Abstract: The present invention provides methods of using antibodies that bind a TSG101 protein to inhibit or reduce viral production. The invention also provides methods of using the TSG101 antibodies for the treatment of viral infections, including HIV infection. The invention further provides methods of detecting viral infected cells using TSG101 antibodies.

Abstract: The present invention relates generally to the field of molecular biology and concerns a method for enhancing various economically important yield-related traits in plants. More specifically, the present invention concerns a method for enhancing yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding an IAA2-like (auxin/indoleacetic acid 2 like) polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding IAA2-like polypeptide, which plants have enhanced yield-related traits relative to control plants. The invention also provides constructs comprising IAA2-like-encoding nucleic acids, useful in performing the methods of the invention. The present invention also relates generally to the field of molecular biology and concerns a method for improving various plant growth characteristics by modulating expression in a plant of a nucleic acid encoding a NAC10-like polypeptide.

Abstract: Disclosed are methods for regulating neurotrophin levels within a human body. The invention utilizes an implantable signal generator to deliver stimulation to neural tissue elements. Alternatively, an implantable pump may be utilized to delivery one or more drugs. The implanted device delivers treatment therapy to the neural tissue to thereby alter the level of neurotrophic factors such as BDNF expressed by the influenced neural tissue. A sensor may be used to detect various symptoms of a nervous system disorder. A microprocessor algorithm may then analyze the output from the sensor to regulate the treatment therapy delivered to the body. The invention describes a novel method to regulate the intrinsic levels of neurotrophins and may be used to treat patients with neurological and cognitive disorders.

Abstract: A self-calibrating current sensor for sensing the state of the current passing through a load line enclosed within a housing comprises a sensor disposed adjacent the load line for sensing a current passing through the load line, the sensor having an output at which a signal indicative of the level of current passing through the load line is present, the sensor being positioned with the housing, a binary input circuit configured to generate at least one binary signal, the binary input circuit being configured to change the level of the at least one binary signal without the need of opening the housing, and a controller circuit having a first input coupled to the output of the sensor for receiving the signal indicative of the level passing through the supply line and having a second input coupled to the binary input circuit for receiving the at least one binary signal, the controller being configured to provide a signal indicative of the status of the current in the load line on an output.

Abstract: The invention comprises systems and methods for treating nociceptive pain including at least one force-regulatable device in mechanical, electrical, or chemical communication with at least one brain area identified as processing nociceptive pain signals. The force-regulatable device acts to alter the nociceptive pain signals in a brain area to alleviate nociceptive pain.

Abstract: Methods and apparatus for improving cognitive function within a human. The invention utilizes an implanted device, such as an implantable signal generator or an implantable pump, to affect tissue elements within a Papez circuit of the human brain as well as tissue upstream or downstream from the Papez circuit. The implanted device delivers treatment therapy to thereby improve cognitive function by the human. A sensor may be used to detect various symptoms of the cognitive disorder. A microprocessor algorithm may then analyze the output from the sensor to regulate delivery of the stimulation and/or drug therapy.

Abstract: Disclosed are methods for regulating neurotrophin levels within a human body. The invention utilizes an implantable signal generator to deliver stimulation to neural tissue elements. Alternatively, an implantable pump may be utilized to delivery one or more drugs. The implanted device delivers treatment therapy to the neural tissue to thereby alter the level of neurotrophic factors such as BDNF expressed by the influenced neural tissue. A sensor may be used to detect various symptoms of a nervous system disorder. A microprocessor algorithm may then analyze the output from the sensor to regulate the treatment therapy delivered to the body. The invention describes a novel method to regulate the intrinsic levels of neurotrophins and may be used to treat patients with neurological and cognitive disorders.

Abstract: The present invention is directed to an ergonomic exercise sash which is contoured to fit a torso of a user. Weight members may be placed in a plurality of pockets of the sash to increase the resistance and intensity of exercise.

Abstract: The present invention provides a novel water-soluble keratin derivative and applications thereof. Water-soluble keratin produced by the alkali treatment of feathers, and modified keratin, gives the following useful materials: (1) a high energy wave absorber, (2) a luminescent substrate, (3) a material weatherproofness improver, (4) a water repellant, and (5) a foaming agent.

Abstract: The present invention relates to transcriptional control sequences derived from GL9 genes, wherein the transcriptional control sequences direct specific or preferential expression of an operably connected nucleotide sequence of interest in one or more parts of a plant seed.

Abstract: The importance of interaction between TSG101 and Vps28 in the release of HIV-1 and other viruses is disclosed. Suppressing or interfering in this interaction may inhibit HIV-1 virion release from infected cells. Agents that modulate this interaction include antibodies that bind to Vps28, polypeptides that bind to Vps28, and nucleic acids that may be used in gene therapy to interfere with the expression of wild type Vps28. Administration of such agents in vitro for screening and diagnostic purposes, and in vivo for diagnostic and therapeutic purposes, is disclosed.

Abstract: A method of selectively inhibiting or driving neural discharge or activity in or from a specific brain area One embodiment of a system and/or method directed toward affecting neurologic function may apply conditioning stimuli to a set of target neural populations. The conditioning stimuli are intentionally timed to occur within an inhibitory time domain or a facilitatory time domain relative to intrinsic neural activity associated with a target neural population. The application of a conditioning stimulus within an inhibitory or facilitatory time domain relative to the occurrence of an intrinsic neural discharge may respectively diminish or enhance an outcome associated with the neural discharge. In one embodiment, conditioning stimuli may be produced by a pulse generator coupled to an electrode that is implanted relative to the location of a target neural population.

Abstract: The invention provides for inhibition of viral disease by the provision to a mammalian host of antibodies directed against an escort protein likeTsg 101. These proteins appear on the surface of a cell, and thus can be bound by circulating antibodies thereto. By binding escort proteins on the cell surface, budding of viral particles is inhibited. The virus infects the initial cells, but cannot escape that cell to infect the body en masse.

Abstract: Caspace inhibition provides inhibition of viral infection across a wide collection of caspaces and viruses. Caspace inhibition, the prevention of the formation of active caspaces, can be achieved either through gene therapy, protein binding an inhibition, or through small molecule administration. Examples for small molecule inhibition allow the formation of a pharmacaphore to identify more and more active small molecules.

Abstract: A composite moldable splint having at least a first splinting member with an inner foam layer, an intermediate thermoplastic layer, and an external securing layer. The inner foam layer provides a soft, moisture transmitting, non-latex padding. The intermediate thermoplastic layer provides remoldable shape, and rigidity and strength after heat forming and cooling. The outer securing layer, preferably covered with continuous loop fabric suitable for hook and loop fastening, provides an essentially infinite plurality of attachment points for retaining straps including at least a section of hook fastening material for holding the splint in place. The layers of the composite moldable splint are preferably heat welded to form a strong unitary structure that is resistant to delamination. Composite moldable splints utilizing multiple splinting members are described.

Abstract: The invention comprises systems and methods for treating nociceptive pain including at least one force-regulatable device in mechanical, electrical, or chemical communication with at least one brain area identified as processing nociceptive pain signals. The force-regulatable device acts to alter the nociceptive pain signals in a brain area to alleviate nociceptive pain.

Abstract: A charging/discharging device having at least one concealed universal serial bus (USB) plug has a housing having at least one plug hoe, and at least one retractable plug assembly mounted in the housing. Each of the at least one retractable plug assembly has a slidable second circuit board, a resilient element pushing the second circuit board toward a corresponding one of the plug hole of the housing, a USB plug mounted on the second circuit board and corresponding to the corresponding plug hole of the housing, and a locker mounted through and selectively engaging the second circuit board to prevent the second circuit board from sliding when the USB plug is stored in or protrudes out of the housing. Therefore, since the USB plug is able to be concealed in the housing, the USB plug is not damaged.