Abstract: This document describes methods and materials for mapping and modulating repolarization. For example, this document relates to methods and devices for mapping and modulating repolarization to target atrial and ventricular arrhythmias to deliver electrical stimulation pacing, ablation and/or electroporation.

Abstract: An eyelid flipper tool is used to flip a patient's eyelid to gain access to the patient's meibomian gland lands and gland openings. The eyelid flipper tool has a concave end and a convex end connected by a center section. The concave end has a concave edge with a concave end width, a concave radius, and a curvature. The convex end of the eyelid flipper tool has a convex edge with a convex end up with, a convex end radius, and a curvature. The radii of the concave end and the convex end and the curvature of the ends are dimensioned to conform to the curvature of the eyelids or the globe of a patient's eye.

Abstract: As disclosed herein, stapled peptides targeting the interaction interface between proteins that maintain the integrity of Wiskott-Aldrich syndrome protein family member 3 (WASF3) leads to destabilization of WASF3 and suppression of invasion. Disclosed are stapled peptides that inhibit the binding of Cytoplasmic FMR1-interacting protein 1 (CYFIP1) to either WASF3 or NCK-associated protein (NCKAP1). Also disclosed are methods for treating or suppressing invasion and metastasis of a cancer in a subject that involve administering to the subject a therapeutically effective amount of a stapled peptide disclosed herein.

Abstract: An exemplary system, method, and computer-accessible medium for generating an image(s) of an three-dimensional anatomical flow map(s) can include receiving an optical coherence tomography (“OCT”) signal(s), splitting the OCT signal(s) into a plurality of subspectra, averaging the plurality of subspectra, and generating the image(s) of the three-dimensional anatomical flow map(s) based on the averaged subspectra. The OCT signal(s) can be a swept-source OCT signal. The OCT signal(s) can be split into the subspectra based on a Hamming window. The Hamming distance window can be optimized to minimize a nearest side lobe for each of the subspectra. A position of at least one of the subspectra can be shifted prior to averaging the subspectra. The position of all but one of the subspectra can be shifted prior to averaging the subspectra.

Abstract: Provided herein are treatments for reducing pain in dogs. The treatments generally comprise a combination of an opioid compound, such as methadone, and an azole compound, such as fluconazole. The treatments may further comprise an opioid abuse deterrent that advantageously inhibits opioid effects in humans while maintaining desirable analgesic effects in dogs. Additionally, the treatments provided herein avoid the undesirable side effects of prior art opioid treatments for dogs. The treatments may be administered as separate doses or in a single formulation product for improved compliance. The treatments have wide use potential in dogs from perioperative patients to inpatients and outpatients and may be used, for example, for sedation in minor procedures, analgesia, and decreasing temperature in canine patients.

Abstract: Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular, and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low-pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high-pressure circuit (e.g., an aortic heart circuit).

Abstract: An apparatus is provided. The apparatus includes a memory, a second type spectrum measurer, and a processor. The memory stores an individualized blood sugar estimation model. The second type spectrum measurer measures second type spectrum data for a skin of a user. The processor calculates blood sugar of the user based on the measured second type spectrum data and the individualized blood sugar model. The blood sugar model is generated based on blood sugar profile data of the user calculated based on a first type spectrum-blood sugar profile relationship model and training second type spectrum data for the skin of the user.

Abstract: A method of decreasing conversion of nicotine to nornicotine is provided herein. The methods includes administering at least one basic region/leucine zipper (bZIP) type transcription factor inhibitor to an organism in need thereof. Also provided herein is a method of decreasing conversion of nicotine to nornicotine including mutating a bZIP type transcription factor binding site on a promoter of a nicotine N-demethylase (NND). Further provided herein is a method of decreasing conversion of nicotine to nornicotine including mutating a plant genome to knockout at least one bZIP type transcription factor.

Abstract: A system for neurorehabilitation is disclosed that includes a motion detector configured to generate a motion detection feedback signal, a transcutaneous auricular vagus nerve stimulation module, and a controller configured to receive the motion detection feedback signal and send a stimulation signal to the transcutaneous auricular vagus nerve stimulation module based on the motion detection feedback signal meeting a minimum threshold criteria. A method for neurorehabilitation is disclosed that includes the steps of detecting patient motor activity, determining if the detected patient motor activity meets a minimum threshold criteria, and stimulating a vagus nerve through transcutaneous auricular vagus nerve stimulation if the minimum threshold criteria is met.

Abstract: Methods and compositions for treating cholangiocarcinoma.

Abstract: The present disclosure relates to consortia of bacteria strains and composition comprising one or more bacterial strains disclosed herein. These consortia of isolated bacteria cultures and compositions comprising said cultures, having greater activity than would be observed for the individual bacteria cultures and compositions. A composition of the disclosure may advantageously be used for enhancing the availability of soil phosphorus and other macronutrients and/or micronutrients to plants, and thereby enhancing their growth and yield.

Abstract: Embodiments of the present disclosure provide for Rh(I) catalysts, methods of making alkenyl substituted arenes (e.g., allyl arene, vinyl arene, and the like), methods of making alkyl substituted arenes, and the like.

Abstract: An apparatus for decoding video data includes a decoder configured to decode, from a bitstream, a syntax element indicating an intra-prediction type of a current block of the video data, and an intra-predictor configured to generate a prediction block for the current block by selectively performing matrix based intra-prediction (MIP) or regular intra-prediction based on the intra-prediction type of the current block indicated by the syntax element.

Abstract: One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source. The neuromuscular stimulator can include a controller and at least one electrode. The controller can be configured to receive certain power and stimulation parameters associated with a therapy signal from the power source. The at least one electrode can be configured to deliver the therapy signal to a target tissue associated with control of a posterior base of the tongue of the subject.

Abstract: Disclosed are a method and an apparatus for high-speed decoding of a linear code on the basis of a soft decision. The method for high-speed decoding of a linear code on the basis of a soft decision may comprise the steps of: obtaining an alignment signal by aligning received signals in order of magnitude; obtaining a hard decision signal by making a hard decision on the alignment signal; obtaining a higher-level signal corresponding to most reliable bases (MRB) from the hard decision signal; obtaining a permuted and corrected codeword candidate by using an error vector according to a current order and the higher signal; calculating a cost for the current order by using a cost function; determining the permuted and corrected codeword candidate as a permuted and corrected codeword according to a result of comparing the calculated cost and the minimum cost; and determining a predefined high-speed condition.

Abstract: Compounds and methods are provided for the treatment of neurological or mitochondrial diseases, including epilepsy. In some embodiments, the compounds are substituted 1,4-naphthoquinones.

Abstract: Apparatus includes a plurality of memory cells (e.g., a dynamic random access memory (DRAM)) addressable as rows and columns and a plurality of matching circuits configured to be coupled to respective bit lines associated with the columns A control circuit is configured to store respective reference sequences (e.g., binary-encoded k-mer patterns) in respective ones of the columns, to sequentially provide rows of bits stored in the memory cells and bits of a query to the matching circuits, and to identify one of the reference sequences as corresponding to the query responsive to comparisons by the matching circuits.

Abstract: Disclosed is a mobile colposcopy device for early diagnosis of cervical cancer, which includes an insertion unit which is inserted into the vagina of a woman, has a penetrating hole formed in one end coming into contact with the uterus, and is provided with a capturing path communicating with the penetrating hole, a capturing unit which is provided in the insertion unit so as to capture the cervix through the capturing path, and a lighting unit which is provided on the capturing path of the insertion unit and irradiates a lighting to the cervix through the penetrating hole. According to the present disclosure, the mobile colposcopy device for early diagnosis of cervical cancer can be simply and easily used so as to perform cervical cancer screening using a mobile colposcopy without environmental constraints including hospitals and allows women to early diagnose cervical cancer.

Abstract: This document describes systems, methods, and devices for sensing electrical activity in a brain of a mammal Some aspects include a cortical electrode assembly configured, in use, to sense electrical activity at a surface of a brain, the assembly comprising: a ring-shaped substrate; and a plurality of electrical sensors affixed to the ring-shaped substrate, wherein the plurality of electrical sensors are spaced along the ring-shaped substrate so as to form a ring of electrical sensors that substantially encircle an aperture formed by the ring-shaped substrate.

Abstract: Methods and apparatuses for compacting soil and granular materials are disclosed. In some embodiments, the soil compaction apparatuses include an arrangement of diametric expansion elements that, in their expanded state, form a larger compaction surface. In another embodiment, a compaction chamber can be provided with diametric restriction elements and a flow-through passage in the upper portion of the chamber exterior of a drive shaft. The diametric expansion or restriction elements can be fabricated from, for example, individual chains, cables, or wire rope, or a lattice of vertically and horizontally connected chains, cables, or wire rope. Embodiments of the soil compaction apparatus include, but are not limited to, closed-ended driving shafts, open-ended driving shafts, flow-through passages, no flow-through passages, removable rings for holding the diametric expansion/restriction elements, and any combinations thereof.