Abstract: The present invention provides antibodies that bind to the C-terminal region of TSG101. The invention also provides methods of using the TSG101 antibodies for the treatment of viral infections, including HIV and Ebola virus infection.

Abstract: The invention reflects enhanced antibody expression of an antibody of interest by cell lines transformed by random homozygous gene perturbation methods to either increase or decrease the expression pattern of a gene of the cell line other than the antibody of interest. The transformed cell line exhibits specific productivity rates, SPR, for the RHGP transformed cell liens of 1.5 or more, as compared with the antibody expressing cell line parents prior to transformation by RHGP. A knock out or anti-sense construct may be devised to reduce expression of the target gene, a promoter may be inserter to enhance expression of the target gene. The antibodies expressed by the transformed cell lines exhibit the binding properties of their parent cell lines prior to transformation with RHGP, and increase Total Volumetric Production of said antibody by said cells in a given volume.

Abstract: For measuring a brain local activity, a predetermined frequency bandwidth wider than a frequency bandwidth of alpha waves of scalp potentials is divided into a predetermined number of frequency banks each having a fixed frequency width, data of each divided frequency bank is divided into segments of a predetermined duration on a time axis, a Z-score of the subject is determined from a first mean value of normalized power variances determined for the segments and a second mean value of normalized power variances predetermined in the same manner as the first mean value for a predetermined normal person group and a standard deviation of the normalized power variances in the group, and a mean value of the Z-scores determined over all of the frequency banks is mapped on a brain surface for each sensor, whereby a template of a specified brain disorder and likelihood of a subject to a specified brain disorder are calculated.

Abstract: The present invention provides methods for identifying peptides in a mammalian. Tsg101 protein that binds to the PTAPP (SEQ ID NO: 3) motif or L domain of human immunodeficiency virus type I (HIV-1). Such peptides can be used to inhibit Tsg101-HIV Gag binding, and is therefore effective in reducing HIV particle production. The invention also provides the peptides identified by the method of the invention and to method of using such peptides for treating HIV infection.

Abstract: A carbon-fiber-reinforced SiC composite having a high tensile strength is produced by impregnating a carbon-fiber-reinforced carbon composite with melted metal Si. The carbon-fiber-reinforced carbon composite includes carbon fibers that are pitch-based short carbon fibers. The pitch-based short carbon fibers are oriented in two-dimensional random directions. The carbon-fiber-reinforced carbon composite has a bulk density of 1.2 to 1.7 g/cm3, a porosity of 15 to 40 vol %, and a carbon fiber volume content of 20 to vol %.

Abstract: A method of manufacturing microneedles is provided, the method includes (i) depositing a substance onto a first surface and (ii) forming a solid needle-like shape from the substance. The substance may be deposited in non-solid form and subsequently solidified. A method provides an array of such microneedles.

Abstract: A sliding material consisting of a carbon-fiber reinforced carbon composite material containing fine particles of a simple substance of any of Group IV to Group VI elements or a carbide, a nitride or an oxide thereof.

Abstract: The present invention provides methods of using antibodies that bind a TSG101 protein to inhibit or reduce viral production. The invention also provides methods of using the TSG101 antibodies for the treatment of viral infections, including HIV infection. The invention further provides methods of detecting viral infected cells using TSG101 antibodies.

Abstract: A method is provided for fortifying a seed, grain, nut, bean, or the like with an essential fatty acid such as docosahexaenoic acid or eicosapentaenoic acid. Using the method, it is possible to produce seeds that can be used as a dietary source of that essential fatty acid. A seed that has been soaked in an aqueous mixture containing an essential fatty acid so as to become fortified with the fatty acid, and a food product formed using the seed are also provided.

Abstract: A process for producing a continuous alumina fiber blanket by heat treating an alumina fiber precursor formed from a spinning solution containing an aluminum compound, by using a specific high-temperature furnace capable of high-temperature-heat treatment. According to this process, a continuous sheet (W) of alumina fiber precursor formed from a spinning solution containing an aluminum compound is supplied continuously into a high-temperature furnace and subjected to heat treatment while being conveyed in one direction by plural conveying mechanisms (2, 3) disposed in said high-temperature furnace. In this operation, the speed of said conveying mechanisms is reduced progressively in the direction of conveyance in correspondence to the rate of heat shrinkage of the continuous sheet (W) of alumina fiber precursor, thereby to lessen fiber crush in the alumina fiber precursor and obtain a continuous alumina fiber blanket with uniform thickness and high bulk density as well as high strength.

Abstract: The present invention provides antibodies that bind to the C-terminal region of TSG101. The invention also provides methods of using the TSG101 antibodies for the treatment of viral infections, including HIV and Ebola virus infection.

Abstract: A device (10) provides for transport of material across or into a biological barrier (2), the device includes a puncturing projection (11c) associated with a first portion of a substrate (1), the first portion of the substrate being movable between a first substrate position in which, in use, the puncturing projection is in puncturing contact with the biological barrier so as to form a flow path for said material across or into said biological barrier and a second substrate position in which, in use, the puncturing projection is at least partially retracted from the first position, wherein the substrate is resiliently deformable or displaceable from the first to the second substrate position by a biasing device associated with the substrate.

Abstract: The invention provides for inhibition of viral disease by the provision to a mammalian host of antibodies directed against an escort protein likeTsg 101. These proteins appear on the surface of a cell, and thus can be bound by circulating antibodies thereto. By binding escort proteins on the cell surface, budding of viral particles is inhibited. The virus infects the initial cells, but cannot escape that cell to infect the body en masse.

Abstract: The present invention relates to a vascular plant including cells expressing a Na+ pumping ATPase.

Abstract: A brain stimulation lead such as a deep brain stimulation (DBS) lead is provided, which lead can also be used to create lesions safely and effectively due to inclusion of temperature sensing. The generating of radio-frequency (RF) lesions via a brain stimulation lead provides a new treatment option, for instance, when hardware-related or other complications necessitate lead removal. An existing implanted DBS lead was used to create lesions in the thalamus and subthalamus of patients with movement disorders. Various brain stimulation leads with temperature sensors are described. Various methods are disclosed, including creation of a lesion with a brain stimulation lead while sensing temperature with a sensor implanted as part of the lead or with a noninvasive sensing device. Another method includes creating a graduated lesion with a brain stimulation lead of the invention or with a chronic lesioning lead.

Abstract: Methods of increasing the amount of one or more functional compounds in medicinal mushroom biomass and mushroom mycelia by growing the mushrooms on a substrate that is high in the functional compound or compounds of interest is provided. More specifically, a method of increasing the amount of anthocyanins in mushrooms is provided. Mushrooms are grown on a substrate rich in anthocyanins, such as purple corn or other suitable red, purple or black-pigmented substrate, and incorporate the anthocyanins during growth. Mushrooms grown by this method, as well as methods of improving the growth rate and potency of mushrooms, are also provided.

Abstract: A foldable floor heating panel can be folded longitudinally and laterally. The foldable floor heating panel includes several small plate-like members of a rectangular plan configuration, which are arranged longitudinally and laterally so as to be adjacent to each other. A flexible thin plate is attached to upper surfaces of the small plate-like members so as to allow longitudinal and lateral folding. Heat carrier flexible tube passages are provided in longitudinal and lateral folding portions of the panel so as to leave some play, and folding margin members are provided at the lateral folding portions. Fit-in members are attachably and detachably provided in respective heat carrier flexible tube passages with some play.

Abstract: The present invention provides a novel water-soluble keratin derivative and applications thereof. Water-soluble keratin produced by the alkali treatment of feathers, and modified keratin, gives the following useful materials: (1) a high energy wave absorber, (2) a luminescent substrate, (3) a material weatherproofness improver, (4) a water repellant, and (5) a foaming agent.