Patents Assigned to FUJIFILM WAKO PURE CHEMICAL CORPORATION
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Publication number: 20200408760Abstract: The invention provides gastroenterological cancer determination methods that involve contacting a specimen, an antibody 1 that recognizes an ? chain of human haptoglobin, and an antibody 2 that recognizes a ? chain of human haptoglobin and does not recognize human haptoglobin in which an S—S bond is cleaved to form a complex 1, or contacting the specimen and two antibodies selected from the antibodies 2 that recognize a ? chain of human haptoglobin and do not recognize human haptoglobin in which an S—S bond is cleaved to form a complex 2. A determination is made based on the measurement of complex 1 or 2. Alternatively, the specimen and two antibodies selected from the antibodies 1 that recognize an ? chain of human haptoglobin are contacted to form a complex 3, and a determination is made by comparing the measurement results of complex 1 or 2 with complex 3.Type: ApplicationFiled: May 25, 2017Publication date: December 31, 2020Applicants: FUJIFILM WAKO PURE CHEMICAL CORPORATION, OSAKA UNIVERSITYInventors: Eiji MIYOSHI, Yoshihiro KAMADA, Shinji TAKAMATSU, Naoya KATAOKA, Kimihiro NISHINO, Kayoko KIDOWAKI, Ayumi AKINAGA, Tatsuo KUROSAWA
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Publication number: 20200393449Abstract: The invention provides a carrier and a method for obtaining, removing, or detecting extracellular membrane vesicle or virus present in a sample. In particular, the invention provides (a) a carrier (a Tim carrier) on which a protein (a Tim protein), selected from a T-cell immunoglobulin and mucin domain-containing molecule-4 (a Tim-4) protein, a Tim-3 protein, and a Tim-1 protein, is bound; (b) a method for obtaining the extracellular membrane vesicle or the virus in the sample; (c) a method for removing the extracellular membrane vesicle or the virus in the sample; (d) a method for detecting the extracellular membrane vesicle or the virus in the sample; (e) a kit for capturing the extracellular membrane vesicle or the virus, comprising the Tim carrier; and (f) a kit for capturing the extracellular membrane vesicle or the virus, comprising a reagent containing the Tim protein and a reagent containing the carrier.Type: ApplicationFiled: August 27, 2020Publication date: December 17, 2020Applicants: FUJIFILM WAKO PURE CHEMICAL CORPORATION, OSAKA UNIVERSITYInventors: Takahiro NISHIBU, Naoko IMAWAKA, Ken NARUSE, Rikinari HANAYAMA
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Patent number: 10862169Abstract: The present invention relates to an electrolytic solution for a magnesium battery, formed by mixing a compound represented by the following general formula (I), a Lewis acid or a compound represented by the following general formula (A), and a solvent; and the like. {In the formula, m represents 0 or 2, n represents 2 in a case of m=0 and represents 0 or 1 in a case of m=2, X1 represents a chlorine atom or a bromine atom, and two R1's each independently represent a magnesium chloride oxy group; a magnesium bromide oxy group; an alkyl group which may have a halogeno group or the like as a substituent; an alkoxy group; an aryl group which may have an alkoxy group or the like as a substituent; an aryloxy group which may have an alkoxy group or the like as a substituent; or a group represented by the following general formula (1), and two R1's may also form the following general formula (2).Type: GrantFiled: May 26, 2017Date of Patent: December 8, 2020Assignee: FUJIFILM WAKO PURE CHEMICAL CORPORATIONInventors: Kazuhiko Sato, Goro Mori, Hiromi Watahiki, Kuniaki Okamoto, Nobutaka Shimamura
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Patent number: 10862127Abstract: It is an object of the present invention to provide an electrode capable of maintaining superior capacity retention without destruction of an electrode structure, even in the case of using an active material including silicon.Type: GrantFiled: November 21, 2017Date of Patent: December 8, 2020Assignees: TOKYO UNIVERSITY OF SCIENCE FOUNDATION, FUJIFILM WAKO PURE CHEMICAL CORPORATIONInventors: Shinichi Komaba, Naoaki Yabuuchi, Zhen-ji Han, Takeo Sasaki, Shota Hashimoto, Kuniaki Okamoto, Tsuneaki Maesawa
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Patent number: 10854881Abstract: It is an object of the present invention to provide an electrode having superior charge-discharge capacity, even in the case of using an active material containing silicon.Type: GrantFiled: April 21, 2015Date of Patent: December 1, 2020Assignees: TOKYO UNIVERSITY OF SCIENCE FOUNDATION, FUJIFILM WAKO PURE CHEMICAL CORPORATIONInventors: Shinichi Komaba, Kiyofumi Yamagiwa, Shoko Aoki, Kuniaki Okamoto, Takahiro Kiyosu, Yasuyoshi Mori, Takatoshi Matsuura, Michihiko Sato
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Patent number: 10794899Abstract: The invention provides a carrier and a method for obtaining, removing, or detecting extracellular membrane vesicle or virus present in a sample. In particular, the invention provides (a) a carrier (a Tim carrier) on which a protein (a Tim protein), selected from a T-cell immunoglobulin and mucin domain-containing molecule-4 (a Tim-4) protein, a Tim-3 protein, and a Tim-1 protein, is bound; (b) a method for obtaining the extracellular membrane vesicle or the virus in the sample; (c) a method for removing the extracellular membrane vesicle or the virus in the sample; (d) a method for detecting the extracellular membrane vesicle or the virus in the sample; (e) a kit for capturing the extracellular membrane vesicle or the virus, comprising the Tim carrier; and f) a kit for capturing the extracellular membrane vesicle or the virus, comprising a reagent containing the Tim protein and a reagent containing the carrier.Type: GrantFiled: November 27, 2015Date of Patent: October 6, 2020Assignees: FUJIFILM WAKO PURE CHEMICAL CORPORATION, OSAKA UNIVERSITYInventors: Takahiro Nishibu, Naoko Imawaka, Ken Naruse, Rikinari Hanayama
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Patent number: 10774062Abstract: An object of the present invention is to provide a photocuring method, which makes it possible to rapidly and efficiently obtain a crosslinked product (resin), a compound used in the photocuring method, and a photocuring resin composition containing the compound. The present invention relates to a photocuring method, which comprises a step 1 and a step 2 performed after the step 1, a compound used in the photocuring method, and a photocuring resin composition containing the compound. Step 1: this is a step in which in the presence of (A) compound having a carbonyl group generating a radical by photoirradiation and a carboxyl group decarboxylated by photoirradiation, (B) silane coupling agent having a mercapto group or a (meth)acryl group is reacted with (C) water under acidic conditions to obtain (D) silane compound having a mercapto group or a (meth)acryl group and at least one silanol group.Type: GrantFiled: January 25, 2017Date of Patent: September 15, 2020Assignees: FUJIFILM Wako Pure Chemical Corporation, TOKYO UNIVERSITY OF SCIENCE FOUNDATIONInventors: Nobuhiko Sakai, Kosuke Yanaba, Shigeaki Imazeki, Koji Arimitsu
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Patent number: 10760115Abstract: A specimen disrupting apparatus includes: a drive unit that rotates the lower portion of a container having a solution that includes a specimen, a great number of small diameter beads, and a large diameter bead stored therein; and a control unit that controls the drive unit. The control unit controls the drive unit such that the lower portion of the container rotates at two or more different rotational speeds which are changed continuously.Type: GrantFiled: November 17, 2015Date of Patent: September 1, 2020Assignee: FUJIFILM WAKO PURE CHEMICAL CORPORATIONInventors: Akito Yoneda, Tomohisa Kawabata, Yoichi Endo, Daisuke Hibe, Mikio Tsuyuki, Tatsuyuki Denawa
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Patent number: 10727534Abstract: An object of the present invention is to provide a highly practical electrolytic solution which has a high oxidative decomposition potential, enables the dissolution and precipitation of magnesium to stably repeatedly proceed, and is easy to prepare. The present invention relates to an electrolytic solution for a magnesium battery comprising: a compound represented by the general formula (I), a Lewis acid or a compound represented by the general formula (A), and a solvent; and to the compound represented by the general formula (I).Type: GrantFiled: March 31, 2017Date of Patent: July 28, 2020Assignee: FUJIFILM Wako Pure Chemical CorporationInventors: Kazuhiko Sato, Goro Mori, Hiromi Watahiki, Takahiro Kiyosu, Kuniaki Okamoto
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Patent number: 10711307Abstract: The invention relates to a method which is capable of determining, at an initial stage of differentiation, the differentiated state of undifferentiated stem cells. The invention provides a method for determining a differentiated state of a cell comprising detecting expression of FOXB2 gene of a stem cell, and determining the differentiated state based on the result, and a differentiation marker selected from mRNA or protein derived from the FOXB2 gene. The invention is applicable to quality management of the stem cells or to methods for preparation and isolation of the differentiated cells. Further, because the differentiated cells can be determined at an initial stage of culture, the invention is useful for an early stage screening of cells and for quality management of the stem cells, and reduction in culturing period and cost reduction in expenditure regarding a culture medium, or the like, can be expected.Type: GrantFiled: August 19, 2015Date of Patent: July 14, 2020Assignee: FUJIFILM WAKO PURE CHEMICAL CORPORATIONInventor: Yukinobu Hayashida
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Patent number: 10696898Abstract: A reverse photochromic compound of the related art has difficulty in sensing light with a wavelength of 600 nm or greater in a visible light region which has been used for medical applications. Therefore, an object of the present invention is to provide a reverse photochromic compound and a polymer which have a high sensitivity to light having a wavelength of 600 nm or greater. The present invention relates to a compound and the like represented by the following general formula (1).Type: GrantFiled: January 31, 2018Date of Patent: June 30, 2020Assignees: FUJIFILM Wako Pure Chemical Corporation, NIHON UNIVERSITYInventors: Ryuzi Katoh, Masami Enoki, Kazuki Nemoto, Katsufumi Suzuki, Tetsuji Murase, Shigeaki Imazeki
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Publication number: 20200148765Abstract: An object of the present invention is to provide a novel molecule which has high specificity to CLDN-5 and recognizes an extracellular domain of CLDN-5. The object is achieved by an antibody which specifically recognizes a three-dimensional structure or a primary structure of an extracellular domain of a Claudin-5 protein.Type: ApplicationFiled: April 26, 2018Publication date: May 14, 2020Applicants: OSAKA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY, FUJIFILM Wako Pure Chemical CorporationInventors: Masuo KONDOH, Kiyohito YAGI, Takefumi DOI, Yoshiaki OKADA, Yosuke HASHIMOTO, Tatsuya SAWASAKI, Hiroyuki TAKEDA, Kohki ENDO, Maki TAMURA
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Publication number: 20200048723Abstract: The invention relates to a method for forming a complex of a substance having a sugar chain and a lectin having affinity with the sugar chain of the substance having a sugar chain. The method includes bringing a sample containing the substance having a sugar chain into contact with the lectin in the presence of a water-soluble polysaccharide having no N-acetylglucosamine or a water-soluble compound having a polysaccharide having no N-acetylglucosamine (polysaccharides according to the invention and to an enhancer for forming a complex of a substance having a sugar chain and a lectin having affinity with the sugar chain of the substance having a sugar chain, wherein the enhancer includes the polysaccharides according to the invention.Type: ApplicationFiled: March 20, 2018Publication date: February 13, 2020Applicant: FUJIFILM WAKO PURE CHEMICAL CORPORATIONInventors: Kenichiro YAMASHITA, Tomokazu ISHIKAWA, Tatsuo KUROSAWA
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Patent number: 10539553Abstract: Provided is a method for detecting a stem cell based on an undifferentiated sugar chain marker having a specific sugar chain structure, wherein the stem cell is detected by detecting podocalyxin contained in a culture supernatant or a lysate of cells by a “lectin-antibody sandwich method” using a combination of a lectin and an antibody and having high sensitivity, the method including steps of: contacting the culture supernatant or the lysate, a lectin capable of binding to a sugar chain represented by (Formula 1) or (Formula 2), and an antibody capable of binding to keratan sulfate to form a complex composed of the lectin, podocalyxin and the antibody; and detecting the complex. wherein R1 represents an OH group or any sugar chain and R2 represents an OH group or any sugar chain, protein, lipid, or another molecule. wherein R1 represents an OH group or any sugar chain and R2 represents an OH group or any sugar chain, protein, lipid, or another molecule.Type: GrantFiled: December 21, 2015Date of Patent: January 21, 2020Assignees: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, FUJIFILM WAKO PURE CHEMICAL CORPORATIONInventors: Hiroaki Tateno, Masaki Warashina, Masakazu Fukuda, Kazunari Hirayasu
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Patent number: 10513574Abstract: The present invention relates to: (1) a graft polymer that has a polyolefin (A) as the main chain, and a polymer (B) polymerized a dye (b) having a radical reactive functional group, in a side chain; (2) the graft polymer which is characterized in that the dye (b) having the radical reactive functional group is a cationic rhodamine derivative, a cationic triarylmethane-type dye derivative or a cationic cyanine-type dye derivative, having an ethylenically unsaturated group; (3) a colored resin consisting of the graft polymer; as well as (4) a method for producing the colored resin, which is characterized by mixing the polyolefin (A), the dye (b) having the radical reactive functional group, and the radical reaction initiator (C), and subjecting a radical reaction of the mixture; and the like.Type: GrantFiled: July 1, 2015Date of Patent: December 24, 2019Assignees: FUJIFILM WAKO PURE CHEMICAL CORPORATION, RHOMBIC CORPORATIONInventors: Tatsuhiko Kimura, Masayuki Tomida, Taeyeon Kim, Yosuke Suzuki, Masahiro Takano
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Patent number: 10513562Abstract: An object of the present invention is to provide a fragment antibody which can be conveniently produced as one having antigen-binding activity, and which has a greater ability to crystallize itself alone or as a complex with an antigen molecule than that of Fv-clasp (v1) even in a case where the fragment antibody is obtained in an E. coli expression system. The present invention relates to a fragment antibody including a complex of a peptide (VH(112C)-SARAH) in which an N-terminus of a SARAH domain is linked to a C-terminus of a heavy chain domain (VH region) of an antibody, and an amino acid residue of antibody residue 112 according to Chothia numbering scheme in the VH region is mutated to cysteine; and a peptide (VL-SARAH(37C)) in which an N-terminus of a SARAH domain is linked to a C-terminus of a light chain domain (VL region) of an antibody, and an amino acid residue at position 13 from the C-terminus in the SARAH domain is mutated to cysteine.Type: GrantFiled: November 7, 2017Date of Patent: December 24, 2019Assignees: FUJIFILM WAKO PURE CHEMICAL CORPORATION, OSAKA UNIVERSITYInventor: Junichi Takagi
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Patent number: 10451967Abstract: It is a subject of the present invention to provide an acid- and radical-generating agent which has high sensitivity to an active energy ray having a wavelength of around 300 to 450 nm, and can exert both high acid-generating performance and high radical-generating performance, and has heat resistance; and a method for generating an acid and a radical.Type: GrantFiled: November 21, 2014Date of Patent: October 22, 2019Assignee: FUJIFILM Wako Pure Chemical CorporationInventors: Nobuhiko Sakai, Kosuke Yanaba
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Patent number: 10450462Abstract: The present invention is to provide a colored composition having higher heat resistance compared with conventional colored compositions. The present invention further relates to: “a polymer having a monomer unit derived from a monomer which has (i) a cationic rhodamine derivative having, as an counter anion, an anion including an aryl group having an electron-withdrawing substituent and an anion group and (ii) an ethylenically unsaturated bond”, “a monomer which has (i) a cationic rhodamine derivative having, as an counter anion, an anion including an aryl group having an electron-withdrawing substituent and an anion group and (ii) an ethylenically unsaturated bond”, “a colored composition comprising the above-described polymer or the monomer”, and “a colored composition for a color filter comprising the above-described polymer or the monomer”.Type: GrantFiled: February 13, 2014Date of Patent: October 22, 2019Assignee: FUJIFILM WAKO PURE CHEMICAL CORPORATIONInventors: Yukihiko Shida, Taeyeon Kim, Tomotaka Totsuka, Masahiro Takano
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Patent number: 10439252Abstract: It is an object of the present invention to provide an electrochemical device having an electrolytic solution having high current density, as well as high safety, where dissolution and deposition of magnesium progress repeatedly and stably. Furthermore, the present invention relates to an electrolytic solution for an electrochemical device, comprising (1) a supporting electrolyte comprising a magnesium salt, and (2) at least one or more kinds of the compound represented by following general formula (I) (wherein n represents an integer of 0 to 6, and n pieces of R1 and n pieces of R2 each independently represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or a halogenoalkyl group having 1 to 6 carbon atoms.Type: GrantFiled: January 22, 2014Date of Patent: October 8, 2019Assignee: FUJIFILM Wako Pure Chemical CorporationInventors: Tsutomu Watahiki, Takahiro Kiyosu, Kazuhiko Sato, Goro Mori, Kuniaki Okamoto
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Base generator, base-reactive composition containing said base generator, and base generation method
Patent number: 10428014Abstract: The present invention relates to a compound represented by the general formula (A), a base generator comprising the compound, a base-reactive composition which comprises the base generator and a base-reactive compound, as well as a method for generating a base, etc.Type: GrantFiled: June 25, 2014Date of Patent: October 1, 2019Assignees: FUJIFILM Wako Pure Chemical Corporation, Tokyo University of Science FoundationInventors: Nobuhiko Sakai, Kosuke Yanaba, Koji Arimitsu