Abstract: Selective azophenol inhibitors of a wild type or an altered ERG protein expression are described, where the inhibitors represent a compound of Formula (I) or Formula (II) wherein X, X1, X2, X3, X4 and X5, R1 through R4 and R9 are as described.

Abstract: A location based mobile device system and application for providing artifact tours is described. The mobile device application of illustrative embodiments provides multimedia information regarding an array of artifacts pertinent to the location of the mobile device. The artifacts include both current and historical events, in addition to landmarks, architecture, famous persons associated with the location, natural phenomenon and age-based activities. Illustrative embodiments generate tours that connect artifacts by common theme and the current location of the mobile device. Information relevant to a particular location may be displayed or pushed on the mobile device unprompted when the device passes in proximity to a Bluetooth beacon.

Abstract: The present invention relates to a dietary supplement, composition, nutraceutical, and/or system for inducing or treating biological responses or conditions (namely sleep or sleep disorders) which utilize ultra-low dosage amounts of vitamins, minerals, amino acids, co-enzymes, stimulants, and/or similar ingredients in a highly bio-active delivery system which bypasses first pass metabolism. In particular, the present invention relates to a nutraceutical composition/formulation which substantially bypasses first pass metabolism and such as, but not limited to, activation of the glymphatic system to facilitate clearance of neuronal metabolites from the CSF and interstitial fluids in the brain.

Abstract: An intravenous (IV) pole assembly comprising: an IV pole having a pole, a plurality of hooks mounted to the pole, and a base with a plurality of wheels, wherein the plurality of hooks are for holding a container of intravenous fluid; and a decorative equipment including a decorative element and a connector bracket attached to the decorative element, the connector bracket for mounting on a top of the pole, the connector bracket comprises a shaft that defines a plurality of slots on one end of the shaft.

Abstract: The invention provides a method for the creation of peptide antigens comprising epitopes with at least a first modification comprising a shortened or lengthened amino acid side chain. By extension or shortening of the side chain with CH3/CH2 groups, for example, made by computer assisted modeling of the tumor antigen (peptide) bound in the MHC-I-groove, immunogenicity can be improved with minimal modification of adjacent tertiary structure, thereby avoiding cross-reactivity. Provided by the invention are methods of creating such antigens, as well as methods for therapeutic or prophylactic treatment of various conditions comprising administration of the antigens.

Abstract: Provided are a method and program for computing a bone age using a deep neural network. The method for computing a bone age using a deep neural network, including: receiving an analysis target image that is a specific medical image to compute the bone age; and analyzing the analysis target image by at least one computer using the deep neural network to compute the bone age. According to the present disclosure, since the bone age is computed by accumulating medical images of a specific race (particularly, Korean) and analyzing the same, it is possible to compute an accurate bone age that conforms to race.

Abstract: This document provides methods and materials involved in treating cardiovascular conditions such as calcific aortic valve stenosis. For example, methods and materials for using sGC agonists or a combination of sGC agonists and PDE5A inhibitors to reduce calcification of heart valves and/or vessels or to slow progression of aortic sclerosis to calcific aortic valve stenosis are provided.

Abstract: Systems and methods are disclosed to determine the concentration of a species within a sample. An example method may include collecting optical loss data over a range of frequencies from the sample using a spectroscopy system; placing the optical loss data into a plurality of bins, each bin having a defined frequency width; determining an average optical loss data value for the optical loss values within each bin that have an optical loss value less than a threshold value; removing the optical loss data within each bin having a value outside a tolerance range bounding the average optical loss data value for the respective bin; fitting a spectral curve to the remaining optical loss data; and determining the concentration of the species within the sample based on the spectral curve.

Abstract: A transparent proxy for malware detection includes a monitor module, a protocol determination module, a challenge generation module, a response determination module, and a data control module. The monitor module examines data originating from an application towards a remote server. The protocol determination module identifies the protocol type used for the data. The challenge generation module produces a challenge for the application based upon the protocol type, sends the challenge to the application, and maintains a state related to the data and the challenge. The response determination module makes a determination if an automatic non-interactive application response is received in response to the challenge from the application. The data control module allows the first data to continue to the remote server when the determination is valid. The data control module reports malware detection and blocks the data to continue to the remote server when the determination is invalid.

Abstract: The present disclosure relates to an auxiliary power supply (APS) for a gate driver in high voltage applications.

Abstract: Provided is an active lens structure. The active lens structure has a configuration in which a polarization switching section and a polarization dependent lens section are integrally formed, wherein a lattice structure is formed on an upper surface of a liquid crystal phase polymer layer of the polarization dependent lens section, and the liquid crystal phase polymer layer is aligned in a top-down manner and is used as a lower alignment film of a liquid crystal layer. Therefore, the polarization switching section of the active lens structure can be fabricated without any lower alignment film and any lower glass substrate, so that it is possible to minimize the total thickness and simplifying the manufacturing process.

Abstract: The present disclosure relates to compositions and methods of carbonic anhydrase IX inhibitors. The present disclosure also relates to targeting conjugates of carbonic anhydrase IX inhibitors. The present disclosure also relates to the use of targeting conjugates of carbonic anhydrase IX inhibitors in SPECT imaging methods.

Abstract: An ophthalmic composition or dosage form can include a therapeutically effective amount of a cross-linking agent and a pharmaceutically acceptable carrier. The composition or dosage form can be used to treat an ophthalmic condition by administering a therapeutically effective amount of the composition to an eye of a subject during a treatment period.

Abstract: A method and a terminal device for executing a radio application are disclosed. The method for executing a radio application comprises the steps of: allowing a radio virtual machine (RVM) of a reconfigurable mobile device to reference a radio programming interface (RH); and replacing at least one abstract processing element (APE) of the RVM with at least one elementary RVM according to an RVM hierarchical structure referenced by the RPI.

Abstract: A defroster nozzle of a vehicle installed below a windshield of the vehicle and discharging conditioned air toward the windshield, the defroster nozzle generating vortex during discharging is disclosed. The defroster nozzle may include a housing formed in a cylindrical shape and having an inlet formed at one end of the housing through which the conditioned air is introduced, and an outlet formed adjacent to the windshield through which the air is discharged, and a vortex generator configured to protrude from an inner side surface of the housing to discharge the air introduced into the housing as vortex in the inner side surface of the housing.

Abstract: This document provides methods and materials for treating patients following an assessment of immune subtypes such as an assessment of peripheral blood phenotypes. For example, methods and materials for treating a mammal having a medical condition after assessing a mammal's level of CD14+/DR? cells (e.g., CD14+/DR? monocytes) and level of CD4+ cells (e.g., CD4+ T cells) and classifying the mammal has being likely to experience a favorable or unfavorable medical outcome based at least in part on the mammal's level of CD14+/DR? cells and level of CD4+ cells are provided.

Abstract: Disclosed are a thin film transistor including a substrate and a gate electrode, a gate insulating film, a semiconductor layer, a source electrode, and a drain electrode formed on the substrate and a method of fabricating the thin film transistor, wherein the gate insulating film is made of a high dielectric ternary material, A2-XBXO3, wherein A is any one selected from the group consisting of aluminum, silicon, gallium, germanium, neodymium, gadolinium, vanadium, lutetium, and actinium, B is any one selected from the group consisting of yttrium, lanthanum, zirconium, hafnium, tantalum, titanium, vanadium, nickel, silicon, and ytterbium, and A is an element different from B. The gate insulating film may be formed through a solution process, and a high-quality insulating film may be obtained through heat treatment at low temperature.

Abstract: A stretchable multimode sensor and a method of fabricating the same are provided. The stretchable multimode sensor may include a substrate which is formed of a flexible material and includes a pressure sensor area, an optical sensor area, a temperature sensor area and a switching element area, a pressure sensor which is disposed on the pressure sensor area and includes an amorphous metal, an optical sensor which is disposed on the optical sensor area and includes an amorphous metal, and a temperature sensor which is disposed on the temperature sensor area and includes an amorphous metal, and a switching element which is disposed on the switching element area and includes an amorphous metal.

Abstract: A group of peptide compounds and their use in identifying molecules that stimulate proteasome or immunoproteasome are disclosed herein.