Abstract: This document relates to methods and materials involved in modulating deubiquitinases (e.g., USP10 polypeptides) and/or ubiquitinated polypeptides (e.g., tumor suppressor polypeptides or mutant versions of tumor suppressor polypeptides). For example, methods and materials for increasing deubiquitinase (e.g., a USP10 polypeptide) expression or activity, methods and materials for decreasing deubiquitinase (e.g., a USP10 polypeptide) expression or activity, methods and materials for stabilizing tumor suppressor polypeptides (e.g., wild-type p53 polypeptides), methods and materials for de-stabilizing mutant versions of tumor suppressor polypeptides (e.g., mutant p53 polypeptides), and methods and materials for reducing cancer cell proliferation, increasing cancer cell apoptosis, and/or treating cancer (e.g., cancers having reduced levels of wild-type p53 polypeptides or cancers having increased levels of mutant p53 polypeptides) are provided.

Abstract: LAMP primer sets for detecting eight mastitis pathogens are disclosed. Methods and kits of using the primer sets to simultaneously detect at least two of the eight mastitis pathogens are also described.

Abstract: The present disclosure relates to an optical gas sensor including at least: an optical wave guide including a first elliptical mirror formed along at least part of a first 3-dimensional ellipsoid and having a first focal point and a second focal point, a second elliptical mirror formed along at least part of a second 3-dimensional ellipsoid and having the first focal point and a third focal point, and a third elliptical mirror formed along at least part of a third 3-dimensional ellipsoid and having the first focal point and a fourth focal point; one or more optical sensors installed at at least one of the first, second, third, and fourth focal points; and one or more light sources installed at at least one of the first, second, third, and fourth focal points where the one or more optical sensors are not installed.

Abstract: A Ligand-guided-Selection (LIGS) method for identifying highly specific aptamers against a predetermined antigen of a target is provided. LIGS uses a stronger and highly specific bivalent binder (e.g. an antibody) interacting with its cognate antigen to displace specific aptamers from a partially enriched SELEX pool. Elution of the displaced aptamers provides aptamers that are specific to the predetermined antigen.

Abstract: A device can be used for delivering a dose of a vaccine, a medicine, a medication, a drug, or a prescription. For example, this document describes a wearable vaccination device that plays an audible sound or a musical tune for distracting or entertaining a patient while an intradermal vaccine is delivered via the patient's skin. A control portion of the wearable vaccination device includes a processing unit, a rhythm producer that produces audible sounds to distract or entertain the patient, and an injection module that provides an intradermal injection using one or more microneedles.

Abstract: A method of predicting NOx generation amount of a compression ignition engine is provided. The method includes predicting a composition ratio of a gas in a mixture and a flame temperature using driving variables of an engine and calculating a nitrogen oxide generation rate using the composition ratio of the gas in the mixture and the flame temperature. Additionally, a nitrogen oxide generation concentration around flame is calculated using the nitrogen oxide generation rate and a total nitrogen oxide generation amount of a cylinder is predicted using the nitrogen oxide generation rate and the nitrogen oxide generation concentration.

Abstract: This document provides systems and methods that can be used for the practice of regenerative medicine. For example, this document provides devices and methods for injecting stem cell material into tissue, such as heart tissue.

Abstract: The invention generally relates to sensing garments.

Abstract: Provided are compositions and methods for making a variety of products. The methods involve mixing sucker ring teeth (SRT) protein and a plasticizer or a solvent to obtain a mixture of the SRT protein and the plasticizer. When the SRT is mixed with a plasticizer it is heated to between 32° C. and 195° C. to obtain an SRT protein melt. The melt is used to form a wide variety of products. When the SRT is mixed with a solvent, such as an organic solvent or an aqueous solvent, a solution of the SRT protein is formed, and is subsequently used to forming a product from the solution, wherein the product contains SRT protein.

Abstract: A delivery system that includes a recombinantly synthesized protein polymer with protease cleavage sites such as matrix metalloproteinase responsive sequences engineered within the protein polymer. The system may be used to treat cancer, wounds, or pathological conditions in other tissues that express excess protease relative to healthy tissue.

Abstract: Visible-light communication (VLC) is an optical wireless communication technique that uses light emitting diodes (LEDs) or other optical sources to transmit information to a user equipment (UE) device. An optically-based location determination approach, such as using VLC infrastructure, can meet a desire for location-based services where use of VLC can provide a solution to an indoor localization or navigation problem. A fingerprinting approach can include use of an optical received signal strength (RSS) or other information (e.g., an image of a scene) to generate a spatial fingerprint map of an area. A later-received RSS on the UE device and the prior-generated fingerprint map representative of RSS can be received, and a fingerprint map and RSS observations can be provided as inputs to a Bayesian filter, such as an Extended Kalman Filter (EKF) or a Particle Filter, to provide an estimated position for the UE device.

Abstract: A positive electrode active material for a magnesium secondary battery, and a positive electrode for a magnesium secondary battery and a magnesium secondary battery in which the positive electrode active material is used are provided. The positive electrode active material consists of a magnesium composite oxide which is represented by Formula (1): MgxM1yM2zO2 and which has a rock salt-type crystal structure of space group Fm-3m. In Formula (1), M1 is Ni, Co, or Mn, M2 is different from M1 and is at least one element selected from the group consisting of Ni, Co, Mn, Ti, V, Cr, Fe, Cu, Nb, W, Mo, and Ru, 0<x?1, 0<y<2, 0<z<1; and 1.5?x+y+z?2.0.

Abstract: The present invention provides N-benzyl-3-sulfonamidopyrrolidines and related compounds, as well as pharmaceutical compositions and sanitizing compositions containing the same. The compounds and compositions are useful as antibiotic agents. Methods for making and using the compounds and compositions are also described.

Abstract: The present invention provides compositions and methods for regulating arterial tone based on the discovery herein of novel expression and regulation of hemoglobin alpha and cytochrome B5 reductase 3 and the effects on NO and NOS.

Abstract: The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer). The system operates without an application of voltage to the probe. In certain embodiments, the probe is oriented such that a distal end faces an inlet of the mass spectrometer. In other embodiments, the distal end of the probe is 5 mm or less from an inlet of the mass spectrometer.

Abstract: A mutant strain of the bacterium Clostridium botulinum having an inactivated botulinal neurotoxin gene is disclosed. The mutant strain contains an artificially created and inserted modified intron vector between nucleotides 580 and 581 of the sense strand of the gene. The mutant strain can be used in microbiological challenge testing of foods and food processing methods.

Abstract: Provided are fusicoccane derivatives and methods of making fusicoccane derivatives. The methods may include contacting a tethered chromophore with light to initiate a photoinduced pericyclic reaction cascade to form a 5-8-5 carbotricycle. The 5-8-5 carbotricycle may be further functionalized.

Abstract: Methods of aligning fibers with an electric field are provided. The fibers may include dielectric fibers, such as carbon fibers. The fibers may be aligned in a liquid that is curable. Composite materials also are provided that include aligned fibers.

Abstract: Disclosed is a method for detecting toxic metal ions in a sample. The method includes: a) preparing a solution of organic acid-bound gold nanoparticles; b) adding a sample containing toxic metal ions to the solution prepared in a) to allow the gold nanoparticles to aggregate; c) dropping the reaction solution obtained in b) onto a silicon substrate and drying the reaction solution such that the gold nanoparticle aggregates are immobilized on the silicon substrate; and d) analyzing the characteristics of the gold nanoparticles immobilized on the silicon substrate. The method enables the detection of even a trace amount of toxic metal ions in a sample with high sensitivity. Therefore, the method can be applied to the management of water quality in food service providers and hospitals, the measurement of contaminants in water supply and drainage systems, and the management of industrial wastewater.

Abstract: Differentially expressed miRNA or small mRNA in the culture media of embryos were found to correlate to and affect embryo developmental fate. Accordingly the present invention provides a method for selecting a bovine embryo for implantation into a female bovine animal for further development based on the levels of specific miRNA or small mRNA. Also provided are methods of improving bovine embryo development fate by reducing in the culture medium the level of selected miRNAs.