Abstract: Various embodiments relate to a compound of the formula (I) and (II), wherein X, X1, X2, X3, and R1-R4 are defined herein, as well as pharmaceutical compositions comprising compounds of the formula (I) and/or (II) and methods of treating an HIV infection comprising administering a therapeutically effective amount of one or more compounds of formula (I) and/or (II), or a pharmaceutical composition comprising compounds of the formula (I) and/or (II), to a patient in need thereof.
Type:
Grant
Filed:
November 9, 2017
Date of Patent:
June 8, 2021
Assignee:
Purdue Research Foundation
Inventors:
Arun K. Ghosh, Hiroaki Mitsuya, Prasanth Reddy Nyalapatla
Abstract: The present invention relates to compositions and methods variously useful in treating cancer, inhibiting graft rejection, and treating autoimmune disease. The compositions and methods include those in which macrophages are conditioned to down regulate or upregulate the expression or activity of SIRP? or its interaction with CD47.
Type:
Grant
Filed:
October 10, 2018
Date of Patent:
June 8, 2021
Assignee:
Georgia State University Research Foundation, Inc.
Abstract: An inter-vehicle communication method and an apparatus for performing the same. The inter-vehicle communication method may include a reception node receiving at least one vehicle-to-vehicle (V2V) message from at least one transmission node and the reception node transmitting a relay V2V message on the basis of the at least one V2V message, wherein the at least one V2V message may include information about adjacent vehicles discovered by the at least one transmission node.
Type:
Grant
Filed:
November 18, 2019
Date of Patent:
June 8, 2021
Assignee:
Seoul National University R&DB Foundation
Inventors:
SunWook Hwang, Seongwon Kim, HoYoung Yoon, ByungJun Kim, SungHyun Choi, SaeWoong Bahk
Abstract: Cyphomycin, an isolated compound of Formula I or IA is provided. A compound isolated from insect Streptomyces and having a chemical formula of C77H122O26 is also provided. Compositions including Cyphomycin, such as pharmaceutical compositions including effective amounts of Cyphomycin for treating fungal infections such as Candida and Aspergillus, including drug-resistant strains thereof, are also disclosed. Methods of treating fungal infections with Cyphomycin and compositions thereof are disclosed.
Type:
Grant
Filed:
October 25, 2019
Date of Patent:
June 8, 2021
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Timothy S. Bugni, Monica Tallarico Pupo, David R. Andes, Cameron R. Currie, Humberto Enrique Ortega Dominguez
Abstract: A system for detecting fake information about a vehicle location may include a radio signal receiver configured to receive a radio signal from a communication system; a message receiver configured to receive the radio signal to generate a message and determine the message to generate information about a location of the communication system; a radio signal incident angle calculator configured to generate a radio signal incident angle; an azimuth calculator configured to generate a location information azimuth angle by use of the information about locations of the communication system and a receiving vehicle, and a fake vehicle generated by the communication system; and a location information fake detector configured to determine whether location information of the fake vehicle is faked by use of a difference value between an angle corresponding to a reference axis of the location information azimuth angle and the location information azimuth angle.
Type:
Grant
Filed:
June 1, 2018
Date of Patent:
June 8, 2021
Assignees:
Hyundai Motor Company, Kia Motors Corporation, Korea University Research and Business Foundation
Inventors:
Jong Rok Park, Dong Gyu Noh, Su Lyun Sung, Dae Sung Hwang, Hahk Rel Noh, Cho Rong Ryu, Tae Jun Lee, Hyo Gon Kim, In Seon An, Yong Tae Park, Tae Ho Kim
Abstract: The present disclosure relates to boron carbide (B4C) composite material and the method of making and using the boron carbide (B4C) composite.
Type:
Grant
Filed:
October 17, 2019
Date of Patent:
June 8, 2021
Assignee:
Purdue Research Foundation
Inventors:
Jeffrey P Youngblood, Erich Weaver, Rodney W. Trice, Andres Diaz-Cano, Andrew Schlup
Abstract: Systems and methods are provided for classifying a tissue mass as malignant or benign. The method includes identifying a region of interest in the tissue mass in computed tomography (CT) imaging data, segmenting the CT imaging data to delimit at least a portion of the tissue mass into image segments, extracting a set of radiomic parameters indicative of the tissue mass. The set of radiomic parameters may include tissue mass location, tissue mass shape, tissue mass surface characteristic, or tissue mass texture distribution indicative of the amount of image segments identified. The method also includes generating a report classifying the indeterminate lung nodule as being malignant or benign based on the set of radiomic parameters of the indeterminate lung nodule.
Type:
Grant
Filed:
October 16, 2018
Date of Patent:
June 8, 2021
Assignees:
Mayo Foundation for Medical Education and Research, Vanderbilt University
Inventors:
Tobias Peikert, Ronald A. Karwoski, Fabien Maldonado, Srinivasan Rajagopalan, Brian J. Bartholmai
Abstract: An electrochemical cell includes an air electrode in flow communication with a storage tank containing an aqueous solution of hydrogen peroxide, a lithium electrode, a catalyst layer in contact with the air electrode or a gas diffusion layer associated with the air electrode, and a separator layer in contact with the lithium electrode and catalyst layer. The catalyst layer includes a catalyst for two electron reversible oxygen reduction. The catalyst comprises gold, and a cobalt coordination complex or polymer thereof. The cobalt coordination complex comprises a cobalt ion chelated by a tetradentate organic chelating ligand.
Type:
Grant
Filed:
November 22, 2019
Date of Patent:
June 8, 2021
Assignee:
University of Tennessee Research Foundation
Inventors:
Ming Qi, Thomas Zawodzinski, Shane Foister
Abstract: Disclosed herein are an apparatus and method for decoding a bootstrap signal. The apparatus for decoding a bootstrap signal according to an embodiment of the present invention includes an operation unit for calculating the relative cyclic shift and the channel gain estimate of a received bootstrap signal and correcting the channel gain estimate using the relative cyclic shift, and a decoding unit for decoding the bootstrap signal using the corrected channel gain estimate.
Type:
Grant
Filed:
May 24, 2018
Date of Patent:
June 8, 2021
Assignees:
Electronics and Telecommunications Research Institute, Korea Maritime University Industry-Academic Cooperation Foundation
Inventors:
Sung-Ik Park, Jeong-Chang Kim, Jae-Young Lee, Sun-Hyoung Kwon, Hyeong-Seok Kim, Heung-Mook Kim, Nam-Ho Hur
Abstract: Compositions, formulas, methods of making, mixing and applying insecticide formulations to different surfaces such as but not limited to interior surfaces of ovitraps, on walls and on chips and tiles to produce a texturized surface to allow for better transfer of the insecticidal active ingredients to insects, such as mosquitoes and the like, which land on or crawl on the surfaces, resulting in faster insect mortality rates. The texture of the insecticidal residue provides better transfer of the insecticidal active ingredients to insects that land on or crawl on the surface, resulting in faster insect mortality. The textured residue also enhances desirable surface characteristics for landing of mosquitoes and potentially other insects.
Type:
Grant
Filed:
May 25, 2017
Date of Patent:
June 8, 2021
Assignee:
University of Florida Research Foundation, Incorporated
Inventors:
Philip G. Koehler, Roberto M. Pereira, Christopher D. Batich
Abstract: The invention provides an implantable vagal nerve stimulator having a “passive” generating power source that harvests the stomach's movements to transform kinetic energy to electrical charge without the need for a battery. In this regard, the invention is self-powering and is automatically timed to stomach peristalsis. While sporadic stimulation to the vagal nerve would seem too infrequent to cause weight loss effects, electrical stimulation delivered at the optimal time (e.g., during food consumption) has been found to optimize the effects of vagal nerve stimulation, giving the user's brain a “full stomach” signal before the user over-consumes food.
Type:
Grant
Filed:
June 15, 2018
Date of Patent:
June 8, 2021
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Xudong Wang, Weibo Cai, Guang Yao, Lei Kang
Abstract: A derivative receiver includes a differentiator configured to differentiate an input signal; a comparator configured to produce a comparison signal by comparing a derivative signal produced using an output from the differentiator with a threshold voltage; and a pattern detecting equalizer configured to output a data signal by sampling an equalization signal generated by adjusting a level of the comparison signal. The level of the comparison signal is adjusted according to a past value of the data signal.
Type:
Grant
Filed:
May 11, 2020
Date of Patent:
June 8, 2021
Assignees:
SK hynix Inc., Seoul National University R&DB Foundation
Abstract: An otoscope provides a disposable speculum sleeve that conducts light to a narrow tip holding an electronic camera. By removing the light source from the tip, the diameter of the tip may be further reduced to allow the space of the ear canal to be shared between the otoscope and a tool such as a curette for removing foreign objects or to permit the tip to navigate around ear obstructions. The sleeve may provide for multidirectional illumination of the ear structure for improved visualization. The tip and sleeve may be flexible for increased patient comfort when using a compact tip design.
Type:
Grant
Filed:
March 15, 2019
Date of Patent:
June 8, 2021
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
James Berbee, Azita Hamedani, Greg Rebella
Abstract: Isolated non-naturally occurring, mutant-human islet amyloid polypeptides (IAPP) polypeptides, which are more soluble at neutral pH than the wild-type human islet amyloid polypeptide (hIAPP) protein are disclosed. These polypeptides can be formulated or co-formulated at physiological pH, which enable the polypeptides to be delivered to a subject in a single injection with an insulin agent. Methods and pharmacological compositions for treating an abnormal condition, such as an amyloid-based disease or type-1 diabetes in a subject are also disclosed.
Type:
Grant
Filed:
February 1, 2018
Date of Patent:
June 8, 2021
Assignee:
The Research Foundation for The State University of New York
Inventors:
Daniel Raleigh, Rehana Akter, Andisheh Abedini
Abstract: This invention generally relates to a device for preparing and transferring a monolayer or thin film. In particular this present invention is a device for preparing and transferring a monolayer or thin film to a substrate using an improved version of the Langmuir-Schaefer technique, which incorporates in situ thermal control, for instance to heat the supporting substrate before and/or during the transfer process.
Type:
Grant
Filed:
July 18, 2018
Date of Patent:
June 8, 2021
Assignee:
Purdue Research Foundation
Inventors:
Shelley A. Claridge, Tyler Hayes, David McMillan
Abstract: A robotic device for providing vertical mobility has a payload disposed inside a central compartment and can move up and down through spring load to keep intimate contact with the surface and cross over bumps. The apparatus uses a flexible seal to create a reliable vacuum chamber. The flexible seal comprises a foam ring inside fabric pocket. A plurality of rod and spring strips are configured to apply a downward force to the flexible seal to conform with surface curvatures. The fabric pocket fills in the gaps or seams to maintain a vacuum. The air flows inside a manifold and passes through a filter to avoid debris from damaging the vacuum motor assembly.
Type:
Grant
Filed:
January 13, 2020
Date of Patent:
June 8, 2021
Assignees:
InnovBot, LLC, Research Foundation of the City University of New York
Abstract: A method of producing phosphoric acid from at least one mineral containing phosphate and an element which is calcium, magnesium, iron, or aluminum. The method includes contacting the at least one mineral (or a combination of them) with a cation exchanger for a time and at a temperature sufficient to yield phosphoric acid from the mineral.
Abstract: A water curtain head according to the present invention may comprise: a head body which is connected to a water supply pipe installed in an inner side of a building and has a water-releasing opening; and a deflector arranged adjacent to the water-releasing opening to allow water discharged by the water-releasing opening to pass therethrough. The deflector may comprise: a first spray nozzle formed on the front surface of the deflector to penetrate the front surface of the deflector; and a second spray nozzle formed to be recessed inward from a side surface of the deflector by a predetermined section.
Type:
Grant
Filed:
November 1, 2016
Date of Patent:
June 8, 2021
Assignees:
Paratech Company Limited, Korea Fire Industry Technology Institute, Chung Ang University Industry Academic Cooperation Foundation
Inventors:
Dongjoon Kim, Junseok Nam, Hongsun Ryou
Abstract: Described herein are various embodiments of a valve that may be opened and closed using a thixotropic or “stress yield” material, or other material that temporarily changes phase upon application of energy to the material. More particularly, some embodiments may include a valve that is opened and closed using a granular gel that is a temporary phase change material.
Type:
Grant
Filed:
September 2, 2016
Date of Patent:
June 8, 2021
Assignee:
University of Florida Research Foundation, Inc.
Inventors:
Joshua Muse, Meghan Hughes, Carl David Crane, Thomas Ettor Angelini, Kyle D. Schulze, Tapomoy Bhattacharjee, Wallace Gregory Sawyer, Curtis Taylor