Patents Assigned to FUND OF THE TEL AVIV MEDICAL CENTER
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Publication number: 20140303508Abstract: A method and system for provoking gait disorders, such as freezing of gait; usable, for example, for diagnosing and/or treatment thereof. In an exemplary embodiment of the invention, displays of situations calculated to cause freezing of gait are presented to a subject, optionally using virtual reality displays. Optionally or alternatively, incipit freezing of gait is identified using changes in gait parameters, and optionally used to guide attempts at causing freezing of gait. Optionally or alternatively, a portable device is provided which detects incipit freezing of gait and generates a corrective signal to the subject.Type: ApplicationFiled: October 9, 2012Publication date: October 9, 2014Applicant: The Medical Research, Infrastructure and Health Service Fund of the Tel Aviv Medical CenterInventors: Meir Plotnik-Peleg, Jeffrey M. Huasdorff, Nir Giladi, Anat Mirelman
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Publication number: 20140257462Abstract: Methods of supporting a vein, featuring deforming a vein support while being mounted on the vein. Such deformation may be sufficient to impose thereupon a plastic deformation that alters a length of the vein support, from a pre-deformation relaxed length to a post-deformation relaxed length different than the pre-deformation relaxed length. Following the plastic deformation, the vein support may maintain a new shape relative to a longitudinal axis thereof.Type: ApplicationFiled: May 25, 2014Publication date: September 11, 2014Applicants: Vascular Graft Solutions Ltd., The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Eyal ORION, Yehuda Bachar, Yanai Ben-Gal, Avraham Rapaport, Gilad Cibulski, Ronny Winshtein
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Patent number: 8785373Abstract: Methods and pharmaceutical compositions for the treatment of cancer or acute ischemia are provided. Also provided are methods of identifying agents capable of preventing the formation of or dissociating the MSF-A-HIF-1alpha protein complex, and methods of determining the prognosis of an individual having cancer by identifying the presence or absence of such a protein complex.Type: GrantFiled: February 6, 2012Date of Patent: July 22, 2014Assignee: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventor: Nicola J. Mabjeesh
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Patent number: 8741315Abstract: A method of treating cancer in an immune-privileged site of a subject in need thereof is provided. The method comprises systemically administering to an area outside the immune-privileged site of the subject, a therapeutically effective amount of naive, viable cells of a tumor of the subject, the tumor being in the immune-privileged site so as to generate an immune response in the subject, thereby treating the cancer in the immune-privileged site of the subject.Type: GrantFiled: September 11, 2008Date of Patent: June 3, 2014Assignees: Yeda Research and Development Co. Ltd., The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Ilan Volovitz, Lea Eisenbach, Irun R. Cohen, Zvi Ram, Shimon Slavin
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Publication number: 20140148657Abstract: A system and method are presented for use in monitoring brain activity of a subject. The system comprises a control unit which comprises: a data input utility for receiving measured data comprising data corresponding to signals measured during a certain time period and being indicative of a subject's brain activity originated from locations in the subject's brain during said certain time period, and a processor utility which is configured and operable for processing the measured data and generating data indicative thereof in the form of a multi-parameter function presenting a relation between frequency and time data of the measured signals and for analyzing said relation and identifying a subject-related signature corresponding to the subject's brain neural activity.Type: ApplicationFiled: February 2, 2012Publication date: May 29, 2014Applicants: RAMOOT AT TEL-AVIV UNIVERSITY LTD., The Medical Research,Ifrastructure,AndHealth Services Fund of the TEL AVIV MEDICAL CENTERInventors: Talma Hendler, Nathan Intrator, IIana Klovatch, Sivan Kinreih, Yehudit Meir-Hasson
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Patent number: 8734503Abstract: An external vein support comprising an elongate axial body including an axis, said body is plastically deformable by at least one of stretching, bending, twisting, and any combination thereof, relative to said axis.Type: GrantFiled: November 24, 2009Date of Patent: May 27, 2014Assignees: Vascular Graft Solutions Ltd., The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Eyal Orion, Yehuda Bachar, Yanai Ben-Gal, Avraham Rapaport, Gilad Cibulski, Ronny Winshtein
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Publication number: 20140031926Abstract: The invention provides a device (50) and system for treating a heart valve having an anchor (54, 56) and one or more sutures attached to the anchor. The anchor has an expanded deployed configuration and a low caliber undeployed configuration. A delivery in a heart includes catheter and a needle slidable in the lumen of the catheter. The distal end of the catheter is inserted through the myocardium of the heart until the catheter tip is juxtaposed to the underside of the valve leaflet to be treated. The leaflet is then pierced with tip of the needle. The needle is pushed until the anchor in its undeployed configuration passes through the needle tip and is released from the catheter. The anchor is then brought to its deployed configuration on one or both surfaces of the valve leaflet.Type: ApplicationFiled: April 4, 2012Publication date: January 30, 2014Applicant: The Medical Research, Infrastructure, and Health Services Fund of the Tel Aviv Medical CenterInventors: Nachman Kudlik, Demitry Pevnay
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Patent number: 8614301Abstract: Anti-CD24 antibodies and adjuvant combinations thereof with chemotherapeutic agents or toxins, which can be used to inhibit growth of CD24-expressing cancer cells and prevent and treat cancer are provided.Type: GrantFiled: November 13, 2008Date of Patent: December 24, 2013Assignee: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventor: Nadir Arber
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Patent number: 8597655Abstract: The present invention relates to a polynucleotide construct encoding a fusion protein consisting of a domain which binds the immunoglobulin Fc region, genetically fused to a truncated form of Pseudomonas exotoxin A (PE). In particular, the invention discloses the fusion protein, ZZ-PE38, and further provides immunotoxins, formed from complexes of the fusion protein with antibodies for targeted cell killing.Type: GrantFiled: September 22, 2011Date of Patent: December 3, 2013Assignees: Ramot at Tel-Aviv University Ltd., The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Itay Barnea, Itai Benhar, Rahamim Ben-Yosef, Akiva Vexler
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Publication number: 20120221090Abstract: Described is a removable shunt adapted for deployment along a brain-supplying artery into an aorta to supply blood to the artery during deployment of a stent-graft in the aorta, the removable shunt including a stiff segment that is stiff enough to remain at least partially open when between the aorta and the stent-graft and large enough to allow sufficient blood supply to the brain during the deployment of the stent-graft; and a mechanism for facilitating safe removal of the shunt from between the stent-graft and the aorta. Also described is a method of deploying a branch stent graft having a flaring portion in a blood vessel branching at a bifurcation from an aorta to connect to an aortic stent graft deployed in the aorta across the bifurcation, a branch stent-graft useful in the method, and a delivery system useful in the method.Type: ApplicationFiled: May 7, 2012Publication date: August 30, 2012Applicant: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventor: Yehuda G. WOLF
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Patent number: 8242076Abstract: A novel laminin polypeptide comprising the amino acid sequence set forth by SEQ ID NO:3 is disclosed. Also disclosed are compositions-of-matter comprising a polysaccharide (e.g., hyaluronic acid) and the novel laminin polypeptide; or hyaluronic acid, a laminin polypeptide and an antioxidant (e.g., superoxide dismutase), as well as matrices and hydrogels comprising same which can be used for ex vivo or in vivo tissue formation and for treatment of pathologies characterized by diseased, damaged or loss of tissue.Type: GrantFiled: August 13, 2008Date of Patent: August 14, 2012Assignees: Ramot at Tel-Aviv University Ltd., The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Shimon Rochkind, Zvi Nevo
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Patent number: 8211158Abstract: Described is a method for deploying a stent-graft in the aorta, the method including positioning a shunt to go along a portion of a brain-supplying artery (BSA) into the aorta; deploying a stent-graft in the aorta along a portion of the shunt; and removing the shunt. Also described is a removable shunt adapted for deployment along a brain-supplying artery into an aorta to supply blood to the artery during deployment of a stent-graft in the aorta, the removable shunt including a stiff segment that is stiff enough to remain at least partially open when between the aorta and the stent-graft and large enough to allow sufficient blood supply to the brain during the deployment of the stent-graft; and a mechanism for facilitating safe removal of the shunt from between the stent-graft and the aorta.Type: GrantFiled: November 19, 2007Date of Patent: July 3, 2012Assignee: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventor: Yehuda G. Wolf
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Publication number: 20120101411Abstract: A method of gait data collection, the method comprising collecting movement data, determining from the data a movement parameter that includes a third order derivative of position, comparing the movement parameter with a threshold value, and counting at least a near fall if the movement parameter exceeds the threshold value.Type: ApplicationFiled: June 24, 2010Publication date: April 26, 2012Applicant: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Jeffrey M. Hausdorff, Nir Giladi
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Publication number: 20120041544Abstract: A method of deploying a stent graft in a blood vessel with at least one side branch vessel, comprising: (a) forming a blood flow conduit between the branch vessel and the blood vessel such that a vessel section of the conduit is axially located inside the blood vessel and a branch section is positioned inside the branch vessel; (b) deploying the stent graft inside the blood vessel so that blood flow into said at least one side branch is blocked by the stent graft and continues through the blood flow conduit; (c) forming an opening suitable for allowing blood flow between the blood vessel and the branch vessel; and (d) interrupting blood flow in the vessel section of the conduit.Type: ApplicationFiled: April 1, 2010Publication date: February 16, 2012Applicant: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventor: Yehuda G. Wolf
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Publication number: 20110280832Abstract: The presently described subject matter is based on the finding that inhibition of eotaxin-2 by polyclonal or monoclonal antibodies, has a significant protective effect in animal models of inflammatory diseases such as rheumatoid arthritis, experimental autoimmune encephalomyelitis (EAE), colitis, diabetes, and atherosclerosis. Thus, provided are pharmaceutical compositions including specific anti-eotaxin 2 antibodies for use alone or in combination with other therapeutic agents in the treatment of inflammatory, autoimmune and cardiovascular diseases. Also provided are specific anti-eotaxin-2 monoclonal antibodies, and methods of treatment utilizing such antibodies.Type: ApplicationFiled: January 28, 2010Publication date: November 17, 2011Applicant: THE MEDICAL RESEARCH, INFRASTRUCTURE, AND HEALTH S ERNICES FUND OF THE TEL AVIV MEDICAL CENTERInventors: Jacob George, Gad Keren
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Publication number: 20110230955Abstract: An external vein support comprising an elongate axial body including an axis, said body is plastically deformable by at least one of stretching, bending, twisting, and any combination thereof, relative to said axis.Type: ApplicationFiled: November 24, 2009Publication date: September 22, 2011Applicants: Vascular Graft Solutions Ltd., The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Eyal Orion, Yehuda Bachar, Yanai Ben-Gal, Avraham Rapaport, Gilad Cibulski, Ronny Winshtein
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Patent number: 7994306Abstract: A method of treating a CD24-related medical condition is disclosed. The method comprises administering to a subject in need thereof at least one siRNA molecule selected from the group consisting of SEQ ID NO: 1 to 4. Pharmaceutical compositions comprising same are also disclosed.Type: GrantFiled: November 13, 2007Date of Patent: August 9, 2011Assignee: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Nadir Arber, Eyal Sagiv
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Patent number: 7985428Abstract: The present invention relates to pharmaceutical composition comprising animal venom and using same in a method for the treatment of Systemic Inflammatory Response Syndrome (SIRS) and related pathologies.Type: GrantFiled: August 16, 2005Date of Patent: July 26, 2011Assignee: The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical CenterInventors: Patrick Sorkine, Inna Froklis, Chaim Locker
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Publication number: 20110123522Abstract: Anti-CD24 antibodies and adjuvant combinations thereof with chemotherapeutic agents or toxins, which can be used to inhibit growth of CD24-expressing cancer cells and prevent and treat cancer are provided.Type: ApplicationFiled: November 13, 2008Publication date: May 26, 2011Applicant: THE MEDICAL RESEARCH, INFRASTRUCTURE, AND HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENTERInventor: Nadir Arber
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Publication number: 20110104225Abstract: A novel laminin polypeptide comprising the amino acid sequence set forth by SEQ ID NO:3 is disclosed. Also disclosed are compositions-of-matter comprising a polysaccharide (e.g., hyaluronic acid) and the novel laminin polypeptide; or hyaluronic acid, a laminin polypeptide and an antioxidant (e.g., superoxide dismutase), as well as matrices and hydrogels comprising same which can be used for ex vivo or in vivo tissue formation and for treatment of pathologies characterized by diseased, damaged or loss of tissue.Type: ApplicationFiled: August 13, 2008Publication date: May 5, 2011Applicants: Ramot At Tel Aviv University Ltd., The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Shimon Rochkind, Zvi Nevo