Abstract: Method of making interconnected layered porous carbon sheets with porosity within the carbon sheets and in-between the carbon sheets for use as an electrode. Method of making a metal-nanoparticle carbon composite, wherein metal particles are surrounded by shells made of amorphous carbon. Electrodes containing an amorphous carbon structure comprising a plurality of interconnected layered porous carbon sheets. Electrodes containing graphitic carbon structure with a surface area in the range of 5-200 m2/g. Electrodes containing a metal-nanoparticle carbon composite comprising metal core-carbon shell like architecture and an amorphous structure, wherein metal particles are surrounded by shells made of amorphous carbon.
Abstract: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.
Type:
Grant
Filed:
August 28, 2015
Date of Patent:
February 2, 2021
Assignee:
CHDI Foundation, Inc.
Inventors:
Celia Dominguez, John Wityak, Jonathan Bard, Christopher John Brown, Michael Edward Prime, Derek Alexander Weddell, Daryl Simon Walter, Paul Richard Giles, Ian James Wigginton, Malcolm George Taylor, Sébastien René Gabriel Galan, Peter David Johnson, Thomas Martin Krülle, Inaki Morao, Daniel Clark-Frew
Abstract: Methods and systems of altering optical reflection via dynamic control of an ultrasonic/acoustic guided wave field in an acousto-optical wave conductor are described. Ultrasonic/acoustic waves transmitted by an acousto-optical wave conductor are used to modify the ability of the acousto-optical wave conductor to propagate light waves via the acousto-optical wave conductor when a light beam impinges onto one surface of the acousto-optical wave conductor. A one-way optical device may be produced by using a dynamic tuning approach to modify the sound field via mode and frequency choice (and possibly beam focusing and steering as well) in order to produce special light reflection and transmission effects. Oscillations in stress (and mass density) along the acousto-optical wave conductor and possibly across the thickness of the acousto-optical wave conductor may serve as a special acousto-optic Bragg diffraction grating that alters the nonspecular reflection of light.
Abstract: Methods of treating acute heart failure in a patient in need thereof. Methods include inserting a therapy delivery device into a pulmonary artery of the patient and applying a therapy signal to autonomic cardiopulmonary fibers surrounding the pulmonary artery. The therapy signal affects heart contractility more than heart rate. Specifically, the application of the therapy signal increases heart contractility and treats the acute heart failure in the patient. The therapy signal can include electrical or chemical modulation.
Type:
Grant
Filed:
January 25, 2018
Date of Patent:
February 2, 2021
Assignee:
The Cleveland Clinic Foundation
Inventors:
Sandra Machado, Marc Penn, Ali R. Rezai
Abstract: Methods of making luminescent perovskite-polymer composites are provided and structures using the same. Perovskite-polymer composites made by the method described herein are provided. The perovskite-polymer composite is useful in many applications including downconverters for backlight units (BLU) of liquid crystal displays (LCDs), as well as for and could be used for light emitting devices, lasers or as active absorber or passive luminescent concentrators for solar photovoltaic applications.
Type:
Grant
Filed:
July 7, 2016
Date of Patent:
February 2, 2021
Assignee:
University of Central Florida Research Foundation, Inc.
Abstract: Provided herein are charge complementary peptides that can be optionally coupled to a cargo polypeptide that are capable of self-assembling under stimulating conditions. The charge complementary peptides can be capable of forming supramolecular structures. Also provided herein are methods of using the charge complementary peptides provided herein.
Type:
Grant
Filed:
August 9, 2017
Date of Patent:
February 2, 2021
Assignee:
University of Florida Research Foundation, Incorporated
Inventors:
Gregory Allan Hudalla, Dillon T. Seroski
Abstract: Provided herein are compositions, systems, kits, and methods for treating nervous system injuries caused by trauma or neurodegeneration or aging in a subject by administering a CSPG or SOCS3 reduction peptide (CRP and SRP respectively), or a nucleic acid sequence encoding the CRP or SRP, wherein both the CRP and SRP comprise a cell membrane penetrating domain, and a lysosome targeting domain, and the CRP further comprises a chondroitin sulfate proteoglycan (CSPG) binding domain, and the SRP further comprises a suppressor of cytokine signaling-3 (SOCS3) binding domain.
Abstract: The invention generally relates to methods for determining whether a peptide includes aspartate or isoaspartate. In certain aspects, methods of the invention involve binding an aspartate/isoaspartate residue in a peptide with a label to produce a labeled peptide. The labeled peptide is then ionized. The ionizing process causes the label to undergo rearrangement in a gas phase at a higher rate if the label is bound to the aspartate residue as compared to if the label is bound to the isoaspartate residue. The methods of the invention then involve performing a mass spectrometry analysis to detect the rearrangement of the label, thereby determining whether the peptide includes aspartate or isoaspartate.
Type:
Grant
Filed:
June 7, 2018
Date of Patent:
February 2, 2021
Assignees:
Purdue Research Foundation, AMGEN INC.
Inventors:
Stephen T. Ayrton, Robert Graham Cooks, Tawnya Flick, Da Ren
Abstract: Provided herein are alpha5-containing GABAA receptor agonists and pharmaceutical compositions and methods of treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders using them.
Type:
Grant
Filed:
March 20, 2017
Date of Patent:
February 2, 2021
Assignees:
UWM Research Foundation, Inc., Centre for Addiction and Mental Health, University of Belgrade—Faculty of Pharmacy
Inventors:
James M. Cook, Guanguan Li, Michael Ming-Jin Poe, Miroslav M. Savic, Etienne Sibille
Abstract: In a control device for a switched reluctance motor, a voltage drop control is executed in which a voltage dropped to be lower than a voltage applied in a case where the switched reluctance motor is driven in a high-load region is applied to the switched reluctance motor, in a case where the switched reluctance motor is driven in a low-load region. The low-load region is a lower load region than the high-load region.
Type:
Grant
Filed:
October 2, 2017
Date of Patent:
February 2, 2021
Assignees:
TOYOTA JIDOSHA KABUSHIKI KAISHA, Tokyo University of Science Foundation
Abstract: Disclosed herein are provided a lithium secondary battery capable of improving an output characteristic, a life characteristic, and stability of electrode adhesion by using a binder containing dopamine-polymerized heparin in a anode containing silicon. In accordance with an aspect of the present disclosure, a lithium secondary battery includes: an cathode; a anode; a separation film disposed between the cathode and the anode; and an electrolyte, wherein the anode comprises an electrode active material comprising a silicon-based material and graphite, a binder and a conductive material, and the binder comprises any one of heparin and lithium polyacrylate (LiPAA).
Type:
Grant
Filed:
July 11, 2018
Date of Patent:
February 2, 2021
Assignees:
Hyundai Motor Company, Kia Motors Corporation, Incheon University Industry Academic Cooperation Foundation
Inventors:
Seung-Min Oh, Yeolmae Yeo, Kiseok Koh, Yoon Sung Lee, Tae-Hyun Kim, Junyoung Mun, Nakgyu Go
Abstract: The present disclosure relates to a calculus removing device which is used in the medical field. More particular, the present disclosure relates to a calculus removing device which has a lithotripsy probe capable of simultaneously destructing and removing the calculus formed in the human body regardless of the size of the calculus by optionally using attractivity or electricity through a lithotripsy probe.
Type:
Grant
Filed:
April 5, 2016
Date of Patent:
February 2, 2021
Assignee:
The Catholic University of Korea Industry-Academic Cooperation Foundation
Abstract: An electronic circuit module is provided. The electronic circuit module prevents damage by efficiently detecting an overcurrent in the electronic circuit module using an SiC MOSFET. The electronic circuit module includes an input unit that is configured to input a reference voltage and a switching unit that is configured to output a first voltage based on a current flow. A converter is configured to output a second voltage based on the first voltage and the reference voltage. An output unit is configured to compare a magnitude of the reference voltage with a magnitude of the second voltage to output a feedback signal when the second voltage is greater than the reference voltage.
Type:
Grant
Filed:
December 7, 2017
Date of Patent:
February 2, 2021
Assignees:
Hyundai Motor Company, Kia Motors Corporation, Postech Academy-Industry Foundation
Inventors:
Jiwoong Jang, Ki Jong Lee, Sangcheol Shin, Ki Young Jang, Kangho Jeong, Kwang Hee Nam, Sung Jin Kim
Abstract: Methods are provided for fabricating functional nanostructures (e.g., nanowires/nanofibers) via chemical vapor deposition polymerization of paracyclophanes or substituted paracyclophanes onto and through a structured fluid, such as a film of liquid crystals, on a substrate. A one-step process is provided that does not require the use of any solid templates, nor does it require any volatile solvents, additives or catalysts. The resulting nanowires/nanofibers can be in the form of aligned nanowires/nanofibers arrays supported on any solid material, in the form of nanofibers mats supported on porous materials, or as individual free-standing nanowires/nanofibers. By using chiral liquid crystals, chiral nanofibers can be fabricated. The functional nanowires/nanofibers can contain one or more type of surface reactive groups that allows for post surface chemical modifications on the nanowires/nanofibers. Such nanostructures can be used in a range of different applications, including in biomedical applications.
Type:
Grant
Filed:
April 14, 2017
Date of Patent:
February 2, 2021
Assignees:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Wisconsin Alumni Research Foundation
Inventors:
Marco A. Bedolla Pantoja, Nicholas L. Abbott, Kenneth Cheng, Joerg Lahann
Abstract: Provided herein are methods off functionalizing a carbon nanotube, functionalized carbon nanotubes, methods of forming a suspension, and methods of forming a sensor. The methods may include contacting one or more carbon nanotubes with a dienophile in the presence of a supercritical fluid to form one or more functionalized carbon nanotubes. The one or more functionalized carbon nanotubes may have a degree of functionalization of about 1% to about 5%.
Type:
Grant
Filed:
September 27, 2018
Date of Patent:
February 2, 2021
Assignee:
Florida State University Research Foundation, Inc.
Abstract: A device for preventing mobile phone loss for reducing the times of erroneous occurrences of an alarm, and to a method for providing an alarm for mobile phone loss prevention are disclosed. A device for preventing mobile phone loss according to an embodiment of the inventive concept includes a receiving unit that receives a predetermined signal from a pre-registered tag, a calculating unit that calculates a distance between a mobile phone and the tag based on the received signal, a controller that determines whether the mobile phone is in a predetermined safe place, and an alarm providing unit that provides an alarm for preventing the mobile phone loss based on whether the mobile phone is in the safe place and whether the calculated distance is equal to or greater than a predetermined reference distance.
Type:
Grant
Filed:
June 14, 2019
Date of Patent:
February 2, 2021
Assignee:
Center for Integrated Smart Sensors Foundation
Abstract: Chiral polyvinylpyrrolidinone (CSPVP), complexes of CSPVP with a core species, such as a metallic nanocluster catalyst, and enantioselective oxidation reactions utilizing such complexes are disclosed. The CSPVP complexes can be used in asymmetric oxidation of diols, enantioselective oxidation of alkenes, and carbon-carbon bond forming reactions, for example. The CSPVP can also be complexed with biomolecules such as proteins, DNA, and RNA, and used as nanocarriers for siRNA or dsRNA delivery.
Type:
Grant
Filed:
March 28, 2017
Date of Patent:
February 2, 2021
Assignee:
Kansas State University Research Foundation
Abstract: An apparatus and related method for determining the optical density and/or change in optical density of a reaction mixture in an agitated vessel or container. The apparatus may include at least one electromagnetic emitter configured to pass radiation through the reaction mixture to at least one receptor, whereby the receptor receives the transmitted or scattered light, while the reaction mixture is subjected to shaking. The emitters may have an interchangeable association with the vessel or container and/or the receptors may have an interchangeable association with the vessel or container. Further, a processor may be provided to receive the transmitted or scattered light data and filter to eliminate or reduce the effect of the frequency at which the reaction mixture is shaken. The processor analyzes the filtered data to provide the optical density and/or change in optical density of the reaction mixture.
Type:
Grant
Filed:
April 29, 2016
Date of Patent:
February 2, 2021
Assignee:
University of Virginia Patent Foundation
Inventors:
Jason A. Papin, Bonnie V. Dougherty, Alisha Mae Geldert, Kevin P. Seitter
Abstract: This invention provides novel 3-amino propanamide selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other 5 hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.
Type:
Application
Filed:
January 29, 2020
Publication date:
January 28, 2021
Applicants:
ONCTERNAL THERAPEUTICS, INC, University of Tennessee Research Foundation
Inventors:
Ramesh NARAYANAN, Duane D. MILLER, Thamarai PONNUSAMY, Dong-Jin HWANG, Charles B. DUKE, Christopher C. COSS, Amanda JONES, James T. DALTON
Abstract: An amorphous polylactic acid polymer having a weight average molecular weight in the range of about 35,000 to 180,000 is described. The polylactic acid polymer composition can be hammer milled without cryogenics result in the form of particles wherein 90% of the particles have particle size of about 250 ?m or less and the material has a glass transition temperature of between about 55° C. to about 58° C. and a relative viscosity of about 1.45 to about 1.95 centipoise. The polymer composition can be used to form an aqueous suspension. The material is ideally suited for use in preparing particleboard. A method is disclosed for preparing such polylactic acid polymers. The method involves obtaining an amorphous polylactic acid polymer having a weight average molecular weight of between about 115,000 to about 180,000. Treating the polylactic acid polymer to reduce the molecular weight to between about 35,000 to 45,000 such that it has a glass transition temperature of between about 55° C. and 58° C.
Type:
Application
Filed:
October 9, 2020
Publication date:
January 28, 2021
Applicant:
Purdue Research Foundation
Inventors:
Rusi P. Taleyarkhan, Brian C. Archambault, Alexander Charles Bakken