Abstract: The present disclosure relates to compounds for activating the enzymatic activity of an E3 ubiquitin ligase and methods for treating a disease or disorder in a subject with diminished E3 ubiquitin ligase enzymatic activity. In some embodiments, the present disclosure provides a compound of Formula (I) or a compound of Formula (II) or pharmaceutically acceptable salts thereof.

Abstract: The present disclosure relates to a bimetal-conductive polymer Janus composite nanostructure having electrical stimulation responsiveness, a colloidal self-assembled structure thereof, a preparation method thereof and biosensing, bioimaging, drug delivery and industrial application using the same.

Abstract: Electrical stimulation devices can be used to treat tinnitus. For example, tinnitus can be treated using implantable electrodes and stimulation devices for delivering electrical stimulation to a patient's cochlear region. Cochlear surface electrode(s), endosteal electrode(s), subendosteal electrode(s), intraosseous electrode(s), or short intracochlear electrode(s) (or a combination there-of), connected to existing or modified cochlear implant receiver/stimulator technology, can provide a successful model for long-term treatment of tinnitus in a large number of patients. In some cases, patients can simply turn on the tinnitus implant when experiencing troublesome tinnitus and gain instant relief.

Abstract: An electrical circuit comprising at least two negative capacitance insulators connected in series, one of the two negative capacitance insulators is biased to generate a negative capacitance. One of the negative capacitance insulators may include an air-gap which is part of a nanoelectromechnical system (NEMS) device and the second negative capacitance insulator includes a ferroelectric material. Both of the negative capacitance insulators may be located between the channel and gate of a field effect transistor. The NEMS device may include a movable electrode, a dielectric and a fixed electrode and arranged so that the movable electrode is attached to at least two points and spaced apart from the dielectric and fixed electrode, and the ferroelectric capacitor is electrically connected to either of the electrodes.

Abstract: Described are nanoparticle complexes comprising paclitaxel, albumin and anti-EGFR antibodies. The nanoparticle complexes are suitable for the treatment of cancer, in particular cancer that expresses EGFR.

Abstract: Provided is a real-time imaging method of NAPDH-dependent metabolic activity in a cell and a use thereof, and more particularly, an imaging method capable of measuring concentration gradient and change in an intracellular coenzyme using a mutant of metagenome-derived blue fluorescent protein (mBFP) in real-time and an application method thereof. In particular, the method of imaging and quantifying the coenzyme contained in various biological samples may be performed by improving fluorescence in a short time even under anaerobic conditions, without adding a substrate required for coenzyme measurement or conversion without destroying cells, and without consuming the time required for formation of a special structure (fluorophore) for generating fluorescence unlike the existing quantitative systems.

Abstract: Some aspects of the present disclosure relate to systems and methods for free-breathing cine DENSE MRI using self-navigation. In one embodiment, a method includes acquiring magnetic resonance data for an area of interest of a subject, wherein the acquiring comprises performing sampling with phase-cycled, cine displacement encoding with stimulated echoes (DENSE) during free-breathing of the subject; identifying, from the acquired magnetic resonance data, a plurality of phase-cycling data pairs corresponding to matched respiratory phases of the free-breathing of the subject; reconstructing, from the plurality of phase-cycling data pairs, a plurality of intermediate self-navigation images; performing motion correction by estimating, from the plurality of intermediate self-navigation images, the respiratory position associated with the plurality of phase-cycling data pairs; and reconstructing a plurality of motion-corrected cine DENSE images of the area of interest of the subject.

Abstract: A disinfectant appliance has a plurality of chlorite absorbent particles, a plurality of redox resin particles, and at least one absorbent material combined such that the absorbent material allows and can promote: infusion of water into the disinfectant appliance; release of the chlorite from the chlorite absorbent particles into the water to form a chlorite comprising solution; contacting of the chlorite comprising solution with the redox resin particles; and the expulsion of ClO2 comprising solution from the disinfectant appliance onto a surface to be disinfected. The disinfectant appliance can include a storage section and can include a handle. The disinfectant appliance can be in the form of a wipe or sponge that can be contacted with a surface suspected of being infected.

Abstract: Disclosed is a quenching circuit including an avalanche photodiode and a quenching diode applying a bias voltage to the avalanche photodiode. Since the quenching circuit includes the quenching diode instead of a quenching resistor, the avalanche photodiode can quickly recover to linear mode from Geiger mode, and the bias voltage applied to the avalanche photodiode is stably maintained even though a current level of the avalanche photodiode fluctuates according to the intensity of incident light.

Abstract: Pericardial modification devices and methods can be used for the treatment of heart conditions. For example, this document describes devices and methods for treating heart failure with preserved ejection fraction, including diastolic heart failure, by performing a pericardial modification procedure. In one example embodiment, a method for treating diastolic heart failure includes creating an opening in a patient's pericardial tissue, or removing a portion of the patient's pericardial tissue. The creation of the opening or the removing of the pericardial tissue reduces pressure exerted by the pericardial tissue on the patient's heart. The pericardial modification procedures are performed while avoiding trauma to the epicardial surface of heart as well as the phrenic nerves.

Abstract: The present disclosure relates to a novel small molecule TLR2 antagonist, and particularly, to 19 novel TLR2 antagonists, a pharmaceutical composition, including the antagonists, for preventing or treating inflammatory diseases, and a TLR4 regulator. The novel TLR2 antagonists according to the present disclosure can be effectively used as a preparation for oral administration by having low molecular weight and high oral bioavailability, and can be useful in pharmaceutical compositions for preventing or treating inflammatory diseases since the secretion of IL-8 is effectively inhibited and in vivo cytotoxicity is not induced. In addition, the novel TLR2 antagonists according to the present disclosure can be used as a TLR4 regulator.

Abstract: Disclosed is a carbon thin-film device and method for manufacturing the same. The method includes forming a functional group on a surface of a substrate and functionalizing the substrate, and depositing a carbon thin film through ALD on the substrate in which the functional group is formed.

Abstract: Alpha particle detecting devices are disclosed that have a chamber that can hold a fluid in a tensioned metastable state. The chamber is tuned with a suitable fluid and tension such that alpha emitting materials such as radon and one or more of its decay products can be detected. The devices can be portable and can be placed in areas, such as rooms in dwellings or laboratories and used to measure radon in these areas, in situ and in real time. The disclosed detectors can detect radon at and below 4 pCi/L in air; also, at and below 4,000 pCi/L or 300 pCi/L in water. When the fluid is tensioned the presence of radon can be determined by the formation of bubbles which give off detectable signals including a shock wave, light-beam cutoff, or a light burst, any of which can be measured to derive information on radon and progeny radioactivity levels in air or water.

Abstract: The present invention provides, on the basis of congestion of a network, an arrangement state of nodes, and a quality of a communication channel, a fast synchronization scheduling apparatus and method for reducing a listening time of a node that desires to join.

Abstract: The invention provides protein tyrosine phosphatase inhibitor compounds, Their pharmaceutical compositions, uses, and methods of use, such as in the treatment of various cancers, and process for making the compounds. Also disclosed is an improved synthesis of protein tyrosine phosphatase inhibitor and precursor compound thienopyridone (5).

Abstract: Disclosed is a holder device for an electron microscope, which efficiently collects light emitted when electrons collide with a sample inside the electron microscope and is selectively usable in various electron microscopes since it can be easily attached to and detached from the electron microscopes. The holder device includes a frame; a sample support block configured to be supported on the frame and comprising a sample mounting portion to support an edge of a sample; a mirror unit configured to comprise an upper mirror and a lower mirror respectively arranged above and below the sample and reflect light radiating from the sample, which is mounted to the sample mounting portion and to which an electron beam is emitted, in a predetermined direction; a condensing lens configured to condense light from the mirror unit on a predetermined target; and an optical fiber configured to collect light from the condensing lens.

Abstract: An apparatus and method for detecting a foreground in an image is provided, and the foreground detecting apparatus includes a context information estimator configured to estimate context information on a scene from an image frame of the image, a background model constructor configured to construct a background model of the image frame using the estimated context information, and a foreground detector configured to detect a foreground from the image frame based on the constructed background model.

Abstract: A system and method for collecting a core sample. The system includes an outer cylindrical tube, a drive head, a drive shoe, a cooling chamber housed inside the outer cylindrical tube, insulation, a core sample liner, an inlet tube, and outlet tube. The drive shoe further comprises a first, second, and third step, the first step configured to receive the insulation, the second step configured to receive the cooling chamber, the third step configured to receive the core sample liner, wherein the first step has a diameter larger than the second step and the second step has a diameter larger than the third step. The method includes drilling a hole in the ground with a drilling tool, enclosing a core sample by a core sample liner, freezing the core sample via a cooling liquid, retrieving the drilling tool at a surface of the ground, and removing the core sample encased in the core sample liner from the cooling chamber.

Abstract: The disclosure provides a method of oil delivery to a chainsaw chain blade using a gerotor pump in sequence with flow control valves to provide lubrication to the chain blade to reduce friction with the chainsaw bar guide and prevent overheating and damage to the chain blade or guide bar.

Abstract: A method for fabricating structures includes on a substrate includes providing a set of control parameters to an ion beam source and to a thermal source corresponding to a desired structure topology. The method also includes using directed irradiation synthesis to form nano structures and/or microstructures in a first surface area of the substrate by exposing the substrate surface to an ion beam from the ion beam source and to thermal particles from the thermal source. The ion beam having a first area of effect on the substrate surface, and the thermal particles having a second area of effect on the substrate surface, each of the first area of effect and the second area of effect including the first surface area.