Abstract: A tactile display device including a nodule having variable stiffness under a surface to provide a near-real feeling of palpation for a physician. The device utilizes granular jamming technology using pneumatic actuation to control a nodule that maintains its shape while allowing the modulation in stiffness. The nodule includes two hemispheres, a contact portion and an actuation portion, forming a sphere. The contact portion and the actuation portion include different thicknesses and/or materials, while the dimensions of the dimensions of the nodule are maintained. As such, a physician can utilize the device to identify the difference between a normal lump and an affected lump even if the shape of each lump appears to be the same. With the tactile display device, due to the different levels of stiffness, a physician can detect the severity of the lump.

Abstract: The present invention provides methods and compostions to improve the efficiency of somatic cell nuclear transfer (SCNT). There is increasing evidence that the epigenetic state of donor nuclei has a significant impact on potential of nuclear transfer embryos to develop into blastocysts, from which pluripotent stem cells are derived. Strategic application of histone agents, capable of altering epigenetic state such as methylation, allows zygotic activation and robust blastocyst generation.

Abstract: The present disclosure relates to a display apparatus including a display panel, a bezel surface formed on a boundary of the display panel, and an antenna located on the bezel surface, wherein the antenna includes a composite right left handed (CRLH) structure including a series inductor, a series capacitor, a parallel inductor, and a parallel capacitor.

Abstract: In accordance with some embodiments, systems, methods, and media for motion adaptive imaging using single-photon image sensor data are provided. In some embodiments, the system comprises: an image sensor comprising single-photon detectors in an array; a processor programmed to: receive a sequence of photon frames, each comprising pixels having a value indicative of whether a photon was received during a frame period, each of the pixels corresponds to a pixel location; identify, for each of the pixel locations, changepoints, each indicative of a change in scene brightness; identify a photon frame in the sequence at which at least a threshold change in brightness has occurred based on the changepoints associated with each of the plurality of pixel locations; and generate a series of changepoint frames, wherein each changepoint frame is based on estimated brightness associated with each pixel location at a point in the sequence of photon frames.

Abstract: The present invention relates to a novel microorganism capable of metabolizing various carbon sources at high rates. A novel microorganism according to the present invention was observed to grow at a very high rate in a minimal medium/nutrient medium, etc., compared to microorganisms such as Escherichia coli, and shows resistance at a high initial sugar/salt concentrations as well as being able to produce lycopene and 2,3-butanediol through genetic manipulation. Therefore, the novel microorganism can be used in various production fields of high value-added compounds using microorganisms.

Abstract: Provided herein are methods related to co-packaging of multiple rAAV particles, e.g., by introducing multiple nucleic acid vectors encoding proteins or polypeptides or RNAs of interest into a single cell preparation.

Abstract: A method of producing a sulfonated polymer. The method includes providing a source for a quantity of a polymer having a shape. The quantity of the polymer is heated while immersed in sulfuric acid to 100-200° C. for a period time in a closed reactor containing an atmosphere and capable of holding pressure generated by a reaction between the quantity of the polymer and the sulfuric acid resulting in a sulfonated polymer, wherein substantially all the quantity of the polymer from the source is converted into sulfonated polymer. The sulfonated polymer is then removed from the reactor and dried. An electrode suitable for use as an electrode in an electrochemical energy storage cell is disclosed. The electrode contains amorphous porous carbon sheets made from a sulfonated polymer with a morphology wherein the amorphous porous carbon sheets have the morphology of the sulfonated polymer from which they are made.

Abstract: An in-memory computing architecture is disclosed that can evaluate the transitive closure of graphs using the natural parallel flow of information in 3-D nanoscale crossbars. The architecture can be implemented using 3-D crossbar architectures with as few as two layers of 1-diode 1-resistor (1D1R) interconnects. The architecture avoids memory-processor bottlenecks and can hence scale to large graphs. The approach leads to a runtime complexity of O(n2) using O(n2) memristor devices. This compares favorably to conventional algorithms with a time complexity of O((n3)/p+(n2) log p) on p processors. The approach takes advantage of the dynamics of 3-D crossbars not available on 2-D crossbars.

Abstract: An instrument for performing thorascopic repair of heart valves includes a shaft for extending through the chest cavity and into a heart chamber providing access to a valve needing repair. A movable tip on the shaft is operable to capture a valve leaflet and a needle is operable to penetrate a capture valve leaflet and draw the suture therethrough. The suture is thus fastened to the valve leaflet and the instrument is withdrawn from the heart chamber transporting the suture outside the heart chamber. The suture is anchored to the heart wall with proper tension as determined by observing valve operation with an ultrasonic imaging system.

Abstract: In a general aspect, an apparatus can include a first carbon nanotube array that is patterned to define a first electrode having a first plurality of electrode segments. The apparatus can also include a second carbon nanotube array that is patterned to define a second electrode having a second plurality of electrode segments. The second plurality of electrode segments can be interdigitated with the first plurality of electrode segments. The apparatus can further include a biorecognition agent disposed on a surface of the first electrode and disposed on a surface of the second electrode. The first plurality of electrode segments can each have a height-to-width aspect ratio of at least 1 to 1.

Abstract: A new compound composition that is free of a side effect to a liver and used for alleviating the toxicity of an acetaminophen (APAP) medicament to the liver. The compound composition comprises (a) a pharmaceutically effective amount of acetaminophen and (b) a frequently-used safe and pharmaceutically acceptable excipient that can be combined with one or more than two medicaments that can reduce the toxicity of a drug via liver enzyme CYP2E1 metabolism to the liver.

Abstract: This application relates to a method for optimizing algorithm performance using precision scaling, wherein the method according to an embodiment of present invention comprises obtaining a number of iterations of a unit operation according to precisions of the algorithm including the unit operation that is repeatedly performed, wherein the precisions include a first precision and a second precision, and the number of iterations include a first number of iterations corresponding to the first precision and a second number of iterations corresponding to the second precision; inspecting available precisions of a device on which the algorithm is to be executed, wherein the available precisions include a first available precision corresponding to the first precision and a second available precision corresponding to the second precision; determining an optimal precision by repeatedly performing the unit operation corresponding to an initial operation of the algorithm using the inspected available precision; and repea

Abstract: In some examples, a device includes a printing device to generate an image on a substrate from a digital image, and a processor to: receive a scanned image of the image on the substrate, identify a plurality of image portions of the scanned image, identify horizontal color changes across a horizontal portion of the plurality of image portions, identify vertical color changes across a vertical portion of the plurality of image portions, compare the horizontal color changes and vertical color changes to corresponding horizontal color changes and corresponding vertical color changes of the digital image, and measure a presence of color plane misregistration, and the color, direction and magnitude of misregistration based on the comparison.

Abstract: Drainage devices and microactuator systems adapted to be incorporated into drainage devices to provide a self-clearing capability for reducing obstructions in the drainage devices and/or a self-monitoring capability to confirm the overall operating condition of the drainage devices and their microactuators. Such a microactuator system includes a microactuator having a base, a cantilever comprising a flexure extending from the base and a plate structure at a distal end of the flexure, a sensing element on the flexure for sensing deflection of the cantilever, and a device for inducing an oscillating deflection of the cantilever relative to the base.

Abstract: The invention relates to a collection of signature peptides representing at least 10 proteins for use in cancer diagnosis and/or prognosis, to an artificial protein comprising signature peptides representing at least 10 proteins and to a nucleic acid construct encoding for such an artificial protein. The invention further relates to a collection of at least 10 proteins for use in cancer diagnosis and/or prognosis. Additionally, the invention relates to a method for cancer diagnosis and/or prognosis comprising the step of analyzing at least 10 proteins in a urine sample of a subject. Finally, the invention relates to an immunoassay product comprising antibodies for detecting at least 10 proteins.

Abstract: A display system for a medical suite comprises a scanning device configured to capture scanning data in the medical suite. At least one display configured to display information in an operating region of the medical suite. A controller is in communication with the scanning device and the display. The controller is configured to control the scanning device to capture identifying information of a patient. Based on the identifying information, the controller is configured to authenticate an identity of the patient. Based on the identity, the controller is configured to access a patient record for the patient. The controller is further configured to control the at least one display to display information based on the patient record.

Abstract: The present disclosure relates to a method of preparing a monomolecular nano-thin film, including: coating, on a substrate, a dispersion solution containing a compound represented by the following Chemical Formula 1; and performing annealing to the coated substrate: in the above Chemical Formula 1, X and Y are each independently nitrogen, carbon, sulfur, or oxygen, R1 and R2 are each independently hydrogen, oxygen, a hydroxy group (—OH), or a linear or branched C1 to C10 alkyl group.

Abstract: A system is disclosed which includes a chamber, one or more transmitters configured to emit EM radiation, one or more power harvesters, one or more EM stirrer, and a processing system configured to a) receive a measure of dimensional characteristics of the chamber b) control the one or more EM stirrers, c) evaluate statistical properties of the statistical EM environment, d) set a new criterion for acceptable statistical properties of the statistical EM environment, e) measure a lowest usable frequency of the chamber below which the statistical properties are not acceptable according to a predetermined criterion, f) determine an efficiency profile of the one or more power harvesters versus frequency, g) select an operating frequency that maximizes efficiencies of the one or more power harvesters, h) measure a collective efficiency of the chamber, and i) return to step d if the measured collective efficiency is below a predetermined efficiency threshold.

Abstract: Microfluidic devices and systems are provided. Methods for conducting immune assays with the devices and systems are also provided.

Abstract: A brake caliper comprising: a set of brake pads positioned on each side of a brake disc; a first actuator including a first drive gearwheel driving a first mobile piston pressing against a first portion of brake pad in order to move same; a second actuator including a second drive gearwheel driving a second mobile piston pressing against a second portion of the pad in order to move same, with a mode of operation that is the opposite of that of the first actuator; a first and a second worm screws which are secured to one another and of opposite hand to one another, rotationally driven and capable of translational movement in their longitudinal direction and in mesh with the first and second gearwheels respectively in order to turn these in opposite directions.