Patents Assigned to Fudan University
-
Patent number: 12215038Abstract: A method for preparing two-dimensional (2D) ordered mesoporous nanosheets by inorganic salt interface-induced assembly includes the following steps: carrying out, by using a soluble inorganic salt as a substrate and an amphiphilic block copolymer as a template, uniform mass diffusion of a target precursor solution at an inorganic salt crystal interface through vacuum filtration or low-speed centrifugation; forming a single-layer ordered mesoporous structure by using the solvent evaporation-induced co-assembly (EICA) technology; and promoting, through gradient temperature-controlled Ostwald ripening, the evaporation and induced formation of an organic solvent, and removing the template in N2 to obtain a 2D single-layer ordered mesoporous nanosheet material. The assembled nanosheet material has a large pore size, regular spherical pores and orderly arrangement. By changing the type of the precursor, a variety of mesoporous metal oxides, metal elements, inorganic non-metal nanosheets are synthesized.Type: GrantFiled: March 9, 2020Date of Patent: February 4, 2025Assignee: FUDAN UNIVERSITYInventors: Yonghui Deng, Liangliang Liu, Yidong Zou, Xuanyu Yang
-
Publication number: 20250040196Abstract: A fin field-effect transistor device with hybrid conduction mechanism, including a fin field-effect transistor, a second source region, and a second drain region; the fin field-effect transistor includes a substrate, a fin channel region, a first source region, and a first drain region; the height of the second source region is not lower than the height of the substrate between the first source region and the first drain region; the first source region, the first drain region and the second drain region are doped with first ions; the second source region is formed between the substrate and the first source region, the second drain region is formed between the substrate and the first drain region, the second source region is doped with second ions. This scheme can realize hybrid conduction of fin channel diffusion drift current and bottom channel band-to-band tunneling current, thus obtaining better ultra-steep switching characteristics.Type: ApplicationFiled: December 30, 2022Publication date: January 30, 2025Applicants: FUDAN UNIVERSITY, SHANGHAI INTEGRATED CIRCUIT MANUFACTURING INNOVATION CENTER CO., LTD.Inventors: Chunlei WU, Yumin XU, Boqian SHEN, Fei ZHAO, Zichen YANG, Wei ZHANG, Min XU
-
Patent number: 12194428Abstract: A multi-layered micro-channel mixer includes a base plate and a cover plate. Two inlet fluid reservoirs, two inlet channels, two groups of fluid distribution channel networks, two groups of process fluid channels, an impinging stream mixing chamber, a fluid mixing intensification channel and an outlet buffer reservoir are provided on the base plate. Two fluids are fed into the two inlet fluid reservoirs, respectively. The fluids then flow into the process fluid channels via the inlet channels and the multi-stage fluid distribution channel networks, respectively. Then the two fluid streams ejected from the opposing process fluid channels impinges upon each other in the impinging stream mixing chamber. The mixed fluid is subjected to vortex or secondary flow generated by the baffles or the internals in the impinging stream mixing chamber and fluid mixing intensification channel, and finally the mixed fluid is discharged through the outlet buffer reservoir.Type: GrantFiled: September 6, 2021Date of Patent: January 14, 2025Assignee: Fudan UniversityInventors: Fener Chen, Dang Cheng, Minjie Liu, Huashan Huang, Meifen Jiang, Jiaqi Wang
-
Publication number: 20240430565Abstract: The invention relates to precision measurement technology, specifically a high-sensitivity three-dimensional topography recovery method using dual-channel differentiation. Enhancing a traditional microscopic imaging system, a beam splitter is added between the objective lens and tube lens. This creates an additional light path equipped with a tube lens and camera identical to the original but with a slightly different distance to the camera. During axial scanning of the object, focusing evaluation function curves for each pixel are calculated from images captured by both cameras. The curves from the two cameras show more significant changes near the optimal focusing depth, improving system sensitivity. This method enhances sensitivity by hardware-fixed differentiation of the focusing evaluation function, while maintaining high scanning efficiency and flexible configuration.Type: ApplicationFiled: May 23, 2024Publication date: December 26, 2024Applicant: FUDAN UNIVERSITYInventors: Xiangchao ZHANG, Yunuo CHEN, Wei LANG, Sihan CHEN, Chengzhuo WANG
-
Publication number: 20240429229Abstract: A gate-all-around transistor with hybrid conduction mechanism, including a GAA MOSFET, a second source region, and a second drain region. The GAA MOSFET includes a substrate, a first source region, and a first drain region. The first source region, the first drain region and the second drain region are doped with first ions, the second source region is doped with second ions. The second source region is formed between the substrate and the first source region, the second drain region is formed between the substrate and the first drain region. The height of the second source region and the second drain region are not less than the height of the substrate between the first source region and the first drain region. It can realize the hybrid conduction of the gate channel diffusion drift current and the bottom channel band tunneling current to obtain better ultra-steep switching characteristics.Type: ApplicationFiled: December 30, 2022Publication date: December 26, 2024Applicants: FUDAN UNIVERSITY, SHANGHAI INTEGRATED CIRCUIT MANUFACTURING INNOVATION CENTER CO., LTD.Inventors: Chunlei WU, Yumin XU, Boqian SHEN, Fei ZHAO, Zichen YANG, Wei ZHANG, Min XU
-
Publication number: 20240428955Abstract: A method and a system of molecular typing and subtyping classifier for immune-related diseases are provided. The method includes: conducting molecular typing via a clustering algorithm in a training set to obtain a plurality of subtypes stably appearing in the training set and a marker gene for each subtype; conducting enrichment analysis on marker genes for the plurality of subtypes, conducting immune cell infiltration evaluation on the plurality of subtypes, and dividing the plurality of subtypes into a plurality of subtype classes according to results of the analysis and the evaluation; comparing treatment response rates of different subtype classes through a comparison set to determine a subtype class to be identified; constructing a support vector machine model with feature genes screened and an optimal parameter combination; and determining whether immune-related disease data to be classified is the subtype class to be identified.Type: ApplicationFiled: August 12, 2022Publication date: December 26, 2024Applicant: HUASHAN HOSPITAL, FUDAN UNIVERSITYInventors: Jie LIU, Feifei LUO, Shaocong MO, Huan SONG
-
Patent number: 12159179Abstract: The present disclosure discloses a three-dimensional integration system of an RFID chip and a supercapacitor and a manufacturing method thereof.Type: GrantFiled: July 2, 2020Date of Patent: December 3, 2024Assignees: Fudan University, Shanghai Integrated Circuit Manuvacturing Innovation Center Co., LtdInventors: Bao Zhu, Lin Chen, Qingqing Sun, Wei Zhang
-
Patent number: 12152017Abstract: A ketoamide compound and a preparation method, a pharmaceutical composition, and a use thereof. Specifically, the ketoamide compound shown in formula (A), a racemate, an enantiomer, or a diastereoisomer thereof, or any mixture of same, or a pharmaceutically active metabolite thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof. The ketoamide compound can effectively inhibit coronavirus or Ebola virus, and thereby implement the prevention or treatment of diseases related to coronavirus or diseases related to Ebola virus.Type: GrantFiled: August 9, 2019Date of Patent: November 26, 2024Assignees: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Fudan UniversityInventors: Hong Liu, Shibo Jiang, Wenhao Dai, Lu Lu, Jingjing Peng, Shuai Xia, Jiang Wang, Jian Li, Hualiang Jiang, Kaixian Chen
-
Publication number: 20240376024Abstract: The present application provides a method for preparing a deuterated chemical by means of a deuteration reaction of a carbon-hydrogen bond with a deuterium gas under the catalysis of an alkali, wherein in the presence of a catalyst, a deuterium gas is added into a compound containing a carbon-hydrogen bond for a deuteration reaction so as to generate a deuterated compound. A deuterium gas is used as a deuterium source, such that multiple water separation operations, tedious steps and the wasting of energy caused by usage of a large amount of deuterium oxide as a deuterium source are avoided. Moreover, a cheap and easily available alkali metal compound is used for replacing an expensive transition metal catalyst and a complex-structure ligand as a catalyst for a deuteration reaction, and the alkali metal compound has the advantages of a low cost, a good compatibility with functional groups of a substrate and a high deuteration rate.Type: ApplicationFiled: April 7, 2022Publication date: November 14, 2024Applicant: FUDAN UNIVERSITYInventors: Bingtao GUAN, Huizhen DU
-
Publication number: 20240321999Abstract: The present invention relates to a photo-response detector, in particular to a ferroelectric field modulated positive and negative photo-response detector, a preparation method and application thereof. The ferroelectric field modulated positive and negative photo-response detector includes a substrate, a gate electrode, a ferroelectric layer, a low-dimensional semiconductor and a source-drain electrode. A pair of gate electrodes are provided and fixedly arranged on the substrate at intervals. The ferroelectric layer is fixedly arranged on the substrate and completely covers the gate electrode. The low-dimensional semiconductor is fixedly arranged on the ferroelectric layer. The source-drain electrode includes a source electrode and a drain electrode separately arranged on two sides of the low-dimensional semiconductor and fixedly arranged on the ferroelectric layer.Type: ApplicationFiled: July 8, 2022Publication date: September 26, 2024Applicant: Fudan UniversityInventors: Jianlu WANG, Guangjian WU
-
Patent number: 12093781Abstract: Provided are a method for coupling any two qubits from among multiple superconducting qubits and a system thereof, which are applied to an occasion provided with a multi-superconducting-qubit array and a magnetic film material capable of implementing spin waves. The method includes: disposing a magnetic film material below a multi-superconducting-qubit array; forming, through a combination of magnetization directions of magnetic domains in the magnetic film material, multiple channels through which the spin waves pass; disposing multiple qubits of the multi-superconducting-qubit array above the multiple channels through which the spin waves pass correspondingly to implement a coupling between each qubit and the spin waves; and disposing at least two qubits above one spin wave channel and implementing a coupling between the at least two qubits through the coupling between each qubit and the spin waves.Type: GrantFiled: March 5, 2019Date of Patent: September 17, 2024Assignees: Southern University of Science and Technology, Fudan UniversityInventors: Dapeng Yu, Jiansheng Wu, Jiang Xiao, Song Liu, Shaojie Yuan
-
Patent number: 12084427Abstract: Disclosed is a method of continuously preparing N,N-Bis(2,2,6,6-tetramethyl-4-piperidyl)-1,6-hexamethylenediamine, which relates to chemical engineering. The Pt/C catalyst and the quartz sand are mixed uniformly and loaded to the continuous-flow fixed-bed reactor. Then, hydrogen gas and a substrate solution containing 2,2,6,6-tetramethyl-4-piperidinone and 1,6-hexanediamine are simultaneously fed to the micro-mixer and the continuous-flow fixed-bed reactor in sequence to undergo a continuous catalytic reductive amination to obtain the N,N-Bis(2,2,6,6-tetramethyl-4-piperidyl)-1,6-hexamethylenediamine.Type: GrantFiled: May 9, 2022Date of Patent: September 10, 2024Assignee: Fudan UniversityInventors: Fener Chen, Liangchuan Lai, Baijun Ye, Meifen Jiang
-
Publication number: 20240286996Abstract: The present disclosure provides naphthalenesulfonyl compounds, preparation methods and application thereof. Specifically disclosed is a compound of formula (I) or a salt thereof, which serves as a specific derivatization reagent capable of reacting with hydroxyl and amino groups. The compound features simple synthesis, high reactivity, and ready availability at low cost, and is capable of improving chromatographic separation behaviors of target compounds and enhancing the detection sensitivities of these compounds.Type: ApplicationFiled: February 7, 2024Publication date: August 29, 2024Applicant: FUDAN UNIVERSITYInventors: Huiru TANG, Pengcheng LI
-
Patent number: 12055555Abstract: An on-line measurement system for aerosol precursors emitted from industrial sources has three parts: online measurement part, pipeline cleaning part and automatic control part. The system includes: a particulate filter, high temperature intake pipe, two detergent tanks, an air pump, a cooling water pump, two detergent pumps, a condenser, an impinger, a cooling water meter, a salinity meter, a liquid flow meter, a gas flow meter, nitrogen cylinders, connecting pipes, control valves, computer control program etc. The aerosol precursor concentration Cg emitted from industrial sources is measured in the online measurement section. After every measurement, the pipeline is cleaned by the pipeline cleaning part to remove organic and inorganic residual. The automatic control part is controlled by the computer through a controlling program to control the working process of the system. The system has small area occupation, low investment cost, simple maintenance, convenient transformation and high applicability.Type: GrantFiled: October 14, 2021Date of Patent: August 6, 2024Assignee: FUDAN UNIVERSITYInventors: Qing Li, Anlin Liu
-
Targeted CD73 antibody and antibody-drug conjugate, and preparation method therefor and uses thereof
Patent number: 12024565Abstract: Disclosed by the present invention are a targeted CD73 antibody and an antibody-drug conjugate (ADC), and a preparation method therefor and application thereof. Further disclosed is a method for preparing the described monoclonal antibody and ADC. The monoclonal antibody and the corresponding ADC disclosed by the present invention can be efficiently and highly specifically combined with purified CD73 protein and CD73 on the surfaces of multiple tumor cells to block the catalytic activity of CD73 enzyme, and have high affinity, low immunogenicity and significant anti-tumor effect.Type: GrantFiled: March 7, 2019Date of Patent: July 2, 2024Assignees: Fudan University, Bliss Biopharmaceutical (Hangzhou) Co., Ltd.Inventors: Ke Yu, Rui Jin, Liang Liu -
Patent number: 12025541Abstract: A manufacturing method for mass production for a tissue or cell microarray, which is characterized in comprising: using a molding device to mold tissue particles, cultivated cells or collected exfoliated cells (such as exfoliated cells from pleural effusion and ascites), forming the tissue particles from blended fresh tissue, tissue fixed by formalin or another solvent (such as alcohol and so on) or a tissue block embedded in paraffin (blended by a tissue blender), implanting the molded tissue or cells cores in a receptor wax or adhering the molded tissue or cells cores onto a metal plate, and then slicing to obtain a tissue or cell microarray.Type: GrantFiled: October 23, 2020Date of Patent: July 2, 2024Assignee: ZHONGSHAN HOSPITAL, FUDAN UNIVERSITYInventors: Yingyong Hou, Chen Xu, Dongxian Jiang, Qi Song, Haixing Wang, Yalan Liu, Jie Huang, Lingli Chen, Rongkui Luo, Qin Hu, Yuan Ji, Shaohua Lu, Jun Hou, Lijuan Luan, Jieakesu Su
-
Publication number: 20240199521Abstract: Disclosed in the present invention is a preparation method for a tetra-substituted allenoic acid compound based on a palladium catalytic system, that is, a highly optically active allenoic acid compound having axial chirality is directly constructed in one step by reacting tertiary propargyl alcohol, carbon monoxide and water in an organic solvent under the action of a palladium catalyst, a chiral bisphosphine ligand, an organophosphoric acid, and an organic additive, and the theoretical yield can reach 100%. The method of the present invention is simple to operate, the raw materials and reagents are readily available, the reaction conditions are mild, the substrate universality is wide, the functional group compatibility is good, the reaction has high enantioselectivity (77%˜96% ee), and the reaction is well compatible with complex natural products or substrates of a drug molecular skeleton.Type: ApplicationFiled: January 19, 2022Publication date: June 20, 2024Applicant: FUDAN UNIVERSITYInventors: Shengming MA, Weifeng ZHENG, Hui QIAN
-
Patent number: 12012711Abstract: An ecological slope protection has an efficient water purification function, built in a land-lake ecozone along the bank of a basin, wherein the body of the ecological slope protection extends into the water of the basin, and has a flexible mattress laid on the surface thereof; an ecological filter pool is provided below the flexible mattress and is isolated from the water of the basin by means of the pool body; the ecological filter pool is contained with a filler layer and a support layer, and the filler layer is supported by the support layer; the sewage pretreated via a sedimentation pool is introduced into the ecological filter pool and treated by the filler layer to clean up pollutants therein and reduce its eutrophication level; and the treated sewage is discharged from the ecological slope protection via the support layer and enters the basin.Type: GrantFiled: March 28, 2019Date of Patent: June 18, 2024Assignee: FUDAN UNIVERSITYInventors: Zheng Zheng, Wenjing Sun, Xingzhang Luo, Jian He
-
Publication number: 20240190717Abstract: A method for promoting the rapid precipitation of travertine crystals by algae is disclosed. Microalgae is added to a body of water having a calcium ion concentration of 100-500 mg/L and stirred. The amount of microalgae is 0.1-8×108 cells/L. The invention adopts a method for promoting the rapid precipitation of travertine crystals by algae, which significantly improves the sedimentation rate of travertine crystals. At the same time, there are pseudomonas in the calcified water body of algae, which can be used for algae-lysing bacteria isolation and purification.Type: ApplicationFiled: February 6, 2023Publication date: June 13, 2024Applicants: Chengdu University of Technology, Jiangnan University, Fudan UniversityInventors: Weizhen ZHANG, Qi LI, Ningfei LEI, Jing ZHANG, Guo LI, Yu LIU, Peng GU, Xiaowei ZHENG, Hanqi WU, Wenhao GAO, Jing LIU, Yunxing XIAO, Qihui LI, Zheng ZHENG
-
Patent number: 12009809Abstract: The present invention provides a drive module for a GaN transistor, including: a first pull-down transistor and a gate ringing and overshoot suppression unit, where the gate ringing and overshoot suppression unit and a first end of the first pull-down transistor are directly or indirectly connected to a gate of the GaN transistor, the gate ringing and overshoot suppression unit is connected between a second end of the first pull-down transistor and the ground; the gate ringing and overshoot suppression unit is configured to: when a gate voltage of the GaN transistor drops, control the release of a gate charge of the GaN transistor with a first impedance if the gate voltage is higher than a specified threshold; and control the release of the gate charge of the GaN transistor with a second impedance if the gate voltage is less than the specified threshold, where the first impedance is less than the second impedance.Type: GrantFiled: May 31, 2022Date of Patent: June 11, 2024Assignee: FUDAN UNIVERSITYInventors: Min Xu, Jian Jin, Mengyuan Sun, Bin Wang, Wei Zhang