Abstract: The present disclosure provides micro-array devices for capturing cells in blood and methods of their use. In some aspects, a method for counting cells in a blood sample is provided, the method comprising applying a blood sample onto a CNT device; allowing cells in the blood sample to differentially settle on the CNT device, and identifying and counting cells of preselected type in the blood sample.
Type:
Grant
Filed:
September 28, 2017
Date of Patent:
May 11, 2021
Assignees:
Worcester Polytechnic Institute, University of Louisville Research Foundation, Inc.
Inventors:
Balaji Panchapakesan, Farhad Khosravi, Shesh N. Rai
Abstract: The present disclosure relates to naltrexone sustained release microparticle delivery systems for the treatment of diseases ameliorated by naltrexone. The injectable microparticle delivery system includes naltrexone encapsulated in biodegradable microparticles administered in a pharmaceutically acceptable vehicle.
Type:
Grant
Filed:
October 15, 2019
Date of Patent:
May 11, 2021
Assignees:
Chong Kun Dang Pharmaceutical Corp., Purdue Research Foundation
Inventors:
Gwangheum Yoon, Bong Kwan Soh, Andrew David Otte, Kinam Park
Abstract: Various examples are provided for point symmetric complementary meander line (PSC-ML) slots, which can be used for mutual coupling reduction. In one example, an antenna array includes first and second patch antenna elements disposed on a first side of a substrate, the first and second patch antenna elements separated by a gap. The antenna array can include point symmetric complementary meander line (PSC-ML) slots formed in a ground plane disposed on a second side of the substrate. The PSC-ML slots can include a pair of ML slots aligned with the gap between the first and second patch antenna elements. In another example, a method includes forming first and second antenna elements on a first side of a substrate and forming PSC-ML slots in a ground plane disposed on a second side of the substrate that are aligned with a gap between the first and second antenna elements.
Type:
Grant
Filed:
June 15, 2017
Date of Patent:
May 11, 2021
Assignees:
University of Florida Research Foundation, Incorporated, Electronics and Telecommunication Research Institute (ETRI)
Inventors:
Yong-Kyu Yoon, Seahee Hwangbo, Hae Yong Yang
Abstract: The current disclosure provides for peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs) antisense oligonucleotides that target plant pathogens and insect pests by targeting the microbes within the insect pest. Methods of delivering PPMOs to bacteria in plants, in insect carriers, and to the insects via plant feeding are also provided.
Type:
Grant
Filed:
May 15, 2019
Date of Patent:
May 11, 2021
Assignees:
The United States of America, as represented by The Secretary of Agriculture, University of Florida Research Foundation, Inc.
Inventors:
Wayne B. Hunter, Kirsten Pelz-Stelinski
Abstract: The carbohydrate processing enzyme PNGase F was catalytically inactivated through mutation. Additional mutations yielded a catalytically inactive carbohydrate-binding protein with lectin-like properties including high affinity and specificity N-linked glycans, O-linked glycans, or both.
Type:
Grant
Filed:
June 14, 2019
Date of Patent:
May 11, 2021
Assignee:
University of Georgia Research Foundation, Inc.
Inventors:
Kausar N. Samli, Robert J. Woods, Loretta Yang
Abstract: The present invention describes novel pharmaceutical compositions and methods for treatment of diseases, disorders, or conditions characterized by recurrent seizures, particularly, epilepsy. According to the invention, compounds which inhibit the activity or expression of non-receptor Fyn tyrosine kinase can prevent activation epileptic pathophysiology and provide protection from and treatment of epilepsy. Particularly preferred is the class of small molecule Fyn kinase inhibitors such as sacaratinib and its prodrugs, derivatives, analogs and the like.
Type:
Grant
Filed:
December 1, 2017
Date of Patent:
May 11, 2021
Assignee:
Iowa State University Research Foundation, Inc.
Inventors:
Thimmasettappa Thippeswamy, Anumantha G. Kanthasamy
Abstract: The present invention provides expandable devices and insertion tools for deploying the expandable devices. The expandable devices are capable of increasing in height and width when expanded from a closed configuration to an open configuration to occupy a larger volume and to present a larger surface area. The expandable devices are lockable and are capable of rigidly occupying a space after expansion. In some embodiments, the expandable devices are useful as interbody devices for spinal fusions.
Type:
Grant
Filed:
October 1, 2018
Date of Patent:
May 11, 2021
Assignee:
MUSC Foundation for Research Development
Inventors:
Stephen Kalhorn, Mark E. Semler, Joseph Ruscito, Christopher Hapstack
Abstract: Provided is a charger with a battery diagnosis function and a control method thereof. The charger with a battery diagnosis function includes a DC-DC converter configured to operate in a charging mode to charge a battery or to operate in a diagnosing mode to apply a perturbation voltage to the battery when the battery is fully charged, and a digital signal processor configured to calculate an equivalent circuit model parameter of the battery according to an output response of the battery with respect to the perturbation voltage, to calculate a charging/discharging frequency of the battery by using an ohmic resistance value among the equivalent circuit model parameter of the battery, and to calculate a residual equivalent capacity of the battery by using the charging/discharging frequency of the battery.
Type:
Grant
Filed:
January 9, 2019
Date of Patent:
May 11, 2021
Assignee:
Foundation of Soongsil University-Industry Cooperation
Abstract: A microphone, comprising at least two electrodes, spaced apart, configured to have a magnetic field within a space between the at least two electrodes; a conductive fiber, suspended between the at least two electrodes; in an air or fluid space subject to waves; wherein the conductive fiber has a radius and length such that a movement of at least a central portion of the conductive fiber approximates an oscillating movement of air or fluid surrounding the conductive fiber along an axis normal to the conductive fiber. An electrical signal is produced between two of the at least two electrodes, due to a movement of the conductive fiber within a magnetic field, due to viscous drag of the moving air or fluid surrounding the conductive fiber. The microphone may have a noise floor of less than 69 dBA using an amplifier having an input noise of 10 nV/?Hz.
Type:
Grant
Filed:
December 11, 2017
Date of Patent:
May 11, 2021
Assignee:
The Research Foundation for the State University
Abstract: An example of the composition incudes at least one amino acid sequence from the octarepeat region of hemin that is modified by substituting at least one proline (P) residue in the amino acid sequence. The composition is effective to bind with hemin and for treating hemorrhagic injury.
Type:
Grant
Filed:
June 26, 2017
Date of Patent:
May 11, 2021
Assignee:
Florida State University Research Foundation, Inc.
Abstract: A label for an antibody or protein is described that is both site-selective and unusually stable in vivo. The label has a general formula given by Formula (I) wherein R1 is a metal chelator, a fluorophore or a click-chemistry synthon.
Type:
Grant
Filed:
May 17, 2018
Date of Patent:
May 11, 2021
Assignee:
Research Foundation of the City University of New York
Inventors:
Brian Zeglis, Pierre Adumeau, Maria Davydova
Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation, regulated expression of one or more antigens of interest, and/or N-glycan modification of secreted/surface antigens.
Type:
Grant
Filed:
January 26, 2018
Date of Patent:
May 11, 2021
Assignee:
University of Florida Research Foundation, Incorporated
Abstract: A simple controllable set-up for drawing single filament nanofibers from polymer solutions or melts using a rotating rod or a set of rods (round brush) is described. The set-up can be assembled in a few minutes and applied to fabricate customized nanofiber scaffolds and meshes for various applications. The resulting fiber diameter is controlled precisely in the range 40 nm to 5 ?m by adjusting the rotational speed and polymer concentration. Owing to the simple design and capability to manipulate single nanofibers, the spinning set-up can be used to wind a single filament into unidirectional, orthogonal or randomly oriented 2D and 3D meshes with controlled density, thickness and combinations of different fibers and materials in the scaffolds. The method is scalable and can be implemented easily for laboratory and industrial manufacturing.
Type:
Grant
Filed:
July 18, 2017
Date of Patent:
May 11, 2021
Assignee:
University of Georgia Research Foundation, Inc.
Inventors:
Alexander Tokarev, Oleksandr Trotsenko, Darya Asheghali, Sergiy Minko
Abstract: An active content playback apparatus according to the present invention includes a storage storing active content including an active content header, embedded content, and an engine code, and a player program for executing the content; a memory temporarily storing data and program; and a central processing unit loading the active content into the memory according to an execution request for the active content and controlling an execution through a process of the player program of the embedded content loaded into the memory by executing the engine code included in the active content.
Type:
Grant
Filed:
January 31, 2019
Date of Patent:
May 11, 2021
Assignee:
Sangmyung University Seoul Industry-Academy Cooperation Foundation
Abstract: A game bird decoy provides for more natural kinematics by providing a smoothly articulating neck, an automatic orientation of the neck with respect to body tipping and improved dual-mode wing activation in which the wings may lift or lift and extend as a function of body angle.
Type:
Grant
Filed:
November 28, 2016
Date of Patent:
May 11, 2021
Assignee:
WiSys Technology Foundation, Inc.
Inventors:
Timothy J. Campbell, Ronald O. T. Campbell
Abstract: This invention relates to 4-substituted isoquinoline compounds and their derivatives and uses thereof for treatment of cancer, for example, acute myeloid leukemia.
Abstract: The present invention provides compounds isolated from avocado seeds for use as a natural colorant in edible materials. The compounds of the invention are useful for coloring edible materials red, orange or yellow. The invention also provides compositions and methods for coloring edible materials to a desired color such as red, orange or yellow.
Type:
Grant
Filed:
November 4, 2016
Date of Patent:
May 11, 2021
Assignee:
The Penn State Research Foundation
Inventors:
Gregory Ray Ziegler, Joshua David Lambert, Rachel Marie Shegog, Emmanouil Chatzakis, Deepti Dabas
Abstract: A transceiver circuit may include: a first NMOS transistor suitable for puffing up a transmission line in response to a TX signal in a TX mode and for being turned on or off according to a voltage level of the transmission line in an RX mode; and a first PMOS transistor suitable for pulling down the transmission line in response to the TX signal in the TX mode and for being turned on or off according to the voltage level of the transmission line in the RX mode.
Type:
Grant
Filed:
October 30, 2019
Date of Patent:
May 11, 2021
Assignees:
SK hynix Inc., Seoul National University R&DB Foundation
Abstract: Standard nested virtualization allows a hypervisor to run other hypervisors as guests, i.e. a level-0 (L0) hypervisor can run multiple level-1 (L1) hypervisors, each of which can run multiple level-2 (L2) virtual machines (VMs), with each L2 VM is restricted to run on only one L1 hypervisor. Span provides a Multi-hypervisor VM in which a single VM can simultaneously run on multiple hypervisors, which permits a VM to benefit from different services provided by multiple hypervisors that co-exist on a single physical machine. Span allows (a) the memory footprint of the VM to be shared across two hypervisors, and (b) the responsibility for CPU and I/O scheduling to be distributed among the two hypervisors. Span VMs can achieve performance comparable to traditional (single-hypervisor) nested VMs for common benchmarks.
Type:
Grant
Filed:
October 7, 2019
Date of Patent:
May 11, 2021
Assignee:
The Research Foundation for The State University
Abstract: An image processing apparatus is provided. The image processing apparatus includes a memory configured to store at least one instruction; and a processor configured to read the at least one instruction and configured to, according to the at least one instruction: apply a learning network model to an input image frame and acquire information on an area of interest; and acquire an output image frame by retargeting the input image frame based on the acquired information on the area of interest. The learning network model is a model that is trained to acquire the information on the area of interest in the input image frame.
Type:
Grant
Filed:
May 23, 2019
Date of Patent:
May 11, 2021
Assignees:
SAMSUNG ELECTRONICS CO., LTD., Sogang University Research & Business Development Foundation
Inventors:
Hyungjun Lim, Suk-Ju Kang, Seung Joon Lee, Youngsu Moon, Siyeong Lee, Sung In Cho