1000 degrees C. to homogenize the alloy for approximately 3 hours. The sample is then cooled at a controlled cooling rate of 120-150 degrees C. per minute to 600 degrees C. The sample is then held at 600 degrees C. for 10 hours to promote isothermal ordering. Finally, the sample is quenched in mineral oil.
Type:
Grant
Filed:
March 19, 2008
Date of Patent:
October 26, 2010
Assignee:
Florida State University Research Foundation
Abstract: The invention relates to an isolated or recombinant Na+/H+ exchanger comprising an isolated or recombinant Na+/H+ exchanger, particularly to the PBO-4 Na+/H+ exchanger. Also disclosed is an isolated or recombinant protein component of an H+-gated channel which can be affected by extracellular Ca2+ concentration. In particular, the invention relates to PBO-5 and/or PBO-8 and/or a H+-gated channel composed of PBO-5 and PBO-8. The invention relates to compounds isolated from a vertebrate organism, wherein said compounds comprise at least a part of a H+-gated channel or Na+/H+ exchanger. The invention also relates to a method for identifying a component of a H+-gated channel in a vertebrate organism.
Type:
Grant
Filed:
August 8, 2008
Date of Patent:
October 26, 2010
Assignee:
University of Utah Research Foundation
Inventors:
Erik M. Jorgensen, Asim A. Beg, Paola Nix
Abstract: A method of managing a routing table by interoperating with a routing block and a radio resource management (RRM)/scheduling block in a plurality of nodes of a multi-hop system, the method including computing a traffic load rate of each path which transmits traffic and updating the routing table with the computed traffic load rate via the routing block; and updating a plurality of metrics included in the routing table based on the traffic load rate and information transmitted from a neighbor node via the RRM/scheduling block.
Type:
Grant
Filed:
August 2, 2007
Date of Patent:
October 26, 2010
Assignees:
Samsung Electronics Co.,Ltd., Industry-University Cooperation Foundation Sogang University
Inventors:
Yongsuk Park, Jin Woo Choe, Jong Ho Bang, Bong Jhin Shin, Dong Kun Kim, Sung Hyuk Lee, Kil Su Hong
Abstract: Diagnostic methods for the detection of multiple myeloma (MM) and the identification of high-risk patients with multiple myeloma-related plasma proliferative disorders, such as MGUS or SMM, likely to progress to active MM are described. The diagnosis is based on the determination of concentrations of bioactive IL-1? produced by the bone marrow plasma cells of these patients. Also described are therapeutic methods for the treatment of MM and for the chemoprevention of the progression from disorders such as MGUS and SMM to active MM, involving the administration of inhibitors of IL-1?.
Type:
Grant
Filed:
January 26, 2005
Date of Patent:
October 26, 2010
Assignee:
Mayo Foundation for Medical Education and Research
Abstract: A composition useful for the production of transformed eukaryotic cells is described. The composition comprises submucosal tissue and a nucleic acid sequence. The nucleic acid sequence is typically recombinant DNA including gene(s) encoding for one or more biofunctional proteins. The submucosal tissue component of the present composition comprises the tunica submucosa of vertebrate intestine delaminated from the tunica muscularis and at least the luminal portion of the tunica mucosa. Injection or implantation of the composition into a host induces the formation of transformed cells capable of expressing gene(s) encoded by the nucleic acid sequence.
Type:
Grant
Filed:
May 2, 2007
Date of Patent:
October 26, 2010
Assignees:
Purdue Research Foundation, The Regents of the University of Michigan, Clarian Health Partners, Inc.
Inventors:
Stephen F. Badylak, Jeffrey Bonadio, Sherry Voytik
Abstract: A series of methods that utilize the incremental truncation of nucleic acids are described to create a plurality of modified nucleic acids and hybrid polypeptides. A plurality of substantially all possible single base-pair deletions of a given nucleic acid sequence is created. A method of making shuffled incremental truncated nucleic acids, which is independent of nucleic acid sequence homology, is also described. These methods can be used in protein engineering, protein folding, protein evolution, and the chemical synthesis of novel hybrid proteins and polypeptides.
Type:
Grant
Filed:
February 19, 2008
Date of Patent:
October 26, 2010
Assignee:
The Penn State Research Foundation
Inventors:
Stephen J. Benkovic, Marc Ostermeier, Stefan Lutz, Andrew E. Nixon
Abstract: The present invention provides a method for the synthesis of ?2-amino acids. The method also provides methods yielding ?-substituted ?-amino aldehydes and ?-substituted ?-amino alcohols. The present method according to this invention allows for increased yield and easier purification using minimal chromatography or crystallization. The methods described herein are based on an aldehyde aminomethylation which involves a Mannich reaction between an aldehyde and a formaldehyde-derived N,O-acetal (iminium precursor) and a catalyst, such as, for example, L-proline or a pyrrolidine. The invention allows for large scale, commercial preparation of ?2-amino acids.
Type:
Grant
Filed:
March 26, 2007
Date of Patent:
October 26, 2010
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Yonggui Chi, Samuel H. Gellman, William C. Pomerantz, William S. Horne, Li Guo, Emily P. English
Abstract: A recombinant herpesvirus, a method for producing the recombinant herpesvirus, and a pharmaceutical composition comprising the recombinant herpesvirus, are provided with a method for producing a recombinant herpesvirus using a BAC vector sequence. In addition, a vector comprising a herpesvirus genomic gene and a BAC vector sequence, a cell comprising the vector, and a nucleic acid cassette comprising a fragment, which is capable of homologous recombination with a herpesvirus genome, and a BAC vector sequence, are provided.
Type:
Grant
Filed:
May 8, 2009
Date of Patent:
October 26, 2010
Assignee:
The Research Foundation for Microbial Diseases of Osaka University
Abstract: A glycolipopeptide comprising a carbohydrate component, a peptide component and a lipid component, for use as a therapeutic or prophylactic vaccine. Also provided are monoclonal and polyclonal antibodies that recognize the glycolipopeptide of the invention, as well as uses thereof.
Type:
Grant
Filed:
July 3, 2008
Date of Patent:
October 26, 2010
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: A film with small hysteresis and high voltage resistance is obtained by reducing the carbon content in a gate insulating film on a SiC substrate. Specifically, the carbon content in the gate insulating film is set to 1×1020 atoms/cm3 or less. For this, using a plasma processing apparatus, a silicon oxide film is formed on the SiC substrate and then the formed silicon oxide film is reformed by exposure to radicals containing nitrogen atoms. Thus, the gate insulating film excellent in electrical properties is obtained.
Type:
Grant
Filed:
June 21, 2007
Date of Patent:
October 26, 2010
Assignees:
Tohoku University, Foundation for Advancement of International Science
Abstract: The present invention relates to a method for remotely controlling a sol-gel transition of hydrogels and a method for delivering a drug using the same. More specifically, the invention relates to a method of remotely controlling a sol-gel transition of polyethylene glycol (PEG)-containing hydrogels—three-dimensional networks of crosslinked polymer chains—by X-ray irradiation, and relates to a method for delivering a drug using the same.
Abstract: Cripto, a developmental oncoprotein, antagonizes activin and TGF-b signaling by forming a complex with activin and TGF-b and their type II receptors. This complex precludes the formation of a functional activin/TGF-b•type II•type I complex, thereby blocking the signaling of activin and TGF-b. Cripto may be generally capable of blocking antiproliferative Smad2/3 signals and provides a novel mechanism of oncogenic action with multiple therapeutic implications. Inhibiting the formation of Cripto and activin/TGF-b complex may enhance antiproliferative effects of activin and TGF-b.
Type:
Grant
Filed:
September 14, 2004
Date of Patent:
October 26, 2010
Assignee:
Research Development Foundation
Inventors:
Wylie Vale, Craig A. Harrison, Peter C. Gray
Abstract: The present invention is directed to compositions comprising lysophosphatidic acid analogs and methods of using such analogs as agonist or antagonists of LPA receptor activity. In addition the invention is directed to LPA receptor agonists that vary in the degree of selectivity at individual LPA receptors (i.e. LPA1, LPA2 and LPA3). More particularly the present invention is directed to LPA analogs wherein the glycerol is replaced with ethanolamine and a variety of substitutions have been linked at the second carbon atom.
Type:
Grant
Filed:
May 6, 2005
Date of Patent:
October 26, 2010
Assignee:
University of Virginia Patent Foundation
Inventors:
Kevin R. Lynch, Timothy L. Macdonald, Brian H. Heasley
Abstract: A method of producing botulinum toxin C-terminal receptor binding domain (HCR) is disclosed. The one embodiment, the method comprises the steps of (a) preparing E. coli transformed with an expression vector comprising DNA encoding HCR protein, (b) inducing expression of the HCR protein at a reduced temperature in a culture media, and (c) purifying the HCR protein via extraction, wherein the extraction comprises a clarification by centrifugation and a filtration, wherein the purified HCR protein is at least 10 mg/L of culture medium.
Type:
Grant
Filed:
February 29, 2008
Date of Patent:
October 26, 2010
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Michael Baldwin, Marite Bradshaw, William H. Tepp, Eric A. Johnson, Joseph T. Barbieri, Christina L. Pier
Abstract: A method of downloading data in a peer-to-peer service on a wired and wireless integrated network and a node therefore includes downloading the data to a requester node only through wired nodes among a plurality of nodes located in a download path between the requester node which requests the data and a holder node which has the data. Thereby, the file download rate can be improved, without reducing the retrieval success ratio according to the peer-to-peer method, and the storage space for the data of each node can be saved.