Patents Assigned to Foundation
  • Recombinant vector having a Streptomyces achromogenes DNA sequence useful for gene amplification
    Patent number: 5240858
    Abstract: An improved means for amplifying DNA sequences is disclosed. The invention provides a means for creating tandemly repeated gene sequences. One attaches a selected foreign gene sequence in a S. achromogenes fragment and then exposes the recombinant segment to antibiotic challenge. Temperature sensitive plasmids or other curable vectors can be used to assist in the amplification and the positioning of the resulting gene directly in chromosomal host DNA.
    Type: Grant
    Filed: January 8, 1991
    Date of Patent: August 31, 1993
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ulfert Hornemann, Guy G. Hoffman, Christopher J. Otto
  • Electrical field-flow fractionation using redox couple added to carrier fluid
    Patent number: 5240618
    Abstract: Improved apparatus and procedures for electrical field-flow fractionation is disclosed. A test sample is injected into the liquid carrier stream flowing through the flow channel of the apparatus. The apparatus comprises a thin flow channel having a top, a bottom, and two side walls, with a fluid carrier inlet at one end and an outlet at the other end. The top and bottom walls are formed such that at least the inner surfaces thereof that face the flow channel are made of an electrically conductive material so that the inner surfaces thereof form electrodes as well as opposite, broad boundary surfaces of the flow channel. A voltage differential is applied to the electrically conductive inner surfaces of the top and bottom walls. The carrier fluid flowing through the channel can be deionized or distilled water as well as water containing a red-ox couple such as quinone/hydroquinone.
    Type: Grant
    Filed: February 3, 1992
    Date of Patent: August 31, 1993
    Assignee: University of Utah Research Foundation
    Inventors: Karin D. Caldwell, Yu-Shu Gao
  • Method of making bonded or sintered permanent magnets
    Patent number: 5240513
    Abstract: An isotropic permanent magnet is made by mixing a thermally responsive, low viscosity binder and atomized rare earth-transition metal (e.g., iron) alloy powder having a carbon-bearing (e.g., graphite) layer thereon that facilitates wetting and bonding of the powder particles by the binder. Prior to mixing with the binder, the atomized alloy powder may be sized or classified to provide a particular particle size fraction having a grain size within a given relatively narrow range. A selected particle size fraction is mixed with the binder and the mixture is molded to a desired complex magnet shape. A molded isotropic permanent magnet is thereby formed. A sintered isotropic permanent magnet can be formed by removing the binder from the molded mixture and thereafter sintering to full density.
    Type: Grant
    Filed: October 9, 1990
    Date of Patent: August 31, 1993
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: R. William McCallum, Kevin W. Dennis, Barbara K. Lograsso, Iver E. Anderson
  • Oncoinhibin
    Patent number: 5241051
    Abstract: The present invention provides a novel human cytokine termed Oncoinhibin. The protein Oncoinhibin is secreted by human erythroblastoid cells, has a molecular weight of approximately 28 kDa and exerts diverse neoplastic activity. The present invention also provides a method for the preparation of human Oncoinhibin.
    Type: Grant
    Filed: April 24, 1992
    Date of Patent: August 31, 1993
    Assignee: Research Development Foundation
    Inventor: Bharat B. Aggarwal
  • In situ formation of metal-ceramic oxide microstructures
    Patent number: 5240495
    Abstract: In situ formation of metal-ceramic oxide microstructures is carried out on a starting oxide phase containing at least a most noble metallic component (e.g., iron) and a least noble metallic component (e.g. manganese) and subjecting the starting oxide phase to a temperature and oxygen partial pressure and for a time period to cause reduction of only part of the most noble metallic component to elemental metal.
    Type: Grant
    Filed: April 2, 1992
    Date of Patent: August 31, 1993
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Rudiger Dieckmann, Stephen L. Sass
  • Arthropodicidal use of 6-methoxy-2-benzoxazolinone combined with insecticides and/or biocontrol agents
    Patent number: 5238724
    Abstract: Control of arthropods, particularly the larvae of Diabrotica spp., by application of 6-methoxy-2-benzoxazolinone (6-MBOA) alone or in combination with an insecticide or biocontrol agent; and arthropodicidal compositions containing 6-MBOA.
    Type: Grant
    Filed: April 10, 1992
    Date of Patent: August 24, 1993
    Assignee: Colorado State University Research Foundation
    Inventors: Louis B. Bjostad, III, Bruce E. Hibbard
  • Peptides that inhibit von Willebrand Factor binding to the platelet SPIB receptor
    Patent number: 5238919
    Abstract: This invention provides a peptide fragment of human von Willebrand Factor (vWF) and sub-fragment thereof isolated as enzymtic digestion products from naturally occurring human vWF, or isolated from synthetic peptide mixtures or isolated from lysates of organisms capable of producing recombinant human vWF. The fragments and sub-fragments are useful in the prevention and treatment of cardiovascular disorders by virtue of their ability to inhibit the binding of vWF to platelets, heparin and/or collagen.
    Type: Grant
    Filed: May 7, 1990
    Date of Patent: August 24, 1993
    Assignee: Scipps Clinic and Research Foundation
    Inventors: Theodore S. Zimmerman, Yoshihiro Fujimura, Richard A. Houghten, Zaverio M. Ruggeri
  • Synthetic piperidinediones with cytostatic activity
    Patent number: 5238947
    Abstract: The present invention are novel compounds of the formula: ##STR1## wherein R is OH, NH.sub.2, OW, or H; X is H, F, Cl, Br, I, OH, OW, NO.sub.2 or NH.sub.2 ; Y is H, F, Cl, I, or Br; W is C(O)Z or a C.sub.1 to C.sub.12 alkyl group; Z is an aliphatic or aromatic group of from C.sub.1 to C.sub.12 ; X and Y can both vary within the molecule; and if R is H, at least one of X or Y is not H. In a preferred embodiment, R is OH or NH.sub.2. The most preferred compound is (4-hydroxy-3-N-phenylacetylamino-2,6-piperidinedione), in which R is OH, X is H and Y is H. These compounds have cytostatic activity and insert stereochemically into DNA.
    Type: Grant
    Filed: May 21, 1991
    Date of Patent: August 24, 1993
    Assignees: University of Georgia Research Foundation, Inc., Stereochemical Genetics, Inc.
    Inventors: Lawrence B. Hendry, Chung K. Chu, Virendra B. Mahesh
  • Method for preparing an optical switching device having multiple quantum wells
    Patent number: 5238867
    Abstract: Disclosed herein is a novel process for the manufacture of optical bistable switching device including multiple quantum wells. The process is carried out by: supplying a first organo-metallic compound as the source of a first metallic element and a reaction gas continuously while supplying a second organo-metallic compound as the source of a second metallic element in a discrete mode into a reactor and cultivating a semiconductor multiple quantum wells region having multiple pairs of intrinsic semiconductor-layer/semiconductor-layer(GaAs/AlGaAs), one of the layer containing said second metallic element(Al), while controlling the mole fraction of said second metallic element(Al) to be in the range of 0.01 to 0.25 of the total first and second metal contents existing in the layer containing the second metallic element, thereby lowering the impurity concentration and optimizing the negative resistance.
    Type: Grant
    Filed: January 10, 1992
    Date of Patent: August 24, 1993
    Assignee: Posco Educational Foundation
    Inventors: O'Dae Kwon, Seung-Won Lee
  • Immortal human mammary epithelial cell sublines
    Patent number: 5238840
    Abstract: Two immortalized human mammary epithelial cell sublines are provided. The sublines do not undergo terminal differentiation and senescence upon exposure to high calcium concentrations. The sublines exhibit positive reactivity with milk-fat globule membrane and cytokeratin anti-sera and are non-tumorigenic in athymic mice. The sublines are useful in evaluating the capacity of preselected agents to bring about a change in epithelial cell growth and in the production of proteins.
    Type: Grant
    Filed: July 9, 1991
    Date of Patent: August 24, 1993
    Assignee: Michigan Cancer Foundation
    Inventors: Robert J. Pauley, Terry J. Paine, Herbert D. Soule
  • 19-nor-vitamin D compounds
    Patent number: 5237110
    Abstract: This invention provides a novel class of vitamin D-related compounds, namely the 1.alpha.-hydroxy-19-nor-vitamin D analogs, as well as a general method for their chemical synthesis. The compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells, including malignant cells, and in inducing their differentiation, and thus represent novel therapeutic agents for the treatment of malignant and other diseases characterized by the proliferative growth of undifferentiated cells. Formulations for therapeutic use and treatment methods are also provided.
    Type: Grant
    Filed: February 16, 1990
    Date of Patent: August 17, 1993
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Kato L. Perlman, Rafal R. Sicinski, Jean M. Prahl
  • Superconducting energy storage magnet
    Patent number: 5237298
    Abstract: A superconducting magnet is formed having composite conductors arrayed in coils having turns which lie on a surface defining substantially a frustum of a cone. The conical angle with respect to the central axis is preferably selected such that the magnetic pressure on the coil at the widest portion of the cone is substantially zero. The magnet structure is adapted for use as an energy storage magnet mounted in an earthen trench or tunnel where the strength the surrounding soil is lower at the top of the trench or tunnel than at the bottom. The composite conductor may be formed having a ripple shape to minimize stresses during charge up and discharge and has a shape for each ripple selected such that the conductor undergoes a minimum amount of bending during the charge and discharge cycle.
    Type: Grant
    Filed: September 21, 1990
    Date of Patent: August 17, 1993
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Roger W. Boom, Yehia M. Eyssa, Mostafa K. Abdelsalam, Xianrui Huang
  • Method of determining energy transfer efficiency of a donor-acceptor pair of fluorescent dyes
    Patent number: 5237515
    Abstract: The energy transfer efficiency of a donor-acceptor pair of fluorescent dyes can be determined by first measuring the fluorescence and absorption spectra of donor-protein, acceptor-protein, mixture of donor-protein and acceptor-protein, and donor-acceptor-protein conjugates, then separating the respective spectra into their respective donor-protein complex and acceptor-protein complex components using multiple linear regression, and then determining the transfer efficiency on the basis of the quenching of the donor fluorescence based on the spectral data thus obtained.
    Type: Grant
    Filed: April 10, 1991
    Date of Patent: August 17, 1993
    Assignee: University of Utah Research Foundation
    Inventors: James N. Herron, Ai-Ping Wei
  • Demodulating method and apparatus particularly for demodulating a differential phase-shift keying signal
    Patent number: 5237287
    Abstract: A method and apparatus are described for demodulating a modulated signal having a carrier component and a data component, in which the modulated signal is split into at least two parts one of which is delayed with respect to the other, and the two parts are multiply-coupled and linearly-combined to produce a combined output corresponding to a function of the data component independent of the carrier component frequency. In the described method and apparatus the undelayed part is coupled with the delayed part in a multiport coupler, wherein the parts are relatively phase-shifted to produce a plurality of phase-shifted signals; and the phase-shifted signals are linearly combined such that the data component, in the function of the combined output, is not affected by variations in frequency or phase of the carrier component. This enables a robust direct-detection DPSK receiver.
    Type: Grant
    Filed: June 24, 1992
    Date of Patent: August 17, 1993
    Assignee: Technion Research and Development Foundation Ltd.
    Inventor: Israel Bar-David
  • Polyvalent metal ion-containing antibody combining site catalysts
    Patent number: 5236825
    Abstract: A catalytic molecule comprising a receptor molecule containing an antibody combining site that immunologically binds to a plurality of polyvalent metal ion-containing coordination complexes is disclosed. The coordination complex of a first immunoligand is kinetically inert, whereas the coordination complex of a second immunoligand is kinetically labile. The receptor molecule catalyzes a reaction of the second immunoligand. Immunogens, antigens, and methods of making and using the catalytic receptors are disclosed, as are receptor molecules that catalyze the hydrolysis of a predetermined peptide bond.
    Type: Grant
    Filed: January 17, 1989
    Date of Patent: August 17, 1993
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Brent L. Iverson, Richard A. Lerner
  • Ternary metal-rich sulfide with a layered structure
    Patent number: 5236691
    Abstract: A ternary Nb-Ta-S compound is provided having the atomic formula, Nb.sub.1.72 Ta.sub.3.28 S.sub.2, and exhibiting a layered structure in the sequence S-M3-M2-M1-M2-M3-S wherein S represents sulfur layers and M1, M2, and M3 represent Nb/Ta mixed metal layers. This sequence generates seven sheets stacked along the [001] direction of an approximate body centered cubic crystal structure with relatively weak sulfur-to-sulfur van der Waals type interactions between adjacent sulfur sheets and metal-to-metal bonding within and between adjacent mixed metal sheets.
    Type: Grant
    Filed: March 8, 1991
    Date of Patent: August 17, 1993
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Hugo F. Franzen, Xiaoqiang Yao
  • Reduced-protein subunit vaccine for swine dysentery
    Patent number: 5236708
    Abstract: The effectiveness of parenteral vaccination of swine with Treponema hyodysenteriae preparations is increased by reducing the protein content of the Treponema hyodysenteriae cells and subcellular components in the vaccine.
    Type: Grant
    Filed: November 3, 1989
    Date of Patent: August 17, 1993
    Assignees: Iowa State University Research Foundation, Inc., Ambico, Inc.
    Inventors: Anthony G. Ostle, Michael J. Wannemuehler
  • Bacterial plasmin receptors as fibrinolytic agents
    Patent number: 5237050
    Abstract: The subject invention concerns novel methods and compositions for thrombolytic therapy. More specifically, a receptor with high affinity for plasmin has been characterized, purified, cloned, and expressed. This receptor can be used in combination therapies where it is administered prior to, concurrently with, or after a plasminogen activator. Also, this receptor can be bound to plasmin and administered to humans or animals in need of fibrinolytic activity. Additionally, the invention pertains to a novel immobilized form of plasmin which advantageously accumulates at the point where antifibrinolytic activity is needed.
    Type: Grant
    Filed: May 15, 1990
    Date of Patent: August 17, 1993
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Michael D. P. Boyle, Richard Lottenberg, Christopher Broder, Gregory Von Mering
  • Methods of fabricating integrated, aligned tunneling tip pairs
    Patent number: 5235187
    Abstract: Self-aligned, opposed, nanometer dimension tips are fabricated in pairs, one of each pair being located on a movable, single crystal beam, with the beam being movable in three dimensions with respect to a substrate carrying the other tip of a pair. Motion of one tip with respect to the other is controlled or sensed by transducers formed on the supporting beams. Spring means in each beam allow axial motion of the beam. The tips and beams are fabricated from single crystal silicon substrate, and the tips may be electrically isolated from the substrate by fabricating insulating segments in the beam structure.
    Type: Grant
    Filed: April 14, 1992
    Date of Patent: August 10, 1993
    Assignee: Cornell Research Foundation
    Inventors: Susanne C. Arney, Noel C. MacDonald, Jun J. Yao
  • Use of sulfonylureas and other potassium channel regulators to treat secretory diarrhea
    Patent number: 5234922
    Abstract: Methods for the treatment of secretory diarrhea comprised of administering to a patient in need thereof, an effective amount of a CFTR chloride channel blocker or a potassium channel opener are disclosed. The CFTR chloride channel blocker is a sulfonylurea of the group consisting of tolbutamide, glibenclamide, and related analogs. The potassium channel opener is selected from the group consisting of diazoxide, lemakalim, and minoxidil sulfate.
    Type: Grant
    Filed: September 28, 1992
    Date of Patent: August 10, 1993
    Assignee: University of Iowa Research Foundation
    Inventors: Michael J. Welsh, David N. Sheppard