Abstract: Embodiments herein report compositions of and methods for making and using alpha-1 antitrypsin (AAT) fusion molecules or peptide derivatives thereof. In certain embodiments, compositions and methods relate to generating an AAT fusion molecule of use in pharmaceutically acceptable compositions to treat a subject in need of AAT therapy or treatment. In other embodiments, compositions and methods disclosed herein concern linking AAT or derivative thereof to an immune fragment.

Abstract: A semiconductor device includes an upper and lower mirror. At least one active region for light generation is between the upper and lower mirror. At least one cavity spacer layer is between at least one of the upper and lower mirror and the active region. The device includes an inner mode confinement region and an outer current blocking region. A depleted heterojunction current blocking region (DHCBR) including a depleting impurity is within the outer current blocking region of ?1 of the upper mirror, lower mirror, and the first active region. A middle layer including a conducting channel is within the inner mode confinement region that is framed by the DHCBR. The DHCBR forces current flow into the conducting channel during normal operation of the light source.

Abstract: Provided herein is a peptide, a cosmetic composition comprising the same, and a method for inhibiting skin-aging or skin-wrinkle formation using the same, the peptide having activities for facilitating the bindings between keratinocytes; and increasing the expressions of junction proteins.

Abstract: A virtual force controlled collapse chip connection (C4) pad placement optimization frame-work for 2D power delivery grids is proposed. The present optimization framework regards power pads as mobile “positive charged particles” and current resources as a “negative charged back-ground.” The virtual electrostatic force is calculated from voltage gradients. This optimization framework optimizes pad locations by moving pads according to the virtual forces exerted on them by other pads and current sources in the system. Within this framework, three algorithms are proposed to meet various requirements of optimization quality and speed. These algorithms minimize resistive voltage drop (IR drop), the maximum current density, and power distribution network metal power dissipation at the same time.

Abstract: A data storage device may include: a memory cell array, a data buffer configured to generate a data chunk including a plurality of pages from input data provided from a host, a data compressor configured to compress the data chunk and output the compressed data chunk as write data, a write queue configured to store the write data on a page basis, a mapping table configured to store a mapping relationship between a logical address and a data chunk address, and a mapping relationship between the data chunk address and a physical address; and a controller configured to control an operation of storing the write data outputted from the write queue in the memory cell array such that a page including both a part of any one compressed data chunk and a part of another compressed data chunk is written to the memory cell array.

Abstract: A superconductive coil module includes a superconductive coil a superconductive coil and a shaking coil. The superconductive coil includes a bobbin having a cylindrical shape, and a superconductive wire member of superconductive property, which surrounds an outer circumferential surface of the bobbin. The superconductive coil is configured to generate a magnetic field along a radial direction in case of a charging event. The shaking coil is disposed adjacent to the superconductive wire member, and is configured to generate an alternating magnetic field to decrease a magnitude of a screening current induced magnetic field formed in the superconductive wire member. Thus, the superconductive coil module includes the shaking coil to decrease the magnitude of a screening current induced magnetic field formed in the superconductive wire member using a voltex shaking effect to maintain a central magnetic field uniform.

Abstract: The lack of clear predictors of prostate cancer progression leads to subjective decision-making regarding courses of treatment. The identification of new biomarkers that are predictive of recurrence after radical prostatectomy would advance the field of prostate cancer treatment. Disclosed are miRNAs that can be used as molecular biomarkers to detect or predict the progression of prostate cancer and to adjust a treatment plan accordingly. Furthermore, kits are included for the detection of these miRNAs.

Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

Abstract: An oscillator using a supply regulation loop and a method of operating the oscillator are provided.

Abstract: The present disclosure relates to a novel use of EI24, and provides a novel use of EI24 involved in the improvement of EGFR-TKI drug resistance by inhibiting IGF-1R signaling. According to the present disclosure, the presence or absence of resistance to anti-cancer drugs may be determined by detecting an expression level of EI24. In addition, resistance to anti-cancer drugs may be inhibited, delayed, or improved using EI24 or an activating agent thereof. Moreover, by regulating a pathway of EI24-mediated resistance to anti-cancer drugs, the efficacy of existing anti-cancer drugs may be enhanced, and resistance to anti-cancer drugs may be inhibited, delayed, or improved.

Abstract: A semiconductor device includes stacked transistors. Each of the transistors includes a semiconductor column including a first conductive region of first conductivity type, a second conductive region of second conductivity type, an intrinsic region disposed between the first conductive region and the second conductive region, and a barrier region of the first conductivity type disposed between the intrinsic region and the second conductive region. A gate electrode is disposed to cover the intrinsic region, and a gate insulating layer is disposed between the gate electrode and the intrinsic region.

Abstract: The invention relates to methods for treating cancer (e.g., EGFR-expressing cancer) in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a pharmaceutically acceptable carrier and antibody-albumin nanoparticle complexes, said complexes comprising albumin, a cetuximab antibody and paclitaxel.

Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

Abstract: This invention provides compositions in the form of skin substitutes comprising epithelial cells and mesenchymal cells, wherein the mesenchymal cells are not isolated from the occipital or nape region of the scalp, as well as methods for using the same.

Abstract: The present disclosure relates to flexible thermoelectric devices. In some embodiments, such devices can comprise a flexible substrate with a first conductive component and a second, different conductive component deposited thereon so as to form a plurality of electrical junctions. The flexible substrate can be a fabric, and the conductive component can be deposited by methods such as stitching of conductive yarns or deposition of conductive inks. The present disclosure further relates to methods of preparing flexible thermoelectric devices and methods of utilizing flexible thermoelectric devices for producing electrical current from waste heat.

Abstract: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.

Abstract: A switched reluctance motor system includes a switched reluctance motor, a rotor including a plurality of salient poles, a stator including a plurality of salient poles, coils of three phases wound around the salient poles of the stator, and an electronic control unit. The electronic control unit is configured to drive the switched reluctance motor in a pole configuration pattern of NSNSNS in which the salient poles of the stator that have different polarities are alternately arranged. The electronic control unit is configured to perform current waveform control when an excitation sound frequency of a given order coincides with a resonance frequency of the switched reluctance motor.

Abstract: An aspect of the invention described herein includes a method for a digestion diagnosis of a subject. The method includes obtaining electrogastrogram (EGG), bowel sound and NIRS signals from one or more sensors positioned about an abdominal region of a subject, removing artifacts from the signals to obtain conditioned signal data, and determining a digestion condition or feeding readiness of the subject based at least in part on the conditioned signal data.

Abstract: A system and process for filtering air by removing pollutants from the air with living plants. The system includes an enclosure, a wall within the enclosure on which living plants are supported and grow in one or more horizontal plant beds defining vertical tiers along the wall, an irrigation system for watering the plants, and a lighting system for simulating sunlight. Air moving through the enclosure flows adjacent leaves of the plants, through a growth media in the plant bed, and then out of the enclosure.

Abstract: A novel material for producing auxetic foams is disclosed. The material comprises a multiphase, multicomponent polymer foam with a filler polymer having a carefully selected glass transition temperature. Novel methods for producing auxetic foams from the material are also disclosed that consistently, reliably and quickly produce auxetic polyurethane foam at about room temperature (25° C.). This technology overcomes challenging issues in the large-scale production of auxetic PU foams, such as unfavorable heat-transmission problem and harmful organic solvents.