Patents Assigned to Fujisawa Pharmaceutical Co., Ltd.
  • Pyridazinone compound and pharmaceutical use thereof
    Publication number: 20040067955
    Abstract: A pyridazinone or pyridone compound of the following formula (I).
    Type: Application
    Filed: September 3, 2003
    Publication date: April 8, 2004
    Applicant: Fujisawa Pharmaceutical Co. Ltd.
    Inventors: Seiichiro Tabuchi, Hideo Tsutumi, Atsushi Akahane, Yoshinari Sato
  • Brain-protective agent
    Publication number: 20040063614
    Abstract: A brain-protective agent containing an NF-&kgr;B decoy. In brain diseases, the brain can be particularly effectively protected against brain disorders (for example, cerebral vasospasm following a subrachnoidal hemorrhage and apoptosis of the nerve cells following a cerebrovasucular accident or serious head injury) caused by the undesired activation of cytokines or cell adhesion factors which are regulated by NF-&kgr;B by administering the brain-protective agent containing an NF-&kgr;B decoy, i.e., a compound antadonistic specifically to a nucleic acid to which NF-&kgr;B binds.
    Type: Application
    Filed: October 3, 2003
    Publication date: April 1, 2004
    Applicant: Fujisawa Pharmaceutical Co. Ltd.
    Inventors: Shigeki Ono, Isao Date
  • Amide compounds
    Patent number: 6710043
    Abstract: This invention relates to amide compounds having the potentiation of the cholinergic activity and represented by formula (I) wherein R1 is acyl, R2 is lower alkyl, A is a single bond, —CO— or —SO2—, E is lower alkylene, X is CH or N, Y is a single bond, Q is —CH2— etc. and R3 and R4 are taken together to form lower alkylene etc., pharmaceutically acceptable salts and processes fro preparation thereof and a pharmaceutical composition comprising the same.
    Type: Grant
    Filed: July 10, 2001
    Date of Patent: March 23, 2004
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Akira Yamada, Satoshi Aoki
  • Supernatant liquid collector with balance weight forming function and centrifugal apparatus using the same
    Patent number: 6709378
    Abstract: Primaiy supernatant liquid collector 1 allows blood A to separate into a primary supernatant liquid B and red blood cells by leaving the blood A stationary for a prescribed period of time, and then it discharges the primary supernatant liquid B and physiological saline W in the same amount into a first treatment container 13 and a first balance container 14, respectively. Centrifuge 61 centrifuges the above primary supernatant liquid B using the first balance container 14 as a balance weight, and a secondary supernatant liquid in the first treatment container 13 is transferred to a second treatment container 109 by take-out device 91 and at the same time the physiological saline W in the same amount as the transferred secondary supernatant liquid is transferred from the first balance container 14 to a second balance container 110.
    Type: Grant
    Filed: April 1, 2002
    Date of Patent: March 23, 2004
    Assignees: Fujisawa Pharmaceutical Co., Ltd., Shibuya Kogyo Co., Ltd.
    Inventors: Shintaro Nishimura, Kazuyoshi Yajima, Satoshi Minoshima, Ichiro Matsunari, Hiroshi Myogan
  • Inducible high expression system
    Publication number: 20040053273
    Abstract: The present invention provides a vector containing a DNA construct containing a first promoter that is a nitrilase gene promoter, a multicloning site and a nitrilase transcription regulatory protein gene (particularly preferably a structural gene is ligated into a multicloning site and a second promoter is placed at the upstream of the nitrilase transcription regulatory protein gene), and the like. The present invention affords a high expression system capable of expressing a large amount of useful proteins by actinomycete host represented by actinomycete belonging to the genus Streptomyces and the like beneficially used for the production of useful proteins.
    Type: Application
    Filed: March 4, 2003
    Publication date: March 18, 2004
    Applicants: Michihiko KOBAYASHI, Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Michihiko Kobayashi, Yoshiteru Hashimoto, Hiroki Higashibata
  • Amide compounds for the potentiation of cholinergic activity
    Publication number: 20040048904
    Abstract: Amide compounds of the formula: 1
    Type: Application
    Filed: September 4, 2003
    Publication date: March 11, 2004
    Applicant: Fujisawa Pharmaceutical Co. Ltd.
    Inventors: Akira Yamada, Satoshi Aoki
  • Crystal forms of 3-(2,4-dichlorobenzyl)-2-methyl-n-(pentylsulfonyl)-3h-benzimidazole-5-carboxamide
    Patent number: 6703410
    Abstract: 3-(2,4-Dichlorobenzyl)-2-methyl-N-(pentylsulfonyl)-3H-benzimidazole-5-carboxamide, a compound having hypoglycemic activity or PDE5 inhibitory effect, has three forms of crystal forms that are distinguishable by their X-ray powder diffraction values. The most crystallographically stable crystal form is useful as a drug substance for medicines. Another crystal form can be purified efficiently by crystallization, since it forms larger crystals and can be very easily isolated by filtration. Thus this crystal form is useful for purifying 3-(2,4-Dichlorobenzyl)-2-methyl-N-(pentylsulfonyl)-3H-benzimidazole-5-carboxamide.
    Type: Grant
    Filed: September 13, 2001
    Date of Patent: March 9, 2004
    Assignees: Fujisawa Pharmaceutical Co., Ltd., Daicel Chemical Industries, Ltd.
    Inventors: Yoshiyuki Murai, Noritsugu Yamasaki, Takafumi Imoto, Masahiro Nishikawa, Kunihiko Dohtsu
  • Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
    Publication number: 20040029908
    Abstract: This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplanation, graft-versus-host diseases by medulla ossium transplanation, autoimmune diseases, infectious diseases, and the like, which can be represented by the formula: 1
    Type: Application
    Filed: May 1, 2003
    Publication date: February 12, 2004
    Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.
    Inventors: Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka
  • Amide compounds
    Publication number: 20040014745
    Abstract: This invention relates to new amide compounds having the potentiation of the cholinergic activity, etc., and represented by general formula [I].
    Type: Application
    Filed: July 15, 2003
    Publication date: January 22, 2004
    Applicant: Fujisawa Pharmaceutical Co. Ltd.
    Inventors: Akira Yamada, Satoshi Aoki
  • Aminoalcohol derivatives
    Publication number: 20040006143
    Abstract: The present invention relates to a compound formula [I]: 1
    Type: Application
    Filed: June 26, 2003
    Publication date: January 8, 2004
    Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.
    Inventors: Kouji Hattori, Yasuyo Tomishima, Masashi Imanishi
  • Medicinal compositions
    Patent number: 6673808
    Abstract: To provide a pharmaceutical composition comprising a macrolide compound, such as tricyclic compound (I) or its pharmaceutically acceptable salt, a dissolution/absorption promoter, a pharmaceutical base, and optionally a compatibilizing agent and/or a thickener. It is satisfactory in stability and absorption kinetics and/or a low irritation potential.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: January 6, 2004
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Rinta Ibuki, Fumio Shimojo, Satoshi Ueda, Toshihiko Toyoda, Masayuki Yamanaka, Erika Yoshida
  • Immunosuppressive imidazole derivatives and their combination preparations with tacrolimus or cyclosporins
    Patent number: 6673807
    Abstract: Methods for increasing graft survival time comprising administering the combination of a compound that inhibits the production of nitric oxide and a compound that is a tricyclic macrolide, such as tacrolimus.
    Type: Grant
    Filed: December 1, 2000
    Date of Patent: January 6, 2004
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Fumihiko Sakai, Harumi Yamazaki, Noboru Chida, Osamu Nakayama, Yoshihiro Yokota
  • Sustained-release formulation
    Publication number: 20030235614
    Abstract: Providing an oral formulation of a macrolide compound where the dissolution of the macrolide compound is under sustained release; and a sustained-release formulation containing a composition in solid solution, where the macrolide compound is present at an amorphous state in a solid base.
    Type: Application
    Filed: April 14, 2003
    Publication date: December 25, 2003
    Applicant: Fujisawa Pharmaceutical Co. Ltd.
    Inventors: Kazunari Yamashita, Eiji Hashimoto, Yukihiro Nomura, Fumio Shimojo, Shigeki Tamura, Takeo Hirose, Satoshi Ueda, Takashi Saitoh, Rinta Ibuki, Toshio Ideno
  • Tricyclo compounds, a process for their production and pharmaceutical composition containing the same
    Publication number: 20030229115
    Abstract: This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: 1
    Type: Application
    Filed: April 25, 2003
    Publication date: December 11, 2003
    Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.
    Inventors: Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka
  • Digital correlation of test samples and the screening of interactions between the same
    Patent number: 6662113
    Abstract: A method for determining the physical, chemical, or biological correlation between test samples in group A and test samples in group B. This correlation can be determined by contacting a mixture of test samples selected according to a certain rule from group A with test samples from group B to detect the interaction(s) between them. The number of reactions needed to detect these interaction(s) is greatly reduced by preparing a mixture of test samples in group A according to the principle of binary notation, and thus enables a rapid screening.
    Type: Grant
    Filed: November 23, 1999
    Date of Patent: December 9, 2003
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Nobuyoshi Shimizu, Shuichi Asakawa
  • 4.5-diaryloxazole compounds with prostaglandin I2 (PGI2) agonistic activity
    Patent number: 6660759
    Abstract: Heterocyclic compounds of formula (I), wherein R1 is carboxy or protected carboxy, R2 is aryl which may have suitable sustituent(s), R3 is aryl which may have suitable substituent(s), R4 is hydrogen, lower alkyl, hydroxy or aryl, A1 is lower alkylene, (a) is (b), etc., —A3— is (c), etc. and n is 0 or 1, and pharmaceutically acceptable salts thereof which are useful as a medicament.
    Type: Grant
    Filed: February 26, 2002
    Date of Patent: December 9, 2003
    Assignee: Fujisawa Pharmaceutical Co. Ltd.
    Inventors: Kouji Hattori, Akira Tanaka
  • Cyclic tetrapeptide compound and use thereof
    Patent number: 6656905
    Abstract: A cyclic tetrapeptide compound and use thereof.
    Type: Grant
    Filed: May 4, 2001
    Date of Patent: December 2, 2003
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Hiroaki Mori, Kazutoshi Sakamoto, Yasuhisa Tsurumi, Shigehiro Takase, Motohiro Hino
  • Bile secretagogues
    Publication number: 20030220269
    Abstract: The invention provides a choleretic composition, a bile acid secretion-promoting composition and a therapeutic composition for cholestasis each comprising insulin-like growth factor I or an analog thereof as well as a method of promoting secretion of bile which comprises administering insulin-like growth factor I or an analog thereof, a method of promoting secretion of bile acids, and a method for therapy of cholestasis in mammals.
    Type: Application
    Filed: May 27, 2003
    Publication date: November 27, 2003
    Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.
    Inventors: Mariko Ota, Ikuo Kawamura, Toshitaka Manda
  • Pharmaceutical composition
    Publication number: 20030220237
    Abstract: A pharmaceutical composition comprising:
    Type: Application
    Filed: April 8, 2003
    Publication date: November 27, 2003
    Applicant: Fujisawa Pharmaceutical Co. Ltd.
    Inventors: Chika Ohnaka, Mayumi Nakai
  • Remedies for intractable wound
    Publication number: 20030207432
    Abstract: This invention provides a therapeutic drug for refractory injuries, comprising a substance having a human leucocyte elastase inhibitory activity as an effective ingredient.
    Type: Application
    Filed: May 7, 2003
    Publication date: November 6, 2003
    Applicant: Fujisawa Pharmaceutical Co., Ltd.,
    Inventors: Shoji Takakura, Kyoko Minoura