Abstract: An apparatus and method for accelerating and/or inhibiting the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of cells without the need for chemokines or glucose. The present invention can also be used to study and quantify the metastatic potential of different cell lines.
Type:
Grant
Filed:
February 2, 2018
Date of Patent:
February 4, 2020
Assignee:
Ohio State Innovation Foundation
Inventors:
Vish Subramaniam, Joseph West, Emily Alkandry, Mohd Nasser, Dinesh Ahirwar, Ramesh Ganju, Travis Jones
Abstract: Disclosed here are peptides derived from a serpin reactive center loop that have anti¬inflammatory, anti-atherogenic and anti-sepsis activity. Compositions containing such serpin-derived peptides are therefore useful in the treatment of transplant vascular disease and also for the treatment of hemorrhagic viral infections as well as lethal viral, fungal or bacterial sepsis in patients.
Type:
Grant
Filed:
March 18, 2016
Date of Patent:
February 4, 2020
Assignee:
University of Florida Research Foundation, Incorporated
Abstract: The disclosure relates to the field of fusion proteins. In some aspects, the invention to artificial fusion proteins comprising cytochrome P450 enzymes linked to reductase enzymes and uses thereof. In some aspects, the disclosures relates to compounds produced by artificial cytochrome P450 enzymes.
Type:
Grant
Filed:
October 30, 2018
Date of Patent:
February 4, 2020
Assignee:
University of Florida Research Foundation, Incorporated
Abstract: Primitive or progenitor hematologic cancer cells have been implicated in the early stages and development of leukemia and malignant lymphoproliferative disorders, including acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML) and chronic lymphoid leukemia (CLL). Interleukin-3 receptor alpha chain (IL-3R? or CD123) is strongly expressed on progenitor hematologic cancer cells, but is virtually undetectable on normal bone marrow cells. The present invention provides methods of impairing progenitor hematologic cancer (e.g., leukemia and lymphomic) cells by selectively targeting cells expressing CD123. These methods are useful in the detection and treatment of leukemias and malignant lymphoproliferative disorders. Also provided are compounds useful for selectively binding to CD123 and impairing progenitor hematologic cancer cells. These compounds may include cytotoxic moieties such as, for example, radioisotopes or chemotherapeutics.
Type:
Application
Filed:
March 7, 2019
Publication date:
January 30, 2020
Applicant:
University of Kentucky Research Foundation
Abstract: A semiconductor component is disclosed. The semiconductor component can include: a semiconductor layer injected with a same type of dopant; a gate electrode formed above the semiconductor layer with a gate insulation film positioned in-between; a dielectric layer formed on the semiconductor layer at both sides of the gate electrode; and source/drain electrodes each formed on the dielectric layer.
Type:
Application
Filed:
July 29, 2019
Publication date:
January 30, 2020
Applicant:
Korea University Research and Business Foundation
Abstract: An image encoding/decoding method using a pixel value range constituting an image is disclosed, wherein the image decoding method using a pixel value range constituting an image comprises the steps of: receiving a bitstream; acquiring information of a pixel value range forming a first unit image included in the received bitstream; and decoding the first unit image on the basis of the acquired information of the pixel value range. Therefore, compression efficiency can be improved in an image encoding or decoding process.
Type:
Application
Filed:
March 22, 2018
Publication date:
January 30, 2020
Applicant:
Industry-University Cooperation Foundation Hanyang University
Abstract: The present disclosure relates to adhesive compositions made from the reaction product of plant protein and phenolics, and method of making and using the adhesive compositions. A maximum bonding strength of 7.8±1.5 MPa was obtained using only 1 weight % tannic acid in a zein matrix of pH=7 and cured at 120° C.
Abstract: An operation apparatus and method for processing a homomorphic encrypted message are disclosed. The method includes producing an approximate polynomial corresponding to an operation function to be applied to a homomorphic encrypted message and approximately operating the homomorphic encrypted message using the approximate polynomial. Thus, an encrypted message may be efficiently processed.
Type:
Application
Filed:
February 7, 2019
Publication date:
January 30, 2020
Applicants:
Crypto Lab Inc., Seoul National University R&DB Foundation
Inventors:
Jung Hee Cheon, Yongsoo Song, Andrey Kim, Miran Kim, Kyoohyung Han
Abstract: This present application disclosed a method for the treatment of treating pain, opioid dependence, alcohol use disorder or autism comprising the step of administering to a mammal in need thereof a therapeutically effective amount of one or more compounds of formula (I), or a pharmaceutically acceptable salt thereof, and one or more carriers, diluents, or excipients. Those compounds are selective adenylyl cyclase 1 (AC1) inhibitors, which may provide an effective method of treatment for chronic/inflammatory pain, and prevent opioid dependence and/or reduce opioid dependence.
Type:
Application
Filed:
September 9, 2019
Publication date:
January 30, 2020
Applicant:
Purdue Research Foundation
Inventors:
Val J. Watts, Richard M. van Rijn, Daniel Patrick Flaherty, Jatinder Kaur
Abstract: Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In some aspects, the present invention relates to polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms. In some aspects, the present invention relates to compositions and methods comprising the polyamine compound. In some aspects, the compounds, compositions, and methods enhance wound healing.
Type:
Application
Filed:
October 4, 2019
Publication date:
January 30, 2020
Applicants:
Curza Global, LLC, University of Utah Research Foundation
Inventors:
Ryan E. Looper, Dustin Williams, Paul R. Sebahar, Travis J. Haussener, Hariprasada R. Kanna Reddy
Abstract: The present disclosure relates to a novel non-conjugated radical polymer film with high electrical conductivity, and methods of making and using the novel non-conjugated radical polymer film.
Type:
Application
Filed:
April 15, 2019
Publication date:
January 30, 2020
Applicant:
Purdue Research Foundation
Inventors:
Bryan W. Boudouris, Brett M. Savoie, Varad Agarkar, Yongho Joo, Seunghyun Sung
Abstract: An embodiment includes an optical transmission module, an optical transceiver, and an optical communication system including the same, the optical transmission module comprising: a light emitting diode; and an optical modulator for modulating first light emitted from the light emitting diode, wherein the light emitting diode and the optical modulator include GaN, and the optical modulator transmits the first light therethrough when a voltage is applied.
Type:
Application
Filed:
October 3, 2019
Publication date:
January 30, 2020
Applicant:
Industry-University Cooperation Foundation Hanyang University Erica Campus
Inventors:
Jong In Shim, Dong Soo Shin, Won Jin Choi
Abstract: The present invention provides a method and apparatus for encoding/decoding an image and for adjusting a reconstructed pixel by scaling an offset of an in-loop filter having a scaled offset value. The method includes: obtaining information of a scale default value of a current block from a bitstream; obtaining offset parameter merge information of the current block from the bitstream; obtaining the offset parameter of the current block on the basis of the offset parameter merge information; determining whether a scale residual value of the current block is obtained from the bitstream on the basis of the offset parameter merge information; obtaining a scale value on the basis of the scale default value and the scale residual value; scaling an offset on the basis of the offset parameter and the scale value; and adjusting a pixel value of the current block on the basis of the scaled offset.
Type:
Application
Filed:
October 2, 2019
Publication date:
January 30, 2020
Applicants:
Electronics and Telecommunications Research Institute, Kwangwoon University Industry-Academic Collaboration Foundation
Inventors:
Jung Won KANG, Hyun Suk KO, Sung Chang LIM, Jin Ho LEE, Dong San JUN, Hui Yong KIM, Dong Gyu SIM, Seoung Jun OH, Jin Soo CHOI, Seoung Hwi KIM, Sea Nae PARK, Yong Jo AHN, Dong Kyu LEE
Abstract: Microorganisms comprising a maltose-inducible promoter and methods of use in producing biologics and introducing biologics to sites in a maltose-dependent manner. The microorganisms include a maltose-inducible promoter operably connected to a coding sequence of a biologic. The biologic may be a polypeptide or a nucleic acid. Polypeptide biologics may include lytic proteins and/or secreted proteins. Nucleic acid biologics may include antisense RNA, other types of RNA, or other types of nucleic acids. The microorganisms can be used to produce the biologics and/or introduce the biologics to in vitro or in vivo sites in a maltose-dependent manner. The microorganisms can also be used in maltose-dependent gene silencing.
Abstract: A bone graft composition includes a biologically-resorbable cement and a plurality of processed bone particles, where each of the bone particles have a shape configured to interconnect with adjacent bone particles. A method for treating a bone defect using the bone graft compositions includes providing the bone graft composition and administering an effective amount of the bone graft composition to a site of a bone defect in a subject. Kits including a biologically-resorbable cement powder and a plurality of processed bone particles are also provided.
Type:
Grant
Filed:
June 17, 2015
Date of Patent:
January 28, 2020
Assignee:
University of Louisville Research Foundation, Inc.
Abstract: The present disclosure is generally related to methods for combining chemotherapy and immunotherapy for the treatment of a cancer. The methods also relate to generating a drug-resistant cytotoxic immune cell line and uses thereof in conjunction with cytotoxic drugs.
Type:
Grant
Filed:
February 22, 2019
Date of Patent:
January 28, 2020
Assignees:
Emory University, The UAB Research Foundation, Children's Healthcare of Atlanta, Inc.
Inventors:
Harold Trent Spencer, Anindya Dasgupta, Lawrence S. Lamb
Abstract: An image processing apparatus includes a core configured to perform a fast Fourier transformation (FFT) operation on the image data, a memory configured to store data that is output by the core, and a controller configured to control the core to perform the FFT operation on the image data. The core is resettable based on an amount of the image data.
Type:
Grant
Filed:
October 4, 2017
Date of Patent:
January 28, 2020
Assignees:
SAMSUNG ELECTRONICS CO., LTD., University of Seoul Industry Cooperation Foundation
Inventors:
Hojung Kim, Kichul Kim, Yongkyu Kim, Hongseok Lee
Abstract: Encoding a file into a plurality of chunks, wherein a subset of the plurality of chunks may be used to create a functional equivalent of the file. At least one additional chunk is created from the plurality of chunks. The at least one additional chunk is directed to be stored in a cache memory and the plurality of chunks are directed to be stored on at least one storage node. Upon demand for the file, at least one additional chunk is cased to be retrieved from the cache and at least a portion of the plurality of chunks are caused to be retrieved from the at least one storage node and the functional equivalent of the file is constructed through utilization of the at least one additional chunk and the portion of the plurality of chunks.
Type:
Grant
Filed:
June 30, 2016
Date of Patent:
January 28, 2020
Assignees:
Purdue Research Foundation, AT&T Intellectual Property I, L.P., The George Washington University
Inventors:
Yu Xiang, Yih-Farn Robin Chen, Vaneet Aggarwal, Tian Lan
Abstract: This document provides methods and materials involved in treating cancer. For example, methods and materials involved in making and using particles (e.g., gold nanoparticles) containing a KTLLPTPYC amino acid sequence (SEQ ID NO:1) or a KTLLPTPYCC amino acid sequence (SEQ ID NO:2) to treat cancer (e.g., pancreatic cancer) are provided.
Type:
Grant
Filed:
May 16, 2018
Date of Patent:
January 28, 2020
Assignee:
Mayo Foundation for Medical Education and Research
Inventors:
Santanu Bhattacharya, Debabrata Mukhopadhyay, Krishnendu Pal