Patents Assigned to FUND OF THE TEL AVIV MEDICAL CENTER
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Publication number: 20210187039Abstract: A method of producing an implant for fecal transplant (FT), including: introducing fecal materials into a container, and processing the fecal materials to a smaller size in the container. According to some embodiments, the container is in ambient conditions, and the processing in the container includes non-ambient conditions. Optionally, the non-ambient conditions include an atmosphere having at most 18% of O2. Optionally, the method includes adding a liquid into the container, the liquid including a preservative material. Optionally, the liquid includes between 10% to 30% glycerol by volume. Optionally, the method includes sealing the container with a sealing lid after the introducing, and processing the fecal materials in the sealed container. Optionally, the processing of the fecal materials includes cutting the fecal materials by a cutting element to increase an exposed surface area of the fecal materials.Type: ApplicationFiled: August 20, 2019Publication date: June 24, 2021Applicants: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center, Fund for Medical Research Development of Infrastructure & Health Services by Barzilai Medical CenterInventors: Arie FELDMAN, Nitsan MAHARSHAK, David GALES
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Publication number: 20210187258Abstract: Described embodiments include apparatus (28) that includes a shunt (26). The shunt includes a flared distal portion (40), a flared proximal portion (44), and an intermediate portion (42), disposed between the distal portion and the proximal portion. The apparatus further includes a constricting flexible longitudinal element (38) passing circumferentially along the intermediate portion of the shunt, configured to constrict the intermediate portion of the shunt, and one or more proximal-portion-collapsing flexible longitudinal elements (36) configured to collapse the proximal portion of the shunt. Other embodiments are also described.Type: ApplicationFiled: March 4, 2021Publication date: June 24, 2021Applicants: The Medical Research, Infrastructure And Health Services Fund Of The Tel-Aviv Medical Center, V-Wave Ltd.Inventor: Gad KEREN
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Publication number: 20210169395Abstract: A system and method are presented for use in monitoring brain activity of a subject. The system comprises a control unit which comprises: a data input utility for receiving measured data comprising data corresponding to signals measured during a certain time period and being indicative of a subject's brain activity originated from locations in the subject's brain during said certain time period, and a processor utility which is configured and operable for processing the measured data and generating data indicative thereof in the form of a multi-parameter function presenting a relation between frequency and time data of the measured signals and for analyzing said relation and identifying a subject-related signature corresponding to the subject's brain neural activity.Type: ApplicationFiled: November 23, 2020Publication date: June 10, 2021Applicant: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Talma HENDLER, Nathan INTRATOR, Ilana KLOVATCH, Sivan KINREIH, Yehudit MEIR-HASSON
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Publication number: 20210161430Abstract: Methods and/or systems for diagnosing, monitoring and/or treating persons at risk for falling and/or other pathological conditions. In an exemplary embodiment of the invention, people are diagnosed before they actually start falling. Optionally, the diagnosis includes trying out and identifying one or more fall triggers using virtual reality tools. Optionally or alternatively, treatment includes training the persons using situations and/or triggers which are determined to be relevant for that person.Type: ApplicationFiled: February 8, 2021Publication date: June 3, 2021Applicant: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Anat MIRELMAN, Jeffrey M. HAUSDORFF, Nir GILADI
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Patent number: 10945641Abstract: Methods and/or systems for diagnosing, monitoring and/or treating persons at risk for falling and/or other pathological conditions. In an exemplary embodiment of the invention, people are diagnosed before they actually start falling. Optionally, the diagnosis includes trying out and identifying one or more fall triggers using virtual reality tools. Optionally or alternatively, treatment includes training the persons using situations and/or triggers which are determined to be relevant for that person.Type: GrantFiled: October 9, 2012Date of Patent: March 16, 2021Assignee: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Anat Mirelman, Jeffrey M. Hausdorff, Nir Giladi
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Patent number: 10940296Abstract: Described embodiments include apparatus (28) that includes a shunt (26). The shunt includes a flared distal portion (40), a flared proximal portion (44), and an intermediate portion (42), disposed between the distal portion and the proximal portion. The apparatus further includes a constricting flexible longitudinal element (38) passing circumferentially along the intermediate portion of the shunt, configured to constrict the intermediate portion of the shunt, and one or more proximal-portion-collapsing flexible longitudinal elements (36) configured to collapse the proximal portion of the shunt. Other embodiments are also described.Type: GrantFiled: May 5, 2016Date of Patent: March 9, 2021Assignees: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center, V-Wave Ltd.Inventor: Gad Keren
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Patent number: 10893822Abstract: A system and method are presented for use in monitoring brain activity of a subject. The system comprises a control unit which comprises: a data input utility for receiving measured data comprising data corresponding to signals measured during a certain time period and being indicative of a subject's brain activity originated from locations in the subject's brain during said certain time period, and a processor utility which is configured and operable for processing the measured data and generating data indicative thereof in the form of a multi-parameter function presenting a relation between frequency and time data of the measured signals and for analyzing said relation and identifying a subject-related signature corresponding to the subject's brain neural activity.Type: GrantFiled: February 2, 2012Date of Patent: January 19, 2021Assignee: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Talma Hendler, Nathan Intrator, Ilana Klovatch, Sivan Kinreih, Yehudit Meir-Hasson
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Publication number: 20200408761Abstract: A method of diagnosing high grade bladder cancer is provided. The method comprising detecting in a urine sample of a subject in need thereof expression of CD24, wherein an increase in said expression of CD24 above a predetermined threshold as compared to a control sample is indicative of said high grade bladder cancer.Type: ApplicationFiled: February 28, 2019Publication date: December 31, 2020Applicant: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Nadir ARBER, Shiran SHAPIRA, Dina KAZANOV
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Patent number: 10729815Abstract: A combined treatment for nerve injury is provided. Accordingly there is provided a composition comprising a hyaluronic acid, a laminin polypeptide, an antioxidant and an anti-gliotic agent. Also provided are matrices and hydrogels of the composition and methods of using same.Type: GrantFiled: November 29, 2017Date of Patent: August 4, 2020Assignees: Ramot at Tel-Aviv University Ltd., The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Shimon Rochkind, Zvi Nevo
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Publication number: 20200174004Abstract: A method of diagnosing a cancer or a pre-malignant lesion is disclosed. The method comprising determining a level of expression of CD24 on leukocytes comprised in a biological sample of a subject, wherein a level of CD24 on small leukocytes and not on large leukocytes above a predetermined threshold is indicative of the cancer or the pre-malignant lesion. A method of monitoring efficacy of cancer therapy and a kit for diagnosing a cancer or a pre-malignant lesion are also disclosed.Type: ApplicationFiled: May 21, 2018Publication date: June 4, 2020Applicant: The Medical Research, Infratructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Nadir ARBER, Shiran SHAPIRA, Diana KAZANOV
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Publication number: 20200170548Abstract: A method of gait data collection, the method comprising collecting movement data, determining from the data a movement parameter that includes a third order derivative of position, comparing the movement parameter with a threshold value, and counting at least a near fall if the movement parameter exceeds the threshold value.Type: ApplicationFiled: February 3, 2020Publication date: June 4, 2020Applicant: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Jeffrey M. HAUSDORFF, Nir GILADI
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Patent number: 10639350Abstract: Provided are methods of improving wound healing in a subject by administering a therapeutically effective amount of CD24. Also provided are pharmaceutical compositions which comprise CD24 being in a formulation with a surfactant and a pharmaceutically acceptable carrier.Type: GrantFiled: August 10, 2016Date of Patent: May 5, 2020Assignee: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Nadir Arber, Shiran Shapira, Dina Kazanov
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Publication number: 20200121200Abstract: A method and system are provided for continuous monitoring perfusion of an organ or extremity, and for early detection of progressive partial occlusion of arterial blood supply or venous drainage of tissue. The method and system measure a delay in wave propagation of a blood perfusion wave, which is associated with flow of blood through a blood vessel. The delay is correlated to an amount of obstruction in the blood vessel.Type: ApplicationFiled: June 26, 2018Publication date: April 23, 2020Applicants: The Medical Research Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Amir Landesberg, Amit Livneh, Yehuda Wolf
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Publication number: 20200071669Abstract: Methods of culturing T cells are provided. Accordingly there is provided a method of culturing T cells comprising culturing T cells in the presence of a T cell stimulator, an exogenous CCL21 and an exogenous ICAM1, thereby culturing the T cells. Also provided are cell cultures, isolated T cells and uses of same.Type: ApplicationFiled: March 2, 2018Publication date: March 5, 2020Applicants: Yeda Research and Development Co. Ltd., The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Benjamin GEIGER, Nir FRIEDMAN, Shimrit LIEBER, Zelig ESHHAR, Tova WAKS, An at GLOBERSON LEVIN
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Publication number: 20200046680Abstract: This invention provides small organic molecules useful as therapeutics of neurodegenerative diseases. Small organic molecules that act as inhibitors of bone morphogenetic proteins (BMPs) are useful in the treatment of neuroinflammatory disorders, in particular multiple sclerosis.Type: ApplicationFiled: April 26, 2018Publication date: February 13, 2020Applicant: THE MEDICAL RESEARCH, INFRASTRUCTURE AND HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENTERInventor: Arnon KARNI
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Patent number: 10548512Abstract: A method of gait data collection, the method comprising collecting movement data, determining from the data a movement parameter that includes a third order derivative of position, comparing the movement parameter with a threshold value, and counting at least a near fall if the movement parameter exceeds the threshold value.Type: GrantFiled: June 24, 2010Date of Patent: February 4, 2020Assignee: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Jeffrey M. Hausdorff, Nir Giladi
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Publication number: 20200022895Abstract: The invention provides a method for skin expansion utilizing at least one polymer.Type: ApplicationFiled: July 19, 2018Publication date: January 23, 2020Applicant: The Medical Research, Infrastructure, and Health Services Fund of the Tel Aviv Medical CenterInventors: Amir INBAL, Andrew GREENSMITH, Nir SHANI
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Publication number: 20190329063Abstract: A method for modifying the effect of a drug by application of an activation protocol, comprising: administering a drug according to a treatment protocol; applying an activation protocol in a timed relationship to the administering, for differentially activation of at least one selected brain region; wherein the differentially activation allows the drug to selectively interact with the at least one selected brain region.Type: ApplicationFiled: December 21, 2017Publication date: October 31, 2019Applicant: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Talma HENDLER, Gal RAZ, Roy Itzhak SAR-EL
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Publication number: 20190117846Abstract: A combined treatment for nerve injury is provided. Accordingly there is provided a composition comprising a hyaluronic acid, a laminin polypeptide, an antioxidant and an anti-gliotic agent. Also provided are matrices and hydrogels of the composition and methods of using same.Type: ApplicationFiled: November 29, 2017Publication date: April 25, 2019Applicants: Ramot at Tel-Aviv University Ltd., The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Shimon ROCHKIND, Zvi NEVO
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Patent number: 10265412Abstract: The present invention relates in general to the field of enzyme replacement therapy, and specifically to chimeric proteins including protein hormone-therapeutic protein conjugates and fusion proteins, wherein the protein hormone is selected from a protein hormone which is able to cross the blood brain barrier, for the treatment of lysosomal storage diseases, compositions of the same and to methods of use thereof.Type: GrantFiled: February 6, 2007Date of Patent: April 23, 2019Assignees: Ramot at Tel-Aviv University Ltd., Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science, The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Naftali Stern, Ruth Navon, Anthony Futerman, Ari Zimran, Etty Osher