Patents Assigned to Foundation
  • Patent number: 5218088
    Abstract: A method for synthesis of oligonucleotide analogs having dithiophosphate internucleosidic linkages is described. Monohalohydrocarbylthiophosphoramidites are utilized to prepare nucleoside thiophosphoramidite intermediates which are activated for nucleoside coupling with tetrazole catalysts. Sulfur oxidation and dehydrocarbylation of the coupled thiophosphite intermediates provide oligonucleotide analogs having achiral dithiophosphate internucleosidic linkages.
    Type: Grant
    Filed: November 2, 1989
    Date of Patent: June 8, 1993
    Assignee: Purdue Research Foundation
    Inventors: David Gorenstein, Nassar Farschtschi
  • Patent number: 5215943
    Abstract: A method of creating a ceramic membrane with enhanced thermal stability is disclosed. The method involves combining quantities of a first metal alkoxide with a second metal, the quantities selected to give a preselected metal ratio in the resultant membrane. A limited amount of water and acid is added to the combination and stirred until a colloidal suspension is formed. The colloid is dried to a gel, and the gel is fired at a temperature greater than approximately 400.degree. C. The porosity and surface area of ceramic membranes formed by this method are not adversely affected by this high temperature firing.
    Type: Grant
    Filed: July 2, 1991
    Date of Patent: June 1, 1993
    Assignee: Wisconsin Alumi Research Foundation
    Inventors: Marc A. Anderson, Qunyin Xu, Brian L. Bischoff
  • Patent number: 5215770
    Abstract: Reduced calorie flavored popcorns are provided having flavored toppings containing significant quantities of polydextrose, together with water and one or more flavoring and sweetening agent(s), e.g., caramel, fruit flavorings or cinnamon, and a minor amount of sodium bicarbonate. Finished popcorns in accordance with the invention have a calorie content of up to about 100 calories per ounce, and in particularly preferred forms a calorie content of from about 60-65 calories per ounce, representing a 50% calorie reduction as compared with conventional products. Where air-popped popcorn is used, the calorie content is up to about 85 calories per ounce.
    Type: Grant
    Filed: March 13, 1992
    Date of Patent: June 1, 1993
    Assignee: Kansas State University Research Foundation
    Inventor: Fadi M. Aramouni
  • Patent number: 5215884
    Abstract: The present invention are nucleic acid probes which are highly selective for DNA specific to one sex of a livestock species, particularly pigs and chickens, and methods for their isolation, characterization, and utilization. These probes can be applied in a variety of methods for assaying the ratio of male to female mammalian sperm in an isolated fraction or the sex of an egg, as well as for determining the sex of an embryo in the early stages of development.Genomic DNA from whole blood taken from a male and a female animal was digested with various restriction enzymes and the products compared on agarose gels. A band of approximately 4 kilobases in a EcoR1 digest of male pig DNA was absent in female pig DNA. In the chickens, a band of approximately 600 bases and a band of approximately 1200 bases were present in a XhoI digest of female DNA which was not present in the male DNA. The sex-specific DNA was then ligated into a vector and transformed into E. coli.
    Type: Grant
    Filed: July 9, 1991
    Date of Patent: June 1, 1993
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: Royal A. McGraw, III
  • Patent number: 5215883
    Abstract: A process and apparatus for detecting the mobility of fluorescently labeled molecules in response to a force is disclosed. The fluorescently labeled molecules are placed in a fluid medium such as an electrophoretic gel in a capillary tube. An electric field is applied to induce the movement of the molecules. A region of the labeled molecules is photobleached leaving a geometrically defined region which has not been photobleached. The region which has not been photobleached is excited by a reading beam. The reading and the photobleaching beams can be generated by focusing a laser through a diffraction grading. The intensity produced by the interaction of the reading beam in the geometrically defined region of the molecule is detected by a photo detector. In detecting more than one spThis invention was partially made with Government support under the polymers program of the National Science Foundation DMR8617820. The Government has certain rights in the invention.
    Type: Grant
    Filed: July 9, 1990
    Date of Patent: June 1, 1993
    Assignee: The Research Foundation
    Inventor: Benjamin Chu
  • Patent number: 5216172
    Abstract: Agents against drug-resistant tumor cells comprising a 1,4-dihydropyridine derivative represented by the following formula (I): ##STR1## wherein R.sup.1 is an aryl group which may be substituted;R.sup.2 and R.sup.3, which may be the same or different, each is a member selected from the group consisting of an alkyl group, an alkyloxycarbonyl group, an aryloxycarbonyl group, an aralkyloxycarbonyl group, an aminocarbonyl group, a hydroxycarbonyl group, a formyl group, and a cyano group, each of which may be substituted;R.sup.4 and R.sup.5 is a hydrogen atom or a member selected from the group consisting of a lower alkyl group, a hydroxymethyl group, a cyano group, an amino group, a formyl group, and a halogen atom; andR.sup.
    Type: Grant
    Filed: January 28, 1991
    Date of Patent: June 1, 1993
    Assignees: Ajinomoto Co., Inc., Japanese Foundation for Cancer Research
    Inventors: Kouzou Toyota, Hisashi Shinkai, Hirozumi Eto, Akira Kamimura, Chikahiko Eguchi, Koji Ohsumi, Takashi Tsuruo
  • Patent number: 5215605
    Abstract: Intermetallic compounds or alloys comprising niobium with and from 10 to 28 atomic percent titanium and from 14 to 17.5 atomic percent aluminum characterized by very high temperature melting points, high compressive strength at room temperature, higher room temperature compressive strength after annealing, machineable with conventional tooling, a B2 crystal structure in the as-cast condition, a two-phase microstructure in the annealed condition consisting of a B2 matrix and a second phase with the A15 crystal structure, an expected low value for coefficient of thermal expansion and susceptible to fabrication into single crystals.
    Type: Grant
    Filed: July 23, 1991
    Date of Patent: June 1, 1993
    Assignee: The Ohio State University Research Foundation
    Inventor: Hamish L. Fraser
  • Patent number: 5215907
    Abstract: A 46,000 Dalton thermostable, very acidic protease, which has been named thermopsin, was purified to homogeneity from the culture medium of Sulfolobus acidocaldarius by a five-step procedure including column chromatographies on DEAE-Sepharose CL-6B, phenyl-Sepharose CL-4B, Sephadex G-100, MonoQ (FPLC), and gel filtration (HPLC). The enzyme is a single polypeptide chain having proteolytic activity over pH range 0 to 11 at temperatures between 0.degree. C. and 100.degree. C., with maximal activity at approximately pH 2 and 90.degree. C. Antibodies directed against thermopsin have been prepared. Through studies using various aspartic protease inhibitors, thiol and metalloprotease inhibitors, and serine protease inhibitors, it was determined that, although similar to some aspartic proteases, the active site of thermopsin is clearly not identical to that of other aspartic proteases.
    Type: Grant
    Filed: January 30, 1992
    Date of Patent: June 1, 1993
    Assignee: Oklahoma Medical Research Foundation
    Inventors: Jordan J. N. Tang, Xin-Li Lin
  • Patent number: 5216155
    Abstract: Silicon and aluminum complexes having the following formula I, II or III: ##STR1## wherein x is 0 or 1, T is H or ##STR2## each R is independently selected from the group consisting of H, OH, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.2-6 alkene, C.sub.6-12 aryl, C.sub.1-6 hydroxyalkyl, C.sub.1-6 thioalkyl, C.sub.2-12 alkoxyalkyl, C.sub.3-20 heteroaromatic, and combinations thereof, wherein R may further contain one or more atoms of a non-carbon element such as Si, Ge, Sn, P, and the like; Y is a cation, and Z is a multivalent cation, are prepared by reacting silica or alumina with a diol, in the presence of a base, while removing water formed during the reaction. Methods for producing such complexes starting with silica or alumina, and methods for converting such complexes into other silicon or aluminum-containing compounds, are disclosed.
    Type: Grant
    Filed: November 12, 1991
    Date of Patent: June 1, 1993
    Assignee: Washington Research Foundation
    Inventors: Richard M. Laine, Kay A. Youngdahl
  • Patent number: 5215904
    Abstract: A method for producing a recombinant mammal in vivo is disclosed. The mammal has a mammary gland, with mammary epithelial cells lining a duct in that gland One increases the rate of mitosis of the mammary epithelial cells (e.g. by using perphenazine or a mitogen), and one then exposes the mammary epithelial cells in vivo in the gland to a recombinant vector (e.g. a retrovirus vector). The mammary epithelial cells can be pretreated (or simultaneously treated) with polybrene to facilitate infection by virus vectors, and the vector can have a signal sequence which causes foreign proteinaceous material to be secreted into the milk produced by the mammary gland. Also disclosed are recombinant non-human mammals produced by such methods and novel milk products that they produce.
    Type: Grant
    Filed: January 27, 1989
    Date of Patent: June 1, 1993
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Michael N. Gould, Bingcheng Wang
  • Patent number: 5216025
    Abstract: A method for treatment of an animal for systemic hypotension induced by internal nitric oxide production caused by endotoxin or cytokines. The method involves administering an .alpha..sub.1 adrenergic agonist and an amount of an inhibitor of nitric oxide formation from argiResearch relating to the development of this invention was supported by the United States Public Health Service grants which gives the United States government certain rights to use of the present invention.
    Type: Grant
    Filed: July 1, 1991
    Date of Patent: June 1, 1993
    Assignees: Board of Regents, The University of Texas System, Cornell Research Foundation, Inc.
    Inventors: Steven S. Gross, Robert G. Kilbourn, Roberto Levi
  • Patent number: 5216372
    Abstract: The thickness of the layers of rubber covering the steel belts within a tire can be measured by transmitting a microwave signal toward the outer surface of the tire and measuring the phase shift of the signal reflected by the tire. In the preferred embodiment, a waveguide is used to direct the microwave signal toward the tire. A standing wave is created within the waveguide by interference between the transmitted microwave signal and the microwave signal reflected from the tire. A series of crystal detectors mounted along the length of the waveguide measure the standing wave. A processor calculates the phase of the reflection coefficient, and determines the thickness of the rubber layer as a predetermined function of the phase. By proper selection of the microwave frequency and the spacing between the waveguide and the tire, the rubber layer thickness can be uniquely determined as a function of phase for any range of rubber thicknesses likely to be encountered in a tire.
    Type: Grant
    Filed: October 13, 1992
    Date of Patent: June 1, 1993
    Assignee: Colorado State University Research Foundation
    Inventors: Reza Zoughi, Sasan Bakhtiari
  • Patent number: 5215917
    Abstract: Genetic material encoding the P22 peptide of Toxoplasma gondii has been isolated and characterized. This genetic material allows the production of peptides for use in diagnosis or immunization or can itself be directly used in hybridization assays.
    Type: Grant
    Filed: November 3, 1989
    Date of Patent: June 1, 1993
    Assignee: Research Institute of Palo Alto Medical Foundation
    Inventors: Fausto G. De Araujo, Jeffrey B. Prince, Jack S. Remington
  • Patent number: 5212895
    Abstract: Cutting apparatus is described which has teeth mounted on a carrier such as an endless belt or chain for advancement through material to be cut. The cutting apparatus includes a tooth mounting assembly which is supported on the carrier whereby a tooth supported thereby may be moved between an extended position at which the tooth's cutting edge extends beyond a side of the carrier and a stowed position. There may also be provided locking lugs for operatively maintaining the tooth in its extended position.
    Type: Grant
    Filed: July 23, 1991
    Date of Patent: May 25, 1993
    Assignee: Foundation Technology Limited
    Inventor: Paul A. Camilleri
  • Patent number: 5214033
    Abstract: Fragments of the factor VIII:C polypeptide have been discovered which exhibit highly specific factor VIII activity. Monoclonal antibodies to the polypeptide fragments and methods for the isolation and purification of said fragments are also disclosed.
    Type: Grant
    Filed: July 15, 1991
    Date of Patent: May 25, 1993
    Assignee: Scripps Clinic & Research Foundation
    Inventors: Theodore S. Zimmerman, Carol A. Fulcher
  • Patent number: 5214226
    Abstract: The present invention teaches an apparatus and method for commercial conversion of methane in the absence of a catalyst to higher hydrocarbons that are generally in short supply, e.g., butane, ethylene, propene, etc. The production of these higher molecular weight hydrocarbons aids in justifying the cost of the conversion process. The inventive conversion technique utilizes small amounts, generally 1% or less, of a low-cost initiator, plus air, which allows for the commercial viability of the process.
    Type: Grant
    Filed: March 13, 1992
    Date of Patent: May 25, 1993
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Simon H. Bauer, Huy-Zu Cheng
  • Patent number: 5214315
    Abstract: An extremely fast high-voltage driver for nanosecond-level switching of gallium arsenide PIN semiconductor devices and other reactive loads utilizes two stages of voltage level translation to permit low voltage TTL logic control signals to control the application of high voltage switching pulses to a load. The circuit utilizes an input stage responsive to TTL level signals to drive a first voltage level translating stage which produces high voltage pulses complementary to the input pulses. The increased voltage pulses are supplied through an intermediate power gain stage to provide amplification of the pulse power level. The amplified pulse is supplied to an output stage for additional level conversion to thereby provide high voltage switching signals to a PIN switch or other reactive load.
    Type: Grant
    Filed: April 23, 1991
    Date of Patent: May 25, 1993
    Assignee: Cornell Research Foundation, Inc.
    Inventor: Curt Dunnam
  • Patent number: 5213026
    Abstract: An apparatus and system is disclosed for extruding commodities such as rice bran and which includes symmetrically disposed beater bar segments on the extruder rotor that will simultaneously impact symmetrically positioned knives mounted within the extruder housing. The apparatus preferably includes a sufficient number of knives and beater bars that impacts occur more than once each ninety degrees of rotation and at substantially equal degrees of rotation from each other. The device includes a widened and lengthened extrusion gap with variable width, a generally solid extrusion rotor, and a control system for adjusting the cooking temperature by varying the width of the extrusion gap. The extruder is fed using a drag conveyor with angled blades which push the rice bran into the extruder housing.
    Type: Grant
    Filed: August 28, 1991
    Date of Patent: May 25, 1993
    Assignee: The NeVentures Foundation
    Inventor: J. Edward House
  • Patent number: 5214173
    Abstract: Novel cyclopentadienyl dicarbollide complexes of titanium, zirconiun and hafnium constitute a new class of neutral, 14-electron, d.degree., mixed-ring, bent-metallocene alkyl complexes which are useful as polymerization catalysts.
    Type: Grant
    Filed: December 31, 1991
    Date of Patent: May 25, 1993
    Assignee: The University of Iowa Research Foundation
    Inventors: Richard F. Jordan, Donna J. Crowther
  • Patent number: RE34271
    Abstract: A high yield method of production of a cross-linked hemoglobin derivative suitable for use as a blood substitute and plasma expander which is cross-linked between Lys 99 Alpha.sub.1 and Lys 99 Alpha.sub.2 in high percentage by adding the cross-linker in the presence of an added polyanion which blocks competing reactions at other sites of the protein.
    Type: Grant
    Filed: May 24, 1990
    Date of Patent: June 1, 1993
    Assignee: University of Iowa Research Foundation
    Inventor: Joseph A. Walder